TW200605897A - Powder comprising new compositions of oligosaccharides and methods for their preparation - Google Patents

Powder comprising new compositions of oligosaccharides and methods for their preparation

Info

Publication number: TW200605897A
Authority: TW; Taiwan
Prior art keywords: linked; saccharose; glu; oligosaccharides; powder
Prior art date: 2004-05-10

Application number

TW094114830A

Other languages

English (en)

Inventor

Stefan Bassarab

Karoline Bechtold-Peters

Richard Fuhrherr

Wolfgang Friess

Patrick Garidel

Torsten Schultz-Fademrecht

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-10

Filing date

2005-05-09

Publication date

2006-02-16

2005-05-09 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2006-02-16 Publication of TW200605897A publication Critical patent/TW200605897A/zh

Links

229920001542 oligosaccharide Polymers 0.000 title abstract 3
150000002482 oligosaccharides Chemical class 0.000 title abstract 3
239000000843 powder Substances 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 3
229960004793 sucrose Drugs 0.000 abstract 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical class O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 2
LERPTDWHHCFIMD-BVEVKQQOSA-N (2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;(2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal Chemical compound O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 LERPTDWHHCFIMD-BVEVKQQOSA-N 0.000 abstract 1
FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 abstract 1
FVVCFHXLWDDRHG-UHFFFAOYSA-N Nigellamose Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 FVVCFHXLWDDRHG-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
FVVCFHXLWDDRHG-KKNDGLDKSA-N erlose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-KKNDGLDKSA-N 0.000 abstract 1
JFISLVOULYSJEI-UHFFFAOYSA-N maltosyl sucrose Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 JFISLVOULYSJEI-UHFFFAOYSA-N 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW094114830A 2004-05-10 2005-05-09 Powder comprising new compositions of oligosaccharides and methods for their preparation TW200605897A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102004022928A DE102004022928A1 (de)	2004-05-10	2004-05-10	Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
TW200605897A true TW200605897A (en)	2006-02-16

Family

ID=35335878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094114830A TW200605897A (en)	2004-05-10	2005-05-09	Powder comprising new compositions of oligosaccharides and methods for their preparation

Country Status (10)

Country	Link
EP (1)	EP1789019B1 (zh)
JP (1)	JP2007536315A (zh)
KR (1)	KR20070043709A (zh)
AT (1)	ATE383850T1 (zh)
CA (1)	CA2564332A1 (zh)
DE (2)	DE102004022928A1 (zh)
DK (1)	DK1789019T3 (zh)
ES (1)	ES2299032T3 (zh)
TW (1)	TW200605897A (zh)
WO (1)	WO2005113007A2 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006030166A1 (de) *	2006-06-29	2008-01-10	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Tempern
DE102006053375A1 (de) *	2006-11-10	2008-05-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mischung von Pulvern
EP2077132A1 (en)	2008-01-02	2009-07-08	Boehringer Ingelheim Pharma GmbH & Co. KG	Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en)	2009-03-31	2018-07-03	Beohringer Ingelheim International Gmbh	Method for coating a surface of a component
US9265910B2 (en)	2009-05-18	2016-02-23	Boehringer Ingelheim International Gmbh	Adapter, inhalation device, and nebulizer
US10016568B2 (en)	2009-11-25	2018-07-10	Boehringer Ingelheim International Gmbh	Nebulizer
WO2011064163A1 (en)	2009-11-25	2011-06-03	Boehringer Ingelheim International Gmbh	Nebulizer
AP3141A (en)	2009-11-25	2015-02-28	Boehringer Ingelheim Int	Nebulizer
US9943654B2 (en)	2010-06-24	2018-04-17	Boehringer Ingelheim International Gmbh	Nebulizer
WO2012130757A1 (de)	2011-04-01	2012-10-04	Boehringer Ingelheim International Gmbh	Medizinisches gerät mit behälter
US9827384B2 (en)	2011-05-23	2017-11-28	Boehringer Ingelheim International Gmbh	Nebulizer
EP3511336B1 (en)	2011-06-28	2023-06-21	Leukocare Ag	Method for preventing the unfolding of a (poly)peptide and/or inducing the (re-)folding of a (poly)peptide
WO2013152894A1 (de)	2012-04-13	2013-10-17	Boehringer Ingelheim International Gmbh	Zerstäuber mit kodiermitteln
JP6643231B2 (ja)	2013-08-09	2020-02-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
EP2835146B1 (en)	2013-08-09	2020-09-30	Boehringer Ingelheim International GmbH	Nebulizer
CN106456913B (zh)	2014-05-07	2019-08-30	勃林格殷格翰国际有限公司	喷雾器和容器
DK3139979T3 (da)	2014-05-07	2023-10-09	Boehringer Ingelheim Int	Enhed, forstøver og fremgangsmåde
EP3139984B1 (en)	2014-05-07	2021-04-28	Boehringer Ingelheim International GmbH	Nebulizer
CA2965759C (en)	2014-10-31	2023-12-12	Glaxosmithkline Intellectual Property Development Limited	Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials
JP7170329B2 (ja)	2016-09-16	2022-11-14	ロイコケア・アクチェンゲゼルシャフト	処理中の生物医薬製品の安定化のための新規な方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4242863A1 (de) *	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
JPH0776527A (ja) *	1993-06-28	1995-03-20	Hayashibara Biochem Lab Inc	半固形製剤とその製造方法
PT745382E (pt) *	1994-01-31	2004-04-30	Yamanouchi Pharma Co Ltd	Forma moldada por compressao com solubilidade intra-oral e processo para a sua producao
US6051256A (en) *	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
US5955448A (en) *	1994-08-19	1999-09-21	Quadrant Holdings Cambridge Limited	Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US6258341B1 (en) *	1995-04-14	2001-07-10	Inhale Therapeutic Systems, Inc.	Stable glassy state powder formulations
US6299871B1 (en) *	1998-07-24	2001-10-09	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	Orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases
WO2002055101A2 (en) *	2000-12-21	2002-07-18	Inhale Therapeutic Syst	Storage stable powder compositions of interleukin-4 receptor
JP2005531611A (ja) *	2002-06-07	2005-10-20	ズートツッカーアクチェンゲゼルシャフトマンハイム／オクセンフルト	ガラクトシル・イソマルト、その製造方法及び使用

