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UA117448C2 - Середовище клітинної культури для культивування ооцита - Google Patents

Середовище клітинної культури для культивування ооцита

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Publication number
UA117448C2
UA117448C2 UAA201400826A UAA201400826A UA117448C2 UA 117448 C2 UA117448 C2 UA 117448C2 UA A201400826 A UAA201400826 A UA A201400826A UA A201400826 A UAA201400826 A UA A201400826A UA 117448 C2 UA117448 C2 UA 117448C2
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UA
Ukraine
Prior art keywords
osc
oocyte
inhibitor
stem cell
nad
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UAA201400826A
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English (en)
Inventor
Джонатан Лі Тіллі
Девід А. Сінклер
Original Assignee
Зе Дженерел Хоспітел Корпорейшн
Президент Енд Феллоус Оф Харвард Колледж
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Application filed by Зе Дженерел Хоспітел Корпорейшн, Президент Енд Феллоус Оф Харвард Колледж filed Critical Зе Дженерел Хоспітел Корпорейшн
Publication of UA117448C2 publication Critical patent/UA117448C2/uk

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    • C12N15/09—Recombinant DNA-technology
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    • A61K31/13—Amines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Винахід стосується середовища клітинної культури для культивування ооцита, стовбурової клітини оогоніїв (OSC), потомка OSC або передімплантаційної зіготи, де зазначена OSC, одержана з оваріальної тканини, являє собою виділену стовбурову клітину, що не є ембріональною та є мітотично компетентною і експресує Vasa, Oct-4, Dazl i Stella, де зазначене середовище клітинної культури містить інгібітор CD38 та попередник нікотинамідаденіндинуклеотиду (NAD), де зазначений інгібітор CD38 являє собою сполуку, вибрану з групи, що складається з апігеніну, лютеоліну, тирфостину-8, берберину і SRT-1720, та де зазначені інгібітор CD38 і попередник NAD присутні у зазначеному середовищі у кількості, ефективній для покращення біоенергетичного стану зазначених ооцита, OSC, потомка OSC або передімплантаційної зиготи, культивованих у зазначеному середовищі. Винахід також стосується композиції, що містить виділений ооцит, стовбурову клітину оогоніїв (OSC), потомок OSC або препарат мітохондрій, та зазначені інгібітор CD38 і попередник NAD; способу культивування ооцита та способу одержання ооцита для застосування у заплідненні in vitro.
UAA201400826A 2011-06-29 2012-04-13 Середовище клітинної культури для культивування ооцита UA117448C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161502840P 2011-06-29 2011-06-29
US201261600529P 2012-02-17 2012-02-17
PCT/US2012/033672 WO2013002880A1 (en) 2011-06-29 2012-04-13 Compositions and methods for enhancing bioenergetic status in female germ cells

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UA117448C2 true UA117448C2 (uk) 2018-08-10

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US (4) US9845482B2 (uk)
EP (2) EP2726601B1 (uk)
JP (3) JP6284475B2 (uk)
CN (1) CN103827293A (uk)
AU (2) AU2012276038B2 (uk)
BR (1) BR112013033797A2 (uk)
CA (1) CA2847292A1 (uk)
EA (1) EA201490050A1 (uk)
IL (2) IL230212B (uk)
MX (1) MX356815B (uk)
UA (1) UA117448C2 (uk)
WO (1) WO2013002880A1 (uk)
ZA (1) ZA201309707B (uk)

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SG194448A1 (en) * 2011-04-14 2013-12-30 Gen Hospital Corp Compositions and methods for autologous germline mitochondrial energy transfer
WO2013035101A1 (en) 2011-09-11 2013-03-14 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
WO2013171752A1 (en) 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
EP4233878B1 (en) 2013-03-15 2025-05-07 Washington University Administration of nicotinamide mononucleotide in the treatment of photoreceptor degeneration or damage
CA2934579A1 (en) * 2013-12-20 2015-06-25 Fertilify Inc. Compositions comprising vitamin c, vitamin e, and coenzyme q10 and use thereof for promoting female fertility and reproductive health
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EP2995948A1 (en) * 2014-09-09 2016-03-16 Ecole Polytechnique Federale de Lausanne (EPFL) Methods and compounds useful in hematopoietic stem cell medicine
EA201790236A1 (ru) * 2014-09-16 2017-11-30 Оувэсайенс, Инк. Антитела против vasa и способы их получения и использования
JP2018502096A (ja) * 2014-12-24 2018-01-25 ピエール、ファーブル、メディカマン 新規ヒト化ａｄａｍ１７抗体
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WO2016144660A1 (en) 2015-03-09 2016-09-15 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
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