TW201909925A - 核酸複合體 - Google Patents

核酸複合體 Download PDF

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Publication number: TW201909925A
Authority: TW; Taiwan
Prior art keywords: compound; nucleic acid; equation; reference example; mmol
Prior art date: 2017-08-02

Application number

TW107126969A

Other languages

English (en)

Chinese (zh)

Inventor

山田陽史

牧野麻奈

長谷川尚

岩井宏徒

上原啓嗣

鈴木康裕

Original Assignee

日商協和醱酵麒麟有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-08-02

Filing date

2018-08-02

Publication date

2019-03-16

2018-08-02 Application filed by 日商協和醱酵麒麟有限公司 filed Critical 日商協和醱酵麒麟有限公司

2019-03-16 Publication of TW201909925A publication Critical patent/TW201909925A/zh

Links

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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW107126969A 2017-08-02 2018-08-02 核酸複合體 TW201909925A (zh)

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JP2017149761		2017-08-02

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CN113226332B (zh) *	2018-11-02	2025-05-09	阿布特斯生物制药公司	二价靶向缀合物
KR20210098477A (ko) *	2018-11-30	2021-08-10	쿄와 기린 가부시키가이샤	핵산 복합체
JP7676377B2 (ja)	2019-10-22	2025-05-14	アルナイラムファーマシューティカルズ，インコーポレイテッド	補体成分Ｃ３ｉＲＮＡ組成物およびその使用方法
MX2022013606A (es) *	2020-04-30	2023-01-16	Alnylam Pharmaceuticals Inc	Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas.
AU2022325715A1 (en) *	2021-07-17	2024-02-01	Sirnaomics, Inc.	Products and compositions
IL311146A (en)	2021-09-02	2024-04-01	Silence Therapeutics Gmbh	Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
EP4423273A1 (en) *	2021-10-29	2024-09-04	Alnylam Pharmaceuticals, Inc.	Complement factor b (cfb) irna compositions and methods of use thereof
US20250115634A1 (en) *	2022-01-30	2025-04-10	Lnctac Co., Ltd.	Ligand, method for preparing same, and use thereof
US12378558B2 (en)	2023-03-21	2025-08-05	Arrowhead Pharmaceuticals, Inc.	RNAi agents for inhibiting expression of complement factor B (CFB), pharmaceutical compositions thereof, and methods of use

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CA2930393C (en) *	2007-12-04	2022-11-29	Alnylam Pharmaceuticals, Inc.	Carbohydrate conjugates as delivery agents for oligonucleotides
MX391815B (es) *	2011-11-18	2025-03-21	Alnylam Pharmaceuticals Inc	AGENTES DE iARN, COMPOSICIONES Y METODOS DE LOS MISMOS PARA USARSE EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON TRANSTITERINA (TTR).
US9127276B2 (en) *	2013-05-01	2015-09-08	Isis Pharmaceuticals, Inc.	Conjugated antisense compounds and their use
US10808246B2 (en) *	2013-07-11	2020-10-20	Alnylam Pharmaceuticals, Inc.	Oligonucleotide-ligand conjugates and process for their preparation
EP3043827B1 (en) *	2013-09-13	2019-07-03	Ionis Pharmaceuticals, Inc.	Modulators of complement factor b
MX382900B (es) *	2013-12-12	2025-03-13	Alnylam Pharmaceuticals Inc	COMPOSICIONES DE ÁCIDO RIBONUCLEICO DE INTERFERENCIA (ARNi) CONTRA EL COMPONENTE DEL COMPLEMENTO Y MÉTODOS PARA SU USO.
WO2015105083A1 (ja) *	2014-01-07	2015-07-16	塩野義製薬株式会社	アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド
CA3012967A1 (en) *	2016-01-29	2017-08-03	Kyowa Hakko Kirin Co., Ltd.	Nucleic acid conjugate
TW201730341A (zh) *	2016-02-05	2017-09-01	Kyowa Hakko Kirin Co Ltd	抑制補體b因子之表現之反義寡核苷酸
EP3498724B1 (en) *	2016-06-30	2023-06-21	Kyowa Kirin Co., Ltd.	Nucleic acid complex

2018
- 2018-08-02 TW TW107126969A patent/TW201909925A/zh unknown
- 2018-08-02 WO PCT/JP2018/029113 patent/WO2019027015A1/ja not_active Ceased

Also Published As

Publication number	Publication date
WO2019027015A1 (ja)	2019-02-07

Publication	Publication Date	Title
JP6853193B2 (ja)	2021-03-31	核酸複合体
TW201909925A (zh)	2019-03-16	核酸複合體
JP7022687B2 (ja)	2022-02-18	核酸複合体
JPWO2017010575A1 (ja)	2018-04-26	β２ＧＰＩ遺伝子発現抑制核酸複合体
US10487103B2 (en)	2019-11-26	Oligonucleotide derivative, oligonucleotide construct using the same, and methods for producing them
EP3888663A1 (en)	2021-10-06	Nucleic acid complex
TW201920668A (zh)	2019-06-01	核酸複合體
JP2019024444A (ja)	2019-02-21	核酸複合体
HK40059056A (en)	2022-04-29	Nucleic acid complex
CA3029508C (en)	2025-09-09	Nucleic acid conjugate