TW200736397A - Method of protein production using anti-senescence compounds - Google Patents
Method of protein production using anti-senescence compoundsInfo
- Publication number
- TW200736397A TW200736397A TW095139179A TW95139179A TW200736397A TW 200736397 A TW200736397 A TW 200736397A TW 095139179 A TW095139179 A TW 095139179A TW 95139179 A TW95139179 A TW 95139179A TW 200736397 A TW200736397 A TW 200736397A
- Authority
- TW
- Taiwan
- Prior art keywords
- cell culture
- protein production
- senescence
- senescence compound
- culture medium
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000014616 translation Effects 0.000 title 1
- 238000004113 cell culture Methods 0.000 abstract 2
- 239000006143 cell culture medium Substances 0.000 abstract 2
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 abstract 1
- 108010087806 Carnosine Proteins 0.000 abstract 1
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 abstract 1
- 229940044199 carnosine Drugs 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000035899 viability Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72957305P | 2005-10-24 | 2005-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200736397A true TW200736397A (en) | 2007-10-01 |
Family
ID=37873105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095139179A TW200736397A (en) | 2005-10-24 | 2006-10-24 | Method of protein production using anti-senescence compounds |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20070110743A1 (zh) |
| EP (1) | EP1941026B1 (zh) |
| JP (2) | JP2009512459A (zh) |
| KR (1) | KR101402634B1 (zh) |
| CN (1) | CN101297027B (zh) |
| AR (1) | AR058140A1 (zh) |
| AU (1) | AU2006306433B2 (zh) |
| BR (1) | BRPI0617744A2 (zh) |
| CA (1) | CA2627003C (zh) |
| CR (1) | CR9897A (zh) |
| DK (1) | DK1941026T3 (zh) |
| EC (1) | ECSP088395A (zh) |
| ES (1) | ES2485374T3 (zh) |
| IL (1) | IL190550A (zh) |
| NI (1) | NI200800111A (zh) |
| NO (1) | NO20081622L (zh) |
| PE (1) | PE20070796A1 (zh) |
| PL (1) | PL1941026T3 (zh) |
| PT (1) | PT1941026E (zh) |
| RU (1) | RU2491347C2 (zh) |
| SI (1) | SI1941026T1 (zh) |
| TW (1) | TW200736397A (zh) |
| WO (1) | WO2007050498A2 (zh) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2041270T3 (pl) | 2006-07-13 | 2014-04-30 | Wyeth Llc | Wytwarzanie glikoprotein |
| EP2500413A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| US8895709B2 (en) | 2008-10-20 | 2014-11-25 | Abbvie Inc. | Isolation and purification of antibodies using protein A affinity chromatography |
| US8859235B2 (en) | 2009-08-14 | 2014-10-14 | Basf Se | Methods in cell cultures, and related inventions, employing certain additives |
| EP2601287B1 (en) | 2010-08-05 | 2015-01-07 | Amgen Inc. | Dipeptides to enhance yield and viability from cell cultures |
| EP2611904A2 (en) * | 2010-08-31 | 2013-07-10 | Friesland Brands B.V. | Culture medium for eukaryotic cells |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| TW201247874A (en) * | 2011-05-25 | 2012-12-01 | United Biomedical Inc | Method for producing the activity of bone activating protein |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| SG11201504249XA (en) | 2012-09-02 | 2015-07-30 | Abbvie Inc | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| MX360649B (es) * | 2013-03-13 | 2018-11-12 | Anteis Sa | Péptidos para el rejuvenecimiento de