TW201828941A - Composition of nasal drops or nasal spray characterized by containing a local anesthetic agent and hydrocortisone acetate at low concentration, thereby facilitating the improvement of rhinitis - Google Patents

Abstract

The current nasal drops or nasal spray of treating rhinitis mostly contains vasoconstrictor which uses nasal mucosal vasoconstriction to achieve the effect of temporarily relieving nasal congestion. But, when the medicinal action begins to gradually wear off, the nasal microvessel dilates again and the nasal congestion comes again. In addition, the more the nasal drops or the nasal spray is used, the shorter the effective period of the spray becomes. Finally, the medicinal action will completely wear off. The present invention utilizes a local anesthetic agent and hydrocortisone acetate to dissolve in a suitable solvent, so as to form a solution having a very low concentration of local anesthetic agent and hydrocortisone acetate. If necessary, one or the combination of several excipients such as preservative, buffering agent, emulsifier, hydrophilic thickener, surfactant, pure water can be added to prepare a nasal drops or a nasal spray so as to directly provide patient to drop or spray or smear nasal mucosa, thereby facilitating the improvement of rhinitis.

Description

 Point nasal or nasal spray composition  

The invention is based on a local anesthetic and Hydrocortisone Acetate, and uses a very low concentration of local anesthetic with a very low concentration of Hydrocortisone Acetate. If necessary, preservatives, buffers, emulsifiers, hydrophilic thickeners, surfactants, pure water, etc. are added. One to several combinations of excipients, etc., to form a nasal or nasal spray composition, when injected or spotted or coated on the nasal mucosa, a very low concentration of Hydrocortisone Acetate is a short-lived corticosteroid with mild properties. It is the safest and best anti-inflammatory swelling agent, it has anti-inflammatory, anti-allergic, anti-proliferation, anti-itch, reduce exudation and other effects [Reference: http://www.baike.com/wiki/%E9%86%8B %E9%85%B8%E6%B0%A2%E5%8C%96%E5%8F%AF%E7%9A%84%E6%9D%BE%E8%BD%AF%E8%86%8F+(HYDROCORTISONE +ACETATE+OINTMENT) (Reference: Annex 1) and the Department of Medicine's Drugs No. 121XX, such as drug copying instructions (Reference: Annex 2)] can anti-inflammatory and swelling effects on nasal mucosa, and existing nasal spray Or the nasal vasoconstrictor and anti-resistance of the nasal spray are different because of its anti-proliferative effect, so that the nasal mucosa does not become thicker. Ventilation, and it has an antipruritic effect to reduce the occurrence of sneezing, because it has reduced oozing to reduce secretion mucus, and a very low concentration of local anesthetic temporarily blocks the nasal mucosa to transmit foreign body intrusion message to the brain, so The brain also suspends the nasal mucosa to continue to strengthen the secretion of the command, the two complement each other, so that the nasal mucus in the nasal cavity is reduced, so that the air can pass through the nasal cavity, so that the inflamed nasal mucosa can rest and rest, so the synergy between the two is greatly increased, very helpful Treatment of nasal diseases.

Most of the traditional rhinitis or nasal sprays for the treatment of rhinitis contain vasoconstrictors, such as Oxymetazoline Hcl, Xylometazoline, Naphazoline Hcl, Phenylephrine Hcl, etc. (Refer to Appendix 3: Drug Search Network Search: Nasal or Point Nose http:// www.fda.gov.tw/MLMS/H0001D.aspx?Type=Lic&LicId=01005125 ) is the use of nasal vasoconstriction to achieve a temporary nasal congestion effect, so for example, nasal congestion, just after the spray, the nose will soon pass However, as the drug effect gradually recedes, the microvessels expand again, the nasal congestion comes again, and the shorter the effective period of the spray, the more the nasal mucosa becomes hypertrophy, and finally becomes habitual, even invalid, and even becomes a drug that is difficult to treat. Rhinitis, hypertrophic rhinitis, chronic rhinitis. The traditional rhinitis or nasal spray for treating rhinitis also contains antihistamines such as Diphenhydramine and Chlorpheniramine Maleate, which are generally prone to lethargy, causing arrhythmia and causing danger. The composition described above is either a vasoconstrictor or an anti-tissue. The anti-inflammatory and anti-tumor ability of amines is far less than that of Hydrocortisone Acetate, and there is no anti-proliferative effect of Hydrocortisone Acetate so that the nasal mucosa does not thicken and not affect nasal ventilation, and there is no anti-itch effect of Hydrocortisone Acetate to reduce the occurrence of sneezing. effect.

