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TWI372785B - Apparatus for identifying a single biomolecule,method for fabricating thereof,optical detection apparatus containing thereof,and method for detecting biomolecules - Google Patents

Apparatus for identifying a single biomolecule,method for fabricating thereof,optical detection apparatus containing thereof,and method for detecting biomolecules

Info

Publication number
TWI372785B
TWI372785B TW097140610A TW97140610A TWI372785B TW I372785 B TWI372785 B TW I372785B TW 097140610 A TW097140610 A TW 097140610A TW 97140610 A TW97140610 A TW 97140610A TW I372785 B TWI372785 B TW I372785B
Authority
TW
Taiwan
Prior art keywords
fabricating
identifying
optical detection
detecting biomolecules
detection apparatus
Prior art date
Application number
TW097140610A
Other languages
English (en)
Other versions
TW200936765A (en
Inventor
Chung Fan Chiou
Cheng Wei Chu
Shang Chia Chang
Yu Tang Li
Chao Chi Pan
bin cheng Yao
Original Assignee
Ind Tech Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40590567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI372785(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ind Tech Res Inst filed Critical Ind Tech Res Inst
Publication of TW200936765A publication Critical patent/TW200936765A/zh
Application granted granted Critical
Publication of TWI372785B publication Critical patent/TWI372785B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
TW097140610A 2007-10-25 2008-10-23 Apparatus for identifying a single biomolecule,method for fabricating thereof,optical detection apparatus containing thereof,and method for detecting biomolecules TWI372785B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99601607P 2007-10-25 2007-10-25
US3665208P 2008-03-14 2008-03-14
US12/255,044 US7767441B2 (en) 2007-10-25 2008-10-21 Bioassay system including optical detection apparatuses, and method for detecting biomolecules

Publications (2)

Publication Number Publication Date
TW200936765A TW200936765A (en) 2009-09-01
TWI372785B true TWI372785B (en) 2012-09-21

Family

ID=40590567

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097140610A TWI372785B (en) 2007-10-25 2008-10-23 Apparatus for identifying a single biomolecule,method for fabricating thereof,optical detection apparatus containing thereof,and method for detecting biomolecules

Country Status (9)

Country Link
US (1) US7767441B2 (zh)
EP (2) EP2129805B1 (zh)
JP (1) JP4755724B2 (zh)
KR (1) KR101024578B1 (zh)
CN (1) CN101743321B (zh)
AU (1) AU2008318087B2 (zh)
CA (1) CA2703177C (zh)
TW (1) TWI372785B (zh)
WO (1) WO2009056065A1 (zh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US9778188B2 (en) * 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
FR2946157B1 (fr) * 2009-06-02 2015-03-27 Commissariat Energie Atomique Systeme d'imagerie a microlentilles et dispositif associe pour la detection d'un echantillon.
US8026559B2 (en) * 2009-11-27 2011-09-27 Visera Technologies Company Limited Biosensor devices and method for fabricating the same
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
WO2011091043A1 (en) 2010-01-19 2011-07-28 Life Technologies Corporation Single molecule nucleic acid sequencing using multiphoton fluorescence excitation
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
CA2790393C (en) 2010-02-19 2019-03-12 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
TWI464388B (zh) * 2012-08-17 2014-12-11 Wistron Corp 光校正裝置、生物檢測校正系統及其操作方法
US9223084B2 (en) 2012-12-18 2015-12-29 Pacific Biosciences Of California, Inc. Illumination of optical analytical devices
EP2959283B1 (en) 2013-02-22 2022-08-17 Pacific Biosciences of California, Inc. Integrated illumination of optical analytical devices
US10605734B2 (en) 2013-04-03 2020-03-31 Life Technologies Corporation Systems and methods for genetic sequencing
DK3080585T3 (da) 2013-12-10 2024-02-05 Illumina Inc Biosensorer til biologisk eller kemisk analyse og fremgangsmåder til fremstilling heraf
WO2016033207A1 (en) 2014-08-27 2016-03-03 Pacific Biosciences Of California, Inc. Arrays of integrated analyitcal devices
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
US10119915B2 (en) 2015-04-09 2018-11-06 Visera Technologies Company Limited Detection device for specimens
WO2016179437A1 (en) 2015-05-07 2016-11-10 Pacific Biosciences Of California, Inc. Multiprocessor pipeline architecture
CA2989344C (en) 2015-06-12 2023-09-26 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
KR102414666B1 (ko) * 2016-06-01 2022-06-29 퀀텀-에스아이 인코포레이티드 분자들을 검출 및 분석하기 위한 통합 디바이스
US10613256B2 (en) * 2017-08-11 2020-04-07 Industrial Technology Research Institute Biometric device
PH12019502895B1 (en) 2017-12-26 2024-04-24 Illumina Inc Sensor system
CN109738403A (zh) * 2019-01-03 2019-05-10 必欧瀚生物技术(合肥)有限公司 一种荧光标准卡及荧光标准卡用荧光膜的制备方法
US20210187503A1 (en) 2019-12-19 2021-06-24 Personal Genomics Taiwan, Inc. Apparatus and system for single-molecule nucleic acids detection
CN113092754B (zh) * 2021-04-09 2022-11-15 四川大学华西医院 一种基于免疫荧光和二维可视化多模式分析HIV p24抗原的检测产品及其应用