la piel y métodos de uso de los mismos. |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| EP2970875B2 (en) | 2013-03-15 | 2025-11-26 | F. Hoffmann-La Roche AG | Cell culture compositions with antioxidants and methods for polypeptide production |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| MX374124B (es) | 2013-10-16 | 2025-03-05 | Outlook Therapeutics Inc | Formulaciones de tampón para la estabilidad de anticuerpo mejorada. |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN104398398A (zh) * | 2014-10-27 | 2015-03-11 | 陈少威 | 一种细胞量子动力素(平衡剂)及其使用方法 |
| MA40864A (fr) * | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères |
| EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| WO2017083224A1 (en) | 2015-11-09 | 2017-05-18 | Bristol-Myers Squibb Company | Methods to manipulate quality attributes of polypeptides produced in cho cells |
| CN109153717A (zh) * | 2016-01-06 | 2019-01-04 | 安口生物公司 | 减少单克隆抗体组合物中的高分子量物类、酸性电荷物类和片段 |
| WO2017136433A1 (en) | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| BR112020003122A2 (pt) * | 2017-10-16 | 2020-08-04 | Regeneron Pharmaceuticals, Inc. | métodos e sistemas para controlar condições de meio de cultura celular e para reduzir modificações pós-translação de uma proteína secretada |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| WO2025053166A1 (ja) * | 2023-09-05 | 2025-03-13 | 味の素株式会社 | 培地組成物 |
| WO2025142807A1 (ja) * | 2023-12-25 | 2025-07-03 | 武田薬品工業株式会社 | 細胞の培養方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE194384T1 (de) * | 1989-09-12 | 2000-07-15 | Hoffmann La Roche | Tnf-bindende proteine |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DE69132032T2 (de) * | 1990-11-23 | 2000-12-21 | Peptech Ltd., North Ryde | Verzögerung, verhinderung und/oder rückgängigmachen von zellalterung |
| JP4124480B2 (ja) * | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| RU2245365C2 (ru) * | 1994-01-03 | 2005-01-27 | Генентек Инк. | Тромбопоэтин |
| US5830761A (en) * | 1995-06-07 | 1998-11-03 | Genetics Institute, Inc. | Medium and methods for culturing mammalian cho cells |
| RU2134120C1 (ru) * | 1995-06-26 | 1999-08-10 | Безруков Михаил Васильевич | Средство для стабилизации пептидной связи в белковом препарате |
| DK1143006T3 (da) * | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| JP4306813B2 (ja) * | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
| US6146847A (en) * | 1996-11-01 | 2000-11-14 | Genespan Corporation | Stabilized transient gene expression |
| WO1998024893A2 (en) * | 1996-12-03 | 1998-06-11 | Abgenix, Inc. | TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM |
| US20030040095A1 (en) * | 2001-03-16 | 2003-02-27 | Achille Arini | Method for the production of pharmaceutically active recombinant proteins |
| RU2274643C2 (ru) * | 2001-04-24 | 2006-04-20 | Иннодженетикс Н.В. | Выделенный оболочечный белок hcv, способ его получения и лекарство, вакцина, фармацевтическая композиция (варианты) его содержащие |
| KR20050088136A (ko) * | 2002-12-23 | 2005-09-01 | 브리스톨-마이어스 스큅 컴퍼니 | 단백질 생산을 위한 포유류 세포 배양 방법 |
| MXPA06004472A (es) * | 2003-10-27 | 2006-06-20 | Wyeth Corp | Eliminacion de agregados de atopeso molecular utilizando cromatografia de hidroxiapatita. |
| WO2005064013A1 (en) * | 2003-12-23 | 2005-07-14 | Bart Janssen | The use of carnosine metabolism-associated genes to determine genetic predisposition/susceptibility to diabetic nephropathy |
