UA55689A - Medicinal composition "ginvacra" - Google Patents

Abstract

The medicinal composition contains the ingredients of plant origin, namely the leaves of Ginkgo biloba, the components of the whortleberry (Vaccinia myrtillus), the flowers of the hawthorn (Crataegus sanguinea), and the honey.

Description

The invention relates to medicine, in particular, pharmacology, and can be used in the pharmaceutical and food industry in the manufacture of medicinal products or food supplements based on natural products.

A well-known medicinal product that includes components of plant origin, in particular the leaves of Ginkgo biloba (Sipkdo Bioba) (1)Y. A well-known drug called Agmelgin is made on the basis of the components of Ginkgo biloba leaves (Siipkdo bBioba), ginkgo flavonoids and is used to improve microcirculation in the vessels of the brain and peripheral capillary blood circulation and supply tissues with oxygen. The pharmacological effect of the well-known medicinal agent in the form of antispasmodic and vasodilator action is due to the significant content of flavonoids, birflavonoid amentoflavone, nonacosan, hexacosanol, pinite and organic acids in the ginkgo leaf.

The disadvantage of the well-known medicinal product is the insufficient spectrum of pharmacological action, which is manifested by an insufficient level of cardiotonic, antispasmodic and sedative effects. The latter is due to the fact that the well-known preparation based on ginkgo leaves has an insufficient content of substances capable of actively influencing the metabolism of the heart muscle, including at the level of peripheral and central regulatory structures of the brain, the shortcomings should also include the insufficient influence of the well-known preparation on the function vision due to the limited content of substances capable of selectively exerting a positive influence on the metabolism of the neuroretinal components of the organ of vision.

The invention is based on the task of improving a well-known medicinal product, in which, by means of the additional content of components of plant origin, the pharmacological action of which is aimed at improving the functions of the heart and the neuroretinal apparatus of the organ of vision, they achieve an expansion of the spectrum of the pharmacological action of the drug, and therefore - an increase in its therapeutic effectiveness.

When considering the technical task, it was taken into account that hawthorn flowers (Staiaediv5 zapdiipea) contain biologically active compounds capable of improving heart function, causing sedative and antispasmodic effects, in particular, due to the content of such compounds as vitexin, orientin, hyperoside, anthocyanin and leucoanthocyanin, triterpene acids, etc., and substances capable of optimizing visual acuity - in the berries of common blueberry (Massipia tupShyv), in particular, such as flavonoids hyperin, astragalin, quercitrin, isoquercitrin, rutin, as well as anthocyanins, phenolic acids, cyclic hexaatomic alcohol inositol , anthracene derivatives, as well as manganese compounds (21. The combination of biologically active compounds from hawthorn flowers and blueberry berries with components of ginkgo leaves can provide mutual potentiation of the pharmacological properties of the mentioned ingredients in the direction of expanding the spectrum of pharmacodynamic effects of the medicinal product, for example, in the form of sustainable optimization of microcirculation function in the tissues of the brain ku, especially at the level of retinal microvessels, strengthening of cardiac muscle functions and visual acuity against the background of a general positive sedative effect.

Based on the above, the task is solved by the fact that the known medicinal product, which includes components of plant origin, in particular the leaves of the two-lobed ginkgo (Sipkdo Biyubra), according to the invention, additionally contains components of common blueberry berries (Massipia tupiPiv), hawthorn flowers (Staiaediv zapocipea) and bee honey in the following ratio of ingredients, mass, 90: ginkgo leaves 25 - 30 blueberry berries 30-25 blood-red hawthorn flowers 10-15 bee honey 35 - 30

The preparation is prepared by pre-grinding the dried ingredients, namely ginkgo leaves, blueberry berries and hawthorn flowers to a powder state, mixing them in the specified ratio with the addition of bee honey, bringing it to a dough-like consistency and then packaging the finished product in the form of briquettes weighing 0.7 g.

