US20030088249A1 - Device for straightening and stabilizing the vertebral column - Google Patents
Device for straightening and stabilizing the vertebral column Download PDFInfo
- Publication number
- US20030088249A1 US20030088249A1 US10/286,458 US28645802A US2003088249A1 US 20030088249 A1 US20030088249 A1 US 20030088249A1 US 28645802 A US28645802 A US 28645802A US 2003088249 A1 US2003088249 A1 US 2003088249A1
- Authority
- US
- United States
- Prior art keywords
- pressure
- supporting implant
- implant
- fluid
- expandable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000087 stabilizing effect Effects 0.000 title claims abstract description 12
- 239000007943 implant Substances 0.000 claims abstract description 47
- 239000012530 fluid Substances 0.000 claims abstract description 27
- 230000006835 compression Effects 0.000 claims abstract description 4
- 238000007906 compression Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 8
- 238000012806 monitoring device Methods 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 description 4
- 239000011796 hollow space material Substances 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers, e.g. stabilisers comprising fluid filler in an implant
- A61B17/7097—Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/885—Tools for expanding or compacting bones or discs or cavities therein
- A61B17/8852—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc
- A61B17/8858—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc laterally or radially expansible
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00539—Surgical instruments, devices or methods pneumatically or hydraulically operated hydraulically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00557—Surgical instruments, devices or methods pneumatically or hydraulically operated inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/02—Surgical instruments, devices or methods for holding wounds open, e.g. retractors; Tractors
- A61B17/025—Joint distractors
- A61B2017/0256—Joint distractors for the spine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
- A61M2025/1004—Balloons with folds, e.g. folded or multifolded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/02—Bones
Definitions
- the present invention relates to a device for straightening and stabilizing the vertebral column, particularly for stabilizing broken vertebrae.
- Devices for straightening and stabilizing broken vertebrae are known to be used. These devices include a catheter which can be inserted into the interior of the vertebra through a duct drilled into the pedicle of the broken vertebra. A pressure line pushed through the catheter into the interior of the vertebra has at the end thereof an expandable pressure balloon which makes it possible to expand once again and return into its original shape a vertebra which has been compressed and possibly broken. The balloon which has subsequently been decompressed and pulled out together with the pressure line leaves a hollow space into which a bone filler material can be introduced through the catheter.
- the device for straightening and stabilizing the vertebral column is characterized by a supporting implant which is plastically expandable by internal pressure.
- Such a supporting implant which is preferably provided for being arranged in the interior of a vertebral body fractured under compression or also, for example, after an intervertebral disc resection for arrangement between adjacent vertebral bodies, can be easily moved to the implantation location because of its small dimensions. After the expansion has been effected, a preliminary stabilization is ensured immediately because the supporting implant maintains its final shape obtained during the plastic expansion.
- a filler material which is initially present in liquid form can be introduced under slight pressure into the created hollow space and can harden in the hollow space. Because of the action of the supporting implant, it is not necessary to wait until the filler material has hardened completely.
- a preferred embodiment of the invention provides for a device which produces the internal pressure by means of a pressure fluid.
- the pressure fluid can be introduced directly into the supporting implant, which requires that the supporting implant and the supply connections are pressure tight.
- a pressure balloon is provided which is arranged in the interior of the supporting implant and into which the pressure fluid can be introduced.
- the expandable supporting implant may include a weakened wall, or a wall which is perforated in the manner of expanded metal and/or folded in the manner of a bellows.
- This type of supporting implant can be expanded with relatively low internal pressure, wherein the stability of the expanded implant is reduced by the weakened or folded portions, however, the implant can still carry out a sufficient supporting function.
- the wall of the expandable supporting implant may have weak portions and/or folds arranged in such a way that the supporting implant expands into a desired shape. For example, if such a supporting implant is arranged between adjacent vertebrae, the desired shape is approximately that of a parallelepiped.
