UA80453C2 - Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) - Google Patents
Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) Download PDFInfo
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- UA80453C2 UA80453C2 UAA200505479A UA2005005479A UA80453C2 UA 80453 C2 UA80453 C2 UA 80453C2 UA A200505479 A UAA200505479 A UA A200505479A UA 2005005479 A UA2005005479 A UA 2005005479A UA 80453 C2 UA80453 C2 UA 80453C2
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- UA
- Ukraine
- Prior art keywords
- alkyl
- perfluoroalkyl
- cycloalkyl
- benzyl
- mammal
- Prior art date
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- 238000000034 method Methods 0.000 claims abstract description 79
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 45
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- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43232702P | 2002-12-10 | 2002-12-10 | |
| PCT/US2003/038932 WO2004052893A2 (fr) | 2002-12-10 | 2003-12-09 | Derives dihydropyrano indole-3,4-dione substitues servant d'inhibiteurs d'un inhibiteur 1 d'activateur du plasminogene (pai-1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA80453C2 true UA80453C2 (en) | 2007-09-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200505479A UA80453C2 (en) | 2002-12-10 | 2003-09-12 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7101903B2 (fr) |
| EP (1) | EP1569639A2 (fr) |
| JP (1) | JP2006514641A (fr) |
| KR (1) | KR20050085589A (fr) |
| CN (1) | CN1726029A (fr) |
| AU (1) | AU2003296322A1 (fr) |
| BR (1) | BR0316586A (fr) |
| CA (1) | CA2509242A1 (fr) |
| CR (1) | CR7865A (fr) |
| EC (1) | ECSP055847A (fr) |
| MX (1) | MXPA05006281A (fr) |
| NI (1) | NI200500106A (fr) |
| NO (1) | NO20053340L (fr) |
| NZ (1) | NZ540865A (fr) |
| RU (1) | RU2337910C2 (fr) |
| UA (1) | UA80453C2 (fr) |
| WO (1) | WO2004052893A2 (fr) |
| ZA (1) | ZA200504723B (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| WO2003000253A1 (fr) | 2001-06-20 | 2003-01-03 | Wyeth | Derives d'acide indole substitue utilises en tant qu'inhibiteurs de l'inhibiteur-1 (pai-1) de l'activateur plasminogene |
| US7078429B2 (en) | 2002-12-10 | 2006-07-18 | Wyeth | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| MXPA05006283A (es) * | 2002-12-10 | 2005-08-19 | Wyeth Corp | Derivados de arilo, ariloxi, y alquiloxi del acido sustituido 1h-indol-3-il glicoxilico como inhibidores del inhibidor-1 activador de plasminogeno (pai-1). |
| ATE331708T1 (de) * | 2002-12-10 | 2006-07-15 | Wyeth Corp | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren |
| US7420083B2 (en) * | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| JP2008510815A (ja) * | 2004-08-23 | 2008-04-10 | ワイス | 血栓症および心臓血管疾患の治療にて有用な調節剤であるプラスミノゲン活性化因子阻害剤１型（ｐａｉ−１）としてのオキサゾロ−ナフチル酸 |
| AU2005277137A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
| AU2005277139A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| CA2617372A1 (fr) * | 2005-08-17 | 2007-02-22 | Wyeth | Indoles substitues et procedes d'utilisation de ceux-ci |
| BRPI0710964A2 (pt) * | 2006-02-27 | 2012-02-28 | Wyeth | método de tratamento de lesão muscular, perda muscular, degeneração muscular, atrofia muscular ou taxa reduzida de reparo muscular; composição farmacêutica; uso de composto na fabricação de um medicamento para o tratamento de lesão muscular, perda muscular, degeneração muscular, atrofia muscular ou taxa reduzida de reparo muscular |
| WO2007120638A2 (fr) * | 2006-04-12 | 2007-10-25 | President And Fellows Of Harvard College | Procedes et compositions permettant de moduler la glycosylation |
| JP5207972B2 (ja) | 2006-10-12 | 2013-06-12 | 株式会社医薬分子設計研究所 | カルボン酸誘導体 |