Traditional nasal sprays and nasal sprays are only a temporary solution, and can only temporarily relieve nasal congestion and cannot be fundamentally treated from their causes. It is stated from the instructions that it can not be used for a long time or after 10 days of continuous use. It should be stopped for 2~3 days before continuing to use or use it for more than one week to know one or two. Therefore, it is likely that the more effective it is, the more effective it will be. The medicine is stuffy. Traditional nose and nasal spray for the treatment of rhinitis are not completely correct, so many patients with nasal diseases are often suffering from nasal allergies, nasal congestion, and sneezing. (Reference: Annex IV, rhinitis is not easy to cure or can not cure the relevant webpages. Please search the website directly at Yahoo!) Page: Nose allergies can be found on many websites).

According to statistics, about 4 million people in Taiwan suffer from rhinitis (see Annex 5: Source: Yahoo! Chimo direct search: about 4 million people suffering from allergic rhinitis in Taiwan); traditional treatment of rhinitis The agent or nasal spray for treating rhinitis is not completely symptomatic. In theory, the present invention is mainly based on a local anesthetic with Hydrocortisone Acetate, and if necessary, a preservative, a buffer, an emulsifier, a hydrophilic thickener, and a surfactant are added. One to several combinations of excipients such as pure water are used to make a nasal or nasal spray composition for treating rhinitis.

The following arguments have not yet been proposed in the world. I now propose that the human body is a complex machine. Many structures and reactions have not been fully understood by humans. In the case of nasal mucosa and the brain, when foreign bodies invade the nasal mucosa. We feel itchy, sneezing, and runny nose, so we must prove that there is a relationship between stimulation and reflex between the nasal mucosa and the brain.

For example, when the nose is allergic to nasal congestion, when the nasal congestion is easy to contact each other on both sides of the nasal cavity, the nasal mucosa may mistakenly invade the nasal mucosa to the brain, and the brain then commands the nasal mucosa to strengthen the secretion of nasal mucus to exclude foreign bodies. As a result of this secretion, the contact area on both sides of the nasal cavity is larger, causing the nasal mucosa to be more intrusive into the foreign body, and transmitting the message of foreign body invasion to the brain. The brain repeatedly commands the nasal mucosa to strengthen the secretion of nasal mucus, so that interaction Repeated entanglement is the cause of nasal allergies, nasal congestion, and sneezing.

The invention is based on a local anesthetic and Hydrocortisone Acetate, and uses a very low concentration of local anesthetic with a very low concentration of Hydrocortisone Acetate. If necessary, preservatives, buffers, emulsifiers, hydrophilic thickeners, surfactants, pure water, etc. are added. One to several combinations of excipients and the like are used to form a nasal or nasal spray composition. When sprayed into the nasal mucosa, the local anesthetic temporarily blocks the nasal mucosa and transmits the message of foreign body invasion to the brain, so the brain is also suspended. The nasal mucosa continues to strengthen the secretion command, which reduces the nasal mucus in the nasal cavity, allowing the air to pass through the nasal cavity, allowing the inflamed nasal mucosa to rest and recover.

The very low amount of steroid Hydrocortisone Acetate is the shortest-acting corticosteroid. It is the safest and best anti-inflammatory and anti-inflammatory agent. It has anti-inflammatory, anti-allergic, anti-proliferative, anti-itching, and anti-exudation effects on the nasal mucosa. It has anti-inflammatory and anti-tumor effect, because it has anti-proliferative effect, so that the nasal mucosa does not become thicker and affects nasal ventilating, and it has anti-itching effect to reduce the occurrence of sneezing, because it has the effect of reducing exudation, which can reduce secretion mucus. The two complement each other and the effect is greatly increased, which is very helpful for the treatment of nasal diseases.

I have been suffering from severe allergic rhinitis more than 30 years ago. I have seen all the doctors in the Department of Otorhinolaryngology are ineffective. I have used commercially available nasal sprays and several kinds of nasal medicines. For many years, not only the symptoms have not been alleviated, but the more heavier the more It becomes drug-induced rhinitis, which is chronic rhinitis, and it is deeply painful. In the absence of help, more than 30 years ago, some acne ointments were inadvertently found to have a great therapeutic effect on nasal allergies. It is determined by the combination of a very low concentration of local anesthetic and a very low concentration of Hydrocortisone Acetate composition that is truly a contributing factor to the improvement of rhinitis.

