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CY1110209T1 - Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα - Google Patents

Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα

Info

Publication number
CY1110209T1
CY1110209T1 CY20101100664T CY101100664T CY1110209T1 CY 1110209 T1 CY1110209 T1 CY 1110209T1 CY 20101100664 T CY20101100664 T CY 20101100664T CY 101100664 T CY101100664 T CY 101100664T CY 1110209 T1 CY1110209 T1 CY 1110209T1
Authority
CY
Cyprus
Prior art keywords
isoxazol
analgesics
amine compounds
substituted benzo
compounds
Prior art date
Application number
CY20101100664T
Other languages
English (en)
Inventor
Beatrix Merla
Robert Frank
Gregor Bahrenberg
Wolfgang Schröder
Saskia Zemolka
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1110209T1 publication Critical patent/CY1110209T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Βρέθηκε, ότι υποκατεστημένες ενώσεις βενζο[d]ισοξαζολ-3-υλ-αμίνης του γενικού τύπου (I) είναι κατάλληλες για τη θεραπεία πόνων και παρουσιάζουν επίσης μία εξαιρετική χημική συγγένεια προς τον δίαυλο KCNQ2/3 Κ+ και για το λόγο αυτό για τη θεραπεία διαταραχών ή ασθενειών, οι οποίες διαμεσολαβούνται μερικώς με διαύλους KCNQ2/3 Κ+.
CY20101100664T 2005-05-18 2010-07-15 Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα CY1110209T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005023589 2005-05-18
DE102005038947A DE102005038947A1 (de) 2005-05-18 2005-08-16 Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
EP06753695A EP1881967B1 (de) 2005-05-18 2006-05-18 Substituierte benzo (d) isoaxol-3-yl-amin-verbindungen als analgetika

Publications (1)

Publication Number Publication Date
CY1110209T1 true CY1110209T1 (el) 2015-01-14

Family

ID=36699120

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091101144T CY1109568T1 (el) 2005-05-18 2009-11-05 Ενωσεις βενζο(d)ισοξαζολ-3-υλαμινης και η χρησιμοποιηση τους σαν προσδεματα υποδοχεα βανιλλοειδων
CY20101100664T CY1110209T1 (el) 2005-05-18 2010-07-15 Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα

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CY20091101144T CY1109568T1 (el) 2005-05-18 2009-11-05 Ενωσεις βενζο(d)ισοξαζολ-3-υλαμινης και η χρησιμοποιηση τους σαν προσδεματα υποδοχεα βανιλλοειδων

Country Status (15)

Country Link
US (2) US7977360B2 (el)
EP (2) EP1881967B1 (el)
JP (2) JP2008540598A (el)
AT (2) ATE438633T1 (el)
AU (1) AU2006249065B2 (el)
CA (2) CA2608386A1 (el)
CY (2) CY1109568T1 (el)
DE (3) DE102005038947A1 (el)
DK (2) DK1888541T3 (el)
ES (2) ES2331259T3 (el)
PL (2) PL1881967T3 (el)
PT (2) PT1888541E (el)
RU (1) RU2416607C2 (el)
SI (2) SI1881967T1 (el)
WO (2) WO2006122800A1 (el)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
US20100080773A1 (en) 2008-09-26 2010-04-01 Sdg, Inc. Orally Bioavailable Lipid-Based Constructs
US8557872B2 (en) 2008-01-28 2013-10-15 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
KR101621444B1 (ko) 2008-07-02 2016-05-19 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염, 및 이를 포함하는 약학 조성물
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
TWI504395B (zh) 2009-03-10 2015-10-21 Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
MX2011008825A (es) 2009-03-10 2011-09-21 Gruenenthal Gmbh 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3.
TWI461197B (zh) 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
TW201038565A (en) 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
CA2789434A1 (en) 2010-02-11 2011-08-18 Vanderbilt University Benzisoxazoles and azabenzisoxazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
SI2609086T1 (sl) 2010-08-27 2015-04-30 Gruenenthal Gmbh Substituirani 2-okso in 2-tiokso-dihidrokinolin-3-karboksamidi kot KCNQ2/3 modulatorji
TW201211007A (en) 2010-08-27 2012-03-16 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
BR112013004562A2 (pt) 2010-08-27 2016-09-06 Gruenenthal Gmbh 2-óxi-quinolina-3-carboxamidas substituídas como moduladores kcnq2/3
MX2013002295A (es) 2010-09-01 2013-05-09 Gruenenthal Gmbh 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
RU2014121983A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Биарильные простоэфирные сульфонамиды и их применение в качестве терапевтических средств
US9630929B2 (en) 2011-10-31 2017-04-25 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
US8952169B2 (en) 2012-05-22 2015-02-10 Xenon Pharmaceuticals Inc. N-substituted benzamides and methods of use thereof
CN104797555B (zh) 2012-07-06 2017-12-22 基因泰克公司 N‑取代的苯甲酰胺及其使用方法
HK1213476A1 (zh) 2013-03-14 2016-07-08 基因泰克公司 取代的三唑並吡啶及其使用方法
CA2898680A1 (en) 2013-03-15 2014-09-18 Genentech,Inc. Substituted benzoxazoles and methods of use thereof
CA2931732A1 (en) 2013-11-27 2015-06-04 Genentech, Inc. Substituted benzamides and methods of use thereof
NZ720807A (en) * 2013-12-20 2017-02-24 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
WO2016007534A1 (en) 2014-07-07 2016-01-14 Genentech, Inc. Therapeutic compounds and methods of use thereof
KR20170034439A (ko) 2014-08-13 2017-03-28 오클랜드 유니서비시즈 리미티드 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도
WO2016100184A1 (en) 2014-12-16 2016-06-23 Forum Pharmaceuticals, Inc. Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
EP3233840B1 (en) 2014-12-16 2018-11-21 Eudendron S.r.l. Heterocyclic derivatives modulating activity of certain protein kinases
PE20180575A1 (es) 2015-05-22 2018-04-04 Genentech Inc Benzamidas sustituidas y metodos para utilizarlas
WO2016201096A1 (en) 2015-06-10 2016-12-15 Forum Pharmaceuticals, Inc. Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors
WO2017027600A1 (en) * 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
CN108349997B (zh) * 2015-08-27 2025-06-10 奥克兰联合服务有限公司 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途
MA42683A (fr) 2015-08-27 2018-07-04 Genentech Inc Composés thérapeutiques et leurs méthodes utilisation
BR112018006189A2 (pt) 2015-09-28 2018-10-09 Genentech Inc compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto
JP2018535234A (ja) 2015-11-25 2018-11-29 ジェネンテック， インコーポレイテッド ナトリウムチャネル遮断薬として有用な置換ベンズアミド
CN109071426A (zh) 2016-03-30 2018-12-21 基因泰克公司 取代的苯甲酰胺及其使用方法
WO2018072602A1 (en) 2016-10-17 2018-04-26 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
EP3759098A1 (en) 2018-02-26 2021-01-06 Genentech, Inc. Pyridine-sulfonamide compounds and their use against pain and related conditions
US10947251B2 (en) 2018-03-30 2021-03-16 Genentech, Inc. Therapeutic compounds and methods of use thereof
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
GB201810581D0 (en) 2018-06-28 2018-08-15 Ctxt Pty Ltd Compounds
PL4299135T3 (pl) 2019-06-18 2025-11-12 Pfizer Inc. Pochodne benzizoksazolosulfonamidu
JP7788377B2 (ja) 2019-12-04 2025-12-18 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物的に活性な縮合二環式芳香族複素環式アミノ化合物
EP4085051A1 (en) * 2019-12-31 2022-11-09 IFM Due, Inc. Compounds and compositions for treating conditions associated with sting activity
WO2021151926A1 (en) 2020-01-30 2021-08-05 Syngenta Crop Protection Ag Pesticidally active fused bicyclic heteroaromatic amino compounds
CN112142683B (zh) * 2020-09-01 2022-05-24 成都大学 一种氮杂十一元环化合物及其制备方法、用途以及包含该化合物的药物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2076253T3 (es) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
ES2188584T3 (es) * 1991-03-28 2003-07-01 Eisai Co Ltd Derivados heterociclicos de amina.
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
NZ258747A (en) * 1992-11-23 1997-02-24 Hoechst Marion Roussel Inc Sub 3-heterocyclyalkylamino benzisoxazole derivatives; medicaments
WO1996039405A1 (en) * 1995-06-06 1996-12-12 Hoechst Marion Roussel, Inc. Pyridiniminyl-1,2-benzisoxazoles and- benzisothiazoles as antipsychotic agents
ID28451A (id) * 1998-10-06 2001-05-24 Janssen Pharmaceutica Nv Trisiklik piperidin-δ3 sebagai bahan farmasi
WO2000027199A1 (en) * 1998-11-12 2000-05-18 Eli Lilly And Company Aminobenzisoxazole compounds and libraries thereof
WO2000027627A1 (en) * 1998-11-12 2000-05-18 Eli Lilly And Company Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
DE60011430T2 (de) * 1999-07-16 2005-07-07 Bristol-Myers Squibb Pharma Co. Stickstoff enthaltende heterobicyclen als factor xa inhibitoren
WO2001087845A2 (en) * 2000-05-15 2001-11-22 Fujisawa Pharmaceutical Co., Ltd. N-containing heterocyclic compounds and their use as 5-ht antagonists
US6855829B2 (en) 2001-02-20 2005-02-15 Bristol-Myers Squibb Company 3-fluoro-2-oxindole modulators of KCNQ potassium channels and use thereof in treating migraine and mechanistically related disease
US6469042B1 (en) * 2001-02-20 2002-10-22 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators if KCNQ potassium channels
HUP0303841A2 (hu) * 2001-02-20 2004-03-01 Bristol-Myers Squibb Company 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk
US6593349B2 (en) * 2001-03-19 2003-07-15 Icagen, Inc. Bisarylamines as potassium channel openers
KR100789567B1 (ko) * 2001-11-06 2007-12-28 동화약품공업주식회사 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도
DE10229070A1 (de) * 2002-06-28 2004-01-15 Merck Patent Gmbh Phenylderivate 5
GB0217757D0 (en) * 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
EP1638941B1 (en) * 2003-05-22 2010-06-02 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
GB0319150D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
JP2007529468A (ja) * 2004-03-16 2007-10-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンズイソオキサゾール
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US7989461B2 (en) * 2005-12-23 2011-08-02 Amgen Inc. Substituted quinazolinamine compounds for the treatment of cancer

