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UA97961C2 - Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови - Google Patents

Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови

Info

Publication number
UA97961C2
UA97961C2 UAA200904468A UAA200904468A UA97961C2 UA 97961 C2 UA97961 C2 UA 97961C2 UA A200904468 A UAA200904468 A UA A200904468A UA A200904468 A UAA200904468 A UA A200904468A UA 97961 C2 UA97961 C2 UA 97961C2
Authority
UA
Ukraine
Prior art keywords
therapy
therapeutic
intravascular coagulation
disseminated intravascular
amelioration method
Prior art date
Application number
UAA200904468A
Other languages
English (en)
Ukrainian (uk)
Inventor
Йосиказу АОКИ
Original Assignee
Асахи Касеи Фарма Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Асахи Касеи Фарма Корпорейшн filed Critical Асахи Касеи Фарма Корпорейшн
Publication of UA97961C2 publication Critical patent/UA97961C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение касается способа лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови (ДВС) и способа снижения вероятности смерти у пациентов, страдающих ДВС, путем введения тромбомодулина пациентам, страдающим ДВС, у которых активность антитромбина в плазме составляет 40 % или менее.
UAA200904468A 2006-10-06 2007-10-05 Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови UA97961C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006274573 2006-10-06
PCT/JP2007/069560 WO2008044631A1 (en) 2006-10-06 2007-10-05 Therapeutic and/or ameliorating agent for disseminated intravascular coagulation

Publications (1)

Publication Number Publication Date
UA97961C2 true UA97961C2 (ru) 2012-04-10

Family

ID=39282827

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200904468A UA97961C2 (ru) 2006-10-06 2007-10-05 Способ лечения и/или улучшения диссеминированного внутрисосудистого свертывания крови

Country Status (16)

Country Link
US (1) US20100152106A1 (ru)
EP (1) EP2062589A4 (ru)
JP (1) JP5579385B2 (ru)
KR (1) KR20090051777A (ru)
CN (1) CN101522206B (ru)
AU (1) AU2007305550B2 (ru)
BR (1) BRPI0720158A2 (ru)
CA (1) CA2665691A1 (ru)
CO (1) CO6160332A2 (ru)
IL (1) IL197509A (ru)
MX (1) MX2009003384A (ru)
MY (1) MY148565A (ru)
NZ (1) NZ575632A (ru)
RU (1) RU2433829C2 (ru)
UA (1) UA97961C2 (ru)
WO (1) WO2008044631A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009314413A1 (en) * 2008-11-12 2010-05-20 Eli Lilly And Company Compositions and methods of use for soluble thrombomodulin variants
AU2019347406B9 (en) * 2018-09-28 2023-11-16 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
MX2021004511A (es) * 2018-10-22 2021-06-08 Asahi Kasei Pharma Corp Medicamento para el tratamiento y/o mejora de la septicemia asociada con la anomalia de la coagulacion.
RU2716492C1 (ru) * 2019-05-14 2020-03-12 Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) Способ регулирования активации нейтрофилов в модели in vitro

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE180496T1 (de) * 1987-01-08 1999-06-15 Asahi Chemical Ind Peptid zur beschleunigung der wirkung des proteins-c mit thrombin
DE3876124T2 (de) 1987-04-01 1993-05-06 Mitsubishi Gas Chemical Co Immunoassay fuer thrombomodulin.
DK299087D0 (da) 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPS646219U (ru) 1987-06-30 1989-01-13
JPS6445398U (ru) 1987-09-11 1989-03-20
JPH0720997B2 (ja) 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
JPH0798840B2 (ja) 1988-12-27 1995-10-25 持田製薬株式会社 尿由来の抗血液疑固物質、その製法およびそれを含有する医薬組成物
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
JPH02255699A (ja) 1989-03-28 1990-10-16 Asahi Chem Ind Co Ltd 新規血液抗凝固物質及びその製法
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
CA2022713A1 (en) 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
JPH03259084A (ja) 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
JP3189052B2 (ja) 1990-06-27 2001-07-16 持田製薬株式会社 抗血液凝固活性を有するポリペプチド
KR930008093B1 (ko) * 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
JPH05213998A (ja) 1990-08-03 1993-08-24 Asahi Chem Ind Co Ltd 新規なポリペプチド及びこれを有効成分とする 医薬組成物
DE69132889T2 (de) 1990-08-15 2002-08-29 Paion Gmbh Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung
JP3220174B2 (ja) 1990-12-12 2001-10-22 第一製薬株式会社 組換ヒトトロンボモジュリン誘導体
PT641215E (pt) 1992-02-05 2004-09-30 Paion Gmbh Analogos de trombomodulina resistentes a proteases
JPH05310787A (ja) 1992-05-01 1993-11-22 Asahi Chem Ind Co Ltd 新規なポリペプチド
JPH06205692A (ja) 1993-01-08 1994-07-26 Asahi Chem Ind Co Ltd 新規な抗ヒトトロンボモジュリンモノクロ−ナル抗体およびその抗体を用いたヒトトロンボモジュリンの高感度測定方法
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
JP2824392B2 (ja) 1994-05-31 1998-11-11 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進する作用を有するペプチドを含有する培養上澄液
JP3745805B2 (ja) 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
JP4157644B2 (ja) 1998-03-30 2008-10-01 旭化成ファーマ株式会社 高純度可溶性トロンボモジュリンの製造方法
EP1476752A4 (en) * 2002-02-27 2008-02-13 Bio Merieux Inc METHOD FOR DIAGNOSING AND MONITORING HEMOSTATIC DYSFUNCTION, SEVERE INFECTION AND SYSTEMATIC INFLAMMATORY RESPONSE SYNDROME
BR0304660A (pt) * 2002-05-01 2005-06-07 Schering Ag Anticorpos direcionados a fator de tecido como anticoagulantes

Also Published As

Publication number Publication date
EP2062589A4 (en) 2010-07-28
US20100152106A1 (en) 2010-06-17
CA2665691A1 (en) 2008-04-17
IL197509A (en) 2015-06-30
RU2433829C2 (ru) 2011-11-20
NZ575632A (en) 2011-12-22
JP5579385B2 (ja) 2014-08-27
MY148565A (en) 2013-04-30
WO2008044631A1 (en) 2008-04-17
RU2009117253A (ru) 2010-11-20
AU2007305550B2 (en) 2010-09-30
BRPI0720158A2 (pt) 2014-05-20
EP2062589A1 (en) 2009-05-27
JPWO2008044631A1 (ja) 2010-02-12
MX2009003384A (es) 2009-04-08
HK1130209A1 (en) 2009-12-24
CN101522206A (zh) 2009-09-02
CN101522206B (zh) 2013-03-27
AU2007305550A1 (en) 2008-04-17
CO6160332A2 (es) 2010-05-20
IL197509A0 (en) 2011-08-01
KR20090051777A (ko) 2009-05-22

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