TWI372623B - Inhibitors of 11β-hydroxysteroid dehydrogenase - Google Patents
Inhibitors of 11β-hydroxysteroid dehydrogenaseInfo
- Publication number
- TWI372623B TWI372623B TW097127011A TW97127011A TWI372623B TW I372623 B TWI372623 B TW I372623B TW 097127011 A TW097127011 A TW 097127011A TW 97127011 A TW97127011 A TW 97127011A TW I372623 B TWI372623 B TW I372623B
- Authority
- TW
- Taiwan
- Prior art keywords
- inhibitors
- hydroxysteroid dehydrogenase
- hydroxysteroid
- dehydrogenase
- Prior art date
Links
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 title 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95016807P | 2007-07-17 | 2007-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200913992A TW200913992A (en) | 2009-04-01 |
| TWI372623B true TWI372623B (en) | 2012-09-21 |
Family
ID=40019292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097127011A TWI372623B (en) | 2007-07-17 | 2008-07-16 | Inhibitors of 11β-hydroxysteroid dehydrogenase |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7790711B2 (zh) |
| EP (1) | EP2178845B1 (zh) |
| JP (1) | JP5189165B2 (zh) |
| KR (1) | KR101158191B1 (zh) |
| CN (1) | CN101743226B (zh) |
| AR (1) | AR067538A1 (zh) |
| AU (1) | AU2008277783B2 (zh) |
| BR (1) | BRPI0814825A2 (zh) |
| CA (1) | CA2693457C (zh) |
| CL (1) | CL2008002052A1 (zh) |
| ES (1) | ES2423181T3 (zh) |
| PE (1) | PE20090813A1 (zh) |
| RU (1) | RU2440989C2 (zh) |
| TW (1) | TWI372623B (zh) |
| WO (1) | WO2009010416A2 (zh) |
| ZA (1) | ZA201000318B (zh) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1953145B1 (en) | 2005-11-21 | 2015-11-04 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| BRPI0811191A2 (pt) | 2007-05-18 | 2014-10-29 | Shionogi & Co | Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1 |
| US7951833B2 (en) | 2008-02-04 | 2011-05-31 | Astrazeneca Ab | Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012020724A1 (ja) * | 2010-08-09 | 2012-02-16 | 塩野義製薬株式会社 | アミノアダマンタンカルバメート誘導体の製造方法 |
| KR101954420B1 (ko) * | 2011-06-10 | 2019-06-13 | 에스케이바이오팜 주식회사 | 5-카바모일 아다만탄-2-일 아마이드 유도체, 이의 약학적으로 허용 가능한 염 및 이의 제조 방법 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6242810B2 (ja) | 2011-12-28 | 2017-12-06 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｌｏｏｄ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN105246477A (zh) * | 2013-03-15 | 2016-01-13 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| MX379228B (es) | 2013-03-15 | 2025-03-10 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulación de la hemoglobina. |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| EA037091B1 (ru) | 2013-03-15 | 2021-02-04 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| JP6487426B2 (ja) | 2013-10-17 | 2019-03-20 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除化合物の調製法 |
| MX2016004942A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
| EP3057431A4 (en) | 2013-10-17 | 2017-04-05 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| CN105636446B (zh) | 2013-10-17 | 2018-07-13 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| CA2926095A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| JP2016536295A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| CN105636440A (zh) | 2013-10-17 | 2016-06-01 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CN114213390A (zh) | 2014-02-07 | 2022-03-22 | 全球血液疗法股份有限公司 | 一种化合物的结晶多晶型物 |
