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TW200639161A - Process for the purification of duloxetine hydrochloride - Google Patents

Process for the purification of duloxetine hydrochloride

Info

Publication number
TW200639161A
TW200639161A TW095108592A TW95108592A TW200639161A TW 200639161 A TW200639161 A TW 200639161A TW 095108592 A TW095108592 A TW 095108592A TW 95108592 A TW95108592 A TW 95108592A TW 200639161 A TW200639161 A TW 200639161A
Authority
TW
Taiwan
Prior art keywords
purification
duloxetine hydrochloride
duloxetine
hydrochloride
duloxetine hcl
Prior art date
Application number
TW095108592A
Other languages
English (en)
Inventor
Santiago Ini
Mili Abramov
Anita Liberman
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of TW200639161A publication Critical patent/TW200639161A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
TW095108592A 2005-03-14 2006-03-14 Process for the purification of duloxetine hydrochloride TW200639161A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66171105P 2005-03-14 2005-03-14
US72650205P 2005-10-12 2005-10-12
US73674605P 2005-11-14 2005-11-14
US77359306P 2006-02-14 2006-02-14

Publications (1)

Publication Number Publication Date
TW200639161A true TW200639161A (en) 2006-11-16

Family

ID=36593962

Family Applications (2)

Application Number Title Priority Date Filing Date
TW095108592A TW200639161A (en) 2005-03-14 2006-03-14 Process for the purification of duloxetine hydrochloride
TW095108594A TW200639162A (en) 2005-03-14 2006-03-14 Pure duloxetine hydrochloride

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW095108594A TW200639162A (en) 2005-03-14 2006-03-14 Pure duloxetine hydrochloride

Country Status (7)

Country Link
US (4) US20060270731A1 (zh)
EP (4) EP1858874A1 (zh)
CA (2) CA2599478A1 (zh)
IL (3) IL184184A0 (zh)
MX (2) MX2007011255A (zh)
TW (2) TW200639161A (zh)
WO (4) WO2006099459A1 (zh)

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US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
WO2006096809A1 (en) * 2005-03-08 2006-09-14 Teva Pharmaceutical Industries Ltd. Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
CA2599478A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the purification of duloxetine hydrochloride
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
US7842717B2 (en) 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
EP1863782A1 (en) 2005-12-05 2007-12-12 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphtol) thiophene, an imputity of duloxetine hydrochloride
ATE507215T1 (de) 2005-12-12 2011-05-15 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
CZ299270B6 (cs) * 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
WO2007077580A2 (en) 2006-01-06 2007-07-12 Msn Laboratories Limited Improved process for pure duloxetine hydrochloride
WO2007139984A2 (en) * 2006-05-23 2007-12-06 Teva Pharmaceutical Industries Ltd. Duloxetine hcl polymorphs
TW200813002A (en) * 2006-05-31 2008-03-16 Teva Pharma Process for preparing duloxetine and intermediates thereof
GB0612509D0 (en) 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
GB0612508D0 (en) 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
CZ300116B6 (cs) * 2006-12-05 2009-02-11 Zentiva, A. S. Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
US8269023B2 (en) * 2007-03-05 2012-09-18 Lupin Ltd. Process for preparation of duloxetine hydrochloride
WO2009109992A1 (en) * 2008-01-23 2009-09-11 Arch Pharmalabs Limited Novel process for preparation of duloxetine and intermediates for use therein
US8278463B2 (en) * 2008-04-04 2012-10-02 Ranbaxy Laboratories Limited Process for the preparation of pure duloxetine hydrochloride
EP2303244A2 (en) * 2008-06-13 2011-04-06 KRKA, D.D., Novo Mesto Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives
WO2010011811A2 (en) * 2008-07-24 2010-01-28 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds
CZ304602B6 (cs) * 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
WO2011148380A1 (en) * 2010-05-25 2011-12-01 Hetero Research Foundation Oral pharmaceutical composition of duloxetine
CN103626735A (zh) * 2012-08-28 2014-03-12 石药集团中奇制药技术（石家庄）有限公司 一种盐酸度洛西汀晶型及其制备方法
CN104478849A (zh) * 2014-02-14 2015-04-01 广东东阳光药业有限公司 制备去甲肾上腺素再摄取双重抑制剂的方法
JP2016172704A (ja) * 2015-03-17 2016-09-29 株式会社トクヤマ デュロキセチン塩酸塩の製造方法、及び新規な結晶構造のデュロキセチン塩酸塩
JP2016222628A (ja) * 2015-06-03 2016-12-28 株式会社トクヤマ デュロキセチン塩酸塩の製造方法

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US3105564A (en) * 1960-10-13 1963-10-01 Alfred N Ormond Apparatus for measuring static loads
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GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
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AU2003263585A1 (en) 2003-08-25 2005-03-10 Hetero Drugs Limited Amorphous duloxetine hydrochloride
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CZ297560B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
US20060270859A1 (en) 2005-01-27 2006-11-30 Santiago Ini Duloxetine HCl polymorphs
AT501846B1 (de) 2005-02-16 2007-08-15 Fronius Int Gmbh Einrichtung und verfahren zur durchführung von software-updates in wechselrichtern und für software-updates ausgelegter wechselrichter
CA2599478A1 (en) 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the purification of duloxetine hydrochloride
WO2006126213A1 (en) 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine
ATE507215T1 (de) 2005-12-12 2011-05-15 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
WO2007077580A2 (en) 2006-01-06 2007-07-12 Msn Laboratories Limited Improved process for pure duloxetine hydrochloride
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine

Also Published As

Publication number Publication date
WO2006099433A1 (en) 2006-09-21
US20060270861A1 (en) 2006-11-30
EP1874754A1 (en) 2008-01-09
EP1858859A1 (en) 2007-11-28
WO2006099457A1 (en) 2006-09-21
MX2007011255A (es) 2007-10-18
WO2006099468A3 (en) 2007-04-05
IL184189A0 (en) 2007-10-31
MX2007011254A (es) 2007-10-18
EP1858874A1 (en) 2007-11-28
IL184184A0 (en) 2007-10-31
CA2599475A1 (en) 2006-09-21
WO2006099459A1 (en) 2006-09-21
US20060276660A1 (en) 2006-12-07
US20060270731A1 (en) 2006-11-30
WO2006099468A2 (en) 2006-09-21
EP1858873A2 (en) 2007-11-28
US20060258871A1 (en) 2006-11-16
CA2599478A1 (en) 2006-09-21
TW200639162A (en) 2006-11-16
US7534900B2 (en) 2009-05-19
IL184185A0 (en) 2007-10-31

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