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UA86616C2 - Novel carboxamides for use as xa inhibitors - Google Patents

Novel carboxamides for use as xa inhibitors

Info

Publication number
UA86616C2
UA86616C2 UAA200610200A UAA200610200A UA86616C2 UA 86616 C2 UA86616 C2 UA 86616C2 UA A200610200 A UAA200610200 A UA A200610200A UA A200610200 A UAA200610200 A UA A200610200A UA 86616 C2 UA86616 C2 UA 86616C2
Authority
UA
Ukraine
Prior art keywords
inhibitors
salts
novel carboxamides
carboxamides
novel
Prior art date
Application number
UAA200610200A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Кай Герлах
Роланд Пфау
Хеннинг Припке
Вольфганг Винен
Аннетте Мариа Шулер-Метц
Георг Даманн
Херберт Нар
Сандра Рут Хандшу
Норберт Хауэль
Ирис Кауффманн-Хефнер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of UA86616C2 publication Critical patent/UA86616C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to the novel substituted carboxamides of general formula (I), wherein А, В and Rto Rare defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, especially the physiologically salts thereof with inorganic or organic acids or bases, which have valuable properties. The inventive compounds have an antithrombotic effect and are factor Xa inhibitors.(I)
UAA200610200A 2004-02-28 2005-02-22 Novel carboxamides for use as xa inhibitors UA86616C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004009835A DE102004009835A1 (en) 2004-02-28 2004-02-28 New 4-heterocyclyl-benzamide derivatives, useful as antithrombotic agents for treating or preventing e.g. deep vein thrombosis or reocclusion after angioplasty, are inhibitors of factor Xa and other serine proteases

Publications (1)

Publication Number Publication Date
UA86616C2 true UA86616C2 (en) 2009-05-12

Family

ID=34853838

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200610200A UA86616C2 (en) 2004-02-28 2005-02-22 Novel carboxamides for use as xa inhibitors

Country Status (5)

Country Link
CN (1) CN101103022B (en)
DE (1) DE102004009835A1 (en)
ES (1) ES2371920T3 (en)
UA (1) UA86616C2 (en)
ZA (1) ZA200604013B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2579514A1 (en) * 2004-09-10 2006-03-23 Janssen Pharmaceutica N.V. Novel imidazolidin-2-one derivatives as selective androgen receptor modulators (sarms)
GB201909190D0 (en) * 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
CN112574181B (en) * 2019-09-30 2024-11-22 天津药业研究院股份有限公司 Preparation method and application of suvorexan intermediate
CN112354005B (en) * 2020-11-11 2021-07-27 问兰药业(苏州)有限公司 Dressing for promoting healing of burn and scald wound surfaces and preparation method thereof

Also Published As

Publication number Publication date
CN101103022A (en) 2008-01-09
ZA200604013B (en) 2007-08-29
DE102004009835A1 (en) 2005-09-15
CN101103022B (en) 2012-06-27
ES2371920T3 (en) 2012-01-11

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