- the expandable supporting implant has an oblong shape so that it is suitable for being arranged at the implantation location by means of a catheter or a guide sleeve.
- the expandable supporting implant, and possibly the pressure balloon may be placed in the manner of a stocking on a pressure line which can be introduced through the guide sleeve, wherein the pressure balloon is arranged between the supporting implant and the pressure line and, in the non-expanded state, forms a hose-type sleeve which surrounds the pressure line and which is connected at its ends in a pressure-tight manner by being placed around the circumference of the pressure line.
- the pressure fluid is preferably not compressible, and a device for measuring the supplied amount of pressure fluid is provided. This makes it possible to control the degree of expansion through the supplied quantity.
- a monitoring device which monitors changes over time of the fluid pressure and the supplied fluid quantity so that the pressure application can be interrupted when predetermined relative values of these changes are exceeded.
- Such a monitoring device prevents fluid which is under high pressure from being released into the body when the supporting implant is destroyed, for example, as a result of a material defect.
- FIG. 1 is a schematic sectional view of a device according to the invention with a supporting implant placed on a pressure line;
- FIG. 2 is an illustration of a detail of the supporting implant of FIG. 1;
- FIG. 3 is an illustration, on a smaller scale, showing the device of FIG. 1 inserted into a broken and compressed vertebral body;
- FIG. 4 shows the vertebral body of FIG. 3 which has been expanded by means of the device of FIG. 1;
- FIG. 5 is an illustration of another embodiment of the supporting implant which can be used in a device of the invention.
- FIG. 1 of the drawing shows a guide sleeve 1 and a pressure line 2 extending through the guide sleeve 1 , wherein the pressure line 2 is provided with an opening 3 for releasing a pressure fluid.
- An elastic hose-type sheath 4 is placed in the manner of a stocking and flush at the ends thereof on the circular cylindrical pressure line 2 .
- the sheath 4 is glued in a pressure-tight manner at its ends to the circumference of the pressure line 2 at 5 and 6 .
- a hollow-cylindrical supporting implant 7 is placed around the elastic sheath 4 .
- the cylindrical wall 8 of the implant 7 is a mesh-like material with openings 9 , wherein wires of the mesh extend at an acute angle relative to each other.
- the wall 8 can be tangentially expanded in the manner of expanded metal in the direction of double arrow 21 , so that the supporting implant 7 is radially expanded.
- the pressure line 2 is in connection with a schematically illustrated device 10 for supplying an incompressible pressure fluid 11 , wherein this device 10 includes a pressure cylinder 12 and a piston 13 .
- the piston 13 may be movable manually, preferably by means of a screw-type pressure gauge, or by means of a motor drive.
- Reference numeral 14 denotes a schematically illustrated control and monitoring device which includes a pressure indicator 16 and a display 17 for the supplied quantity of pressure fluid.
- FIGS. 1 and 2 The manner of operation of the device is shown in FIGS. 1 and 2 and shall now be explained in connection with FIGS. 3 and 4.
- a duct 18 is drilled through the pedicle 20 , wherein a catheter and a drilling tool extending through the catheter can be used for this purpose.
- the guide sleeve 1 is now placed in the duct 18 and the pressure fluid 2 with the supporting implant 7 can be forwardly pushed into the interior of the compressed vertebra which has compression folds at 19 .
- the incompressible pressure fluid 11 is pressed by means of the device 10 into the pressure line 2 , the pressure fluid 11 emerges from the opening 3 and the elastic sheath 4 is expanded into a balloon.
- the expanding sheath or balloon 4 expands the supporting implant 7 , as illustrated in FIG. 4, wherein the wall 8 of the supporting implant 7 is plastically deformed in the direction of arrow 21 shown in FIG. 2 and the acute angles between the mesh wires at 17 are widened.
- the quantity of supplied pressure fluid during the expansion can be read at the display 17 of the control and monitoring device 14 and, thus, the extent of the achieved expansion can be determined.
