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TWI368521B - A spontaneous pharmaceutical composition for treatment and prevention of proliferative diseases,uses and preparation thereof - Google Patents

A spontaneous pharmaceutical composition for treatment and prevention of proliferative diseases,uses and preparation thereof

Info

Publication number
TWI368521B
TWI368521B TW094140699A TW94140699A TWI368521B TW I368521 B TWI368521 B TW I368521B TW 094140699 A TW094140699 A TW 094140699A TW 94140699 A TW94140699 A TW 94140699A TW I368521 B TWI368521 B TW I368521B
Authority
TW
Taiwan
Prior art keywords
spontaneous
prevention
preparation
treatment
pharmaceutical composition
Prior art date
Application number
TW094140699A
Other languages
English (en)
Other versions
TW200631606A (en
Inventor
Isabel Ottinger
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35691476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI368521(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of TW200631606A publication Critical patent/TW200631606A/zh
Application granted granted Critical
Publication of TWI368521B publication Critical patent/TWI368521B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW094140699A 2004-11-19 2005-11-18 A spontaneous pharmaceutical composition for treatment and prevention of proliferative diseases,uses and preparation thereof TWI368521B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62975704P 2004-11-19 2004-11-19

Publications (2)

Publication Number Publication Date
TW200631606A TW200631606A (en) 2006-09-16
TWI368521B true TWI368521B (en) 2012-07-21

Family

ID=35691476

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094140699A TWI368521B (en) 2004-11-19 2005-11-18 A spontaneous pharmaceutical composition for treatment and prevention of proliferative diseases,uses and preparation thereof

Country Status (28)

Country Link
US (1) US8518961B2 (zh)
EP (1) EP1814520B1 (zh)
JP (1) JP4982378B2 (zh)
KR (1) KR101283840B1 (zh)
CN (1) CN101056619A (zh)
AR (1) AR052033A1 (zh)
AU (1) AU2005306018B2 (zh)
BR (1) BRPI0518448A2 (zh)
CA (1) CA2584343C (zh)
DK (1) DK1814520T3 (zh)
ES (1) ES2572133T3 (zh)
GT (1) GT200500310A (zh)
HR (1) HRP20160446T1 (zh)
HU (1) HUE027135T2 (zh)
IL (1) IL182703A (zh)
MA (1) MA29076B1 (zh)
MX (1) MX2007005897A (zh)
MY (1) MY148647A (zh)
NO (1) NO342592B1 (zh)
NZ (1) NZ554551A (zh)
PE (1) PE20061077A1 (zh)
PL (1) PL1814520T3 (zh)
RU (3) RU2007122470A (zh)
SI (1) SI1814520T1 (zh)
TN (1) TNSN07193A1 (zh)
TW (1) TWI368521B (zh)
WO (1) WO2006053755A1 (zh)
ZA (1) ZA200703148B (zh)

Families Citing this family (15)

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GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
CA2618084A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Microparticle compositions of the topoisomerase i inhibitor 7-tert-butoxyiminomethylcamptothecin
CL2007003145A1 (es) * 2006-10-31 2008-01-25 Wyeth Corp Composicion farmaceutica que comprende un compuestos derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 10-50% de un segundo solubilizante y 10-30% de un diluyente; proceso de preparacion; y forma farmaceutica.
US20100070052A1 (en) * 2008-08-19 2010-03-18 Robb Fujioka System and method for providing applications and peripherals to a fixed price component-based computing platform
EP2588081A4 (en) * 2010-06-29 2014-12-10 Verastem Inc ORAL FORMULATION OF CHINESE INHIBITORS
CN103168037A (zh) 2010-06-30 2013-06-19 博尼亚德医药品股份有限公司 激酶抑制剂的合成和用途
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
IL284061B2 (en) 2018-12-19 2025-02-01 Corcept Therapeutics Inc A preparation containing a relaxant
US12318372B2 (en) * 2021-09-05 2025-06-03 Tairx, Inc. Formulations with enhanced SN-38 solubility and oral absorption
IL322745A (en) * 2022-08-24 2025-10-01 LYOTROPIC DELIVERY SYSTEMS Ltd Oral administration of active ingredients for the treatment of glycogen storage diseases
WO2024077169A1 (en) 2022-10-06 2024-04-11 Corcept Therapeutics Incorporated Formulations of glucocorticoid receptor modulators
KR20250102046A (ko) 2022-10-28 2025-07-04 코어셉트 쎄라퓨틱스 인코포레이티드 다주코릴란트를 이용한 근위축성 측삭경화증의 치료

