[go: up one dir, main page]

UA111841C2 - BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION - Google Patents

BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION

Info

Publication number
UA111841C2
UA111841C2 UAA201312204A UAA201312204A UA111841C2 UA 111841 C2 UA111841 C2 UA 111841C2 UA A201312204 A UAA201312204 A UA A201312204A UA A201312204 A UAA201312204 A UA A201312204A UA 111841 C2 UA111841 C2 UA 111841C2
Authority
UA
Ukraine
Prior art keywords
compounds
formula
pharmaceutical application
benzothiazol
benzothiazol compounds
Prior art date
Application number
UAA201312204A
Other languages
Ukrainian (uk)
Inventor
Майкл Л. Мітчелл
Пол А. Ротл
Ліанхонг Ксу
Хонг ЯНГ
Райан Макфадден
Керім Бабаоглу
Original Assignee
Гіліад Сайєнсіз, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гіліад Сайєнсіз, Інк. filed Critical Гіліад Сайєнсіз, Інк.
Publication of UA111841C2 publication Critical patent/UA111841C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Винахід стосується сполук формули Іабо їх солей, а також фармацевтичних композицій, що містять сполуку формули І, способу одержання сполук формули І, проміжних сполук, що є прийнятними для одержання сполук формули І, та терапевтичних способів лікування проліферації вірусу ВІЛ, лікування СНІД або відстрочення прояву СНІД або симптомів ARC у ссавця із застосуванням сполук формули І.The invention relates to compounds of formula I or their salts, as well as pharmaceutical compositions containing a compound of formula I, a method of obtaining compounds of formula I, intermediate compounds that are acceptable for the preparation of compounds of formula I, and therapeutic methods for treating HIV virus proliferation, AIDS treatment or delay Aids or ARC symptoms in a mammal using compounds of formula I.

UAA201312204A 2011-04-21 2012-04-20 BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION UA111841C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161477922P 2011-04-21 2011-04-21
PCT/US2012/034593 WO2012145728A1 (en) 2011-04-21 2012-04-20 Benzothiazole compounds and their pharmaceutical use

Publications (1)

Publication Number Publication Date
UA111841C2 true UA111841C2 (en) 2016-06-24

Family

ID=46028194

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201312204A UA111841C2 (en) 2011-04-21 2012-04-20 BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION

Country Status (24)

