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HK1256687A1 - 对用於产生能生育的 xy 雌性小鼠的多能细胞的选择 - Google Patents

对用於产生能生育的 xy 雌性小鼠的多能细胞的选择 Download PDF

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Publication number
HK1256687A1
HK1256687A1 HK18115672.3A HK18115672A HK1256687A1 HK 1256687 A1 HK1256687 A1 HK 1256687A1 HK 18115672 A HK18115672 A HK 18115672A HK 1256687 A1 HK1256687 A1 HK 1256687A1
Authority
HK
Hong Kong
Prior art keywords
compositions
methods
cells
pluripotent
fertile
Prior art date
Application number
HK18115672.3A
Other languages
English (en)
Inventor
Jennifer SCHMAHL
David Frendewey
Junko Kuno
Chia-Jen Siao
Gustavo Droguett
Yu Bai
Wojtek Auerbach
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of HK1256687A1 publication Critical patent/HK1256687A1/zh

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/12Animals modified by administration of exogenous cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/35Animals modified by environmental factors, e.g. temperature, O2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Environmental Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK18115672.3A 2015-09-17 2016-09-16 对用於产生能生育的 xy 雌性小鼠的多能细胞的选择 HK1256687A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219927P 2015-09-17 2015-09-17
US62/219,927 2015-09-17
PCT/US2016/052345 WO2017049240A1 (en) 2015-09-17 2016-09-16 Selection of pluripotent cells for production of fertile xy female mice

Publications (1)

Publication Number Publication Date
HK1256687A1 true HK1256687A1 (zh) 2019-10-04

Family

ID=57113699

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18115672.3A HK1256687A1 (zh) 2015-09-17 2016-09-16 对用於产生能生育的 xy 雌性小鼠的多能细胞的选择

Country Status (13)

Country Link
US (2) US10893666B2 (zh)
EP (1) EP3349573A1 (zh)
JP (1) JP6868615B2 (zh)
KR (1) KR102382458B1 (zh)
CN (1) CN108697068B (zh)
AU (1) AU2016324305B2 (zh)
CA (1) CA2998642C (zh)
HK (1) HK1256687A1 (zh)
IL (1) IL257982B2 (zh)
MX (1) MX388475B (zh)
RU (1) RU2729407C1 (zh)
SG (1) SG10201913789VA (zh)
WO (1) WO2017049240A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697068B (zh) 2015-09-17 2022-02-11 瑞泽恩制药公司 对用于产生能生育的xy雌性小鼠的多能细胞的选择
CN108998540A (zh) * 2018-08-18 2018-12-14 兰州大学 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用
CN110656167A (zh) * 2019-09-27 2020-01-07 中国科学院苏州生物医学工程技术研究所 用于y染色体微缺失检测的引物组、试剂盒及基于数字pcr的检测方法
CN111321232B (zh) * 2020-03-18 2022-08-16 西北农林科技大学 一种快速检测肉牛eif4a2基因拷贝数变异的方法及其应用
CN113558012A (zh) * 2021-08-05 2021-10-29 陈米米 一种哺乳动物繁育雌性多胎的方法
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法
CN115251007B (zh) * 2022-09-02 2024-01-26 山西医科大学 一种新品系裸大鼠、其培育方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0907722A1 (en) 1996-04-29 1999-04-14 Leuven Research & Development V.Z.W. Pluripotent rabbit embryonic stem (es) cell lines and their use in the generation of chimeric rabbits
EP1067141A1 (en) 1999-06-11 2001-01-10 Rijksuniversiteit te Leiden A male-specific protein homologue involved in histocompatibility
CA2388510A1 (en) 1999-11-02 2001-05-10 James M. Robl Use of haploid genomes for genetic diagnosis, modification and multiplication
BR0016531A (pt) 1999-12-20 2002-12-24 Anthony C F Perry Método para produzir embriões clonados e adultos a partir de células cultivadas
EP1486116A4 (en) 2002-02-27 2008-01-23 Yasumitsu Nagao METHOD FOR CONSTRUCTING CHEMICAL ANIMAL WITH GERMINAL LINE
DE60301953T2 (de) 2002-03-05 2006-07-27 Artemis Pharmaceuticals Gmbh Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse
EP1516924A1 (en) 2003-09-17 2005-03-23 Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) Generation of human embryonic stem cells from triploid zygotes
BRPI0509179A (pt) 2004-03-23 2007-09-18 Daiichi Asubio Pharma Co Ltd método de crescimento de célula tronco pluripotente
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
AU2007283564B2 (en) 2006-08-09 2013-07-25 Valneva Method of production of transgenic avian using embryonic stem cells
GB0623635D0 (en) 2006-11-27 2007-01-03 Stem Cell Sciences Uk Ltd Pluripotent cell growth media
WO2009037337A1 (en) 2007-09-20 2009-03-26 Novartis Ag Robust and tissue independent gender-specific transcript markers for molecular gender determination
RU2011137066A (ru) 2009-02-08 2013-03-20 Дзе Юниверсити Оф Мельбурн Определение пола и способы его определения
WO2011044684A1 (en) 2009-10-13 2011-04-21 Stemcell Technologies Inc. Manipulation of osmolality for differentiating stem cells
PT2579711T (pt) 2010-06-11 2019-06-11 Regeneron Pharma Produção de fêmeas férteis xy a partir de células es xy
WO2012022634A1 (en) * 2010-08-16 2012-02-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Classification, diagnosis and prognosis of multiple myeloma
PT3161128T (pt) * 2014-06-26 2018-11-21 Regeneron Pharma Métodos e composições para modificações genéticas alvejadas e métodos de utilização
EP3207124B1 (en) 2014-10-15 2019-06-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for generating or maintaining pluripotent cells
CN108697068B (zh) 2015-09-17 2022-02-11 瑞泽恩制药公司 对用于产生能生育的xy雌性小鼠的多能细胞的选择

Also Published As

Publication number Publication date
US12041918B2 (en) 2024-07-23
CA2998642C (en) 2023-09-12
MX2018003354A (es) 2018-05-28
KR20180058731A (ko) 2018-06-01
JP2018527005A (ja) 2018-09-20
US20210112788A1 (en) 2021-04-22
CN108697068A (zh) 2018-10-23
US10893666B2 (en) 2021-01-19
IL257982B2 (en) 2023-05-01
CA2998642A1 (en) 2017-03-23
IL257982B1 (en) 2023-01-01
US20170079250A1 (en) 2017-03-23
CN108697068B (zh) 2022-02-11
NZ740899A (en) 2021-11-26
RU2729407C1 (ru) 2020-08-06
AU2016324305A1 (en) 2018-04-12
MX388475B (es) 2025-03-20
AU2016324305B2 (en) 2022-03-03
EP3349573A1 (en) 2018-07-25
AU2016324305A9 (en) 2019-01-03
WO2017049240A1 (en) 2017-03-23
WO2017049240A8 (en) 2018-05-24
SG10201913789VA (en) 2020-03-30
JP6868615B2 (ja) 2021-05-12
KR102382458B1 (ko) 2022-04-04
IL257982A (en) 2018-05-31

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