[go: up one dir, main page]

UA111725C2 - Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол - Google Patents

Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол

Info

Publication number
UA111725C2
UA111725C2 UAA201303378A UAA201303378A UA111725C2 UA 111725 C2 UA111725 C2 UA 111725C2 UA A201303378 A UAA201303378 A UA A201303378A UA A201303378 A UAA201303378 A UA A201303378A UA 111725 C2 UA111725 C2 UA 111725C2
Authority
UA
Ukraine
Prior art keywords
dichloropyridin
indazol
pyrazol
ethoxy
vinyl
Prior art date
Application number
UAA201303378A
Other languages
English (en)
Inventor
Бенджамін Алан Дісероуд
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA111725(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA111725C2 publication Critical patent/UA111725C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даний винахід стосується кристалічного (R)-(E)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етокси)-1Н-індазол-3-іл)вініл)-1Н-піразол-1-іл)етанолу, придатного для лікування раку.
UAA201303378A 2010-10-05 2011-09-29 Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол UA111725C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38991110P 2010-10-05 2010-10-05
PCT/US2011/053798 WO2012047699A1 (en) 2010-10-05 2011-09-29 Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Publications (1)

Publication Number Publication Date
UA111725C2 true UA111725C2 (uk) 2016-06-10

Family

ID=44999860

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201303378A UA111725C2 (uk) 2010-10-05 2011-09-29 Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол

Country Status (35)

Country Link
US (1) US8530665B2 (uk)
EP (1) EP2625175B1 (uk)
JP (1) JP5940547B2 (uk)
KR (1) KR101527661B1 (uk)
CN (1) CN103153983B (uk)
AR (1) AR083091A1 (uk)
AU (1) AU2011312485B2 (uk)
BR (1) BR112013006336A2 (uk)
CA (1) CA2813329C (uk)
CL (1) CL2013000884A1 (uk)
CO (1) CO6710911A2 (uk)
DK (1) DK2625175T3 (uk)
DO (1) DOP2013000072A (uk)
EA (1) EA021817B1 (uk)
EC (1) ECSP13012539A (uk)
ES (1) ES2558777T3 (uk)
HR (1) HRP20151299T1 (uk)
HU (1) HUE026379T2 (uk)
IL (1) IL224850A (uk)
JO (1) JO3062B1 (uk)
MA (1) MA34552B1 (uk)
ME (1) ME02307B (uk)
MX (1) MX2013003907A (uk)
NZ (1) NZ608482A (uk)
PE (1) PE20140252A1 (uk)
PH (1) PH12013500649A1 (uk)
PL (1) PL2625175T3 (uk)
PT (1) PT2625175E (uk)
RS (1) RS54457B1 (uk)
SG (1) SG188286A1 (uk)
SI (1) SI2625175T1 (uk)
TW (1) TWI418554B (uk)
UA (1) UA111725C2 (uk)
WO (1) WO2012047699A1 (uk)
ZA (1) ZA201301560B (uk)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
PE20190736A1 (es) 2012-06-13 2019-05-23 Incyte Holdings Corp Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr)
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
KR102269032B1 (ko) 2013-04-19 2021-06-24 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
ES2895769T3 (es) 2015-02-20 2022-02-22 Incyte Corp Heterociclos bicíclicos como inhibidores de FGFR
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
SI3788047T1 (sl) 2018-05-04 2024-11-29 Incyte Corporation Trdne oblike inhibitorja fgfr in postopki priprave le-teh
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US11607416B2 (en) 2019-10-14 2023-03-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111705099B (zh) * 2020-07-01 2022-03-08 天津药明康德新药开发有限公司 一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法
AU2021401741A1 (en) * 2020-12-17 2023-06-29 Blossomhill Therapeutics, Inc. Macrocycles and their use
CN116635076A (zh) * 2020-12-17 2023-08-22 荣山医药股份有限公司 大环化合物及其用途
WO2022221170A1 (en) 2021-04-12 2022-10-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
WO2022261159A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20250164828A (ko) 2023-03-30 2025-11-25 레볼루션 메디슨즈, 인크. Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
ES2302106T3 (es) 2000-09-11 2008-07-01 Novartis Vaccines And Diagnostics, Inc. Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina.
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
AU2005223486A1 (en) * 2004-03-17 2005-09-29 Pfizer Inc. Polymorphic and amorphous forms of 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((e)-2-pyridin-2-yl-vinyl)-1H-indasol-6-ylamino]-phenyl}-amide
JP4746299B2 (ja) * 2004-07-16 2011-08-10 ジュズ インターナショナル ピーティーイー エルティーディー 金属酸化物粉末の製造方法
JP2006163651A (ja) 2004-12-03 2006-06-22 Sony Computer Entertainment Inc 表示装置、表示装置の制御方法、プログラム及びフォントデータ
US20060160863A1 (en) * 2005-01-05 2006-07-20 Agouron Pharmaceuticals, Inc. Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
EP2134702B2 (en) * 2007-04-05 2023-08-30 Pfizer Products Inc. Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole suitable for the treatment of abnormal cell growth in mammals
AR078411A1 (es) * 2009-05-07 2011-11-09 Lilly Co Eli Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende

Also Published As

Publication number Publication date
SG188286A1 (en) 2013-04-30
IL224850A (en) 2016-09-29
HUE026379T2 (en) 2016-06-28
KR101527661B1 (ko) 2015-06-09
DOP2013000072A (es) 2013-08-15
BR112013006336A2 (pt) 2019-09-24
CN103153983A (zh) 2013-06-12
AU2011312485B2 (en) 2014-09-04
CO6710911A2 (es) 2013-07-15
EP2625175B1 (en) 2015-11-18
MA34552B1 (fr) 2013-09-02
ES2558777T3 (es) 2016-02-08
JO3062B1 (ar) 2017-03-15
DK2625175T3 (en) 2016-02-01
AU2011312485A1 (en) 2013-03-07
TW201249826A (en) 2012-12-16
JP2013538875A (ja) 2013-10-17
ECSP13012539A (es) 2013-06-28
ZA201301560B (en) 2014-08-27
AR083091A1 (es) 2013-01-30
PL2625175T3 (pl) 2016-04-29
US20120083511A1 (en) 2012-04-05
ME02307B (me) 2016-06-20
HRP20151299T1 (hr) 2016-01-01
MX2013003907A (es) 2013-06-03
PH12013500649A1 (en) 2013-05-06
CA2813329A1 (en) 2012-04-12
TWI418554B (zh) 2013-12-11
EA021817B1 (ru) 2015-09-30
CN103153983B (zh) 2014-11-05
PE20140252A1 (es) 2014-03-12
PT2625175E (pt) 2016-01-22
NZ608482A (en) 2014-03-28
EA201390275A1 (ru) 2013-07-30
WO2012047699A1 (en) 2012-04-12
SI2625175T1 (sl) 2016-01-29
US8530665B2 (en) 2013-09-10
KR20130052680A (ko) 2013-05-22
EP2625175A1 (en) 2013-08-14
HK1184147A1 (zh) 2014-01-17
RS54457B1 (sr) 2016-06-30
CA2813329C (en) 2015-05-26
JP5940547B2 (ja) 2016-06-29
CL2013000884A1 (es) 2013-10-18

Similar Documents

Publication Publication Date Title
UA111725C2 (uk) Кристалічний (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпіридин-4-іл)етоксі)-1h-індазол-3-іл)вініл)-1h-піразол-1-іл)етанол
CO6450624A2 (es) Compuestos vinil indazolilo
IL210174A0 (en) 4-(pyridin-4-yl)-1h-(1,3,5)triazin-2-one derivatives as gsk3-beta inhibitors for the treatment of neurodegenerative diseases
AR089818A1 (es) Inhibidor de la quinasa que regula la señal de la apoptosis
UY34202A (es) Compuestos fungicidas 2-(2-clor0-4-(4-cloro-fenoxi)-fenil]-1-(1,2,4]triazol-1-1l-etanol alquilo sustituidos
PH12012500674A1 (en) Heterocyclic compounds useful as pdk1 inhibitors
NO20083568L (no) Hydantoinforbindelser for behandling av inflammatoriske forstyrrelser
TN2015000521A1 (en) Processes of making and crystalline forms of a mdm2 inhibitor
UA122520C2 (uk) Кристалічна форма 2-[4-(4-хлорфенокси)-2-(трифторметил)феніл]-1-(1,2,4-триазол-1-іл)пропан-2-олу, агрохімічна композиція, застосування та спосіб боротьби зі шкідливими грибами
EA201170252A1 (ru) Амидофеноксиндазолы в качестве ингибиторов c-мет
NZ627113A (en) Substituted pyrimidine compounds and their use as syk inhibitors
EA200900091A1 (ru) Новые показания к применению прямых ингибиторов тромбина в лечении сердечно-сосудистых заболеваний
EA201691997A1 (ru) Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы
NO20085029L (no) Substituerte pyridylamidforbindelser som modulatorer av histamin H3 reseptoren
UA106880C2 (uk) Нові гербіциди
MX2016007810A (es) Derivados de n1-(3,3,3-trifluoro-2-hidroxo-2-metilpropionil)-piper idina como inhibidores de piruvato deshidrogenasa cinasa.
EA201400001A1 (ru) Новые производные фталазинонпирролопиримидинкарбоксамида
TN2013000142A1 (en) Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor
CY1117146T1 (el) Κρυσταλλικη (r)-(ε)-2-(4-(2-(5-(1-(3,5-διχλωροπυριδινο-4-υλ)αιθοξυ)-1 η-ινδαζολο-3-υλ)βινυλο)-1 η-πυραζολο-1-υλ)αιθανολη και η χρηση της ως αναστολεα του fgfr
TH132151A (th) ((r)-(e)-2-(4-(2-(5-(1-(3,5-ไดคลอโรไพริดิน-4-อิล)เอทธอกซี)-1h-อินดาซอล-3-อิล)ไวนิล)-1h-ไพราซอล-1-อิล)เอทธานอลเชิงผลึก
UA88738U (uk) 5-(гептилтіо)-3-(феноксиметил)-1н-1,2,4-тріазол, що виявляє антигіпоксичну активність
UA88008U (en) 3-(phenoxymethyl)-5-(propylthio)-1h-1,2,4-triazole exhibiting actoprotector activity
UA75996U (uk) Похідні 1,2,4-триазолів, що проявляють аналгетичну активність
UA41094U (en) Derivatives of 4-(bromomethyl)-2-r-1,3-thiazol-3-ium bromides and 4-bromomethyl-2-r-1,3-thiazoles
TH115254A (th) สารประกอบไวนิลอินดาโซลอิล