Country Link
US (3) US9006229B2 (en)
EP (2) EP3181555B1 (en)
JP (2) JP5918848B2 (en)
KR (1) KR20140027295A (en)
CN (2) CN103797001B (en)
AP (2) AP2015008931A0 (en)
AU (2) AU2012245187B2 (en)
BR (1) BR112013027096A2 (en)
CA (1) CA2833377C (en)
CL (1) CL2013003019A1 (en)
CO (1) CO6801774A2 (en)
CR (1) CR20130560A (en)
EA (1) EA024952B1 (en)
EC (1) ECSP13013021A (en)
ES (2) ES2707997T3 (en)
IL (1) IL228925A0 (en)
MA (1) MA35804B1 (en)
MX (1) MX2013012266A (en)
PE (1) PE20141066A1 (en)
PH (2) PH12013502180A1 (en)
PT (1) PT2699558T (en)
SG (1) SG194512A1 (en)
UA (1) UA111841C2 (en)
WO (1) WO2012145728A1 (en)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2745295C (en) 2008-12-09 2017-01-10 Gilead Sciences, Inc. Modulators of toll-like receptors
SG186821A1 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
EP2588450B1 (en) 2010-07-02 2017-05-24 Gilead Sciences, Inc. Napht-2-ylacetic acid derivatives to treat aids
SG194512A1 (en) 2011-04-21 2013-12-30 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
ES2553449T3 (en) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compounds for HIV treatment
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
CN103204822B (en) 2012-01-17 2014-12-03 上海科州药物研发有限公司 Benzoxazole compounds as protein kinase inhibitors, and preparation method and application thereof
CA2850881C (en) * 2012-04-20 2021-02-16 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
SI3067358T1 (en) 2012-12-21 2019-12-31 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
TW201443037A (en) 2013-01-09 2014-11-16 Gilead Sciences Inc Therapeutic compounds
EP2943493B1 (en) 2013-01-09 2017-08-02 Gilead Sciences, Inc. Therapeutic compounds for the treatment of viral infections
EP2943487B1 (en) 2013-01-09 2016-11-16 Gilead Sciences, Inc. 5-membered heteroaryls and their use as antiviral agents
TW201441197A (en) 2013-01-31 2014-11-01 Shionogi & Co HIV replication inhibitor
TWI694071B (en) 2013-03-01 2020-05-21 美商基利科學股份有限公司 Therapeutic compounds for the treatment of retroviridae virus infections
EP2821082A1 (en) 2013-07-05 2015-01-07 Laboratoire Biodim Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
EP2821104A1 (en) 2013-07-05 2015-01-07 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
NO2865735T3 (en) 2013-07-12 2018-07-21
AU2014286993B2 (en) 2013-07-12 2018-10-25 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
US9944656B2 (en) 2014-02-12 2018-04-17 VIIV Healthcare UK (No.5) Limited Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication
US10202353B2 (en) 2014-02-28 2019-02-12 Gilead Sciences, Inc. Therapeutic compounds
JP6579549B2 (en) 2014-05-16 2019-09-25 塩野義製薬株式会社 Tricyclic heterocyclic derivatives having HIV replication inhibitory action
NO2717902T3 (en) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
MA40238A (en) 2014-07-11 2017-05-17 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
EP3186254B1 (en) * 2014-08-27 2019-03-06 VIIV Healthcare UK (No.5) Limited Imidazo[1,2-a]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication
WO2016036759A1 (en) 2014-09-04 2016-03-10 Gilead Sciences, Inc. Methods of treating or preventing hiv in patients using a combination of tenofovir alafenamide and dolutegravir
BR102015023450A2 (en) 2014-09-16 2016-04-12 Gilead Sciences Inc solid forms of a toll-like receptor modulator
TWI695003B (en) 2014-12-23 2020-06-01 美商基利科學股份有限公司 Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EA032430B1 (en) 2014-12-24 2019-05-31 Джилид Сайэнс, Инк. Fused pyrimidines for the treatment of hiv
TW202237569A (en) 2014-12-24 2022-10-01 美商基利科學股份有限公司 Quinazoline compounds