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5149625A (en) * 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
US4942124A (en) * 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US6013434A (en) * 1989-12-22 2000-01-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
US6153737A (en) * 1990-01-11 2000-11-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US5529679A (en) * 1992-02-28 1996-06-25 Hitachi, Ltd. DNA detector and DNA detection method
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH0622798A (ja) * 1992-07-07 1994-02-01 Hitachi Ltd 塩基配列決定法
US5547859A (en) * 1993-08-02 1996-08-20 Goodman; Myron F. Chain-terminating nucleotides for DNA sequencing methods
ATE424927T1 (de) * 1993-10-28 2009-03-15 Houston Advanced Res Ct Mikrofabriziertes poröses durchflussgerät zur diskreten bestimmung von bindungsreaktionen
EP0754240B1 (en) * 1994-02-07 2003-08-20 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5994058A (en) * 1995-03-20 1999-11-30 Genome International Corporation Method for contiguous genome sequencing
US5750341A (en) * 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5981186A (en) * 1995-06-30 1999-11-09 Visible Genetics, Inc. Method and apparatus for DNA-sequencing using reduced number of sequencing mixtures
US5968740A (en) * 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
NZ318277A (en) 1995-09-19 1999-02-25 Cornell Res Foundation Inc Multi-photon laser microscopy
CA2240667A1 (en) * 1995-12-18 1997-06-26 Washington University Method for nucleic acid analysis using fluorescence resonance energy transfer
US5789168A (en) * 1996-05-01 1998-08-04 Visible Genetics Inc. Method for amplification and sequencing of nucleic acid polymers
US5795722A (en) * 1997-03-18 1998-08-18 Visible Genetics Inc. Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
CA2251643A1 (en) * 1996-04-15 1997-10-23 University Of Alberta Synthesis of fluorophore-labeled dna
JP3418292B2 (ja) * 1996-04-24 2003-06-16 株式会社日立製作所 遺伝子解析装置
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5965446A (en) * 1996-10-24 1999-10-12 Hamamatsu Photonics K.K. Method for placing fluorescent single molecules on surface of substrate and method for visualizing structural defect of surface of substrate
US6017702A (en) * 1996-12-05 2000-01-25 The Perkin-Elmer Corporation Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
EP0960215A1 (en) * 1997-01-15 1999-12-01 Brax Genomics Limited Nucleic acid sequencing
US6046005A (en) * 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
US5945284A (en) * 1997-05-27 1999-08-31 The Perkin-Elmer Corporation Length determination of nucleic acid repeat sequences by discontinuous primer extension
US6511803B1 (en) * 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6049380A (en) * 1997-11-12 2000-04-11 Regents Of The University Of California Single molecule identification using selected fluorescence characteristics
US6322968B1 (en) * 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
US7267948B2 (en) * 1997-11-26 2007-09-11 Ut-Battelle, Llc SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips
CA2320390C (en) * 1998-02-11 2010-06-08 Perkin-Elmer Corporation Pna and dna conjugates and methods for preparation thereof
AU3463699A (en) * 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
WO1999067641A2 (en) * 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
US6787308B2 (en) * 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) * 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE19844931C1 (de) * 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
