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UA111868C2 - Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти - Google Patents

Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти

Info

Publication number
UA111868C2
UA111868C2 UAA201406835A UAA201406835A UA111868C2 UA 111868 C2 UA111868 C2 UA 111868C2 UA A201406835 A UAA201406835 A UA A201406835A UA A201406835 A UAA201406835 A UA A201406835A UA 111868 C2 UA111868 C2 UA 111868C2
Authority
UA
Ukraine
Prior art keywords
ilmethylindol
quinolin
fluor
methyl
acetic acid
Prior art date
Application number
UAA201406835A
Other languages
English (en)
Inventor
Жакуес Тоннел
Тоні Пінтус
Алаін Бургос
Original Assignee
Атопікс Терапеутікс Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атопікс Терапеутікс Лімітед filed Critical Атопікс Терапеутікс Лімітед
Publication of UA111868C2 publication Critical patent/UA111868C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід стосується способу одержання сполуки формули (І):, (І)де R- С-Салкіл або бензил;шляхом введення в реакцію сполуки формули (II):, (II)де R- як це визначено для формули (І); з 2-хінолінкарбоксальдегідом.Спосіб доцільно використовувати у промисловому масштабі.
UAA201406835A 2011-12-15 2012-12-14 Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти UA111868C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201121557A GB201121557D0 (en) 2011-12-15 2011-12-15 Process
PCT/GB2012/000903 WO2013088108A1 (en) 2011-12-15 2012-12-14 Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid esters

Publications (1)

Publication Number Publication Date
UA111868C2 true UA111868C2 (uk) 2016-06-24

Family

ID=45560499

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201406835A UA111868C2 (uk) 2011-12-15 2012-12-14 Спосіб одержання естерів (5-фтор-2-метил-3-хінолін-2-ілметиліндол-1-іл)-оцтової кислоти

Country Status (27)

Country Link
US (1) US9102658B2 (uk)
EP (1) EP2791129B1 (uk)
JP (2) JP6300277B2 (uk)
KR (1) KR102018929B1 (uk)
CN (1) CN104114548B (uk)
AU (1) AU2012351341B2 (uk)
BR (1) BR112014014604B1 (uk)
CA (1) CA2859281C (uk)
CY (1) CY1117087T1 (uk)
DK (1) DK2791129T3 (uk)
EA (1) EA026617B1 (uk)
ES (1) ES2557762T3 (uk)
GB (1) GB201121557D0 (uk)
HR (1) HRP20151422T1 (uk)
HU (1) HUE028257T2 (uk)
IL (1) IL233132A (uk)
ME (1) ME02348B (uk)
MX (1) MX342273B (uk)
PL (1) PL2791129T3 (uk)
PT (1) PT2791129E (uk)
RS (1) RS54523B1 (uk)
SG (1) SG11201402798RA (uk)
SI (1) SI2791129T1 (uk)
SM (1) SMT201500327B (uk)
UA (1) UA111868C2 (uk)
WO (1) WO2013088108A1 (uk)
ZA (1) ZA201404246B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201103837D0 (en) 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
GB201322273D0 (en) * 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407807D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
EP3902795A1 (en) 2018-12-27 2021-11-03 Chiesi Farmaceutici S.p.A. Pharmaceutical composition comprising spherical agglomerates of timapiprant
CN111978245A (zh) * 2020-09-15 2020-11-24 上海毕得医药科技有限公司 一种3-氟-2-异丁基吡啶的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004283139A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having CRTH2 antagonist activity
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0504150D0 (en) * 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
US7188489B2 (en) 2005-04-12 2007-03-13 Martello Russell A Portable air conditioner
GB0605743D0 (en) * 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
AU2007279079A1 (en) 2006-07-22 2008-01-31 Oxagen Limited Compounds having CRTH2 antagonist activity
US20110124683A1 (en) 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
HRP20140045T1 (hr) 2008-01-18 2014-02-14 Atopix Therapeutics Limited Spojevi koji imaju antagonistiäśku aktivnost na crth2
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
JP2011509990A (ja) 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
GB201103837D0 (en) 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
CN104114169A (zh) 2011-12-16 2014-10-22 阿托佩斯治疗有限公司 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物

Also Published As

Publication number Publication date
EA026617B1 (ru) 2017-04-28
US9102658B2 (en) 2015-08-11
HUE028257T2 (en) 2016-12-28
US20140350264A1 (en) 2014-11-27
RS54523B1 (sr) 2016-06-30
BR112014014604A2 (pt) 2017-06-13
EP2791129B1 (en) 2015-10-07
EA201490998A1 (ru) 2014-11-28
JP6300277B2 (ja) 2018-03-28
AU2012351341A1 (en) 2014-07-24
KR20140113927A (ko) 2014-09-25
CA2859281A1 (en) 2013-06-20
ZA201404246B (en) 2016-10-26
IL233132A0 (en) 2014-08-03
JP2015500325A (ja) 2015-01-05
CN104114548A (zh) 2014-10-22
CA2859281C (en) 2020-10-27
KR102018929B1 (ko) 2019-09-05
MX342273B (es) 2016-09-21
BR112014014604B1 (pt) 2021-01-12
CY1117087T1 (el) 2017-04-05
GB201121557D0 (en) 2012-01-25
EP2791129A1 (en) 2014-10-22
ME02348B (me) 2016-06-20
HK1197671A1 (zh) 2015-02-06
CN104114548B (zh) 2016-01-20
HRP20151422T1 (hr) 2016-02-26
PT2791129E (pt) 2016-01-26
SI2791129T1 (sl) 2016-02-29
JP2018008985A (ja) 2018-01-18
AU2012351341B2 (en) 2017-08-24
DK2791129T3 (en) 2015-12-14
PL2791129T3 (pl) 2016-05-31
MX2014007129A (es) 2014-09-04
NZ626732A (en) 2015-09-25
ES2557762T3 (es) 2016-01-28
SMT201500327B (it) 2016-02-25
WO2013088108A1 (en) 2013-06-20
IL233132A (en) 2015-09-24
SG11201402798RA (en) 2014-06-27

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