| US7884234B2 (en) | 2006-10-12 | 2011-02-08 | Institute Of Medicinal Molecular Design, Inc. | N-phenyloxamide derivatives |
| WO2008097953A2 (fr) * | 2007-02-05 | 2008-08-14 | Wyeth | Compositions pharmaceutiques comprenant des dérivés acides d'indole substitués en tant qu'inhibiteurs de l'inhibiteur-1 d'activateur de plasminogène (pai-1) |
| WO2008156676A1 (fr) | 2007-06-15 | 2008-12-24 | President And Fellows Of Harvard College | Procédés et compositions de détection et de modulation de o-glycosylation |
| US20090239868A1 (en) * | 2007-10-23 | 2009-09-24 | Institute Of Medical Molecular Design, Inc. | Inhibitor of pai-1 production |
| BRPI0816560A2 (pt) | 2007-10-23 | 2015-09-01 | Inst Med Molecular Design Inc | Método de inibição de produção de pai-1 método para prevenção ou melhora de uma doença causada por uma super-produção de pai-1" |
| MY158994A (en) * | 2008-02-04 | 2016-11-30 | Mercury Therapeutics Inc | Ampk modulators |
| US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
| JPWO2009125606A1 (ja) | 2008-04-11 | 2011-08-04 | 株式会社医薬分子設計研究所 | Ｐａｉ−１阻害剤 |
| GB0812192D0 (en) * | 2008-07-03 | 2008-08-13 | Lectus Therapeutics Ltd | Calcium ion channel modulators & uses thereof |
| CN102292101A (zh) * | 2008-11-26 | 2011-12-21 | 五佳医疗股份有限公司 | 通过serpine2来调节胶原和平滑肌肌动蛋白表达的组合物和方法 |
| EP2438046A4 (fr) | 2009-06-01 | 2013-04-17 | Harvard College | Inhibiteurs de la o-glcnac transférase et leurs utilisations |
| WO2013006758A1 (fr) | 2011-07-06 | 2013-01-10 | President And Fellows Of Harvard College | Mimétiques de diphosphate et leurs utilisations |
| CN103724357B (zh) * | 2012-10-11 | 2016-06-08 | 中国药科大学 | 一种3,4-二氢吡喃并[3,2-b]吲哚-2-酮类化合物的合成方法 |
| RU2675240C1 (ru) * | 2018-04-28 | 2018-12-18 | Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук | Пираноиндолы с противотуберкулезной активностью |
| KR102484697B1 (ko) * | 2020-03-25 | 2023-01-05 | 울산과학기술원 | 전기 분해 반응에 의한 인돌로파이란 유도체의 합성 방법 및 이에 의해 합성된 인돌로파이란 유도체 |
| WO2021260139A1 (fr) | 2020-06-25 | 2021-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de traitement et de diagnostic d'états pathologiques associés à un stress intense |
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| WO2000035859A1 (fr) | 1998-12-16 | 2000-06-22 | Boehringer Ingelheim Pharma Kg | Derives aryle et heteroaryle substitues, leur production et leur utilisation comme medicaments |
| GB9827882D0 (en) | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
| EP1156045A4 (fr) | 1999-01-28 | 2002-04-17 | Nippon Shinyaku Co Ltd | Derives d'amides et compositions de medicaments |
| GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| CA2371308A1 (fr) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Derives d'acide tri-aryle en tant que ligands pour recepteur de peroxisome a activation par proliferateur (ppar) |
| RU2267484C2 (ru) | 1999-04-28 | 2006-01-10 | Авентис Фарма Дойчланд Гмбх | Производные диариловой кислоты и фармацевтическая композиция на их основе |
| GB9919413D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| FR2799756B1 (fr) * | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19963178A1 (de) | 1999-12-27 | 2001-07-05 | Gruenenthal Gmbh | Substituierte Indol-Mannichbasen |
| US6787651B2 (en) | 2000-10-10 | 2004-09-07 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents |
| US7002019B2 (en) | 2002-02-12 | 2006-02-21 | Wisconsin Alumni Research Foundation | Synthesis of indole thiazole compounds as ligands for the Ah receptor |
| EP1377549A1 (fr) | 2001-03-12 | 2004-01-07 | Millennium Pharmaceuticals, Inc. | Heterocycles fonctionnalises en tant que modulateurs de la fonction du recepteur de chimiokines et procedes de mise en oeuvre |
| FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| WO2003000253A1 (fr) | 2001-06-20 | 2003-01-03 | Wyeth | Derives d'acide indole substitue utilises en tant qu'inhibiteurs de l'inhibiteur-1 (pai-1) de l'activateur plasminogene |
| KR100810468B1 (ko) | 2001-10-10 | 2008-03-07 | 씨제이제일제당 (주) | 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1ｈ-인돌 유도체 |
| EP1495016A2 (fr) | 2002-04-09 | 2005-01-12 | Astex Technology Limited | Composes heterocycliques et leur utilisation comme modulateurs de la kinase p38 map |
| BR0316584A (pt) | 2002-12-10 | 2005-10-04 | Wyeth Corp | Derivados de ácido acético indol oxo-acetil amino substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) |
| ATE331708T1 (de) | 2002-12-10 | 2006-07-15 | Wyeth Corp | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| US7078429B2 (en) | 2002-12-10 | 2006-07-18 | Wyeth | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| MXPA05006283A (es) * | 2002-12-10 | 2005-08-19 | Wyeth Corp | Derivados de arilo, ariloxi, y alquiloxi del acido sustituido 1h-indol-3-il glicoxilico como inhibidores del inhibidor-1 activador de plasminogeno (pai-1). |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US20050215626A1 (en) | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
-
2003
- 2003-09-12 UA UAA200505479A patent/UA80453C2/uk unknown
- 2003-12-09 CN CNA2003801057346A patent/CN1726029A/zh active Pending
- 2003-12-09 MX MXPA05006281A patent/MXPA05006281A/es active IP Right Grant
- 2003-12-09 CA CA002509242A patent/CA2509242A1/fr not_active Abandoned
- 2003-12-09 JP JP2004559411A patent/JP2006514641A/ja active Pending
- 2003-12-09 AU AU2003296322A patent/AU2003296322A1/en not_active Abandoned
- 2003-12-09 KR KR1020057010698A patent/KR20050085589A/ko not_active Ceased
- 2003-12-09 BR BR0316586-8A patent/BR0316586A/pt not_active IP Right Cessation
- 2003-12-09 WO PCT/US2003/038932 patent/WO2004052893A2/fr not_active Ceased
- 2003-12-09 US US10/731,290 patent/US7101903B2/en not_active Expired - Fee Related
- 2003-12-09 EP EP03812845A patent/EP1569639A2/fr not_active Withdrawn
- 2003-12-09 NZ NZ540865A patent/NZ540865A/en unknown
- 2003-12-09 RU RU2005118982/04A patent/RU2337910C2/ru not_active IP Right Cessation
-
2005
- 2005-06-09 CR CR7865A patent/CR7865A/es not_active Application Discontinuation
- 2005-06-09 EC EC2005005847A patent/ECSP055847A/es unknown
- 2005-06-09 ZA ZA200504723A patent/ZA200504723B/en unknown
- 2005-06-09 NI NI200500106A patent/NI200500106A/es unknown
- 2005-07-08 NO NO20053340A patent/NO20053340L/no not_active Application Discontinuation
-
2006
- 2006-06-05 US US11/446,838 patent/US7459478B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200504723B (en) | 2007-12-27 |
| CA2509242A1 (fr) | 2004-06-24 |
| US7101903B2 (en) | 2006-09-05 |
| BR0316586A (pt) | 2005-10-11 |
| NI200500106A (es) | 2006-02-02 |
| JP2006514641A (ja) | 2006-05-11 |
| MXPA05006281A (es) | 2005-08-19 |
| NO20053340D0 (no) | 2005-07-08 |
| WO2004052893A3 (fr) | 2004-08-12 |
| RU2005118982A (ru) | 2006-02-27 |
| EP1569639A2 (fr) | 2005-09-07 |
| US20060270728A1 (en) | 2006-11-30 |
| KR20050085589A (ko) | 2005-08-29 |
| CN1726029A (zh) | 2006-01-25 |
| AU2003296322A1 (en) | 2004-06-30 |
| NO20053340L (no) | 2005-09-12 |
| US20050113436A1 (en) | 2005-05-26 |
| NZ540865A (en) | 2008-11-28 |
| WO2004052893A2 (fr) | 2004-06-24 |
| ECSP055847A (es) | 2005-11-22 |
| US7459478B2 (en) | 2008-12-02 |
| RU2337910C2 (ru) | 2008-11-10 |
| CR7865A (es) | 2005-09-23 |
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