TW200613303A - 2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity - Google Patents
2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activityInfo
- Publication number
- TW200613303A TW200613303A TW094130504A TW94130504A TW200613303A TW 200613303 A TW200613303 A TW 200613303A TW 094130504 A TW094130504 A TW 094130504A TW 94130504 A TW94130504 A TW 94130504A TW 200613303 A TW200613303 A TW 200613303A
- Authority
- TW
- Taiwan
- Prior art keywords
- adenosine
- purine derivatives
- substituted
- trifluoromethyl
- antagonistic activity
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 3
- -1 2-substituted-6-trifluoromethyl-purine Chemical class 0.000 title abstract 2
- 230000003042 antagnostic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940123786 Adenosine A3 receptor antagonist Drugs 0.000 abstract 1
- 239000002580 adenosine A3 receptor antagonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104344 | 2004-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200613303A true TW200613303A (en) | 2006-05-01 |
Family
ID=34929557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094130504A TW200613303A (en) | 2004-09-09 | 2005-09-06 | 2-substituted-6-trifluoromethyl-purine derivatives with adenosine- A3 antagonistic activity |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1797092A1 (zh) |
| AR (1) | AR050630A1 (zh) |
| CA (1) | CA2579302A1 (zh) |
| TW (1) | TW200613303A (zh) |
| WO (1) | WO2006027365A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0602412D0 (en) * | 2006-02-07 | 2006-03-15 | Univ York | Compounds |
| WO2010009190A1 (en) * | 2008-07-16 | 2010-01-21 | King Pharmaceuticals Research And Development, Inc. | Methods of treating atherosclerosis |
| US8680098B2 (en) * | 2010-03-05 | 2014-03-25 | Janssen Pharmaceutica, Nv | Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators |
| US12415816B2 (en) | 2018-11-07 | 2025-09-16 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP4146639A1 (en) | 2020-05-06 | 2023-03-15 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4430042A1 (en) | 2021-11-09 | 2024-09-18 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004217582A (ja) * | 2003-01-16 | 2004-08-05 | Abbott Japan Co Ltd | ９ｈ−プリン誘導体 |
| JP2006516641A (ja) * | 2003-02-03 | 2006-07-06 | シーブイ・セラピューティクス・インコーポレイテッド | アデノシン受容体の完全アゴニストおよび部分アゴニスト |
-
2005
- 2005-09-06 TW TW094130504A patent/TW200613303A/zh unknown
- 2005-09-06 AR ARP050103720A patent/AR050630A1/es not_active Application Discontinuation
- 2005-09-07 WO PCT/EP2005/054404 patent/WO2006027365A1/en not_active Ceased
- 2005-09-07 EP EP05779103A patent/EP1797092A1/en not_active Withdrawn
- 2005-09-07 CA CA002579302A patent/CA2579302A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006027365A1 (en) | 2006-03-16 |
| CA2579302A1 (en) | 2006-03-16 |
| EP1797092A1 (en) | 2007-06-20 |
| AR050630A1 (es) | 2006-11-08 |
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