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UA102787C2 - Process for preparing crystalline forms a and b of ilaprazole and a process of the conversion of crystalline forms - Google Patents

Process for preparing crystalline forms a and b of ilaprazole and a process of the conversion of crystalline forms

Info

Publication number
UA102787C2
UA102787C2 UAA201207006A UAA201207006A UA102787C2 UA 102787 C2 UA102787 C2 UA 102787C2 UA A201207006 A UAA201207006 A UA A201207006A UA A201207006 A UAA201207006 A UA A201207006A UA 102787 C2 UA102787 C2 UA 102787C2
Authority
UA
Ukraine
Prior art keywords
ilaprazole
crystalline forms
preparing
conversion
crystalline form
Prior art date
Application number
UAA201207006A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Донг Эон Ким
Яае Соо Шин
Юн Эоун Ли
Кви Хиунг Чо
Сунг Тае Парк
Юнг Ву Ким
Санг Дон Нам
Хи Юн Ким
Original Assignee
Ил-Янг Фарм. Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ил-Янг Фарм. Ко., Лтд. filed Critical Ил-Янг Фарм. Ко., Лтд.
Publication of UA102787C2 publication Critical patent/UA102787C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent) a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
UAA201207006A 2009-12-08 2010-12-08 Process for preparing crystalline forms a and b of ilaprazole and a process of the conversion of crystalline forms UA102787C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (en) 2009-12-08 2009-12-08 Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Publications (1)

Publication Number Publication Date
UA102787C2 true UA102787C2 (en) 2013-08-12

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201207006A UA102787C2 (en) 2009-12-08 2010-12-08 Process for preparing crystalline forms a and b of ilaprazole and a process of the conversion of crystalline forms

Country Status (7)

Country Link
KR (1) KR101144600B1 (en)
BR (1) BR112012012212A2 (en)
CO (1) CO6541539A2 (en)
EA (1) EA019058B1 (en)
IN (1) IN2012DN03176A (en)
UA (1) UA102787C2 (en)
WO (1) WO2011071314A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204843B (en) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 Crystalline ilaprazole sodium ethanolate and preparation method thereof
CN103204842B (en) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 Crystalline Ilaprazole sodium hydrate and preparation method thereof
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746277B (en) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 Crystal-form ilaprazole sodium and preparation method thereof
CN102746275B (en) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 Crystallization-type ilaprazole sodium and preparation method thereof
CN102746276B (en) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 Ilaprazole sodium crystal form and preparation method thereof
CN113045544A (en) * 2014-09-04 2021-06-29 江苏奥赛康药业有限公司 Ilaprazole sodium compound and pharmaceutical composition thereof
CN115403560B (en) * 2017-11-06 2024-09-03 丽珠医药集团股份有限公司 A kind of ilaprazole magnesium crystal form and preparation method thereof
KR102027388B1 (en) 2017-11-15 2019-10-01 주식회사 다산제약 Process for preparing high purity ilaprazole crystalline form B
CN111187255B (en) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 Preparation method of D-ilaprazole potassium salt and preparation method of D-ilaprazole
KR20220065235A (en) 2020-11-13 2022-05-20 주식회사 파마코스텍 Process for the crystalline form of Ilaprazole
KR102250509B1 (en) * 2020-12-09 2021-05-11 유니셀랩 주식회사 Novel co-crystal of ilaprazole/xylitol
KR20210019469A (en) 2021-02-02 2021-02-22 주식회사 파마코스텍 Crystalline form of Ilaprazole sodium and its new process
KR20250156870A (en) 2024-04-25 2025-11-04 엠에프씨 주식회사 Method for producing ilaprazole magnesium salt hydrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008083319A1 (en) * 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
MY146462A (en) * 2006-12-29 2012-08-15 Il Yang Pharmaceutical Company Ltd Crystalline forms of solvated ilaprazole

Also Published As

Publication number Publication date
KR20110064545A (en) 2011-06-15
CO6541539A2 (en) 2012-10-16
BR112012012212A2 (en) 2015-09-08
IN2012DN03176A (en) 2015-09-25
EA019058B1 (en) 2013-12-30
EA201200716A1 (en) 2012-10-30
WO2011071314A2 (en) 2011-06-16
KR101144600B1 (en) 2012-05-16
WO2011071314A3 (en) 2011-11-10

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