TW200833695A - Use of spiro-oxindole compounds as therapeutic agents - Google Patents
Use of spiro-oxindole compounds as therapeutic agentsInfo
- Publication number
- TW200833695A TW200833695A TW096138356A TW96138356A TW200833695A TW 200833695 A TW200833695 A TW 200833695A TW 096138356 A TW096138356 A TW 096138356A TW 96138356 A TW96138356 A TW 96138356A TW 200833695 A TW200833695 A TW 200833695A
- Authority
- TW
- Taiwan
- Prior art keywords
- spiro
- therapeutic agents
- oxindole compounds
- oxindole
- compounds
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85178706P | 2006-10-12 | 2006-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200833695A true TW200833695A (en) | 2008-08-16 |
Family
ID=39339863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096138356A TW200833695A (en) | 2006-10-12 | 2007-10-12 | Use of spiro-oxindole compounds as therapeutic agents |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8466188B2 (zh) |
| EP (1) | EP2073806B1 (zh) |
| JP (2) | JP5460324B2 (zh) |
| CN (2) | CN103271906A (zh) |
| AR (1) | AR063280A1 (zh) |
| AT (1) | ATE545416T1 (zh) |
| AU (1) | AU2007319580B2 (zh) |
| BR (1) | BRPI0719210A2 (zh) |
| CA (1) | CA2665698A1 (zh) |
| CL (1) | CL2007002950A1 (zh) |
| MX (1) | MX2009003876A (zh) |
| RU (1) | RU2009117642A (zh) |
| TW (1) | TW200833695A (zh) |
| WO (1) | WO2008060789A2 (zh) |
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| CL2007002950A1 (es) | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Uso de compuestos derivados de espiro-oxindol en el tratamiento de hipercolesterolemia, hiperplasia benigna de prostata, pruritis, cancer |
| BRPI0719857A2 (pt) * | 2006-10-12 | 2014-06-03 | Xenon Pharmaceuticals Inc | Compostos espiro-oxindol úteis no tratamento de doenças ou condições mediadas por canal de sódio. |
| CN105175433A (zh) * | 2008-10-17 | 2015-12-23 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| US8101647B2 (en) | 2008-10-17 | 2012-01-24 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| US8217051B2 (en) * | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| PH12012500726A1 (en) | 2009-10-14 | 2019-07-10 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| RU2596488C2 (ru) * | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
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| CA2869547A1 (en) | 2012-04-12 | 2013-10-17 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
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| CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
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| JP2017517555A (ja) | 2014-06-12 | 2017-06-29 | アダムド エスピー．ゼット オー．オー．Ａｄａｍｅｄ Ｓｐ．Ｚ Ｏ．Ｏ． | 阻害剤ｐ５３−Ｍｄｍ２タンパク質−タンパク質相互作用としての、１，１’，２，５’−テトラヒドロスピロ［インドール−３，２’−ピロール］−２，５’−ジオン系を含む化合物 |
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| AU2022285758A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
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| JP2024520649A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | （２ｒ，３ｓ，４ｓ，５ｒ）－４－［［３－（３，４－ジフルオロ－２－メトキシ－フェニル）－４，５－ジメチル－５－（トリフルオロメチル）テトラヒドロフラン－２－カルボニル］アミノ］ピリジン－２－カルボキサミドを含む固体剤形及び投与レジメン |
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-
2007
- 2007-10-12 CL CL200702950A patent/CL2007002950A1/es unknown
- 2007-10-12 CN CN2013101646702A patent/CN103271906A/zh active Pending
- 2007-10-12 AR ARP070104540A patent/AR063280A1/es unknown
- 2007-10-12 AU AU2007319580A patent/AU2007319580B2/en not_active Ceased
- 2007-10-12 MX MX2009003876A patent/MX2009003876A/es active IP Right Grant
- 2007-10-12 TW TW096138356A patent/TW200833695A/zh unknown
- 2007-10-12 EP EP07868434A patent/EP2073806B1/en not_active Not-in-force
- 2007-10-12 AT AT07868434T patent/ATE545416T1/de active
- 2007-10-12 JP JP2009532606A patent/JP5460324B2/ja not_active Expired - Fee Related
- 2007-10-12 CN CN200780038111A patent/CN101631546A/zh active Pending
- 2007-10-12 RU RU2009117642/15A patent/RU2009117642A/ru not_active Application Discontinuation
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- 2007-10-12 CA CA002665698A patent/CA2665698A1/en not_active Abandoned
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101631546A (zh) | 2010-01-20 |
| BRPI0719210A2 (pt) | 2015-05-05 |
| RU2009117642A (ru) | 2010-11-20 |
| WO2008060789A3 (en) | 2008-07-24 |
| US20100173967A1 (en) | 2010-07-08 |
| CL2007002950A1 (es) | 2008-02-01 |
| JP2013256539A (ja) | 2013-12-26 |
| AU2007319580B2 (en) | 2012-11-29 |
| US8466188B2 (en) | 2013-06-18 |
| EP2073806A2 (en) | 2009-07-01 |
| WO2008060789A2 (en) | 2008-05-22 |
| ATE545416T1 (de) | 2012-03-15 |
| MX2009003876A (es) | 2009-05-11 |
| AU2007319580A1 (en) | 2008-05-22 |
| AR063280A1 (es) | 2009-01-21 |
| US20110172282A9 (en) | 2011-07-14 |
| CN103271906A (zh) | 2013-09-04 |
| JP2010506854A (ja) | 2010-03-04 |
| CA2665698A1 (en) | 2008-05-22 |
| JP5460324B2 (ja) | 2014-04-02 |
| EP2073806B1 (en) | 2012-02-15 |
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