TW201613907A - Antibacterial basic biaromatic derivatives with aminoalkoxy substitution - Google Patents
Antibacterial basic biaromatic derivatives with aminoalkoxy substitutionInfo
- Publication number
- TW201613907A TW201613907A TW104133759A TW104133759A TW201613907A TW 201613907 A TW201613907 A TW 201613907A TW 104133759 A TW104133759 A TW 104133759A TW 104133759 A TW104133759 A TW 104133759A TW 201613907 A TW201613907 A TW 201613907A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- aminoalkoxy
- substitution
- antibacterial
- gram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14189026 | 2014-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201613907A true TW201613907A (en) | 2016-04-16 |
Family
ID=51743312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104133759A TW201613907A (en) | 2014-10-15 | 2015-10-14 | Antibacterial basic biaromatic derivatives with aminoalkoxy substitution |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9850256B2 (zh) |
| EP (1) | EP3207042B1 (zh) |
| JP (1) | JP2017531008A (zh) |
| KR (1) | KR20170066644A (zh) |
| CN (1) | CN106795171A (zh) |
| AR (1) | AR102256A1 (zh) |
| AU (1) | AU2015332747A1 (zh) |
| BR (1) | BR112017007438A2 (zh) |
| CA (1) | CA2963699A1 (zh) |
| ES (1) | ES2702214T3 (zh) |
| MX (1) | MX2017004891A (zh) |
| RU (1) | RU2017116617A (zh) |
| TW (1) | TW201613907A (zh) |
| WO (1) | WO2016059097A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6330040B2 (ja) | 2013-07-22 | 2018-05-23 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | １−（ピペラジン−１−イル）−２−（［１，２，４］トリアゾール−１−イル）−エタノン誘導体 |
| PT3245203T (pt) * | 2015-01-15 | 2019-02-08 | Idorsia Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como modeladores do recetor cxcr3 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| AR108108A1 (es) * | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| BR112019023152B1 (pt) | 2017-05-04 | 2023-10-03 | Discovery Purchaser Corporation | Compostos heterocíclicos derivados de 2-{[2-(feniloximetil) piridina-5-il] oxi}-etanamina, seus usos e seus intermediários, formulações, e método para controle de pragas |
| JP2019019124A (ja) * | 2017-07-19 | 2019-02-07 | 日本化薬株式会社 | ピラジン化合物 |
| EP4405352A1 (en) * | 2021-09-20 | 2024-07-31 | F. Hoffmann-La Roche AG | New compounds and their use in the treatment of bacterial infection |
| WO2023041757A1 (en) * | 2021-09-20 | 2023-03-23 | F. Hoffmann-La Roche Ag | New compounds and their use in the treatment of bacterial infection |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CA2690229C (en) | 2007-06-29 | 2013-10-29 | Acucela, Inc. | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| CN101903380B (zh) | 2007-12-18 | 2013-04-17 | 埃科特莱茵药品有限公司 | 5-氨基环甲基-噁唑啶-2-酮衍生物 |
| ES2411930T3 (es) | 2008-02-20 | 2013-07-09 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos azatricíclicos |
| JP5404652B2 (ja) | 2008-02-22 | 2014-02-05 | アクテリオン ファーマシューティカルズ リミテッド | オキサゾリジノン誘導体 |
| WO2010015985A1 (en) * | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| MY158520A (en) | 2008-10-07 | 2016-10-14 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds |
| WO2010041218A2 (en) | 2008-10-10 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Oxazolidinyl antibiotics |
| CN102164915A (zh) | 2008-10-10 | 2011-08-24 | 埃科特莱茵药品有限公司 | 作为抗菌剂的2-苯并噻吩基-和2-萘基-噁唑烷酮及其氮杂等排体类似物 |
| US8575364B2 (en) | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| MX2014001680A (es) * | 2011-08-11 | 2014-05-27 | Actelion Pharmaceuticals Ltd | Derivados de quinazolina-2, 4-diona. |
| EP2776431B1 (en) | 2011-11-08 | 2016-05-04 | Actelion Pharmaceuticals Ltd. | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| MX362338B (es) | 2013-04-16 | 2019-01-11 | Idorsia Pharmaceuticals Ltd | Derivados biaromaticos antibacterianos. |
-
2015
- 2015-10-13 AR ARP150103308A patent/AR102256A1/es unknown
- 2015-10-14 WO PCT/EP2015/073751 patent/WO2016059097A1/en not_active Ceased
- 2015-10-14 CN CN201580055488.0A patent/CN106795171A/zh active Pending
- 2015-10-14 KR KR1020177012871A patent/KR20170066644A/ko not_active Withdrawn
- 2015-10-14 TW TW104133759A patent/TW201613907A/zh unknown
- 2015-10-14 BR BR112017007438A patent/BR112017007438A2/pt not_active Application Discontinuation
- 2015-10-14 US US15/516,290 patent/US9850256B2/en not_active Expired - Fee Related
- 2015-10-14 ES ES15778983T patent/ES2702214T3/es active Active
- 2015-10-14 CA CA2963699A patent/CA2963699A1/en not_active Abandoned
- 2015-10-14 JP JP2017520323A patent/JP2017531008A/ja not_active Ceased
- 2015-10-14 RU RU2017116617A patent/RU2017116617A/ru unknown
- 2015-10-14 EP EP15778983.5A patent/EP3207042B1/en not_active Not-in-force
- 2015-10-14 AU AU2015332747A patent/AU2015332747A1/en not_active Abandoned
- 2015-10-14 MX MX2017004891A patent/MX2017004891A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20170305927A1 (en) | 2017-10-26 |
| WO2016059097A1 (en) | 2016-04-21 |
| RU2017116617A (ru) | 2018-11-15 |
| BR112017007438A2 (pt) | 2018-01-16 |
| EP3207042B1 (en) | 2018-10-03 |
| EP3207042A1 (en) | 2017-08-23 |
| AU2015332747A1 (en) | 2017-06-01 |
| CA2963699A1 (en) | 2016-04-21 |
| JP2017531008A (ja) | 2017-10-19 |
| CN106795171A (zh) | 2017-05-31 |
| KR20170066644A (ko) | 2017-06-14 |
| AR102256A1 (es) | 2017-02-15 |
| ES2702214T3 (es) | 2019-02-27 |
| MX2017004891A (es) | 2017-12-07 |
| US9850256B2 (en) | 2017-12-26 |
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