TW201201857A - Agent suppressing decrease in preservative ability in amino-acid containing composition - Google Patents

Abstract

Disclosed is an agent that suppresses a decrease in preservative ability in an amino-acid containing composition that has a sufficient preservative ability even if as low a concentration of preservative as possible is used in combination therewith. The agent that suppresses a decrease in preservative ability is of an amino-acid containing composition that contains D-amino acids. The aforementioned D-amino acids may be D-glutamic acid and/or D-lysine hydrochloride. The amount contained of the agent that suppresses a decrease in preservative ability in the amino-acid containing composition is 0.000015 mass% to 10 mas%, and may be used in combination with 0.01 mass% to 1.0 mass% of preservative. Provided is a cosmetic material that contains the aforementioned agent that suppresses a decrease in preservative ability in an amino-acid containing composition.

Description

201201857 VI. Description of the Invention: [Technical Field] The present invention relates to a corrosion-inhibiting inhibitor in an amino acid-containing composition containing a D-amino acid, in particular, a D-glutamic acid-containing And/or an anti-corrosion reducing inhibitor in the amino acid-containing composition of d-lysamine hydrochloride. [Prior Art] Cosmetics such as lotions, lotions, and creams are usually filled in one container for dozens of times, and it is difficult to avoid the incorporation of microorganisms such as fingers or air during use. In order to prevent cosmetics from deteriorating due to the microorganism, preservatives are used in cosmetics. Representative cosmetic preservatives include isopropyl phenol, p-hydroxybenzoic acid ester, phenoxyethanol, phenolic acid such as benzyl alcohol, benzoic acid and its salts, salicylic acid and its salts, dehydroacetic acid and An acid such as a salt, a sorbic acid or a salt thereof, a quaternary ammonium chloride, an ammonium cerium chloride, an alkyl tridecyl ammonium halide, a 4- to ammonium, an alkylaminoethyl glycine hydrochloride, or a chlorine The stearyl hydrazine is subjected to an amphoteric surfactant such as sodium by a base beet test. However, such preservatives may cause skin irritation or such as benzoic acid, salicylic acid, etc., which may precipitate at a low temperature and thus have low stability of the preparation. Further, it is volatile as in the case of 2_oxyethanol, and volatilizes, and the antiseptic property of the cosmetic is lowered in use. [Problem 1] Unexamined Patent Publication No. 2006-249049 [Draft of the Invention] [A problem to be solved] An amino acid or a salt thereof is formulated as a cosmetic component having a moisturizing effect or a nutrient component of a food. However, the previously formulated amino acid (generally, I56307.doc 201201857) or a salt thereof becomes a nutrient source of microorganisms, and there is a problem that the antiseptic property of the formulation is lowered. Therefore, in order to have sufficient corrosion resistance even if the aforementioned preservative formulated in the amino acid-containing composition is used in the lowest possible concentration, it is required to develop an anti-corrosion reducing inhibitor in the amino acid-containing composition. [Technical means for solving the problem] The present invention provides a corrosion-inhibiting inhibitor in an amino acid-containing composition containing a D-amino acid. In the anti-corrosion reducing inhibitor of the amino acid-containing composition t of the present invention, the aforementioned D-amino acid is sometimes D-glutamic acid and/or D-lysine hydrochloride. The amount of the anti-corrosion reducing inhibitor in the amino acid-containing composition of the present invention is 0.000015 mass% / Torr to 1 〇 mass%, which is sometimes used in combination with 〇1% by mass to 1% by mass