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TW200613303A - 2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity - Google Patents

2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity

Info

Publication number
TW200613303A
TW200613303A TW094130504A TW94130504A TW200613303A TW 200613303 A TW200613303 A TW 200613303A TW 094130504 A TW094130504 A TW 094130504A TW 94130504 A TW94130504 A TW 94130504A TW 200613303 A TW200613303 A TW 200613303A
Authority
TW
Taiwan
Prior art keywords
adenosine
purine derivatives
substituted
trifluoromethyl
antagonistic activity
Prior art date
Application number
TW094130504A
Other languages
Chinese (zh)
Inventor
Melle Koch
Jacobus A J Den Hartog
Gerrit-Jan Koomen
Martinus J Wanner
Roelof W Feenstra
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of TW200613303A publication Critical patent/TW200613303A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives The compounds have the general formula (1), wherein the symbols have the meanings given in the specification.
TW094130504A 2004-09-09 2005-09-06 2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity TW200613303A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04104344 2004-09-09

Publications (1)

Publication Number Publication Date
TW200613303A true TW200613303A (en) 2006-05-01

Family

ID=34929557

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094130504A TW200613303A (en) 2004-09-09 2005-09-06 2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity

Country Status (5)

Country Link
EP (1) EP1797092A1 (en)
AR (1) AR050630A1 (en)
CA (1) CA2579302A1 (en)
TW (1) TW200613303A (en)
WO (1) WO2006027365A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0602412D0 (en) * 2006-02-07 2006-03-15 Univ York Compounds
WO2010009190A1 (en) * 2008-07-16 2010-01-21 King Pharmaceuticals Research And Development, Inc. Methods of treating atherosclerosis
US8680098B2 (en) * 2010-03-05 2014-03-25 Janssen Pharmaceutica, Nv Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
US12415816B2 (en) 2018-11-07 2025-09-16 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
EP4146639A1 (en) 2020-05-06 2023-03-15 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4267574B1 (en) 2020-12-23 2025-04-23 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4430042A1 (en) 2021-11-09 2024-09-18 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
TW202325289A (en) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Forms and compositions of inhibitors of jak2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004217582A (en) * 2003-01-16 2004-08-05 Abbott Japan Co Ltd 9H-purine derivative
JP2006516641A (en) * 2003-02-03 2006-07-06 シーブイ・セラピューティクス・インコーポレイテッド Full and partial agonists of adenosine receptors

Also Published As

Publication number Publication date
WO2006027365A1 (en) 2006-03-16
CA2579302A1 (en) 2006-03-16
EP1797092A1 (en) 2007-06-20
AR050630A1 (en) 2006-11-08

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