It is related to the relationship between stimulation and reflex in human organs and organs. Naturally, there is also a relationship between stimulation and reflex between the nasal mucosa and the brain. Therefore, when the nasal congestion is easy to contact with each other on both sides of the nasal cavity, the nasal mucosa misjudges foreign matter intrusion. The message is transmitted to the brain, so the brain commands the nasal mucosa to strengthen the secretion of nasal mucus, causing the nasal cavity to contact each other more. Therefore, the alternation of nasal mucosa and brain stimulation and reflex is an important cause of nasal congestion and nasal allergy. If the nasal mucosa is no longer The misinformation of the foreign body intrusion message will not be transmitted to the brain for a period of time, and the brain will no longer order the nasal mucosa to strengthen the secretion of nasal mucus. The nasal mucosa naturally has a rest for a period of time, so if it contains a very low concentration of local anesthetic and very low The concentration of Hydrocortisone Acetate is diluted by a suitable solvent to a very low proportion of safely sprayed or applied to the nose of the nasal mucosa. The effect should be much greater than the traditional nasal spray or nasal spray. I have a nasal mucosa. The inference between the stimulus and the reflection between the brain and the brain should be justified, and the use of very low concentrations of local anesthetics with very low concentrations but very good quality The anti-proliferative and anti-itch ability of Hydrocortisone Acetate is a nasal or nasal spray composition for the treatment of rhinitis. In theory, it should be correct and feasible. In fact, I accidentally discovered that the effect was better than any commercial one 30 years ago. It is effective for nasal spray or nasal spray, and it has a total of 102 kinds of nasal sprays and a total of 101 kinds of nasal sprays. There have never been a local anesthetic with Hydrocortisone Acetate for rhinitis nasal allergic rhinitis. Or nasal spray (Reference: Drugs Enquiry Network http://www.fda.gov.tw/MLMS/H0001D.aspx?Type=Lic&LicId=01005125 Search: Nasal or Nose), search for patent files There is also no such information.

After checking a drug certificate containing Naphazoline Hcl, Diphenhydramine, and a drug test containing Naphazoline Hcl, Chlorpheniramine Maleate, and Naphazoline Hcl it is only effective for vasoconstriction, no anti-allergic effect, no anti-proliferation and anti-itch effect, so imitation All of them are indicated: they cannot be used for a long time or after 7 to 10 days of continuous use, they should be suspended for 2~3 days before continuing to use. It is far less effective than Hydrocortisone Acetate in anti-inflammatory, anti-allergic, anti-proliferative, anti-itching, and reduced exudation. Anti-histamine Diphenhydramine and Chlorpheniramine Maleate generally have very weak anti-inflammatory and anti-tumor properties, and have no anti-proliferative and anti-itching effects on the nasal mucosa, and are prone to lethargy, causing arrhythmia and causing danger, so the anti-inflammatory and swelling ability is far less than that. Hydrocortisone Acetate.

Therefore, the theoretical effect of the present invention is far greater than that of the currently available nasal spray or nasal spray. The present invention has also been inadvertently found to have an excellent effect, so that a patent application is filed, and only manufacturers are willing to spend money to spend more time. One step to the applicant's clinical trial, after passing the human clinical trial and then by the pharmaceutical factory to safely serve the majority of rhinitis patients.

The present invention provides a nasal spray or nasal spray composition of the present invention by means of a nose or spray or by application through the patient's nasal passages, which is the most direct and effective way to use the least amount of the agent with no side effects.

In general, the relevant medical inventions should first be tested in animals. It is impossible to determine whether nasal congestion or nasal allergy is improved by using orangutans or other animals such as pikas. This experiment uses human anal acne as a citation test because it is just around it. The mucosa is very similar to the mucosa in the nasal cavity, so as the general medical invention application can only be used for side-by-side examination before the human clinical trials. The above-mentioned invention for the treatment of swollen acne (Fig. 1) produces strong in a few hours. The swelling effect (Fig. 2) is extremely easy to observe (and the present invention is a new use of acne medicine, so it is also legally used for acne), and the main cause of nasal allergic nasal congestion is as shown in Fig. 3 due to swelling of the nose. Blocking the nasal passages, and after swelling, as shown in Figure 4, is very similar to hemorrhoids, so it can be inferred that the acne medicine is very helpful for the treatment of nasal allergic nasal congestion.