JP2002540802A (ja) * 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6692915B1 (en) * 1999-07-22 2004-02-17 Girish N. Nallur Sequencing a polynucleotide on a generic chip
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001023610A2 (en) * 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6325977B1 (en) * 2000-01-18 2001-12-04 Agilent Technologies, Inc. Optical detection system for the detection of organic molecules
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6413722B1 (en) * 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
GB0016472D0 (en) * 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method and apparatus
US6716629B2 (en) * 2000-10-10 2004-04-06 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US20030148544A1 (en) 2001-06-28 2003-08-07 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
US6613523B2 (en) * 2001-06-29 2003-09-02 Agilent Technologies, Inc. Method of DNA sequencing using cleavable tags
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20040038331A1 (en) 2002-08-23 2004-02-26 Reddy M. Parameswara Solid phase synthesis of biomolecule conjugates
US20060021666A1 (en) * 2002-11-01 2006-02-02 Waseda University Microsystem, microopening film, and system and method for analizing interaction between biomolecules
US7169560B2 (en) * 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
DE102004015272A1 (de) 2004-03-29 2005-11-03 Infineon Technologies Ag Biosensor-Anordnung zum Erfassen von Biomolekülen und Verfahren zum Erfassen von Biomolekülen
CN100535634C (zh) 2004-04-26 2009-09-02 中国科学院光电技术研究所 具有光强实时检测的生物芯片检测方法及其检测系统
US7462452B2 (en) * 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US20050287523A1 (en) * 2004-06-01 2005-12-29 The Regents Of The University Of California Functionalized platform for individual molecule or cell characterization
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7361516B2 (en) 2004-09-24 2008-04-22 The United States Of America As Represented By The Secretary Of The Navy Field of modular multifunctional ligands
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
AU2006211150A1 (en) 2005-01-31 2006-08-10 Pacific Biosciences Of California, Inc. Use of reversible extension terminator in nucleic acid sequencing
US20070141598A1 (en) * 2005-02-09 2007-06-21 Pacific Biosciences Of California, Inc. Nucleotide Compositions and Uses Thereof
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US20100019155A1 (en) * 2005-06-23 2010-01-28 Koninklijke Philips Electronics, N.V. Luminescence sensors using sub-wavelength apertures or slits
WO2007075987A2 (en) * 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
US7858386B2 (en) 2006-03-07 2010-12-28 The United States Of America As Represented By The Secretary Of The Navy Method of controlling quantum dot photoluminescence and other intrinsic properties through biological specificity
US8637436B2 (en) * 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray

Also Published As

Publication number Publication date
JP4755724B2 (ja) 2011-08-24
AU2008318087A1 (en) 2009-05-07
EP2129805A1 (en) 2009-12-09
JP2011504223A (ja) 2011-02-03
US7767441B2 (en) 2010-08-03
EP3037553B1 (en) 2019-04-17
CA2703177C (en) 2014-07-08
CA2703177A1 (en) 2009-05-07
KR101024578B1 (ko) 2011-03-31
US20090146076A1 (en) 2009-06-11
CN101743321A (zh) 2010-06-16
TW200936765A (en) 2009-09-01
EP3037553A1 (en) 2016-06-29
CN101743321B (zh) 2014-06-11
WO2009056065A1 (en) 2009-05-07
AU2008318087B2 (en) 2012-03-08
EP2129805A4 (en) 2012-02-08
KR20100082784A (ko) 2010-07-19
EP2129805B1 (en) 2016-03-16

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