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UA118549C2 - 2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену - Google Patents

2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену

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Publication number
UA118549C2
UA118549C2 UAA201507943A UAA201507943A UA118549C2 UA 118549 C2 UA118549 C2 UA 118549C2 UA A201507943 A UAA201507943 A UA A201507943A UA A201507943 A UAA201507943 A UA A201507943A UA 118549 C2 UA118549 C2 UA 118549C2
Authority
UA
Ukraine
Prior art keywords
4аlkуl
disubstituted
acyl
amino
bromodomain inhibitors
Prior art date
Application number
UAA201507943A
Other languages
English (en)
Inventor
Домінік Ейманз
Стівен Джон Еткінсон
Лі Ендрю Гаррісон
Дейвід Джонатан Герст
Роберт Пітер Ло
Меттью Ліндон
Елікзендер Престон
Джонатан Томас Сіл
Крістофер Роланд Веллавей
Original Assignee
Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50390051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA118549(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед filed Critical Ґлаксосмітклайн Інтеллекчуал Проперті (№ 2) Лімітед
Publication of UA118549C2 publication Critical patent/UA118549C2/uk

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Винахід стосується нових сполук, таких як (2S,3R,4R)-1-ацетил-2-циклопропіл-3-метил-4-((4-метилпіримідин-2-іл)аміно)-1,2,3,4-тетрагідрохінолін-6-карбоксамід, що має структурну формулу (І): , фармацевтичних композицій, які містять такі сполуки, та їх застосування в лікуванні гострого або хронічного аутоімунного та/або запального стану.
UAA201507943A 2013-03-14 2014-03-12 2,3-дизаміщені похідні 1-ацил-4-аміно-1,2,3,4-тетрагідрохіноліну та їх застосування як інгібіторів бромодомену UA118549C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781583P 2013-03-14 2013-03-14
US201361882798P 2013-09-26 2013-09-26
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