BR112017013440A2 (en) 2014-12-24 2018-01-09 Gilead Sciences, Inc. isoquinoline compounds for the treatment of hiv
JP7381190B2 (en) 2014-12-26 2023-11-15 エモリー・ユニバーシテイ N4-hydroxycytidine and derivatives and related antiviral uses
SI3321265T1 (en) 2015-03-04 2020-07-31 Gilead Sciences, Inc. 4,6-diamino-pyrido(3,2-d)pyrimidine compounds and their utilisation as modulators of toll-like receptors
CA2980362C (en) 2015-04-02 2020-02-25 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
SG11201709634QA (en) 2015-05-29 2017-12-28 Shionogi & Co Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
AU2016312508A1 (en) 2015-08-26 2018-02-15 Gilead Sciences, Inc. Deuterated toll-like receptor modulators
AU2016322763A1 (en) 2015-09-15 2018-04-19 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of HIV
NZ741785A (en) 2015-09-30 2019-07-26 Gilead Sciences Inc 3-cyano-1h-1,2,4-triazol-1-yl compounds and uses thereof for the treatment of hiv
AU2016370591C1 (en) 2015-12-15 2020-09-03 Gilead Sciences, Inc. Human immunodeficiency virus neutralizing antibodies
EP3597646B1 (en) 2016-08-19 2023-06-21 Gilead Sciences, Inc. Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
WO2018042331A1 (en) 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
WO2018042332A1 (en) 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
JP6746776B2 (en) 2016-09-02 2020-08-26 ギリアード サイエンシーズ， インコーポレイテッド Toll-like receptor modulator compound
ES2826748T3 (en) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivatives of 4,6-diamino-pyrido [3,2-d] pyrimidine as modulators of Toll-like receptors
WO2018051250A1 (en) 2016-09-14 2018-03-22 Viiv Healthcare Company Combination comprising tenofovir alafenamide, bictegravir and 3tc
WO2018064080A1 (en) 2016-09-28 2018-04-05 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating hiv infection
WO2018081292A1 (en) 2016-10-27 2018-05-03 Gilead Sciences, Inc. Crystalline forms of darunavir free base, hydrate, solvates and salts
TW201835068A (en) 2017-01-03 2018-10-01 英商Viiv醫療保健英國(No.5)有限公司 Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
WO2018127801A1 (en) 2017-01-03 2018-07-12 VIIV Healthcare UK (No.5) Limited Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
TW202510891A (en) 2017-01-31 2025-03-16 美商基利科學股份有限公司 Crystalline forms of tenofovir alafenamide
JOP20180009A1 (en) 2017-02-06 2019-01-30 Gilead Sciences Inc Hiv inhibitor compounds
KR102324568B1 (en) 2017-06-21 2021-11-10 길리애드 사이언시즈, 인코포레이티드 Multispecific antibodies targeting HIV gp120 and CD3
JP7287906B2 (en) 2017-06-30 2023-06-06 ヴィーブ ヘルスケア カンパニー Combinations and their uses and treatments
ES2969496T3 (en) 2017-08-01 2024-05-20 Gilead Sciences Inc Crystalline forms of ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl Ethyl (phenoxy)phosphoryl)-L-alaninate to treat viral infections
AR112412A1 (en) 2017-08-17 2019-10-23 Gilead Sciences Inc CHOLINE SALT FORMS OF AN HIV CAPSID INHIBITOR
AR112413A1 (en) 2017-08-17 2019-10-23 Gilead Sciences Inc SOLID FORMS OF AN HIV CAPSID INHIBITOR
EP3672970A1 (en) 2017-08-22 2020-07-01 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
JOP20180092A1 (en) 2017-10-13 2019-04-13 Gilead Sciences Inc Hiv protease inhibitors
WO2019084020A1 (en) 2017-10-24 2019-05-02 Gilead Sciences, Inc. Methods of treating patients co-infected with a virus and tuberculosis
KR102626210B1 (en) 2017-12-07 2024-01-18 에모리 유니버시티 N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2019123339A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
WO2019123340A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