- the expansion or supply of pressure fluid is stopped when a predetermined value of the supplied pressure fluid quantity has been reached.
- the control and monitoring device 14 further ensures that the application of pressure is stopped immediately if the balloon 4 ruptures during the expansion, for example, due to a material defect, and pressure fluid is released from the vertebra; this is the case when the supplied pressure fluid quantity increases significantly over time, while the pressure stays constant or increases only slightly.
- the pressure fluid is withdrawn through the opening 3 which is located near the lowest point of the balloon 4 .
- the pressure line 2 with the empty pressure balloon or the empty sheath 4 can now be pulled back through the guide sleeve 1 .
- the plastically deformed supporting implant 7 maintains its shape and supports the vertebra in such a way that it maintains the shape shown in FIG. 4 and the damage shown at 19 can heal.
- a filler material is introduced into the interior of the supporting implant.
- FIG. 2 is a cross-sectional view of another embodiment of a supporting implant 7 a according to the invention.
- the supporting implant 7 a has in its wall 8 a folds 22 , wherein the folds on opposite sides have different lengths, so that the expanded implant has a rectangular shape in cross-section.
- a salt solution containing an x-ray contrast agent is used as the pressure fluid.
- two of the above-described supporting implants can be and are usually inserted into a broken vertebra, wherein ducts are drilled in both pedicles for inserting a catheter.
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
- Fertilizers (AREA)
- Soil Working Implements (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/268,215 US8491591B2 (en) | 2001-11-03 | 2008-11-10 | Device for straightening and stabilizing the vertebral column |
| US13/924,881 US9295502B2 (en) | 2001-11-03 | 2013-06-24 | Device for straightening and stabilizing the vertebral column |
| US15/044,367 US9861401B2 (en) | 2001-11-03 | 2016-02-16 | Device for straightening and stabilizing the vertebral column |
| US15/833,011 US10357291B2 (en) | 2001-11-03 | 2017-12-06 | Device for straightening and stabilizing the vertebral column |
| US16/124,282 US11051862B2 (en) | 2001-11-03 | 2018-09-07 | Device for straightening and stabilizing the vertebral column |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10154163A DE10154163A1 (de) | 2001-11-03 | 2001-11-03 | Vorrichtung zum Aufrichten und Stabilisieren der Wirbelsäule |
| DE10154163.5 | 2001-11-03 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/268,215 Division US8491591B2 (en) | 2001-11-03 | 2008-11-10 | Device for straightening and stabilizing the vertebral column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20030088249A1 true US20030088249A1 (en) | 2003-05-08 |
Family
ID=7704603
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/286,458 Abandoned US20030088249A1 (en) | 2001-11-03 | 2002-11-01 | Device for straightening and stabilizing the vertebral column |
| US12/268,215 Expired - Fee Related US8491591B2 (en) | 2001-11-03 | 2008-11-10 | Device for straightening and stabilizing the vertebral column |
| US13/924,881 Expired - Fee Related US9295502B2 (en) | 2001-11-03 | 2013-06-24 | Device for straightening and stabilizing the vertebral column |
| US15/044,367 Expired - Lifetime US9861401B2 (en) | 2001-11-03 | 2016-02-16 | Device for straightening and stabilizing the vertebral column |
| US15/833,011 Expired - Fee Related US10357291B2 (en) | 2001-11-03 | 2017-12-06 | Device for straightening and stabilizing the vertebral column |
