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UA84318C2 - Гетерополициклические соединения и их применение как метаботропических антагонистов рецепторов глутамата, фармацевтическая композиция на их основе - Google Patents

Гетерополициклические соединения и их применение как метаботропических антагонистов рецепторов глутамата, фармацевтическая композиция на их основе

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Publication number
UA84318C2
UA84318C2 UAA200608867A UAA200608867A UA84318C2 UA 84318 C2 UA84318 C2 UA 84318C2 UA A200608867 A UAA200608867 A UA A200608867A UA A200608867 A UAA200608867 A UA A200608867A UA 84318 C2 UA84318 C2 UA 84318C2
Authority
UA
Ukraine
Prior art keywords
pharmaceutical composition
receptor antagonists
composition based
glutamate receptor
metabotropic glutamate
Prior art date
Application number
UAA200608867A
Other languages
English (en)
Ukrainian (uk)
Inventor
Луиз Эдвардс
Метвин Айзек
Мартин Йохансон
Йохан Малмберґ
Доналд Маклеод
Александер Минидис
Карин Стааф
Абдельмалик Слесси
Томислав Стефанак
Томас Сторменн
Дейвид Венсбо
Тао Синь
Джалай Арора
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA84318C2 publication Critical patent/UA84318C2/ru

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
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  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Заявленное изобретение касается новых соединений формулы І(I),фармацевтических композиций, которые содержат соединения, и применение соединений в лечении и/или предупреждении опосредованных рецептором mGlu5 расстройств.
UAA200608867A 2004-02-18 2005-02-15 Гетерополициклические соединения и их применение как метаботропических антагонистов рецепторов глутамата, фармацевтическая композиция на их основе UA84318C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60896004P 2004-02-18 2004-02-18
PCT/US2005/004774 WO2006014185A1 (en) 2004-02-18 2005-02-15 Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

Publications (1)

Publication Number Publication Date
UA84318C2 true UA84318C2 (ru) 2008-10-10

Family

ID=35447957

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200608867A UA84318C2 (ru) 2004-02-18 2005-02-15 Гетерополициклические соединения и их применение как метаботропических антагонистов рецепторов глутамата, фармацевтическая композиция на их основе

Country Status (26)

Country Link
US (6) US7585881B2 (ru)
EP (2) EP2311830A1 (ru)
JP (1) JP4912157B2 (ru)
CN (2) CN101096368A (ru)
AT (1) ATE483706T1 (ru)
AU (1) AU2005270208A1 (ru)
BR (1) BRPI0507497A (ru)
CA (1) CA2555566A1 (ru)
CY (1) CY1110965T1 (ru)
DE (1) DE602005023963D1 (ru)
DK (1) DK1723144T3 (ru)
ES (1) ES2352110T3 (ru)
HR (1) HRP20100654T1 (ru)
IL (1) IL177394A0 (ru)
NO (1) NO20063599L (ru)
NZ (1) NZ548954A (ru)
PL (1) PL1723144T3 (ru)
PT (1) PT1723144E (ru)
RS (1) RS51516B (ru)
RU (1) RU2370495C2 (ru)
SG (1) SG146657A1 (ru)
SI (1) SI1723144T1 (ru)
UA (1) UA84318C2 (ru)
UY (1) UY28766A1 (ru)
WO (1) WO2006014185A1 (ru)
ZA (1) ZA200606551B (ru)

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