TW366350B - Processes for the diastereoselective synthesis of nucleosides - Google Patents

Processes for the diastereoselective synthesis of nucleosides

Info

Publication number: TW366350B
Authority: TW; Taiwan
Prior art keywords: processes; nucleosides; diastereoselective synthesis; diastereoselective; synthesis
Prior art date: 1991-05-21

Application number

TW081104323A

Other languages

English (en)

Inventor

Tarek Mansour

Allan H L Tse

Original Assignee

Shire Biochem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-21

Filing date

1992-06-02

Publication date

1999-08-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24825144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW366350(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-06-02 Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc

1999-08-11 Application granted granted Critical

1999-08-11 Publication of TW366350B publication Critical patent/TW366350B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Furan Compounds (AREA)
Catalysts (AREA)

TW081104323A 1991-05-21 1992-06-02 Processes for the diastereoselective synthesis of nucleosides TW366350B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US70337991A	1991-05-21	1991-05-21

Publications (1)

Publication Number	Publication Date
TW366350B true TW366350B (en)	1999-08-11

Family

ID=24825144

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
TW088109433A TWI245046B (en)	1991-05-21	1992-06-02	Intermediates useful in processes for the diastereoselective synthesis of nucleosides
TW081104321A TW366349B (en)	1991-05-21	1992-06-02	Processes for the diastereoselective synthesis of nucleosides
TW088109374A TW467907B (en)	1991-05-21	1992-06-02	Intermediates useful in processes for the diastereoselective synthesis of nucleosides
TW081104323A TW366350B (en)	1991-05-21	1992-06-02	Processes for the diastereoselective synthesis of nucleosides

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
TW088109433A TWI245046B (en)	1991-05-21	1992-06-02	Intermediates useful in processes for the diastereoselective synthesis of nucleosides
TW081104321A TW366349B (en)	1991-05-21	1992-06-02	Processes for the diastereoselective synthesis of nucleosides
TW088109374A TW467907B (en)	1991-05-21	1992-06-02	Intermediates useful in processes for the diastereoselective synthesis of nucleosides

Country Status (34)

Country	Link
US (5)	US5756706A (zh)
EP (2)	EP0515157B1 (zh)
JP (3)	JP3330972B2 (zh)
KR (3)	KR100232012B1 (zh)
CN (6)	CN1038591C (zh)
AT (2)	ATE133958T1 (zh)
AU (4)	AU668086B2 (zh)
BG (2)	BG61696B1 (zh)
CA (2)	CA2069024C (zh)
CZ (3)	CZ285220B6 (zh)
DE (2)	DE69221936T2 (zh)
DK (2)	DK0515157T3 (zh)
EE (1)	EE03044B1 (zh)
ES (2)	ES2084937T3 (zh)
FI (3)	FI109025B (zh)
GR (2)	GR3018941T3 (zh)
GT (1)	GT199800047A (zh)
HK (1)	HK132196A (zh)
HU (2)	HU221850B1 (zh)
IE (2)	IE921618A1 (zh)
IL (6)	IL116176A (zh)
MD (1)	MD1155C2 (zh)
MX (2)	MX9202395A (zh)
NO (2)	NO301010B1 (zh)
NZ (2)	NZ242818A (zh)
OA (1)	OA10212A (zh)
PL (3)	PL176026B1 (zh)
RO (1)	RO116812B1 (zh)
RU (4)	RU2223960C2 (zh)
SG (1)	SG43863A1 (zh)
SK (2)	SK279438B6 (zh)
TW (4)	TWI245046B (zh)
WO (2)	WO1992020696A1 (zh)
ZA (2)	ZA923641B (zh)

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1992
- 1992-05-19 ZA ZA923641A patent/ZA923641B/xx unknown
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1995
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1996
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Also Published As