Family Cites Families (32)

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GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
WO1994014415A1 (en) * 1992-12-24 1994-07-07 Hemagen/Pfc Fluorocarbon emulsions
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5597829A (en) * 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
KR100509776B1 (ko) 1997-07-29 2005-08-24 파마시아 앤드 업존 캄파니 엘엘씨 친지성 화합물의 자가유화 제제
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
EP1075252A2 (en) 1998-05-07 2001-02-14 ELAN CORPORATION, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
US20030059465A1 (en) 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
EP1185301A1 (en) * 1999-05-24 2002-03-13 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
GB9918885D0 (en) 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules
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US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
GB0001928D0 (en) * 2000-01-27 2000-03-22 Novartis Ag Organic compounds
US20020150615A1 (en) * 2001-02-12 2002-10-17 Howard Sands Injectable pharmaceutical composition comprising microdroplets of a camptothecin
US6653319B1 (en) * 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
IL160927A0 (en) 2001-10-15 2004-08-31 Crititech Inc Compositions and methods for delivery of poorly water soluble drugs and method of treatment
US20060078618A1 (en) 2001-12-11 2006-04-13 Constantinides Panayiotis P Lipid particles and suspensions and uses thereof
JP2003267891A (ja) 2002-03-13 2003-09-25 Mitsubishi-Kagaku Foods Corp Ｗ／ｏ／ｗ型エマルション製剤
CZ294371B6 (cs) 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
EP1393719A1 (en) 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
JP4426749B2 (ja) 2002-07-11 2010-03-03 株式会社産学連携機構九州 Ｏ／ｗ型エマルション製剤
US20040171560A1 (en) * 2002-12-23 2004-09-02 Dabur Research Foundation Stabilized pharmaceutical composition
JP2006199590A (ja) * 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
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EP1706098A4 (en) * 2003-11-26 2012-08-15 Supernus Pharmaceuticals Inc MICELLAR SYSTEMS SUITABLE FOR THE DELIVERY OF LIPOPHILIC OR HYDROPHOBIC COMPOUNDS
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GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
NO20072258L (no) 2007-08-10
ZA200703148B (en) 2008-09-25
PE20061077A1 (es) 2006-11-13
NO342592B1 (no) 2018-06-18
JP4982378B2 (ja) 2012-07-25
AU2005306018A1 (en) 2006-05-26
RU2620331C2 (ru) 2017-05-24
EP1814520B1 (en) 2016-04-13
RU2015131700A (ru) 2017-02-02
WO2006053755A1 (en) 2006-05-26
HUE027135T2 (en) 2016-08-29
CA2584343C (en) 2013-09-24
CN101056619A (zh) 2007-10-17
TW200631606A (en) 2006-09-16
GT200500310A (es) 2006-06-19
RU2012120388A (ru) 2013-11-27
NZ554551A (en) 2010-01-29
KR101283840B1 (ko) 2013-07-15
MA29076B1 (fr) 2007-12-03
IL182703A0 (en) 2007-09-20
TNSN07193A1 (en) 2008-11-21
MX2007005897A (es) 2007-06-19
AU2005306018B2 (en) 2009-12-17
US20080125450A1 (en) 2008-05-29
DK1814520T3 (en) 2016-05-30
AR052033A1 (es) 2007-02-28
SI1814520T1 (sl) 2016-06-30
RU2007122470A (ru) 2008-12-27
CA2584343A1 (en) 2006-05-26
ES2572133T3 (es) 2016-05-30
BRPI0518448A2 (pt) 2008-11-18
MY148647A (en) 2013-05-15
JP2008520606A (ja) 2008-06-19
IL182703A (en) 2015-11-30
EP1814520A1 (en) 2007-08-08
HRP20160446T1 (hr) 2016-05-20
PL1814520T3 (pl) 2016-08-31
US8518961B2 (en) 2013-08-27
KR20070084357A (ko) 2007-08-24

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