JP7068474B2 (en) 2018-01-19 2022-05-16 ギリアード サイエンシーズ， インコーポレイテッド Metabolites of victegravir
WO2019161017A1 (en) 2018-02-15 2019-08-22 Gilead Sciences, Inc. Pyridine derivatives and their use for treating hiv infection
US10696657B2 (en) 2018-02-16 2020-06-30 Gilead Sciences, Inc. Methods and intermediates for preparing therapeutic compounds
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TW202014193A (en) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 2’3’-cyclic dinucleotides comprising carbocyclic nucleotide
SG11202012043RA (en) 2018-07-03 2021-01-28 Gilead Sciences Inc Antibodies that target hiv gp120 and methods of use
CN112384505B (en) 2018-07-06 2025-05-27 吉利德科学公司 Therapeutic heterocyclic compounds
US11186579B2 (en) 2018-07-06 2021-11-30 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
TWI842721B (en) 2018-07-16 2024-05-21 美商基利科學股份有限公司 Capsid inhibitors for the treatment of hiv
TWI829205B (en) 2018-07-30 2024-01-11 美商基利科學股份有限公司 Anti-hiv compounds
AU2019344929B2 (en) 2018-09-19 2023-03-30 Gilead Sciences, Inc. Integrase inhibitors for the prevention of HIV
EP3860717A1 (en) 2018-10-03 2021-08-11 Gilead Sciences, Inc. Imidozopyrimidine derivatives
US11071730B2 (en) 2018-10-31 2021-07-27 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
PL3873903T3 (en) 2018-10-31 2024-05-20 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
WO2020176510A1 (en) 2019-02-25 2020-09-03 Gilead Sciences, Inc. Protein kinase c agonists
WO2020176505A1 (en) 2019-02-25 2020-09-03 Gilead Sciences, Inc. Protein kinase c agonists
CN113543851B (en) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 2'3'-Cyclic dinucleotides and prodrugs thereof
WO2020178768A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
US20220143061A1 (en) 2019-03-07 2022-05-12 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202104210A (en) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv protease inhibitors
TWI751517B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
US20200347036A1 (en) 2019-04-17 2020-11-05 Gilead Sciences, Inc. Solid forms of an hiv protease inhibitor
TWI762925B (en) 2019-05-21 2022-05-01 美商基利科學股份有限公司 Methods of identifying hiv patients sensitive to therapy with gp120 v3 glycan-directed antibodies
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
RU2717101C1 (en) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Anellated 9-hydroxy-1,8-dioxo-1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine-7-carboxamides - integrase inhibitors, methods for preparing and using thereof
WO2020255038A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
US20210009718A1 (en) 2019-06-25 2021-01-14 Gilead Sciences, Inc. FLT3L-Fc FUSION PROTEINS AND METHODS OF USE
KR20220047277A (en) 2019-07-16 2022-04-15 길리애드 사이언시즈, 인코포레이티드 HIV Vaccines, and Methods of Making and Using the Same
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
EP4017476A1 (en) 2019-08-19 2022-06-29 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
US11807625B2 (en) 2019-11-26 2023-11-07 Gilead Sciences, Inc. Capsid inhibitors for the prevention of HIV
MX2022007930A (en) 2019-12-24 2022-08-08 Carna Biosciences Inc Diacylglycerol kinase modulating compounds.
BR112022015771A2 (en) 2020-02-24 2022-10-11 Gilead Sciences Inc TETRACYCLIC COMPOUNDS TO TREAT HIV INFECTION
TW202421168A (en) 2020-03-20 2024-06-01 美商基利科學股份有限公司 Prodrugs of 4’-c-substituted-2-halo-2’-deoxyadenosine nucleosides and methods of making and using the same
EP4153181A1 (en) 2020-05-21 2023-03-29 Gilead Sciences, Inc. Pharmaceutical compositions comprising bictegravir