| BR112017000418A2 (pt) | 2014-07-31 | 2017-11-07 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| CA2954345A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| EP3186230A4 (en) | 2014-07-31 | 2018-01-10 | Dow AgroSciences, LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| EP3183238A4 (en) | 2014-08-19 | 2018-01-10 | Dow AgroSciences LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| BR112017004613A2 (pt) | 2014-09-12 | 2017-12-05 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| KR101759874B1 (ko) | 2015-08-07 | 2017-07-21 | 코스맥스 주식회사 | 11β-hydroxysteroid dehydrogenase type 1의 활성을 저해하는 화합물을 포함하는 화장료 조성물 또는 피부 외용제 조성물 |
| US10324166B2 (en) * | 2015-09-28 | 2019-06-18 | Rockwell Collins, Inc. | Affordable combined pulsed/FMCW radar AESA |
| FI3383392T3 (fi) | 2015-12-04 | 2025-09-11 | Global Blood Therapeutics Inc | Annosteluohjelmat 2-hydroksi-6-((2-(1-isopropyyli-1h-pyratsol-5-yyli)pyridin-3-yyli)metoksi)bentsaldehydille |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| EP3258288B1 (en) * | 2016-06-14 | 2024-07-31 | Rohde & Schwarz GmbH & Co. KG | Method for testing the transmission and reflection properties of an automotive radome body as well as apparatus for testing the transmission and reflection properties of an automotive radome body |
| TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| US10100033B2 (en) | 2016-12-29 | 2018-10-16 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| WO2020163689A1 (en) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 20-hete formation inhibitors |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732967B1 (fr) * | 1995-04-11 | 1997-07-04 | Sanofi Sa | 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant |
| EP0979228A4 (en) * | 1997-03-18 | 2000-05-03 | Smithkline Beecham Corp | CANNABINOID RECEPTOR AGONISTS |
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法 |
| DE602004027171D1 (de) * | 2003-04-11 | 2010-06-24 | High Point Pharmaceuticals Llc | Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase |
| JP2006522744A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | グルココルチコイド受容体アゴニスト療法に伴う副作用を最小化するための、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤およびグルココルチコイド受容体アゴニストを使用する併用療法 |
| WO2004099156A1 (en) | 2003-05-01 | 2004-11-18 | Bristol-Myers Squibb Company | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
| CN1832741A (zh) | 2003-08-07 | 2006-09-13 | 默克公司 | 作为11－β－羟甾类脱氢酶－1抑制剂的吡唑甲酰胺类 |
| US20050245534A1 (en) * | 2004-04-29 | 2005-11-03 | Link James T | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20050261302A1 (en) * | 2004-04-29 | 2005-11-24 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
| US20050245533A1 (en) * | 2004-04-29 | 2005-11-03 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application |
| US20050245532A1 (en) * | 2004-04-29 | 2005-11-03 | Hoff Ethan D | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application |
| US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| JP2007536369A (ja) | 2004-05-06 | 2007-12-13 | ファイザー・インク | プロリン及びモルホリン誘導体の新規化合物 |
| NZ551076A (en) | 2004-05-07 | 2009-05-31 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| CN1993320A (zh) | 2004-08-06 | 2007-07-04 | 默克公司 | 作为11－β－羟基类固醇脱氢酶－1的抑制剂的磺酰化合物 |
| KR101197674B1 (ko) | 2004-08-30 | 2012-11-07 | 얀센 파마슈티카 엔.브이. | １１-베타 하이드록시스테로이드 탈수소효소 저해제로서의 ｎ-2 아다만타닐-２-페녹시-아세트아미드 유도체 |
| CN101039908B (zh) | 2004-08-30 | 2010-06-23 | 詹森药业有限公司 | 作为11-β羟甾类脱氢酶抑制剂的三环内酰胺衍生物 |
| DK1807072T3 (da) | 2004-10-29 | 2009-03-16 | Lilly Co Eli | Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1 |