The present invention contains a very low concentration of local anesthetic with a very low concentration of Hydrocortisone Acetate to make a nasal or nasal spray composition compared with traditional nasal or nasal spray: more than 30 years ago, I was also a patient with severe allergic rhinitis Since the nose disease has been seen for many years, both Chinese and Western doctors have been ineffective in otolaryngology. They have used commercially available nasal sprays and several kinds of nasal medicines. For several consecutive years, not only the symptoms have not been alleviated, but the more they use, the more they become drug-induced rhinitis. , that is, chronic rhinitis, the pain of deep nose disease, in the absence of help, unintentionally found that some acne coated ointment has great effect on the treatment of nasal allergic nasal congestion, after long-term research mainly because it contains local anesthetic and contains Hydrocortisone The combination of Acetate's composition contributes greatly to the improvement of rhinitis.

Traditional nasal spray or nasal spray (Fig. 5, Fig. 6); traditional nasal sprays are mostly vasoconstrictors, which are comfortable after about 10 minutes of use, but the effective time is just about 5 at the beginning. 6 hours, 4 to 5 times a day (Figure 2), with the use of a long time, the effective time is shorter and shorter only 1 to 2 hours, the number of daily use increased to more than 10 times, such as continuous use of 5 to After 7 days, it finally failed (Figure 6).

The present invention contains a very low concentration of local anesthetic agent combined with Hydrocortisone Acetate as a nasal spray or nasal spray composition (Fig. 7); a very low concentration local anesthetic of the present invention is combined with a very low concentration of Hydrocortisone Acetate, a nasal spray or nasal spray The composition, in theory, when it is sprayed on the nasal mucosa, the local anesthetic is used to temporarily block the invasion of foreign bodies. The message is transmitted from the nasal mucosa to the brain. Therefore, the brain also suspends the command of the nasal mucosa to secrete a large amount of mucus, while the extremely low amount of Hydrocortisone Acetate is short. The mild corticosteroid is the safest and best anti-inflammatory and anti-tumor agent. It has anti-inflammatory, anti-allergic, anti-proliferative, antipruritic and anti-exudation effects. It can inhibit the inflammation and swelling of the nasal mucosa. The proliferative effect makes the nasal mucosa not thicken and affects the nasal passage ventilation, and it has an antipruritic effect to reduce the occurrence of sneezing, because it has reduced leakage and can reduce the secretion mucus, which complement each other, thus greatly contributing to the nose. The treatment of the disease, so it should be the cure. Figure 7 is a schematic diagram showing the relationship between nasal patency and time after inadvertently found in the nose 30 years ago, using the present invention.

In the first embodiment of the present invention, the nostrils on both sides are as long as 0.5 ml each of the following examples, and 1 ml of the nostrils on both sides, the total amount of Lidocain is about 0.3 mg, and the Hydrocortisone Acetate is about 0.02 mg. Other skin or acne application is about one-tenth of the amount, so it should be safe. It will feel relaxed and comfortable for about one hour, but it will last for one to several days. The effect is amazing, even better, so there is no habitual problem.

The invention is based on a local anesthetic and Hydrocortisone Acetate, and is dissolved in a suitable solvent by using a very low concentration of local anesthetic and a very low concentration of Hydrocortisone Acetate. If necessary, a preservative, a buffer, an emulsifier, a hydrophilic thickener, and an interfacial activity are added. One or several combinations of excipients, pure water and the like are used to form a nasal spray nasal spray composition. When sprayed into the nasal mucosa, the extremely low concentration of Hydrocortisone Acetate is the safest of short-acting corticosteroids. The best anti-inflammatory and swelling agent can anti-inflammatory and swelling of the nasal mucosa, and has anti-allergic, anti-proliferative and anti-itching effects, while a very low concentration of local anesthetic temporarily blocks the nasal mucosa and transmits the message of foreign body invasion to the brain. Therefore, the brain also suspends the nasal mucosa to continue to strengthen the secretion of the command, the two complement each other, so that the nasal mucus in the nasal cavity is reduced, so that the air can pass through the nasal cavity, allowing the inflamed nasal mucosa to rest and rest, the synergy between the two is greatly increased, very Help with the treatment of nasal diseases.

There are many types of local anesthetics, such as Lidocain, Pilocaine, Cinchocaine, Procaine, Dibucaine, Cinchocaine Hyddrochloride, Tetracaine Hcl, Benzocaine, etc., while Hydrocortisone Acetate is a mild glucocorticoid with strong anti-inflammatory, anti-rejection and swelling. Anti-proliferative, anti-itching effect, another alternative to Hydrocortisone Acetate, but also not found in the drug information of the nose or nasal spray component with the local anesthetic users also have Prednisolone, Betamethasone Valerate.

The invention is prepared by adding a preservative, a buffering agent, an emulsifier, a hydrophilic thickener, a surfactant, a pure water and the like to the local anesthetic agent Lidocain and Hydrocortisone Acetate. Forming a nasal or nasal spray composition is an example and is merely representative of the preferred embodiment and is not intended to limit the scope of the invention.

The invention can further be added with a compatible astringent Aluminium acetate or Zinc Oxide as an astringent to eliminate swelling and inflammation, and has a bactericidal effect. It can be added with a compatible antimicrobial preservative such as P-Hydroxybenzoic acid (P-hydroxybenzoic acid) or Propylene Glycol (propylene glycol) as a solvent, moisturizer and antiseptic effect. It can be added to Cetearyl Alcohol palmitol. Surfactant, emulsifier, hydrophilic thickener, disodium edetate, as a mineral chelating agent, and synergistic antiseptic effect. It can be diluted with pure water to dilute solvents and other pharmaceutical compatibility and buffers.

 Embodiment 1:  

Making a nasal spray or nasal spray composition with the following ingredients

This solution was prepared as follows

In a suitable reaction vessel, first add excipient: Paraffinum Liquidum liquid paraffin amount (about 7-10%), Cetearyl Alcohol palmitol (about 5-9%) as a surfactant, emulsifier, hydrophilic thick Properizer, Propylene Glycol propylene glycol (about 9-15%) as a solvent, moisturizer also helps antiseptic effect, use water to heat to 50 degrees Celsius, add Lidocaine mixed for at least 5 minutes to become a very low concentration of local anesthetic Then continue to add Hydrocortistis Acetate and mix for 5 minutes, mix well, then add Purified Water (about 85-90%) and mix and mix to form a suspension nose, plus a small amount of antimicrobial preservative Benzalkonium Chloride amount (0.001 -0.02%)) Mix evenly to further improve the storage of the pharmaceutical composition.

 Embodiment 2:  

Making a nasal spray or nasal spray composition with the following ingredients

In a suitable reaction vessel, first add about 99% of the solvent (water) of the excipient. After heating to 50 degrees Celsius, add Lidocaine (local anesthetic) to the right amount (about 0.3%) and Hydrocortisone Acetate (0.02%). Mix for at least 5 minutes to become a very low concentration of local anesthetic and then continue to add stirring and mixing for at least 5 minutes, mix evenly and then cool, then filter with filtration equipment and then add a trace amount of antimicrobial preservative (Benzalkonium Chloride amount (0.001-0.02 %), Ethanol ethanol (0.2-0.5%), L-Menthol (L-Menthol L-Menthol), evenly mixed to further improve the storage of the pharmaceutical composition, the mixed solution as a nasal spray.

 Embodiment 3:  

Making a nasal spray or nasal spray composition with the following ingredients

In a suitable reaction vessel, first add about 98% of the solvent (water) of the excipient, warm to 50 degrees Celsius, add Lidocaine for at least 5 minutes to become a very low concentration of local anesthetic and then continue to add Prednisolone to mix and mix at least 5 minutes, mix evenly and then cool, then filter with filter equipment and then add a trace amount of antimicrobial preservative (Benzalkonium Chloride amount (0.001-0.02%), Ethanol ethanol amount (0.2-0.5%), L-Menthol (L-Menthol The mixture is uniformly mixed to further improve the storage property of the pharmaceutical composition. The mixed solution is used as a nasal spray.

 Embodiment 4:  

Making a nasal spray or nasal spread composition with the following ingredients and ratios

This nasal preparation is prepared by the following method for direct application or in the nasal cavity in a suitable reaction container. Firstly, the amount of the liquid paraffin is added (about 60-90%), white soft Paraffin white Vaseline ( About 10-20%), Wool fat lanolin amount (about 10-20%), use Caspochine after heating to 50-70 degrees Celsius, stir and mix for at least 5 minutes, so that it becomes a very low concentration of local anesthetic, then Continue to add Hydrocortisone Acetate, mix for at least 5 minutes, mix well and cool, then filter with filter and cool.

 Embodiment 5:  

Making a nasal spray or nasal spray composition with the following ingredients

This solution was prepared as follows

In a suitable reaction vessel, first add about 99% of the solvent (water) of the excipient. After heating to 50 degrees Celsius, add Lidocaine (local anesthetic) to the right amount (about 0.3%) and Betamethasone Valerate (0.006%). Mix for at least 5 minutes to become a very low concentration of local anesthetic and then continue to add stirring and mixing for at least 5 minutes, mix well and then cool, then filter with filter equipment and then add a trace amount of antimicrobial preservative (Benzalkonium Chloride amount (0.001-0.02%) Ethanol Ethanol (0.2-0.5%), L-Menthol (L-Menthol L-Menthol) (0.001-0.02%), evenly mixed to further improve the storage of the pharmaceutical composition, the mixed solution as a nasal spray .

Figure 1 is a photo of swelling in the onset of acne (cited).

Figure 2 is a photo of the swelling of the acne by the invention. The drug is used in the acne (Reference: Annex 6), which contains the local anesthetic Cinchocaine and Hydrocortisone, among other brands. The local anesthetic lidocaine and Hydrocortisone have the same effect on acne] (cited).

Figure 3 is a schematic diagram of nasal congestion caused by obstruction of the nasal passages in the nasal cavity of the left nasal cavity (taking the left nasal cavity as an example).

Fig. 4 The left nasal cavity can make the nasal turbinate enlargement by eliminating the smoothness of the nasal passages and the ventilation according to the present invention (taking the left nasal cavity as an example).

Figure 5 is a schematic diagram showing the relationship between nasal patency and time after the traditional rhinoplasty or nasal spray containing vasoconstrictor has just begun to be placed in the nasal cavity. (73.02.01-73.12.31 I was a severe nasal disease patient 30 years ago, using the experience of using a nose spray or nasal spray under the direction of a doctor pharmacist).

Fig. 6 is a schematic diagram showing the effect of the nasal fluency and time after the traditional nasal injection or nasal spray containing vasoconstrictor for several days into the nasal cavity for about 5 to 7 days. (73.02.01-73.12.31 I was a severe nasal disease patient 30 years ago, using the experience of using a nose spray or nasal spray under the direction of a doctor pharmacist).

Figure 7 is a nasal or nasal spray composition containing a very low concentration of a local anesthetic with a very low concentration of Hydrocortisone Acetate, such as sprayed or applied or coated on the nasal mucosa, the nasal effect is smooth Schematic diagram of degree versus time. (73.02.01-73.12.31).

Notes: 1. The Medical Law was promulgated on November 24, 1975. 2. The present invention complies with the provisions of Article 5 of the Regulations on the Implementation of the Pharmaceutical Affairs Law: Approved, unauthorized manufacturers, do not include non-trafficking research, trial production of drugs.

Claims (2)

 A nasal or nasal spray composition is mainly prepared by adding a local anesthetic agent and Hydrocortisone Acetate at a suitable temperature to a local anesthetic and a Hydrocortisone Acetate solution at a very low concentration, if necessary, adding a preservative, a buffer, and emulsifying. One to several combinations of agents, hydrophilic thickeners, surfactants, pure water and the like to form a nasal spray or nasal spray composition, when sprayed or spotted or coated on the nasal mucosa At the time of mucosa, the extremely low concentration of Hydrocortisone Acetate can anti-inflammatory and anti-tumor effect on the nasal mucosa, because it has anti-proliferative effect, which can make the nasal mucosa not thicken and affect the nasal passage, and it has an anti-itch effect to reduce sneezing. The occurrence of this, because it has reduced leakage, can reduce the secretion of mucus, and a very low concentration of local anesthetic can temporarily block the nasal mucosa to spread the message of foreign body invasion to the brain, so the brain also suspends the nasal mucosa to continue to strengthen the secretion command The two complement each other, reducing the nasal mucus in the nasal cavity, so that the air can pass through the nasal cavity, allowing the inflamed nasal mucosa to rest and recover. If a surge of very helpful in treating nasal.    A nasal or nasal spray composition according to the first aspect of the invention, wherein the Hydrocortisone Acetate can be replaced by Prednisolone or Betamethasone Valerate.