| US16/124,282 Expired - Fee Related US11051862B2 (en) | 2001-11-03 | 2018-09-07 | Device for straightening and stabilizing the vertebral column |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/268,215 Expired - Fee Related US8491591B2 (en) | 2001-11-03 | 2008-11-10 | Device for straightening and stabilizing the vertebral column |
| US13/924,881 Expired - Fee Related US9295502B2 (en) | 2001-11-03 | 2013-06-24 | Device for straightening and stabilizing the vertebral column |
| US15/044,367 Expired - Lifetime US9861401B2 (en) | 2001-11-03 | 2016-02-16 | Device for straightening and stabilizing the vertebral column |
| US15/833,011 Expired - Fee Related US10357291B2 (en) | 2001-11-03 | 2017-12-06 | Device for straightening and stabilizing the vertebral column |
| US16/124,282 Expired - Fee Related US11051862B2 (en) | 2001-11-03 | 2018-09-07 | Device for straightening and stabilizing the vertebral column |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US20030088249A1 (fr) |
| EP (1) | EP1308134B1 (fr) |
| JP (1) | JP2003180700A (fr) |
| AT (1) | ATE349958T1 (fr) |
| DE (2) | DE10154163A1 (fr) |
| ES (1) | ES2280474T3 (fr) |
Cited By (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050261781A1 (en) * | 2004-04-15 | 2005-11-24 | Sennett Andrew R | Cement-directing orthopedic implants |
| US20060184192A1 (en) * | 2005-02-11 | 2006-08-17 | Markworth Aaron D | Systems and methods for providing cavities in interior body regions |
| US20060264945A1 (en) * | 2005-05-18 | 2006-11-23 | Edidin Avram A | Selectively-expandable bone scaffold |
| US20070010848A1 (en) * | 2005-07-11 | 2007-01-11 | Andrea Leung | Systems and methods for providing cavities in interior body regions |
| US20070055201A1 (en) * | 2005-07-11 | 2007-03-08 | Seto Christine L | Systems and methods for providing cavities in interior body regions |
| US20070055274A1 (en) * | 2005-06-20 | 2007-03-08 | Andreas Appenzeller | Apparatus and methods for treating bone |
| US20070055276A1 (en) * | 2005-07-11 | 2007-03-08 | Edidin Avram A | Systems and methods for inserting biocompatible filler materials in interior body regions |
| US20070093822A1 (en) * | 2005-09-28 | 2007-04-26 | Christof Dutoit | Apparatus and methods for vertebral augmentation using linked expandable bodies |
| US20070093846A1 (en) * | 2005-10-12 | 2007-04-26 | Robert Frigg | Apparatus and methods for vertebral augmentation |
| US20070093899A1 (en) * | 2005-09-28 | 2007-04-26 | Christof Dutoit | Apparatus and methods for treating bone |
| US20070232905A1 (en) * | 2006-04-04 | 2007-10-04 | Francis Tom J | Unconstrained Balloon Sizer |
| WO2007067726A3 (fr) * | 2005-12-08 | 2007-10-18 | Synthes Usa | Appareil et méthodes pour traiter un tissu osseux |
| US20080009875A1 (en) * | 2006-07-07 | 2008-01-10 | Meera Sankaran | Medical device with dual expansion mechanism |
| US20080215151A1 (en) * | 2007-03-02 | 2008-09-04 | Andrew Kohm | Bone barrier device, system, and method |
| US20090105732A1 (en) * | 2005-06-15 | 2009-04-23 | Matthew Yurek | Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement |
| US20090125028A1 (en) * | 2007-11-14 | 2009-05-14 | Jacques Teisen | Hybrid bone fixation element and methods of using the same |
| EP2074956A1 (fr) * | 2007-12-28 | 2009-07-01 | BIEDERMANN MOTECH GmbH | Implant pour la stabilisation des vertèbres |
| WO2010063111A1 (fr) * | 2008-12-03 | 2010-06-10 | The Royal Institution For The Advancement Of Learning/Mcgill University | Dispositif et procédé d'ostéotomie intravertébrale percutanée |
| US7909873B2 (en) | 2006-12-15 | 2011-03-22 | Soteira, Inc. | Delivery apparatus and methods for vertebrostenting |