Medicinal product "Ginvakra" in the form of briquettes weighing 0.7 g with the indicated content of ingredients is used for therapeutic and preventive purposes by using inside 2-Z times a day after meals. The tool is prescribed to relieve general nervous fatigue and tension, as well as to restore visual acuity after prolonged work in insufficient lighting, after working with a computer, to improve memory and sleep.

Example 1. A medicinal product was prepared from the named ingredients, taken in quantitative composition (g) in accordance with the ratio indicated above, namely: ginkgo leaves 15.0 blueberry berries 12.5 blood-red hawthorn flowers 7.5 bee honey 15. 0

Pre-ground dried ingredients, namely ginkgo leaves, blueberry berries and hawthorn flowers, were mixed and honey was added, after which it was kneaded until a dough-like consistency was obtained. Briquettes weighing 0.7 g were made from the rolled layer with a thickness of 8-10 mm. The resulting briquettes had a pleasant bitter honey taste.

Example 2. Patient D., 46 years old, complained of palpitations, rapid fatigue, especially after working on a computer, memory impairment, sleep disorders. Deterioration of vision, especially at the end of the working day.

Frequent unexplained anxiety and tension. Objectively: blood pressure 145/95 mm Hg. Pulse 88 beats/min. Decreased visual acuity of both eyes: Hypertensive retinopathy.

In order to correct the disturbed functions of the central nervous and cardiovascular systems, an outpatient course of treatment was carried out with the use of the therapeutic agent "Ginvakra" 0.7 g three times a day after meals for 30 days. No side effects were detected. Already after three days of treatment, the patient noted an improvement in general well-being, improvement in sleep and vision. Starting from 7 - 8 days, the cardiorhythm normalized, that is, the pulse rate decreased to the level of 76 - 84 beats/min., blood pressure stabilized at 135/90 mm Hg. After 2 weeks, he noted a steady improvement in visual function: the feeling of fatigue after working at the computer disappeared. Indicators of redox homeostasis were normalized, microcirculatory function improved significantly, as evidenced by the data shown in the table.

Table

Laboratory examination data of patient D. at the beginning and at the end of treatment

In addition, during ophthalmoscopy at the end of the treatment, the patient was found to have a more pronounced filling of the retinal arterioles than before the treatment.

The proposed medicinal product was used in the treatment of 14 patients of different sexes and ages (28-57 years old) for various somatic diseases with the phenomena of meteopathies, in which, in addition to deterioration of general well-being, there were disorders of vision, sleep and memory. As a result of the use of the product in all of the above cases, there was a significant improvement in well-being, normalization of blood pressure in patients with hypertension, improvement of sleep and vision.

Thus, the medicinal product based on the leaves of Ginkgo biloba in combination with the components of blueberry berries, blood-red hawthorn flowers and bee honey ensures the normalization of redox and microcirculatory processes in the brain, including at the level of the microvascular apparatus of the organ of vision with simultaneous optimization functions of the heart and vascular tone, improvement of general well-being and work capacity, which indicates the expediency of using the specified drug for therapeutic and preventive purposes in general medical practice.

Sources of information: 1. Declaratory patent 43011 Sha. Medical agent "Agmelgin". Meo2000116696 November 27, 2001 Publ. 15.11.2001,

Bul. Me10. 2. Medicinal plants. Encyclopedic guide / Ed. Academician of the Academy of Sciences of Ukraine A.M. Grodzinsky. K.: Main editorial office of the Ukrainian Soviet Encyclopedia named after M.P. Bazhana, 1989. - P.103 - 104, 112 - 113, 470 - 471.

Claims (1)

A medicinal product that includes components of plant origin, in particular the leaves of Ginkgo biloba ((Sipkdo Bioba), which is distinguished by the fact that it additionally contains the components of the berries of common blueberry (Massipia tup Pyv), hawthorn flowers (Staiaedys zapdpiipea) and honey bee in such a ratio of ingredients, mass 95: Ginkgo biloba leaves 25-30 Blueberry berries 30-25 Blood-red hawthorn flowers 10-15 Bee honey 35-30.