MX2009003384A - Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada. - Google Patents
Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada.Info
- Publication number
- MX2009003384A MX2009003384A MX2009003384A MX2009003384A MX2009003384A MX 2009003384 A MX2009003384 A MX 2009003384A MX 2009003384 A MX2009003384 A MX 2009003384A MX 2009003384 A MX2009003384 A MX 2009003384A MX 2009003384 A MX2009003384 A MX 2009003384A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic
- intravascular coagulation
- disseminated intravascular
- ameliorating agent
- dic
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 5
- 208000009190 disseminated intravascular coagulation Diseases 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000004019 antithrombin Substances 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describe un agente terapéutico y/o de mejoramiento o una terapia y/o método de mejoramiento para la coagulación intravascular diseminada (DIC), que tiene un efecto terapéutico mayor. Específicamente se describe un agente terapéutico y/o profiláctico para la DIC, que comprende trombomodulina como un ingrediente activo. El agente terapéutico y/o profiláctico se administra a un paciente que tiene un nivel de antitrombina disminuido, a saber, un paciente que tiene un valor de activación de antitrombina en el plasma de menos del 50%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006274573 | 2006-10-06 | ||
| PCT/JP2007/069560 WO2008044631A1 (en) | 2006-10-06 | 2007-10-05 | Therapeutic and/or ameliorating agent for disseminated intravascular coagulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009003384A true MX2009003384A (es) | 2009-04-08 |
Family
ID=39282827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009003384A MX2009003384A (es) | 2006-10-06 | 2007-10-05 | Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20100152106A1 (es) |
| EP (1) | EP2062589A4 (es) |
| JP (1) | JP5579385B2 (es) |
| KR (1) | KR20090051777A (es) |
| CN (1) | CN101522206B (es) |
| AU (1) | AU2007305550B2 (es) |
| BR (1) | BRPI0720158A2 (es) |
| CA (1) | CA2665691A1 (es) |
| CO (1) | CO6160332A2 (es) |
| IL (1) | IL197509A (es) |
| MX (1) | MX2009003384A (es) |
| MY (1) | MY148565A (es) |
| NZ (1) | NZ575632A (es) |
| RU (1) | RU2433829C2 (es) |
| UA (1) | UA97961C2 (es) |
| WO (1) | WO2008044631A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009314413A1 (en) * | 2008-11-12 | 2010-05-20 | Eli Lilly And Company | Compositions and methods of use for soluble thrombomodulin variants |
| AU2019347406B9 (en) * | 2018-09-28 | 2023-11-16 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
| MX2021004511A (es) * | 2018-10-22 | 2021-06-08 | Asahi Kasei Pharma Corp | Medicamento para el tratamiento y/o mejora de la septicemia asociada con la anomalia de la coagulacion. |
| RU2716492C1 (ru) * | 2019-05-14 | 2020-03-12 | Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) | Способ регулирования активации нейтрофилов в модели in vitro |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE180496T1 (de) * | 1987-01-08 | 1999-06-15 | Asahi Chemical Ind | Peptid zur beschleunigung der wirkung des proteins-c mit thrombin |
| DE3876124T2 (de) | 1987-04-01 | 1993-05-06 | Mitsubishi Gas Chemical Co | Immunoassay fuer thrombomodulin. |
| DK299087D0 (da) | 1987-06-12 | 1987-06-12 | Novo Industri As | Proteins and derivatives thereof |
| JPS646219U (es) | 1987-06-30 | 1989-01-13 | ||
| JPS6445398U (es) | 1987-09-11 | 1989-03-20 | ||
| JPH0720997B2 (ja) | 1988-08-29 | 1995-03-08 | 興和株式会社 | 新規なトロンビン結合性物質及びその製法 |
| JPH0798840B2 (ja) | 1988-12-27 | 1995-10-25 | 持田製薬株式会社 | 尿由来の抗血液疑固物質、その製法およびそれを含有する医薬組成物 |
| US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
| JPH02255699A (ja) | 1989-03-28 | 1990-10-16 | Asahi Chem Ind Co Ltd | 新規血液抗凝固物質及びその製法 |
