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EA201200716A1 - METHOD FOR OBTAINING CRYSTALLINE FORMS A AND B IN ILAPRAZOL AND METHOD FOR TURNING THE INDICATED CRYSTALLINE FORMS - Google Patents

METHOD FOR OBTAINING CRYSTALLINE FORMS A AND B IN ILAPRAZOL AND METHOD FOR TURNING THE INDICATED CRYSTALLINE FORMS

Info

Publication number
EA201200716A1
EA201200716A1 EA201200716A EA201200716A EA201200716A1 EA 201200716 A1 EA201200716 A1 EA 201200716A1 EA 201200716 A EA201200716 A EA 201200716A EA 201200716 A EA201200716 A EA 201200716A EA 201200716 A1 EA201200716 A1 EA 201200716A1
Authority
EA
Eurasian Patent Office
Prior art keywords
crystalline forms
obtaining
ilaprazole
ilaprazol
turning
Prior art date
Application number
EA201200716A
Other languages
Russian (ru)
Other versions
EA019058B1 (en
Inventor
Кви Хьюнг Чо
Сунг Тае Парк
Юнг Воо Ким
Санг Дон Нам
Хее Юн Ким
Донг Йеон Ким
Джае Соо Шин
Джун Йеоун Лее
Original Assignee
Ил-Янг Фармасьютикал Компани Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ил-Янг Фармасьютикал Компани Лтд. filed Critical Ил-Янг Фармасьютикал Компани Лтд.
Publication of EA201200716A1 publication Critical patent/EA201200716A1/en
Publication of EA019058B1 publication Critical patent/EA019058B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Представляются новые способы получения кристаллических форм А и В илапразола и превращения указанных кристаллических форм. Указанные новые способы включают способ получения кристаллической формы А высокой чистоты путём получения неорганической соли илапразола или её гидрата и последующей нейтрализации полученной неорганической соли илапразола или её гидрата с помощью кислоты в органическом растворителе (индивидуальном растворителе или в смеси растворителей); способ получения кристаллической формы В высокой чистоты путём удаления примесей из илапразола с использованием органического растворителя (индивидуального растворителя или смеси растворителей); и способ превращения кристаллической формы А в кристаллическую форму В или кристаллической формы В в кристаллическую форму А.New methods of obtaining crystalline forms A and B of ilaprazole and converting said crystalline forms are presented. These new methods include a method for obtaining high purity crystalline form A by obtaining an inorganic salt of ilaprazole or its hydrate and then neutralizing the resulting inorganic salt of ilaprazole or its hydrate with an acid in an organic solvent (an individual solvent or in a mixture of solvents); a method of obtaining a crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (an individual solvent or a mixture of solvents); and a method of converting crystal form A to crystal form B or crystal form B to crystal form A.

EA201200716A 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms EA019058B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (en) 2009-12-08 2009-12-08 Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Publications (2)

Publication Number Publication Date
EA201200716A1 true EA201200716A1 (en) 2012-10-30
EA019058B1 EA019058B1 (en) 2013-12-30

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200716A EA019058B1 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Country Status (7)

Country Link
KR (1) KR101144600B1 (en)
BR (1) BR112012012212A2 (en)
CO (1) CO6541539A2 (en)
EA (1) EA019058B1 (en)
IN (1) IN2012DN03176A (en)
UA (1) UA102787C2 (en)
WO (1) WO2011071314A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204843B (en) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 Crystalline ilaprazole sodium ethanolate and preparation method thereof
CN103204842B (en) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 Crystalline Ilaprazole sodium hydrate and preparation method thereof
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746276B (en) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 Ilaprazole sodium crystal form and preparation method thereof
CN102746275B (en) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 Crystallization-type ilaprazole sodium and preparation method thereof
CN102746277B (en) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 Crystal-form ilaprazole sodium and preparation method thereof
CN105461692A (en) * 2014-09-04 2016-04-06 江苏奥赛康药业股份有限公司 Ilaprazole sodium compound and pharmaceutical composition thereof
CN115403560B (en) * 2017-11-06 2024-09-03 丽珠医药集团股份有限公司 A kind of ilaprazole magnesium crystal form and preparation method thereof
KR102027388B1 (en) 2017-11-15 2019-10-01 주식회사 다산제약 Process for preparing high purity ilaprazole crystalline form B
CN111187255B (en) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 Preparation method of D-ilaprazole potassium salt and preparation method of D-ilaprazole
KR20220065235A (en) 2020-11-13 2022-05-20 주식회사 파마코스텍 Process for the crystalline form of Ilaprazole
KR102250509B1 (en) * 2020-12-09 2021-05-11 유니셀랩 주식회사 Novel co-crystal of ilaprazole/xylitol
KR20210019469A (en) 2021-02-02 2021-02-22 주식회사 파마코스텍 Crystalline form of Ilaprazole sodium and its new process
KR20250156870A (en) 2024-04-25 2025-11-04 엠에프씨 주식회사 Method for producing ilaprazole magnesium salt hydrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008083319A1 (en) * 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
CN101687849B (en) * 2006-12-29 2013-05-29 一洋药品株式会社 Crystalline forms of solvated ilaprazole

Also Published As

Publication number Publication date
BR112012012212A2 (en) 2015-09-08
CO6541539A2 (en) 2012-10-16
WO2011071314A3 (en) 2011-11-10
KR20110064545A (en) 2011-06-15
EA019058B1 (en) 2013-12-30
KR101144600B1 (en) 2012-05-16
WO2011071314A2 (en) 2011-06-16
IN2012DN03176A (en) 2015-09-25
UA102787C2 (en) 2013-08-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU