TW200738689A - Salts and polymorphs of a VEGF-R inhibitor - Google Patents
Salts and polymorphs of a VEGF-R inhibitorInfo
- Publication number
- TW200738689A TW200738689A TW095128889A TW95128889A TW200738689A TW 200738689 A TW200738689 A TW 200738689A TW 095128889 A TW095128889 A TW 095128889A TW 95128889 A TW95128889 A TW 95128889A TW 200738689 A TW200738689 A TW 200738689A
- Authority
- TW
- Taiwan
- Prior art keywords
- salts
- polymorphs
- vegf
- inhibitor
- free base
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 229940124674 VEGF-R inhibitor Drugs 0.000 title 1
- 239000012458 free base Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- LGXVKMDGSIWEHL-UHFFFAOYSA-N n,2-dimethyl-6-[7-(2-morpholin-4-ylethoxy)quinolin-4-yl]oxy-1-benzofuran-3-carboxamide Chemical compound C=1C=C2C(C(=O)NC)=C(C)OC2=CC=1OC(C1=CC=2)=CC=NC1=CC=2OCCN1CCOCC1 LGXVKMDGSIWEHL-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70633205P | 2005-08-08 | 2005-08-08 | |
| US75018905P | 2005-12-14 | 2005-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200738689A true TW200738689A (en) | 2007-10-16 |
Family
ID=37320417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095128889A TW200738689A (en) | 2005-08-08 | 2006-08-07 | Salts and polymorphs of a VEGF-R inhibitor |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7928226B2 (zh) |
| EP (1) | EP1915368A1 (zh) |
| JP (1) | JP4536688B2 (zh) |
| KR (1) | KR20080027923A (zh) |
| AR (1) | AR055600A1 (zh) |
| AU (1) | AU2006277742B2 (zh) |
| BR (1) | BRPI0614115A2 (zh) |
| CA (1) | CA2615760A1 (zh) |
| IL (1) | IL188851A0 (zh) |
| MX (1) | MX2008001838A (zh) |
| RU (1) | RU2369607C1 (zh) |
| TW (1) | TW200738689A (zh) |
| WO (1) | WO2007017740A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080027923A (ko) | 2005-08-08 | 2008-03-28 | 화이자 인코포레이티드 | Ｖｅｇｆ-ｒ 억제제의 염 및 다형체 |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| US8211911B2 (en) | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
| CA2770545C (en) * | 2009-08-21 | 2015-11-03 | F. Hoffmann-La Roche Ag | Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT772610E (pt) * | 1994-07-22 | 2001-03-30 | Byk Gulden Lomberg Chem Fab | Di-hidrobenzofuranos |
| NZ505362A (en) * | 1997-12-22 | 2004-12-24 | Upjohn Co | 4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents |
| CN1165532C (zh) | 1998-09-29 | 2004-09-08 | 惠氏控股有限公司 | 作为蛋白质酪氨酸激酶抑制剂的取代的3-氰基喹啉 |
| WO2001040192A1 (en) * | 1999-12-03 | 2001-06-07 | Kyoto Pharmaceutical Industries, Ltd. | Novel heterocyclic compounds and salts thereof and medicinal use of the same |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| MXPA03000252A (es) | 2000-08-09 | 2003-06-06 | Astrazeneca Ab | Derivados de quinolina que tienen actividad de inhibicion de fcev. |
| CA2478050A1 (en) | 2002-03-01 | 2003-09-12 | Pfizer Inc. | Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents |
| UA82577C2 (en) * | 2003-12-23 | 2008-04-25 | Пфайзер Инк. | Quinoline derivatives |
| US8091987B2 (en) | 2005-07-07 | 2012-01-10 | Xaar Plc | Ink jet print head with improved reliability |
| KR20080027923A (ko) | 2005-08-08 | 2008-03-28 | 화이자 인코포레이티드 | Ｖｅｇｆ-ｒ 억제제의 염 및 다형체 |
-
2006
- 2006-07-27 KR KR1020087002993A patent/KR20080027923A/ko not_active Ceased
- 2006-07-27 EP EP06779948A patent/EP1915368A1/en not_active Withdrawn
- 2006-07-27 CA CA002615760A patent/CA2615760A1/en not_active Abandoned
- 2006-07-27 BR BRPI0614115-3A patent/BRPI0614115A2/pt not_active IP Right Cessation
- 2006-07-27 US US12/063,076 patent/US7928226B2/en not_active Expired - Fee Related
- 2006-07-27 AU AU2006277742A patent/AU2006277742B2/en not_active Ceased
- 2006-07-27 RU RU2008104776/04A patent/RU2369607C1/ru not_active IP Right Cessation
- 2006-07-27 WO PCT/IB2006/002171 patent/WO2007017740A1/en not_active Ceased
- 2006-07-27 MX MX2008001838A patent/MX2008001838A/es active IP Right Grant
- 2006-08-07 TW TW095128889A patent/TW200738689A/zh unknown
- 2006-08-07 JP JP2006214277A patent/JP4536688B2/ja not_active Expired - Fee Related
- 2006-08-07 AR ARP060103431A patent/AR055600A1/es unknown
-
2008
- 2008-01-17 IL IL188851A patent/IL188851A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090048254A1 (en) | 2009-02-19 |
| RU2008104776A (ru) | 2009-08-20 |
| AU2006277742A1 (en) | 2007-02-15 |
| BRPI0614115A2 (pt) | 2011-03-09 |
| US7928226B2 (en) | 2011-04-19 |
| AU2006277742B2 (en) | 2010-08-26 |
| AR055600A1 (es) | 2007-08-29 |
| JP4536688B2 (ja) | 2010-09-01 |
| EP1915368A1 (en) | 2008-04-30 |
| CA2615760A1 (en) | 2007-02-15 |
| IL188851A0 (en) | 2008-04-13 |
| RU2369607C1 (ru) | 2009-10-10 |
| MX2008001838A (es) | 2008-04-09 |
| JP2007045822A (ja) | 2007-02-22 |
| WO2007017740A1 (en) | 2007-02-15 |
| KR20080027923A (ko) | 2008-03-28 |
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