TW202502766A (en) 2020-06-25 2025-01-16 美商基利科學股份有限公司 Capsid inhibitors for the treatment of hiv
WO2022031894A1 (en) 2020-08-07 2022-02-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
TW202222798A (en) 2020-09-30 2022-06-16 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and uses thereof
TWI815194B (en) 2020-10-22 2023-09-11 美商基利科學股份有限公司 INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE
WO2022103758A1 (en) 2020-11-11 2022-05-19 Gilead Sciences, Inc. METHODS OF IDENTIFYING HIV PATIENTS SENSITIVE TO THERAPY WITH gp120 CD4 BINDING SITE-DIRECTED ANTIBODIES
CA3202957A1 (en) 2021-01-19 2022-07-28 Hang CHU Substituted pyridotriazine compounds and uses thereof
TW202313094A (en) 2021-05-18 2023-04-01 美商基利科學股份有限公司 Methods of using flt3l-fc fusion proteins
US11976072B2 (en) 2021-06-23 2024-05-07 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359411A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
MX2023014762A (en) 2021-06-23 2024-01-15 Gilead Sciences Inc DIACYL GLYCEROL KINASE MODULATING COMPOUNDS.
JP7765637B2 (en) 2021-12-03 2025-11-06 ギリアード サイエンシーズ， インコーポレイテッド Therapeutic compounds for HIV virus infections
CN118369316A (en) 2021-12-03 2024-07-19 吉利德科学公司 Therapeutic compounds for HIV infection
CA3235937A1 (en) 2021-12-03 2023-06-08 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
TWI843506B (en) 2022-04-06 2024-05-21 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and uses thereof
TW202434566A (en) 2022-07-01 2024-09-01 美商基利科學股份有限公司 Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection
EP4554628A1 (en) 2022-07-12 2025-05-21 Gilead Sciences, Inc. Hiv immunogenic polypeptides and vaccines and uses thereof
AU2023330037A1 (en) 2022-08-26 2025-03-06 Gilead Sciences, Inc. Dosing and scheduling regimen for broadly neutralizing antibodies
EP4598934A1 (en) 2022-10-04 2025-08-13 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
AR132464A1 (en) 2023-04-19 2025-07-02 Gilead Sciences Inc CAPSID INHIBITOR DOSAGE REGIMEN
WO2024249592A1 (en) 2023-05-31 2024-12-05 Gilead Sciences, Inc. Quinazolinyl-indazole derivatives as therapeutic compounds for hiv
TW202504592A (en) 2023-05-31 2025-02-01 美商基利科學股份有限公司 Solid forms
WO2024249517A1 (en) 2023-05-31 2024-12-05 Gilead Sciences, Inc. Anti-hiv compounds
WO2025029247A1 (en) 2023-07-28 2025-02-06 Gilead Sciences, Inc. Weekly regimen of lenacapavir for the treatment and prevention of hiv
WO2025042394A1 (en) 2023-08-23 2025-02-27 Gilead Sciences, Inc. Dosing regimen of hiv capsid inhibitor
WO2025076542A1 (en) 2023-10-05 2025-04-10 Jones R Brad Atovaquone as an ros inducer for use in the elimination of hiv-infected t-cells
US20250122219A1 (en) 2023-10-11 2025-04-17 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2025080850A1 (en) 2023-10-11 2025-04-17 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and uses thereof
TW202515549A (en) 2023-10-11 2025-04-16 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2025137245A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Solid forms of hiv integrase inhibitors
WO2025184447A1 (en) 2024-03-01 2025-09-04 Gilead Sciences, Inc. Pharmaceutical compositions comprising hiv integrase inhibitors
US20250289822A1 (en) 2024-03-01 2025-09-18 Gilead Sciences, Inc. Solid forms of hiv integrase inhibitors
US20250333424A1 (en) 2024-03-01 2025-10-30 Gilead Sciences, Inc. Antiviral compounds
US20250326779A1 (en) 2024-04-03 2025-10-23 Gilead Sciences, Inc. Anti-hiv compounds
WO2025260028A1 (en) 2024-06-14 2025-12-18 Gilead Sciences, Inc. Pharmaceutical compositions comprising hiv integrase inhibitors