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EP1888541A1 (de) 2008-02-20
AU2006249065B2 (en) 2011-04-21
DE502006006854D1 (de) 2010-06-10
PT1888541E (pt) 2009-11-10
DK1881967T3 (da) 2010-08-16
DE502006004453D1 (de) 2009-09-17
PT1881967E (pt) 2010-06-30
PL1888541T3 (pl) 2010-01-29
US7696238B2 (en) 2010-04-13
SI1888541T1 (sl) 2010-01-29
ES2331259T3 (es) 2009-12-28
ES2344272T3 (es) 2010-08-23
US20090042945A1 (en) 2009-02-12
EP1881967B1 (de) 2010-04-28
JP2008540598A (ja) 2008-11-20
ATE466002T1 (de) 2010-05-15
CA2608386A1 (en) 2006-11-23
RU2416607C2 (ru) 2011-04-20
AU2006249065A1 (en) 2006-11-23
DE102005038947A1 (de) 2006-11-30
EP1888541B1 (de) 2009-08-05
DK1888541T3 (da) 2009-12-07
EP1881967A1 (de) 2008-01-30
HK1112238A1 (zh) 2008-08-29
ATE438633T1 (de) 2009-08-15
WO2006122799A1 (de) 2006-11-23
PL1881967T3 (pl) 2010-10-29
CA2608773A1 (en) 2006-11-23
SI1881967T1 (sl) 2010-08-31
RU2007146385A (ru) 2009-10-27
US20080176915A1 (en) 2008-07-24
JP2008540597A (ja) 2008-11-20
US7977360B2 (en) 2011-07-12
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