| EP1812407A2 (en) | 2004-11-02 | 2007-08-01 | Pfizer, Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| US20060148871A1 (en) * | 2005-01-05 | 2006-07-06 | Rohde Jeffrey J | Metabolic stabilization of substituted adamantane |
| CA2594098C (en) | 2005-01-05 | 2014-04-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| AU2006203918B2 (en) * | 2005-01-05 | 2011-05-19 | Abbvie Inc. | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| JPWO2006104280A1 (ja) | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
| JP2008537939A (ja) | 2005-03-31 | 2008-10-02 | エクソンモービル・ケミカル・パテンツ・インク | 多相アルキル芳香族の製造 |
| BRPI0610459A2 (pt) * | 2005-04-05 | 2010-06-22 | Hoffmann La Roche | composto, processo para a sua preparação, composições farmacêuticas que o compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróides-11b e utilização do composto |
| US8952176B2 (en) * | 2005-06-07 | 2015-02-10 | Shionogi & Co., Ltd. | Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity |
| EP1953145B1 (en) * | 2005-11-21 | 2015-11-04 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i |
| ES2548002T3 (es) * | 2006-03-22 | 2015-10-13 | F. Hoffmann-La Roche Ag | Pirazoles como 11beta-SD1 |
| TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
-
2008
- 2008-07-07 CN CN2008800247172A patent/CN101743226B/zh not_active Expired - Fee Related
- 2008-07-07 ES ES08774850T patent/ES2423181T3/es active Active
- 2008-07-07 JP JP2010516456A patent/JP5189165B2/ja not_active Expired - Fee Related
- 2008-07-07 KR KR1020107003122A patent/KR101158191B1/ko not_active Expired - Fee Related
- 2008-07-07 CA CA2693457A patent/CA2693457C/en not_active Expired - Fee Related
- 2008-07-07 AU AU2008277783A patent/AU2008277783B2/en not_active Ceased
- 2008-07-07 WO PCT/EP2008/058804 patent/WO2009010416A2/en not_active Ceased
- 2008-07-07 BR BRPI0814825-2A2A patent/BRPI0814825A2/pt not_active IP Right Cessation
- 2008-07-07 RU RU2010105299/04A patent/RU2440989C2/ru not_active IP Right Cessation
- 2008-07-07 EP EP08774850.5A patent/EP2178845B1/en not_active Not-in-force
- 2008-07-14 CL CL2008002052A patent/CL2008002052A1/es unknown
- 2008-07-14 US US12/172,389 patent/US7790711B2/en not_active Expired - Fee Related
- 2008-07-14 AR ARP080103024A patent/AR067538A1/es not_active Application Discontinuation
- 2008-07-15 PE PE2008001191A patent/PE20090813A1/es not_active Application Discontinuation
- 2008-07-16 TW TW097127011A patent/TWI372623B/zh not_active IP Right Cessation
-
2010
- 2010-01-15 ZA ZA201000318A patent/ZA201000318B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010533670A (ja) | 2010-10-28 |
| CN101743226A (zh) | 2010-06-16 |
| CL2008002052A1 (es) | 2009-05-22 |
| RU2010105299A (ru) | 2011-08-27 |
| WO2009010416A3 (en) | 2009-03-05 |
| BRPI0814825A2 (pt) | 2015-02-03 |
| EP2178845B1 (en) | 2013-06-19 |
| PE20090813A1 (es) | 2009-06-27 |
| EP2178845A2 (en) | 2010-04-28 |
| AU2008277783A1 (en) | 2009-01-22 |
| US7790711B2 (en) | 2010-09-07 |
| CN101743226B (zh) | 2012-10-10 |
| WO2009010416A2 (en) | 2009-01-22 |
| ZA201000318B (en) | 2010-10-27 |
| ES2423181T3 (es) | 2013-09-18 |
| KR20100034763A (ko) | 2010-04-01 |
| KR101158191B1 (ko) | 2012-06-19 |
| CA2693457C (en) | 2012-10-23 |
| US20090023709A1 (en) | 2009-01-22 |
| JP5189165B2 (ja) | 2013-04-24 |
| AR067538A1 (es) | 2009-10-14 |
| CA2693457A1 (en) | 2009-01-22 |
| AU2008277783B2 (en) | 2012-09-20 |
| TW200913992A (en) | 2009-04-01 |
| RU2440989C2 (ru) | 2012-01-27 |
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