TW430657B - 4a-Aryldecahydroisoquinoline compound and pharmaceutical uses of the same - Google Patents
4a-Aryldecahydroisoquinoline compound and pharmaceutical uses of the sameInfo
- Publication number
- TW430657B TW430657B TW085110865A TW85110865A TW430657B TW 430657 B TW430657 B TW 430657B TW 085110865 A TW085110865 A TW 085110865A TW 85110865 A TW85110865 A TW 85110865A TW 430657 B TW430657 B TW 430657B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- nerve cell
- disorder
- same
- prevention
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 210000002569 neuron Anatomy 0.000 abstract 3
- 230000000202 analgesic effect Effects 0.000 abstract 2
- 230000000954 anitussive effect Effects 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010028851 Necrosis Diseases 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18381195 | 1995-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW430657B true TW430657B (en) | 2001-04-21 |
Family
ID=16142292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085110865A TW430657B (en) | 1995-07-20 | 1996-09-05 | 4a-Aryldecahydroisoquinoline compound and pharmaceutical uses of the same |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5776945A (zh) |
| EP (1) | EP0787721B1 (zh) |
| JP (1) | JP3858273B2 (zh) |
| KR (1) | KR970706258A (zh) |
| CN (1) | CN1163487C (zh) |
| AU (1) | AU6470996A (zh) |
| CA (1) | CA2200324C (zh) |
| DE (2) | DE69602248D1 (zh) |
| ES (1) | ES2133975T3 (zh) |
| TW (1) | TW430657B (zh) |
| WO (1) | WO1997003968A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204139C (zh) * | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
| EA024846B1 (ru) * | 2011-10-18 | 2016-10-31 | Астеллас Фарма Инк. | Бициклическое гетероциклическое соединение |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2655150A1 (de) * | 1975-12-16 | 1977-06-23 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US4301290A (en) * | 1975-12-16 | 1981-11-17 | Sandoz Ltd. | Organic compounds |
| AT371445B (de) * | 1977-05-24 | 1983-06-27 | Sandoz Ag | Verfahren zur herstellung von neuen cis-4a-phenyl-isochinolinderivaten und ihren saeureadditionssalzen |
| DE2907461A1 (de) * | 1978-03-10 | 1979-09-20 | Sandoz Ag | Isochinolinderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| US4189583A (en) * | 1978-04-26 | 1980-02-19 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of 4A-aryl-decahydroisoquinolines |
| DE69125099T2 (de) * | 1990-06-05 | 1997-06-19 | Toray Industries, Inc., Tokio/Tokyo | Indolderivate |
| JPH04297458A (ja) * | 1991-03-27 | 1992-10-21 | Toray Ind Inc | イソキノリン誘導体およびその製造方法 |
| JP2985322B2 (ja) * | 1991-03-01 | 1999-11-29 | 東レ株式会社 | イソキノリン誘導体およびその医薬用途 |
| JPH05155857A (ja) * | 1991-12-03 | 1993-06-22 | Toray Ind Inc | ４ａ−アリールデカヒドロイソキノリン誘導体および鎮痛剤 |
-
1996
- 1996-07-19 US US08/809,226 patent/US5776945A/en not_active Expired - Fee Related
- 1996-07-19 KR KR1019970701817A patent/KR970706258A/ko not_active Ceased
- 1996-07-19 EP EP96924167A patent/EP0787721B1/en not_active Expired - Lifetime
- 1996-07-19 JP JP50654497A patent/JP3858273B2/ja not_active Expired - Fee Related
- 1996-07-19 CA CA002200324A patent/CA2200324C/en not_active Expired - Fee Related
- 1996-07-19 DE DE69602248A patent/DE69602248D1/de not_active Expired - Fee Related
- 1996-07-19 ES ES96924167T patent/ES2133975T3/es not_active Expired - Lifetime
- 1996-07-19 WO PCT/JP1996/002030 patent/WO1997003968A1/ja not_active Ceased
- 1996-07-19 CN CNB961910666A patent/CN1163487C/zh not_active Expired - Fee Related
- 1996-07-19 DE DE69602248T patent/DE69602248T4/de not_active Expired - Lifetime
- 1996-07-19 AU AU64709/96A patent/AU6470996A/en not_active Abandoned
- 1996-09-05 TW TW085110865A patent/TW430657B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69602248D1 (de) | 1999-06-02 |
| CN1165513A (zh) | 1997-11-19 |
| US5776945A (en) | 1998-07-07 |
| DE69602248T4 (de) | 2000-10-26 |
| KR970706258A (ko) | 1997-11-03 |
| ES2133975T3 (es) | 1999-09-16 |
| EP0787721A4 (zh) | 1997-09-17 |
| CN1163487C (zh) | 2004-08-25 |
| AU6470996A (en) | 1997-02-18 |
| DE69602248T2 (de) | 1999-09-23 |
| CA2200324C (en) | 2008-07-08 |
| WO1997003968A1 (en) | 1997-02-06 |
| EP0787721A1 (en) | 1997-08-06 |
| JP3858273B2 (ja) | 2006-12-13 |
| CA2200324A1 (en) | 1997-02-06 |
| EP0787721B1 (en) | 1999-04-28 |
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