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895028A (en) * 1972-09-12 1975-07-15 Tokyo Tanabe Co Alpha-(2-phenylbenzothiazol-5-yl)propionic acid
JPS4994667A (en) 1973-01-23 1974-09-09
FR2453163A1 (en) * 1979-04-03 1980-10-31 Rolland Sa A BENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
GB8403739D0 (en) * 1984-02-13 1984-03-14 Roussel Lab Ltd Chemical compounds
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
ATE131825T1 (en) 1990-06-13 1996-01-15 Arnold Glazier PHOSPHORYLATED PRODRUGS
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
MX9308016A (en) 1992-12-22 1994-08-31 Lilly Co Eli HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITING COMPOUNDS, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATION CONTAINING THEM.
US5733906A (en) 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
DE69434931T2 (en) 1993-04-02 2007-11-22 Rigel Pharmaceuticals, Inc., South San Francisco METHOD FOR THE SELECTIVE INACTIVATION OF VIRAL REPLICATION
JP3287558B2 (en) 1993-07-27 2002-06-04 株式会社半導体エネルギー研究所 Method for manufacturing semiconductor device
US5434188A (en) 1994-03-07 1995-07-18 Warner-Lambert Company 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV
DE4428932A1 (en) 1994-08-16 1996-02-22 Hoechst Ag Substituted quinoline derivatives, process for their preparation and their use
WO1999052850A1 (en) 1998-04-09 1999-10-21 Merck & Co., Inc. Oxidation process using periodic acid
WO2000063152A1 (en) 1999-02-22 2000-10-26 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Acetylated and related analogues of chicoric acid as hiv integrase inhibitors
US20020052323A1 (en) 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
EP1441228B1 (en) 2000-11-21 2006-06-28 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
FR2819507B1 (en) 2001-01-17 2007-09-28 Inst Rech Developpement Ird SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS
FR2839646B1 (en) 2002-05-17 2008-04-11 Bioalliance Pharma USE OF QUINOLINE DERIVATIVES WITH ANTI-INTEGRASE EFFECT AND APPLICATIONS THEREOF
PL374948A1 (en) * 2002-08-02 2005-11-14 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
KR101327772B1 (en) * 2002-08-02 2013-11-11 얀센 알 앤드 디 아일랜드 Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
DE60322920D1 (en) 2002-08-13 2008-09-25 Shionogi & Co HETEROCYCLIC COMPOUNDS WITH HIV INTEGRATE-INHIBITOR EFFECT
EP1546331B2 (en) 2002-09-26 2016-01-13 K.U.Leuven Research & Development Integrase cofactor
BRPI0306214B1 (en) 2002-11-20 2017-08-08 Japan Tobacco Inc. 4-OXOQUINOLINE COMPOUND AND USE OF THIS AS HIV INTEGRASE INHIBITOR
UA80571C2 (en) 2002-11-22 2007-10-10 Lilly Co Eli Quinolinyl-pyrrolopyrazoles
WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
AU2005257859A1 (en) 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
US7087610B2 (en) * 2004-06-03 2006-08-08 Bristol-Myers Squibb Company Benzothiazole antiviral agents
CA2571309A1 (en) 2004-06-22 2006-01-05 Smithkline Beecham Corporation Chemical compounds
TWI306401B (en) 2004-08-13 2009-02-21 Nat Health Research Institutes Benzothiazolium compounds
US20060094755A1 (en) 2004-10-28 2006-05-04 Bioflexis, Llc Novel quinoline-based metal chelators as antiviral agents
TWI370820B (en) 2005-04-27 2012-08-21 Takeda Pharmaceutical Fused heterocyclic compounds
WO2006124780A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
US7473784B2 (en) * 2005-08-01 2009-01-06 Bristol-Myers Squibb Company Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
US7939545B2 (en) 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
EP2032578A2 (en) 2006-05-30 2009-03-11 Pfizer Products Incorporated Triazolopyridazine derivatives
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-( substituted-amino)- benzothiazole sulfonamide HIV protease INHIBITORS
US8435774B2 (en) 2006-06-28 2013-05-07 Qiagen Gmbh Enhancing reactivation of thermostable reversibly inactivated enzymes
WO2008053478A2 (en) 2006-10-30 2008-05-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions and methods for inhibiting hiv-1 replication and integrase activity
AU2007332654B2 (en) 2006-12-13 2013-06-20 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
ATE541841T1 (en) 2007-11-15 2012-02-15 Boehringer Ingelheim Int INHIBITORS OF REPLICATION OF THE HUMAN IMMUNODEFICIENCY VIRUS