of the preservative. The present invention provides a cosmetic comprising the anti-corrosion reducing inhibitor in the aforementioned amino acid-containing composition. In the present specification, the anti-corrosion reducing inhibitor in the amino acid-containing composition means a composition which can reduce the amount of the preservative when used together with other preservatives, although it has no activity as a preservative alone. Specifically, an amino acid-containing composition having a small amount of preservative is provided as compared with the amino acid-containing (L body) composition formulated by the sputum. The antiseptic reducing agent in the amino acid-containing composition of the present invention can be used not only in cosmetics or skin external preparations, but also in medicines, foods, beverages, and any kind of articles which are spoiled by the incorporation of microorganisms. Case 0 156307.doc 8 4· 201201857 The D-amino acid used in the anti-corrosion reducing inhibitor of the amino acid-containing composition of the present invention comprises glycine, alanine, cysteine, aspartame Aminic acid, glutamic acid, phenylalanine, histidine, isoleucine, lysine, leucine, methionine, aspartame, valine, glutamine, arginine, silk a stereoisomer D-amino acid of 19 amino acids other than glycine in the amino acid consisting of acid, echinoic acid, guanamine, tryptophan and tyrosine, and It is not limited to any of these natural or non-natural amino acids. The applicant of the present invention has found, for example, that the Japanese Patent Application No. 2009-2 11255 (Ultraviolet Damage Reduction Composition), Japanese Patent Application No. 2009-220983 (Ultraviolet Damage Reduction Composition), and the Japanese Patent Application No. 2009-223327 (UV Damage Reduction Combination) ) 特 2009 2009-224742 (antioxidant composition), Japan's special offer 2〇〇9_ 224743 (composition for promoting collagen production), Japan's special offer 2〇〇9· 225870 (composition for promoting collagen production) ), Japanese special offer 2〇〇9_ 225871 (composition for promoting laminin 332), Japanese Patent No. 2009-225872 (combination for promoting laminin 332), Japanese Patent No. 2009-226075 (Reducing skin roughness) Oral composition), Japanese Patent Application No. 2009-226076 (oral composition for reducing wrinkle formation), Japanese Patent Application No. 2009-228267 (oral composition for reducing ultraviolet damage), PCT/JP2〇10/53569 (whitening agent and whitening) Various cosmetic application methods of PCT/JP2010/55841 (oral composition for reducing ultraviolet damage), PCT/JP2010/55842 (antioxidant composition), and pcT/JP2010/55648 (ultraviolet damage reduction composition) As indicated, D-amino acids have a variety of useful properties and provide novel uses based on such findings. The contents of these application notes are hereby incorporated by reference in its entirety by reference in its entirety by reference in its entirety in its entirety in its entirety in a preservative sometimes used in combination with a preservative lowering inhibitor in the amino acid-containing composition of the present invention, comprising isopropylmethylphenol, p-hydroxyformate, 2-phenoxyethanol, eucalypol, etc. (4), Benzoic acid and its salts, salicylic acid and its salts, dehydroacetic acid and its salts, acid such as sorbic acid and its salts, benzylammonium chloride, benzylammonium chloride, alkyltrimethylammonium vaporate, etc. Ammonium, alkylaminoethylglycine hydrochloride, vaporized stearin, amphoteric surfactant such as sodium formate test, etc., but not limited thereto. [Embodiment] The embodiments of the present invention described below are for illustrative purposes only and do not limit the technical scope of the present invention. The technical scope of the present invention is limited only by the description of the scope of the patent application. Example 1

The antiseptic effect test was carried out as follows: L_body 0.5% (mass ratio, glutamic acid or lysine hydrochloride D· the same below), 5% nitroglycerin (Dynamite glycerol), 〇.5% of 2 • Phenoxyethanol is dissolved in the remaining deionized water to prepare a sample. A sample without added amino acid was used as a control. A 30 g sample was inoculated with 106 cfu/g of Escherichia coli or Staphylococcus aureus and stored at 25 °C. When the sample was prepared (0 days) and stored for 3, 5, 1 and 14 days, a part of the sample was taken with a sterile cotton swab, spread on an agar medium, and cultured at 30 ° C for 2 days, and the measurement was formed. The number of colonies. When the number of colonies exceeds about 100, the number of colonies is recorded as +++, and +. Recorded as - when the colony was not formed at all. The results of the antiseptic effect test are shown in Tables 2 and 2 below. 156307.doc -6 · 201201857 [Table 1] Escherichia coli control trough β (0. Τ 5%) lysine hydrochloride (0.5%) Day 0 +-H- ++Η- D +Ή-- L +-H- D HH- Brother 3 days 5th day 24 6 ··~~~-~~-- ++ 8 + one + 10 days in the 7th day - "1_2 — 66 〇 7 — 窠 14 days — Z / 18 — [Table 2] Staphylococcus aureus control Gu Yue (0. * 5%) lysine hydrochloride (0.5%) Day 0 Day 3 +++ -L +++ I -- , LD + ++ +++ +-H- Day 5 +++ 6 + 5 24 1 Day 7 107 3 Day 10 Γ 9 m 1 Today ------ One Table 1 and Table 2 will be utilized separately A summary of the results of the measurement of the number of bacteria inoculated with a sample of Escherichia coli and Staphylococcus aureus. As shown in Table i, a control sample of Escherichia coli was inoculated, and the sample was confirmed to be stored on the 3rd and 5th day at 25t. The bacteria were detected, but the bacteria were not detected at the 7th day. In the case of any amino acid, more bacteria than the control sample were detected in the sample with the amino acid added, but the 〇-amino group was added. The acid sample confirmed that only the tendency of the bacteria to be less than the control sample was detected. As shown in Table 2, inoculation The sample of Golden Grape 9® also detected more bacteria than the control sample in the sample containing L_amino acid, but only the sample added with D_amino acid detected less than L-amino acid. The number of bacteria is also in the range of 6.1, which does not affect the proliferation of Escherichia coli and Staphylococcus aureus. Also, the 1_body and D_ of the same amino acid The difference in optical heterogeneity of the added amino acid is considered to be the reason for the large difference in the number of bacteria of 156307.doc 201201857. That is, L_amino acid makes 2-phenoxyethanol The anti-corrosion power is lowered, but the D-amino acid inhibits the reduction of the anti-corrosion power of the 2-phenyl alcohol. D-glutamic acid and D-lysine hydrochloride have a remarkable effect of inhibiting the reduction of the anti-corrosion of 2-phenoxyethanol. Example 2 The following is based on the present invention and shows a beverage containing D_glutamic acid and/or guanidine-lysine acid, a cream, a body cream, a gel, a peeling mask, a soaking mask, Examples of the preparation of emulsions, lotions, and aerosols. These formulations are listed for the purpose of illustration and are not intended to limit the present invention. Technical range. Formulation Example 1 (beverage) Formulation amount (g/60 mL) 1.6 1.6 (Composition) Honeysuckle extract Ginseng extract D-glutamic acid and/or D-lysine hydrochloride 1> 6 Reducing Maltose Syrup 28 Erythritol 8 Citric Acid 2 Perfume 1.3 N-Acetyl Glucosamine 1 Sodium Hyaluronate 0.5 Vitamin E 0.3 Vitamin B6 〇.2 156307.doc 201201857 Vitamin B 2 0.1 α-Lipoic Acid 0.2 Coenzyme Q10 1.2 Neural guanamine (konjac extract) 0.4 L-proline 2 pure water remaining 60 ration (% by mass) 3 1

8 5 2 3 6 2 0.5 4 0.5 m 3 Formulation Example 2 (cream) Liquid paraffin Vaseline dimercapto polyoxyalkylene stearyl behenyl glycerol dipropylene glycol macadamia nut oil hardening oil squalane stearic acid hydroxy hard Cholesteric acid cholesterol ester 2-ethylhexanoic acid hexahydrate 酉 聚 polyoxyethylene hardened castor oil self-emulsifying monostearic acid glycerol 156307.doc 201201857 potassium hydroxide 0.15 sodium hexametaphosphate 0.05 trimethylglycine 2 α - Tocopherol 2-L-ascorbyl phosphate diester potassium 1 Tocopherol acetate 0.1 D-glutamic acid and / or D-lysamine hydrochloride 0.5 Parabens amount Ethylenediaminetetraacetic acid trisodium 0.05 4 -t-butyl-4'-decyloxybenzophenone 0.05 di-p-oxy cinnamic acid mono-2-ethylhexanoic acid glyceride 0.05 coloring agent appropriate amount of tethered polymer 0.05 pure water remaining 100.00 Formulation Example 3 (Body Emulsion) Formulation amount (% by mass) 3 13 12 (Composition) Dimethyl polyoxane decamethylcyclopentaoxane, 12-fluorenylcyclohexaoxane, polyoxyethylene, A Polyoxyalkylene copolymer 156307.doc -10· 201201857 Ethanol 2 Isopropanol 1 Glycerin 3 Dipropylene glycol 5 Polyethylene glycol 6000 5 Sodium metaphosphate 0.05 Tocopherol acetate 0.1 D-glutamic acid and/or D-lysine hydrochloride 0.1 Fennel extract 0.1 Witch hazel extract 0.1 Ginseng extract 0.1 L-menthol Phenyl paraben Appropriate amount of trisodium edetate 0.05 吗 淋 琏 琏 秦 酮 0.01 0.01 0.01 0.01 Trimethoxy cinnamic acid methyl bis (tridecyl decyloxy) decyl isoamyl ester 0.1 yellow iron oxide 'the right amount of titan acid recorded two Mercapto distearyl ammonium hectorite 1.5 polyvinyl alcohol 0.1 hydroxyethyl cellulose 0.1 tridecyl decyloxy decanoic acid 2 156307.doc -π - 201201857 Perfume pure water amount remaining 100.00 Preparation example 4 (gelling agent) (composition) dimethyl polyoxyalkylene glycerol 1,3-butanediol polyethylene glycol 1500 polyethylene glycol 20000 cetyl octyl citrate citrate sodium hexametaphosphate glycyrrhizic acid two D-valley Amino acid and / or D-lysamine hydrochloride tocopherol extract Astragalus extract Saxifrag extract Ethylenediaminetetraacetic acid trisodium xanthan gum Acrylic acid / Methacrylic acid blending amount (mass ° / 〇) 5 2 5 3 3 3 0.01 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.3 156307.doc -12- 201201857 Polymer (Pemulen TR-2) 0.05 Agar powder 1.5 2-Phenoxyethanol Appropriate amount of dibutylhydroxyindole Benzene Appropriate amount of pure water remaining 100.00 Formulation Example 5 (peeling mask) (composition) Formulation amount (% by mass) Ethanol 10 1 ,3-butanediol polyethylene glycol olive oil macadamia nut oil hydroxystearic acid plant sterol lactate lactate L-ascorbyl sulfate 2 sodium alpha-tocopherol 2-L-ascorbate two S-sex 6 6 0.05