Publication number	Publication date
ATE157662T1 (de)	1997-09-15
CN1109030C (zh)	2003-05-21
IL116109A (en)	1998-12-27
GR3018941T3 (en)	1996-05-31
IL101932A0 (en)	1992-12-30
NO301010B1 (no)	1997-09-01
IE921619A1 (en)	1992-12-02
EP0515157B1 (en)	1997-09-03
WO1992020696A1 (en)	1992-11-26
TW366349B (en)	1999-08-11
ES2104832T3 (es)	1997-10-16
CZ280857B6 (cs)	1996-04-17
IL116176A (en)	1998-02-08
US5756706A (en)	1998-05-26
CZ285220B6 (cs)	1999-06-16
IL101932A (en)	1997-04-15
AU1639492A (en)	1992-11-26
PL170869B1 (pl)	1997-01-31
DK0515157T3 (da)	1997-09-29
EE03044B1 (et)	1997-10-15
JP2001354667A (ja)	2001-12-25
FI20001900A7 (fi)	2000-08-29
CZ249293A3 (en)	1994-03-16
AU668086B2 (en)	1996-04-26
SK129493A3 (en)	1994-11-09
KR100242921B1 (ko)	2000-03-15
ZA923640B (en)	1993-02-24
IL101931A (en)	1996-12-05
BG61695B1 (bg)	1998-03-31
US5693787A (en)	1997-12-02
DE69221936D1 (de)	1997-10-09
ZA923641B (en)	1993-02-24
HU221850B1 (hu)	2003-02-28
DE69208144T2 (de)	1996-09-05
JP3229013B2 (ja)	2001-11-12
IL116109A0 (en)	1996-01-31
SG43863A1 (en)	1997-11-14
IE921618A1 (en)	1992-12-02
DE69221936T2 (de)	1998-01-02
FI106377B (fi)	2001-01-31
AU1690892A (en)	1992-12-30
KR920021576A (ko)	1992-12-18
AU655973B2 (en)	1995-01-19
CN1229080A (zh)	1999-09-22
CZ249393A3 (en)	1994-04-13
KR920021575A (ko)	1992-12-18
CN1038591C (zh)	1998-06-03
MX9202404A (es)	1993-08-31
RU2163909C2 (ru)	2001-03-10
CZ222496A3 (cs)	1999-04-14
CA2069063A1 (en)	1992-11-22
HK1002431A1 (zh)	1998-08-21
FI20001900L (fi)	2000-08-29
HUT67726A (en)	1995-04-28
US5696254A (en)	1997-12-09
FI935151L (fi)	1993-11-19
MX9202395A (es)	1993-02-01
JP3704055B2 (ja)	2005-10-05
MD1155B2 (en)	1999-02-28
US5744596A (en)	1998-04-28
OA10212A (en)	1997-10-07
GR3024617T3 (en)	1997-12-31
NO921988L (no)	1992-11-23
MD1155C2 (ro)	1999-10-31
JPH05186463A (ja)	1993-07-27
DE69208144D1 (de)	1996-03-21
HU9303296D0 (en)	1994-03-28
AU1691392A (en)	1992-12-30
TWI245046B (en)	2005-12-11
CN1050603C (zh)	2000-03-22
RU2223960C2 (ru)	2004-02-20
CN1067654A (zh)	1993-01-06
EP0515156B1 (en)	1996-02-07
JPH05186465A (ja)	1993-07-27
NO921989L (no)	1992-11-23
NZ242817A (en)	1995-03-28
BG98310A (bg)	1994-01-03
WO1992020669A1 (en)	1992-11-26
IE76741B1 (en)	1997-11-05
CN1067245A (zh)	1992-12-23
ES2084937T3 (es)	1996-05-16
IL116176A0 (en)	1996-01-31
FI935150L (fi)	1993-11-19
CA2069024A1 (en)	1992-11-22
BG61696B1 (bg)	1998-03-31
SK129393A3 (en)	1994-07-06
CN1116204A (zh)	1996-02-07
NO300593B1 (no)	1997-06-23
HK132196A (en)	1996-07-26
CN1229079A (zh)	1999-09-22
FI935151A0 (fi)	1993-11-19
NO921989D0 (no)	1992-05-20
KR0160144B1 (ko)	1998-11-16
SK279438B6 (sk)	1998-11-04
JP3330972B2 (ja)	2002-10-07
KR100232012B1 (ko)	1999-12-01
BG98311A (bg)	1994-08-30
MD950172A (en)	1996-08-30
GT199800047A (es)	1999-08-26
FI109025B (fi)	2002-05-15
ATE133958T1 (de)	1996-02-15
HUT67471A (en)	1995-04-28
EP0515156A1 (en)	1992-11-25
IL101931A0 (en)	1992-12-30
RO116812B1 (ro)	2001-06-29
SK281954B6 (sk)	2001-09-11
RU2140925C1 (ru)	1999-11-10
DK0515156T3 (da)	1996-06-17
EP0515157A1 (en)	1992-11-25
PL176026B1 (pl)	1999-03-31
CN1083450C (zh)	2002-04-24
CZ284975B6 (cs)	1999-04-14
CN1097049C (zh)	2002-12-25
US5663320A (en)	1997-09-02
CA2069024C (en)	1997-09-23
RU2105009C1 (ru)	1998-02-20
CN1035555C (zh)	1997-08-06
HU9303297D0 (en)	1994-03-28
HU223838B1 (hu)	2005-02-28
CA2069063C (en)	1997-07-15
NZ242818A (en)	1994-04-27
AU1639592A (en)	1992-11-26
TW467907B (en)	2001-12-11
NO921988D0 (no)	1992-05-20
CN1229078A (zh)	1999-09-22
PL168910B1 (pl)	1996-05-31
FI935150A0 (fi)	1993-11-19

Publication	Publication Date	Title
TW366349B (en)	1999-08-11	Processes for the diastereoselective synthesis of nucleosides
RU93058554A (ru)	1996-12-27	Способы диастереоселективного синтеза нуклеозидов
RU93058362A (ru)	1997-01-20	Способы диастереоселективного синтеза нуклеозидов, промежуточные соединения, способы получения промежуточных соединений
BG100916A (en)	1997-07-31	Process for the diastereoselective synthesis of nucleoside analogues
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