NZ585297A (en) 2007-11-15 2012-06-29 Gilead Sciences Inc Inhibitors of human immunodeficiency virus replication
WO2009062285A1 (en) 2007-11-16 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
EP2220084B1 (en) 2007-11-16 2014-02-19 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
GB0801940D0 (en) 2008-02-01 2008-03-12 Univ Leuven Kath Inhibitors of lentiviral replication
EP2265270A1 (en) 2008-02-04 2010-12-29 OSI Pharmaceuticals, Inc. 2-aminopyridine kinase inhibitors
WO2010059658A1 (en) 2008-11-20 2010-05-27 Glaxosmithkline Llc Chemical compounds
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
CN102469788A (en) 2009-06-30 2012-05-23 西佳技术公司 Treatment and prevention of dengue virus infection
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
US9095596B2 (en) 2009-10-15 2015-08-04 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
SG10201408512RA (en) 2009-12-23 2015-02-27 Univ Leuven Kath Novel antiviral compounds
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
NZ603644A (en) 2010-05-24 2014-10-31 Univ Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
EP2588450B1 (en) 2010-07-02 2017-05-24 Gilead Sciences, Inc. Napht-2-ylacetic acid derivatives to treat aids
SG186821A1 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
US8633200B2 (en) 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
BR112013011737A2 (en) 2010-11-15 2016-08-09 Univ Leuven Kath compound, use of a compound pharmaceutical composition, and method of treating or preventing an HIV infection
WO2012066442A1 (en) 2010-11-15 2012-05-24 Pfizer Limited Inhibitors of hiv replication
AR084457A1 (en) 2010-12-22 2013-05-15 Lundbeck & Co As H BICYCLE DERIVATIVES [3,2,1] OCTILAMIDE
WO2012102985A1 (en) 2011-01-24 2012-08-02 Glaxosmithkline Llc Isoquinoline compounds and methods for treating hiv
JP2014510139A (en) 2011-04-04 2014-04-24 ギリアード サイエンシーズ， インコーポレイテッド HIV inhibitor in solid form
EP2694479A1 (en) 2011-04-04 2014-02-12 Gilead Sciences, Inc. Process for the preparation of an hiv integrase inhibitor
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
ES2742261T3 (en) 2011-04-15 2020-02-13 Hivih Inhibitors of viral replication, its preparation process and its therapeutic uses
EP2699572B1 (en) 2011-04-21 2016-08-10 Origenis GmbH Heterocyclic compounds as kinase inhibitors
SI2699575T1 (en) 2011-04-21 2015-10-30 Bayer Intellectual Property Gmbh Triazolopyridines
WO2012143144A1 (en) 2011-04-21 2012-10-26 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
SG194512A1 (en) 2011-04-21 2013-12-30 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
WO2013002357A1 (en) 2011-06-30 2013-01-03 塩野義製薬株式会社 Hiv replication inhibitor
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
ES2632443T3 (en) 2011-09-22 2017-09-13 Viiv Healthcare Uk Limited Pyrrolopyridinone compounds and HIV treatment procedures
WO2013058448A1 (en) 2011-10-20 2013-04-25 한국해양연구원 Marine medaka genes responding to the exposure of endocrine-disrupting chemicals, and method for diagnosing an aquatic eco-system contamination using same
EP2772480B2 (en) 2011-10-25 2020-12-09 Shionogi & Co., Ltd. Hiv replication inhibitor
US8332160B1 (en) * 2011-11-17 2012-12-11 Amyris Biotechnologies, Inc. Systems and methods for engineering nucleic acid constructs using scoring techniques
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
MX394449B (en) 2012-01-12 2025-03-11 Univ Yale COMPOUNDS AND METHODS FOR ENHANCED DEGRADATION OF TARGETED PROTEINS AND OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE.
US8629276B2 (en) 2012-02-15 2014-01-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9034882B2 (en) 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013157622A1 (en) 2012-04-19 2013-10-24 塩野義製薬株式会社 Hiv replication inhibitor
CA2850881C (en) 2012-04-20 2021-02-16 Gilead Sciences, Inc. Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
JP6129962B2 (en) 2012-07-12 2017-05-17 ヴィーブ ヘルスケア ユーケー リミテッド Compounds and methods for treating HIV
US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US20140094485A1 (en) 2012-10-03 2014-04-03 Gilead Sciences, Inc. Solid state forms of hiv inhibitor
WO2014055603A1 (en) 2012-10-03 2014-04-10 Gilead Sciences, Inc. Process for the preparation of an hiv integrase inhibitor