| US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| CA2022713A1 (en) | 1989-08-11 | 1991-02-12 | Nils U. Bang | Human thrombomodulin derivatives |
| JPH03259084A (ja) | 1990-03-06 | 1991-11-19 | Kowa Co | トロンビン結合性物質の製造法 |
| JP3189052B2 (ja) | 1990-06-27 | 2001-07-16 | 持田製薬株式会社 | 抗血液凝固活性を有するポリペプチド |
| KR930008093B1 (ko) * | 1990-08-03 | 1993-08-25 | 아사히가세이고오교 가부시끼가이샤 | 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물 |
| JPH05213998A (ja) | 1990-08-03 | 1993-08-24 | Asahi Chem Ind Co Ltd | 新規なポリペプチド及びこれを有効成分とする 医薬組成物 |
| DE69132889T2 (de) | 1990-08-15 | 2002-08-29 | Paion Gmbh | Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung |
| JP3220174B2 (ja) | 1990-12-12 | 2001-10-22 | 第一製薬株式会社 | 組換ヒトトロンボモジュリン誘導体 |
| PT641215E (pt) | 1992-02-05 | 2004-09-30 | Paion Gmbh | Analogos de trombomodulina resistentes a proteases |
| JPH05310787A (ja) | 1992-05-01 | 1993-11-22 | Asahi Chem Ind Co Ltd | 新規なポリペプチド |
| JPH06205692A (ja) | 1993-01-08 | 1994-07-26 | Asahi Chem Ind Co Ltd | 新規な抗ヒトトロンボモジュリンモノクロ−ナル抗体およびその抗体を用いたヒトトロンボモジュリンの高感度測定方法 |
| US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
| US5916874A (en) * | 1994-04-20 | 1999-06-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for treating liver injury |
| JP2824392B2 (ja) | 1994-05-31 | 1998-11-11 | 旭化成工業株式会社 | トロンビンによるプロテインｃの活性化を促進する作用を有するペプチドを含有する培養上澄液 |
| JP3745805B2 (ja) | 1995-10-24 | 2006-02-15 | 日本ケミカルリサーチ株式会社 | トロンボモジュリンの精製方法 |
| JP4157644B2 (ja) | 1998-03-30 | 2008-10-01 | 旭化成ファーマ株式会社 | 高純度可溶性トロンボモジュリンの製造方法 |
| EP1476752A4 (en) * | 2002-02-27 | 2008-02-13 | Bio Merieux Inc | METHOD FOR DIAGNOSING AND MONITORING HEMOSTATIC DYSFUNCTION, SEVERE INFECTION AND SYSTEMATIC INFLAMMATORY RESPONSE SYNDROME |
| BR0304660A (pt) * | 2002-05-01 | 2005-06-07 | Schering Ag | Anticorpos direcionados a fator de tecido como anticoagulantes |
-
2007
- 2007-10-05 CN CN2007800368187A patent/CN101522206B/zh active Active
- 2007-10-05 JP JP2008538700A patent/JP5579385B2/ja active Active
- 2007-10-05 WO PCT/JP2007/069560 patent/WO2008044631A1/ja not_active Ceased
- 2007-10-05 UA UAA200904468A patent/UA97961C2/ru unknown
- 2007-10-05 KR KR1020097006989A patent/KR20090051777A/ko not_active Ceased
- 2007-10-05 US US12/444,342 patent/US20100152106A1/en not_active Abandoned
- 2007-10-05 BR BRPI0720158-3A2A patent/BRPI0720158A2/pt not_active Application Discontinuation
- 2007-10-05 AU AU2007305550A patent/AU2007305550B2/en active Active
- 2007-10-05 CA CA002665691A patent/CA2665691A1/en not_active Abandoned
- 2007-10-05 EP EP07829298A patent/EP2062589A4/en not_active Withdrawn
- 2007-10-05 MX MX2009003384A patent/MX2009003384A/es active IP Right Grant
- 2007-10-05 MY MYPI20091065A patent/MY148565A/en unknown
- 2007-10-05 NZ NZ575632A patent/NZ575632A/en unknown
- 2007-10-05 RU RU2009117253/15A patent/RU2433829C2/ru active
-
2009
- 2009-03-10 IL IL197509A patent/IL197509A/en active IP Right Grant
- 2009-03-20 CO CO09029277A patent/CO6160332A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2062589A4 (en) | 2010-07-28 |
| US20100152106A1 (en) | 2010-06-17 |
| CA2665691A1 (en) | 2008-04-17 |
| IL197509A (en) | 2015-06-30 |
| RU2433829C2 (ru) | 2011-11-20 |
| UA97961C2 (ru) | 2012-04-10 |
| NZ575632A (en) | 2011-12-22 |
| JP5579385B2 (ja) | 2014-08-27 |
| MY148565A (en) | 2013-04-30 |
| WO2008044631A1 (en) | 2008-04-17 |
| RU2009117253A (ru) | 2010-11-20 |
| AU2007305550B2 (en) | 2010-09-30 |
| BRPI0720158A2 (pt) | 2014-05-20 |
| EP2062589A1 (en) | 2009-05-27 |
| JPWO2008044631A1 (ja) | 2010-02-12 |
| HK1130209A1 (en) | 2009-12-24 |
| CN101522206A (zh) | 2009-09-02 |
| CN101522206B (zh) | 2013-03-27 |
| AU2007305550A1 (en) | 2008-04-17 |
| CO6160332A2 (es) | 2010-05-20 |
| IL197509A0 (en) | 2011-08-01 |
| KR20090051777A (ko) | 2009-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |