UA77816C2 - 1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors - Google Patents
1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors Download PDFInfo
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- UA77816C2 UA77816C2 UA20041210642A UA20041210642A UA77816C2 UA 77816 C2 UA77816 C2 UA 77816C2 UA 20041210642 A UA20041210642 A UA 20041210642A UA 20041210642 A UA20041210642 A UA 20041210642A UA 77816 C2 UA77816 C2 UA 77816C2
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- alkyl
- general formula
- compounds according
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- compounds
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- 239000003446 ligand Substances 0.000 title abstract description 6
- 101000783645 Homo sapiens Adenosine receptor A3 Proteins 0.000 title abstract description 3
- 102000046278 human ADORA3 Human genes 0.000 title abstract description 3
- 125000003363 1,3,5-triazinyl group Chemical class N1=C(N=CN=C1)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 47
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- -1 /M-(di)-alkyl(1-3C) Chemical group 0.000 claims description 18
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- 208000035475 disorder Diseases 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 8
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 239000000651 prodrug Substances 0.000 claims description 7
- 229940002612 prodrug Drugs 0.000 claims description 7
- 125000005322 morpholin-1-yl group Chemical group 0.000 claims description 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 3
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical class CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077310 | 2002-05-30 | ||
| PCT/EP2003/050203 WO2003101980A1 (fr) | 2002-05-30 | 2003-05-28 | Derives de 1,3,5-triazine comme ligands pour des recepteurs humains de l'adenosine a3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77816C2 true UA77816C2 (en) | 2007-01-15 |
Family
ID=29595045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041210642A UA77816C2 (en) | 2002-05-30 | 2003-05-28 | 1,3,5- triazine derivatives as ligands for human adenosine-a3 receptors |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1513827A1 (fr) |
| JP (1) | JP4590260B2 (fr) |
| CN (1) | CN1329388C (fr) |
| AR (1) | AR040231A1 (fr) |
| AU (1) | AU2003250232B2 (fr) |
| BR (1) | BR0304925A (fr) |
| CA (1) | CA2484981C (fr) |
| HR (1) | HRP20040970A2 (fr) |
| IL (1) | IL164240A (fr) |
| MX (1) | MXPA04011948A (fr) |
| PL (1) | PL372418A1 (fr) |
| RU (1) | RU2312859C2 (fr) |
| UA (1) | UA77816C2 (fr) |
| WO (1) | WO2003101980A1 (fr) |
| ZA (1) | ZA200408029B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006528640A (ja) * | 2003-07-22 | 2006-12-21 | ニューロジェン・コーポレーション | 置換ピリジン−２−イルアミン類縁体 |
| WO2005028467A1 (fr) | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Composes heteroaromatiques et aromatiques a substitution 3,5-diaminopiperidine antibacteriens |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| PT2871180T (pt) | 2012-07-04 | 2018-05-08 | Agro Kanesho Co Ltd | Derivado de éster do ácido 2-aminonicotínico e bactericida que o contém como ingrediente ativo |
| MX2020008816A (es) | 2018-02-26 | 2020-09-28 | AlzeCure Pharma AB | Derivados de triazina para el tratamiento de enfermedades relacionadas con neurotrofinas. |
| GB201810668D0 (en) | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
| WO2022243331A1 (fr) * | 2021-05-19 | 2022-11-24 | Barlaa B.V. | Acide silicique en aquaculture |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226735D0 (en) * | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
| CN1163401A (zh) * | 1996-02-13 | 1997-10-29 | 李占元 | 全自动血球计数仪试剂及配制方法 |
| DE19735800A1 (de) * | 1997-08-18 | 1999-02-25 | Boehringer Ingelheim Pharma | Triazine mit adenosinantagonistischer Wirkung |
| JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
-
2003
- 2003-05-28 PL PL03372418A patent/PL372418A1/xx not_active Application Discontinuation
- 2003-05-28 CA CA2484981A patent/CA2484981C/fr not_active Expired - Fee Related
- 2003-05-28 BR BR0304925-6A patent/BR0304925A/pt not_active IP Right Cessation
- 2003-05-28 AU AU2003250232A patent/AU2003250232B2/en not_active Ceased
- 2003-05-28 MX MXPA04011948A patent/MXPA04011948A/es active IP Right Grant
- 2003-05-28 RU RU2004138803/04A patent/RU2312859C2/ru not_active IP Right Cessation
- 2003-05-28 UA UA20041210642A patent/UA77816C2/uk unknown
- 2003-05-28 HR HR20040970A patent/HRP20040970A2/xx not_active Application Discontinuation
- 2003-05-28 JP JP2004509671A patent/JP4590260B2/ja not_active Expired - Fee Related
- 2003-05-28 EP EP03755982A patent/EP1513827A1/fr not_active Withdrawn
- 2003-05-28 WO PCT/EP2003/050203 patent/WO2003101980A1/fr not_active Ceased
- 2003-05-28 CN CNB038090937A patent/CN1329388C/zh not_active Expired - Fee Related
- 2003-05-30 AR ARP030101920A patent/AR040231A1/es unknown
-
2004
- 2004-09-23 IL IL164240A patent/IL164240A/en not_active IP Right Cessation
- 2004-10-05 ZA ZA200408029A patent/ZA200408029B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1329388C (zh) | 2007-08-01 |
| MXPA04011948A (es) | 2005-03-31 |
| AU2003250232A1 (en) | 2003-12-19 |
| BR0304925A (pt) | 2004-09-28 |
| CN1646520A (zh) | 2005-07-27 |
| JP4590260B2 (ja) | 2010-12-01 |
| CA2484981C (fr) | 2011-07-26 |
| IL164240A (en) | 2010-12-30 |
| HRP20040970A2 (en) | 2005-06-30 |
| JP2005531600A (ja) | 2005-10-20 |
| ZA200408029B (en) | 2005-10-06 |
| AU2003250232B2 (en) | 2008-09-11 |
| HK1075045A1 (en) | 2005-12-02 |
| WO2003101980A1 (fr) | 2003-12-11 |
| CA2484981A1 (fr) | 2003-12-11 |
| AR040231A1 (es) | 2005-03-23 |
| RU2004138803A (ru) | 2005-06-10 |
| PL372418A1 (en) | 2005-07-25 |
| RU2312859C2 (ru) | 2007-12-20 |
| EP1513827A1 (fr) | 2005-03-16 |
| IL164240A0 (en) | 2005-12-18 |
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