Also Published As

Publication number Publication date
EP2699558A1 (en) 2014-02-26
ECSP13013021A (en) 2014-01-31
SG194512A1 (en) 2013-12-30
CA2833377A1 (en) 2012-10-26
AU2016234985C1 (en) 2018-08-23
CN103797001B (en) 2016-04-20
US20140045818A1 (en) 2014-02-13
ES2707997T3 (en) 2019-04-08
CL2013003019A1 (en) 2014-02-14
US9464096B2 (en) 2016-10-11
KR20140027295A (en) 2014-03-06
AP2013007249A0 (en) 2013-11-30
JP2014514323A (en) 2014-06-19
CN103797001A (en) 2014-05-14
EA201391395A1 (en) 2014-05-30
EP2699558B1 (en) 2016-11-23
MX2013012266A (en) 2013-11-22
CR20130560A (en) 2014-02-18
US20160024104A1 (en) 2016-01-28
CN105712948A (en) 2016-06-29
AP2015008931A0 (en) 2015-12-31
WO2012145728A1 (en) 2012-10-26
CO6801774A2 (en) 2013-11-29
US9879023B2 (en) 2018-01-30
US20170088554A1 (en) 2017-03-30
IL228925A0 (en) 2013-12-31
PH12015502056A1 (en) 2016-09-19
NZ715889A (en) 2017-06-30
MA35804B1 (en) 2014-12-01
JP5918848B2 (en) 2016-05-18
AU2012245187A1 (en) 2013-05-02
ES2615734T3 (en) 2017-06-08
BR112013027096A2 (en) 2016-12-27
PE20141066A1 (en) 2014-09-05
AU2016234985A1 (en) 2016-10-27
AU2016234985B2 (en) 2018-02-01
PH12013502180A1 (en) 2014-01-06
NZ617996A (en) 2016-02-26
EP3181555A1 (en) 2017-06-21
US9006229B2 (en) 2015-04-14
EP3181555B1 (en) 2018-11-28
PT2699558T (en) 2016-12-29
CA2833377C (en) 2019-02-12
AU2012245187B2 (en) 2016-06-30
EA024952B1 (en) 2016-11-30
JP2016065110A (en) 2016-04-28

Similar Documents

Publication Publication Date Title
UA111841C2 (en) BENZOTHIAZOL COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION
EA201291300A1 (en) DERIVATIVES OF NAFT-2-LUCUS ACID FOR THE TREATMENT OF AIDS
EA201490228A1 (en) NEW DERIVATIVES OF TRIFTOROMETHYLOROXIAZOLE AND THEIR APPLICATION FOR THE TREATMENT OF DISEASE
EA201590358A1 (en) Inhibitors of Human Immunodeficiency Virus Replication
EA201890333A1 (en) ANTI-VIRUS COMPOUNDS
EA201491060A1 (en) NEW DERIVATIVES OF TRIFTOROMETHYLOROXIAZOLE AND THEIR APPLICATION FOR THE TREATMENT OF DISEASE
JOP20180009A1 (en) Hiv inhibitor compounds
UA111770C2 (en) BROMDOMEN INHIBITORS
EA201391127A1 (en) C-17 AND C-3 MODIFIED TRITERPENOIDS WITH INHIBITOR ACTIVITY OF HIV MATURATION
EA201391561A1 (en) NEW CONNECTIONS-MODULATORS GPR-119
UA116083C2 (en) PURINE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS
EA201491028A8 (en) METHOD OF OBTAINING SUBSTITUTED 5-FLUOR-1H-PYRAZOLOPIRIDINES
MD20140136A2 (en) Inhibitors of hepatitis C virus
EA201490588A1 (en) METHODS OF TREATMENT OF HEPATITIS C VIRUS
EA201391615A1 (en) DATED POTENTIATORS CFTR
EA201301019A1 (en) Benzodioxan inhibitors of leukotriene production
EA201590693A1 (en) INHIBITORS GDF-8
EA201490854A1 (en) ANTI-VIRUS COMPOUNDS
EA201491247A1 (en) DERIVATIVES OF DIHYDROBENZOOXIN AND DIHYDROPYRIDOXAZINE
EA201490471A1 (en) PYRIDAZINOUS COMPOUNDS AND THEIR APPLICATION AS DAAO INHIBITORS
EA201490650A1 (en) PHARMACEUTICAL COMPOSITIONS
MX347692B (en) HEPATITIS VIRUS INHIBITORS C.
EA201301181A1 (en) TRIAZOLOPRYRIDINS
EA201600337A1 (en) 2,6-SUBSTITUTED PURINE DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF PROLIFERATIVE DISEASES
EA201490223A1 (en) COMPOSITIONS BASED ON DARUNAVIR