| US20110137317A1 (en) * | 2009-12-07 | 2011-06-09 | O'halloran Damien | Methods and Apparatus For Treating Vertebral Fractures |
| US20110202062A1 (en) * | 2010-02-18 | 2011-08-18 | O'halloran Damien | Methods and Apparatus For Treating Vertebral Fractures |
| US20110213402A1 (en) * | 2005-05-24 | 2011-09-01 | Kyphon Sarl | Low-compliance expandable medical device |
| US20120010713A1 (en) * | 2009-12-07 | 2012-01-12 | O'halloran Damien | Methods and Apparatus For Treating Vertebral Fractures |
| US20120010624A1 (en) * | 2009-12-07 | 2012-01-12 | O'halloran Damien | Methods and Apparatus For Treating Vertebral Fractures |
| US8535380B2 (en) | 2010-05-13 | 2013-09-17 | Stout Medical Group, L.P. | Fixation device and method |
| US8709042B2 (en) | 2004-09-21 | 2014-04-29 | Stout Medical Group, LP | Expandable support device and method of use |
| US20140128877A1 (en) * | 2012-11-05 | 2014-05-08 | Globus Medical, Inc. | Methods and Apparatus for Treating Vertebral Fractures |
| US20140207193A1 (en) * | 2013-01-24 | 2014-07-24 | Kyphon Sarl | Surgical system and methods of use |
| US9050112B2 (en) | 2011-08-23 | 2015-06-09 | Flexmedex, LLC | Tissue removal device and method |
| US9149286B1 (en) | 2010-11-12 | 2015-10-06 | Flexmedex, LLC | Guidance tool and method for use |
| US9155578B2 (en) | 2012-02-28 | 2015-10-13 | DePuy Synthes Products, Inc. | Expandable fastener |
| US9192397B2 (en) | 2006-12-15 | 2015-11-24 | Gmedelaware 2 Llc | Devices and methods for fracture reduction |
| US9289240B2 (en) | 2005-12-23 | 2016-03-22 | DePuy Synthes Products, Inc. | Flexible elongated chain implant and method of supporting body tissue with same |
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|---|---|---|---|---|
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| US20040267367A1 (en) | 2003-06-30 | 2004-12-30 | Depuy Acromed, Inc | Intervertebral implant with conformable endplate |
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| FR2871366A1 (fr) | 2004-06-09 | 2005-12-16 | Ceravic Soc Par Actions Simpli | Implant expansible prothetique osseux |
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| US20070088436A1 (en) * | 2005-09-29 | 2007-04-19 | Matthew Parsons | Methods and devices for stenting or tamping a fractured vertebral body |
| WO2008070863A2 (fr) | 2006-12-07 | 2008-06-12 | Interventional Spine, Inc. | Implant intervertébral |
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| CA2705709C (fr) | 2007-11-16 | 2016-03-15 | Synthes Usa, Llc | Dispositif de contention poreux et procede associe permettant de stabiliser des fractures par compression de corps vertebral |
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| BRPI1014890A2 (pt) | 2009-04-09 | 2016-05-03 | Synthes Gmbh | sistema e método minimamente invasivos de aumento e estabilização de coluna |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20130310877A1 (en) | 2013-11-21 |
| EP1308134B1 (fr) | 2007-01-03 |
| US9861401B2 (en) | 2018-01-09 |
| US11051862B2 (en) | 2021-07-06 |
| US20190008566A1 (en) | 2019-01-10 |
| DE50209149D1 (de) | 2007-02-15 |
| US9295502B2 (en) | 2016-03-29 |
| EP1308134A2 (fr) | 2003-05-07 |
| US20180153594A1 (en) | 2018-06-07 |
| ATE349958T1 (de) | 2007-01-15 |
| EP1308134A3 (fr) | 2003-07-09 |
| US8491591B2 (en) | 2013-07-23 |
| US10357291B2 (en) | 2019-07-23 |
| JP2003180700A (ja) | 2003-07-02 |
| DE10154163A1 (de) | 2003-05-22 |
| ES2280474T3 (es) | 2007-09-16 |
| US20160157898A1 (en) | 2016-06-09 |
| US20090069850A1 (en) | 2009-03-12 |
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