D-glutamic acid and/or D-lysamine hydrochloride 0.1 Fish collagen 0.1 Chondroitin sulfate 0.1 156307.doc -13- 201201857 Sodium hydroxymethylcellulose 0.2 Polyvinyl alcohol 12 Parabens Appropriate amount of pure water remaining 100.00 Formulation Example 6 (Immersion Mask) (Composition) Formulation amount (% by mass) Glycerin 1 1,3-butanediol 8 Xylitol 2 Polyethylene glycol 1500 2 Rosemary oil 0.01 Sage Oil 0.1 Citric acid 0.02 Sodium citrate 0.08 Sodium hexametaphosphate 0.01 Hydroxypropyl-β-cyclodextrin 0.1 D-glutamic acid and / or D-lysamine hydrochloride 0.5 White birch extract 0.1 Lavender oil 0.01 Huangyuan Gum 0.05 156307.doc -14· 201201857 Carboxyvinyl polymer p-hydroxybenzoate pure water formulation Example 7 (emulsion) (composition) Liquid paraffin Vaseline pentamethylcyclopentaoxane Camelliere glycerol dipropylene glycol polyethylene Glycol 1500 jojoba oil isostearic acid stearic acid behenic acid tetrakis(2-ethylhexanoic acid) pentaerythritol ester 2-ethylhexanoic acid hexahydrate glycerol monostearate monostearate Oxyethylene glyceride potassium hydroxide hexaploxate 0.15 appropriate amount of remaining 100.00 Mass%) 7 3 2 1.5 5 7 2 1 0.5 0.5 0.5 3 3 0.05 156307.doc 15 201201857 Glycyrrhetinic acid stearyl ester 0.05 D-glutamic acid and / or D-lysamine hydrochloride 1 Royal jelly extract 0.1 Yeast Extract 0.1 Tocopherol Acetate 0.1 Acetate Sodium Hyaluronate 0.1 Ethylenediaminetetraacetic Acid Trisodium 0.05 4-t-Butyl-4'-decyloxybenzhydryldecane 0.1 P-Methoxy Cinnamon Acid 2-ethylhexyl ester 0.1 Carboxyvinyl polymer 0.15 Parabens Appropriate amount of spices Right amount of pure water remaining 100.00 Formulation Example 8 (emulsion) (composition) Formulation amount (% by mass) Dimethylpolysiloxane 2 Kaempferol 1 Shark liver alcohol 0.5 Glycerol 5 1,3-butanediol 7 Erythritol 2 156307.doc -16- 201201857 Hardened oil 3 Squalene 6 Tetrakis(2-ethylhexanoate) pentaerythritol 2 Stearic acid polyoxyethylene glycerol 1 monostearate polyoxyethylene glycerol 1 D-glutamic acid and / or D-lysamine hydrochloride 0.3 potassium hydroxide amount of sodium hexametaphosphate 0.05 2-phenoxyethanol appropriate amount of carboxyl Ethylene polymer 0.1 pure water remaining formulation example 9 (makeup) (composition) ethanol glycerin 100.00 dosage (% by mass) 5 1,3-butanediol 5 polyethylene oxide polypropylene oxide decyltetradecyl ether 0.2 sodium hexametaphosphate 0.03 trimethylglycine 1 polyaspartic sodium citrate 0.1 156307.doc • 17- 201201857 α-Tocopherol 2-Ascorbyl Phosphate Diester Potassium 0.1 Thio Taurine 0.1 D-Glutamic Acid and/or D-Lysamine Hydrochloride 0.01 EDTA3 Sodium 0.1 Carboxyvinyl Polymer 0.05 Potassium Hydroxide 0.02 2-phenoxyethanol, the right amount of spices, the amount of pure water remaining anoea·——a—ani, a ιι 丨_ ga—aesanaiaca—casaaagaca—aegxaasaMnae—iea!ani,.mn_i8»acceaiEsa 100.00 Formulation Example 10 (lotion) (Combination Formulation (I ethanol 10 dipropylene glycol 1 polyethylene glycol 1000 1 polyoxyethylene methyl glucoside 1 jojoba oil 0.01 triethyl 2-ethylhexanoate 0.1 polyoxyethylene hardened castor oil 0.2 diisostearyl Acid polyglyceride 0.15 N-stearyl sulfhydryl-L-glutamate 0.1 • 18- 156307.doc 201201857 Citric acid 0.05 sodium citrate 0.2 potassium hydroxide 0.4 dipotassium glycyrrhizinate 0.1 arginine hydrochloride 0.1 L-ascorbic acid 2-glucoside 2 D-glutamic acid and / or D-lysamine hydrochloride 0.5 Ethylenediaminetetraacetic acid trisodium 0.05 p-Oxyl cinnamic acid 2-ethylhexyl ester 0.01 Dibutyl hydroxy fluorene benzophenone p-hydroxyphenyl phthalate Appropriate amount of marine deep water 3 Perfume amount of pure water remaining 100.00 Preparation example 11 ( Aerosol urea external preparation) (composition) Formulation ethanol 15.0 Polyoxyethylene hardened castor oil 50 1.5 Diphenhydramine 1.0 dicocaine 2.0 Tocopherol acetate 0.5 -19- 156307.doc 201201857 D-glutamine Acid and / or D-lysamine hydrochloride 0.1 isostearic acid 0.1 1,3-butanediol 3.0 polyethylene glycol 4 〇〇 3.0 camphor 0.05 urea 20.0 pure water remaining 100.00 Preparation example 12 (aerosol urea injection Agent) (composition) Formulation amount (mass 〇 / 〇) Aerosol exhibitant external preparation stock solution 65.0 35.0 Dimethyl ether 100.00 Preparation method 12 (aerosol urea spray agent) filling method Aerosol urine material preparation liquid and 2 The formazan is filled in a pressure-resistant aerosol aluminum can coated with Teflon (registered trademark) to prepare an aerosol. 156307.doc

Claims (1)

201201857 VII. Patent Application Range·· u An anti-corrosion reduction inhibitor in an amino acid-containing composition, which is characterized in that it contains a D-amino acid. 2. The antiseptic reduction inhibitor according to the amino acid-containing composition of claim 1, wherein the D-amino acid is D-glutamic acid and/or D_lysine hydrochloride. 3. The anti-corrosion reducing inhibitor in the amino acid-containing composition of claim 1 or 2, which is formulated in an amount of from 0.00015% by mass to 1% by mass, and with from 1% by mass to 1.0% by mass of the preservative And use it. A cosmetic comprising the anti-corrosion reducing inhibitor in the amino acid-containing composition according to any one of claims 1 to 3. 156307.doc 201201857 IV. Designation of the representative representative: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best indication of the characteristics of the invention. Chemical formula: (none) 156307.doc