| US7335491B2 (en) * | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| US7294484B2 (en) * | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| US7426440B2 (en) * | 2004-09-24 | 2008-09-16 | Nutritional Bioscience Ltd. | Repair and protection factor scoring method for bioactive agents |
-
2006
- 2006-10-23 AR ARP060104624A patent/AR058140A1/es unknown
- 2006-10-23 PE PE2006001284A patent/PE20070796A1/es not_active Application Discontinuation
- 2006-10-24 KR KR1020087009856A patent/KR101402634B1/ko not_active Expired - Fee Related
- 2006-10-24 PT PT68442110T patent/PT1941026E/pt unknown
- 2006-10-24 TW TW095139179A patent/TW200736397A/zh unknown
- 2006-10-24 ES ES06844211.0T patent/ES2485374T3/es active Active
- 2006-10-24 DK DK06844211.0T patent/DK1941026T3/da active
- 2006-10-24 EP EP06844211.0A patent/EP1941026B1/en active Active
- 2006-10-24 JP JP2008537834A patent/JP2009512459A/ja not_active Withdrawn
- 2006-10-24 WO PCT/US2006/041256 patent/WO2007050498A2/en not_active Ceased
- 2006-10-24 RU RU2008113220/10A patent/RU2491347C2/ru active
- 2006-10-24 PL PL06844211T patent/PL1941026T3/pl unknown
- 2006-10-24 US US11/585,607 patent/US20070110743A1/en not_active Abandoned
- 2006-10-24 BR BRPI0617744-1A patent/BRPI0617744A2/pt not_active Application Discontinuation
- 2006-10-24 AU AU2006306433A patent/AU2006306433B2/en not_active Ceased
- 2006-10-24 CN CN2006800396267A patent/CN101297027B/zh not_active Expired - Fee Related
- 2006-10-24 CA CA2627003A patent/CA2627003C/en active Active
- 2006-10-24 SI SI200631796T patent/SI1941026T1/sl unknown
-
2008
- 2008-04-01 IL IL190550A patent/IL190550A/en active IP Right Grant
- 2008-04-02 NO NO20081622A patent/NO20081622L/no not_active Application Discontinuation
- 2008-04-09 NI NI200800111A patent/NI200800111A/es unknown
- 2008-04-18 CR CR9897A patent/CR9897A/es not_active Application Discontinuation
- 2008-04-23 EC EC2008008395A patent/ECSP088395A/es unknown
-
2013
- 2013-04-26 JP JP2013094315A patent/JP5907928B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CR9897A (es) | 2008-07-29 |
| BRPI0617744A2 (pt) | 2011-08-02 |
| AU2006306433A1 (en) | 2007-05-03 |
| DK1941026T3 (da) | 2014-07-21 |
| JP2009512459A (ja) | 2009-03-26 |
| AR058140A1 (es) | 2008-01-23 |
| JP5907928B2 (ja) | 2016-04-26 |
| NO20081622L (no) | 2008-06-18 |
| IL190550A (en) | 2017-01-31 |
| IL190550A0 (en) | 2008-11-03 |
| EP1941026B1 (en) | 2014-06-04 |
| CN101297027A (zh) | 2008-10-29 |
| PE20070796A1 (es) | 2007-08-15 |
| PL1941026T3 (pl) | 2014-12-31 |
| CN101297027B (zh) | 2013-04-03 |
| AU2006306433B2 (en) | 2013-04-18 |
| US20070110743A1 (en) | 2007-05-17 |
| KR20080063365A (ko) | 2008-07-03 |
| HK1120552A1 (zh) | 2009-04-03 |
| ES2485374T3 (es) | 2014-08-13 |
| CA2627003A1 (en) | 2007-05-03 |
| EP1941026A2 (en) | 2008-07-09 |
| RU2491347C2 (ru) | 2013-08-27 |
| RU2008113220A (ru) | 2009-12-10 |
| KR101402634B1 (ko) | 2014-06-03 |
| SI1941026T1 (sl) | 2014-07-31 |
| ECSP088395A (es) | 2008-05-30 |
| NI200800111A (es) | 2009-03-03 |
| JP2013165728A (ja) | 2013-08-29 |
| PT1941026E (pt) | 2014-07-31 |
| WO2007050498A2 (en) | 2007-05-03 |
| WO2007050498A3 (en) | 2007-07-12 |
| CA2627003C (en) | 2018-08-28 |
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