2004
- 2004-05-10 DE DE102004022928A patent/DE102004022928A1/de not_active Withdrawn
2005
- 2005-05-04 DE DE502005002596T patent/DE502005002596D1/de not_active Expired - Lifetime
- 2005-05-04 AT AT05745334T patent/ATE383850T1/de active
- 2005-05-04 EP EP05745334A patent/EP1789019B1/de not_active Expired - Lifetime
- 2005-05-04 ES ES05745334T patent/ES2299032T3/es not_active Expired - Lifetime
- 2005-05-04 WO PCT/EP2005/004808 patent/WO2005113007A2/de not_active Ceased
- 2005-05-04 JP JP2007512009A patent/JP2007536315A/ja active Pending
- 2005-05-04 KR KR1020067025985A patent/KR20070043709A/ko not_active Ceased
- 2005-05-04 DK DK05745334T patent/DK1789019T3/da active
- 2005-05-04 CA CA002564332A patent/CA2564332A1/en not_active Abandoned
- 2005-05-09 TW TW094114830A patent/TW200605897A/zh unknown

Also Published As

Publication number	Publication date
WO2005113007A3 (de)	2006-08-03
EP1789019A2 (de)	2007-05-30
DE502005002596D1 (de)	2008-03-06
WO2005113007A2 (de)	2005-12-01
KR20070043709A (ko)	2007-04-25
ATE383850T1 (de)	2008-02-15
CA2564332A1 (en)	2005-12-01
JP2007536315A (ja)	2007-12-13
EP1789019B1 (de)	2008-01-16
ES2299032T3 (es)	2008-05-16
DK1789019T3 (da)	2008-05-26
DE102004022928A1 (de)	2005-12-08

Publication	Publication Date	Title
TW200605897A (en)	2006-02-16	Powder comprising new compositions of oligosaccharides and methods for their preparation
TW200605917A (en)	2006-02-16	Spray-dried powder comprising at least one 1,4 o-linked saccharose-derivative and methods for their preparation
WO2001062737A3 (en)	2002-03-14	Amino pyrazole derivatives useful for the treatment of obesity and other disorders
BG104877A (en)	2001-06-29	N-substituted anminotetralins as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders
CA2339991A1 (en)	2000-02-24	Microemulsions as solid dosage forms for oral administration
SG147450A1 (en)	2008-11-28	Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
WO2002074247A3 (en)	2002-12-05	Pharmaceutical formulations for sustained release
EA200900264A1 (ru)	2009-08-28	Композиции флибансерина и способ их приготовления
WO2008027557A3 (en)	2008-10-30	Topiramate compositions and methods of enhancing its bioavailability
NZ527157A (en)	2005-04-29	Compositions for delivering bisphosphonates
HUP0303148A3 (en)	2009-08-28	4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, pharmaceutical compositions containing the compounds and processes for their preparation
IL116674A (en)	2003-05-29	Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
PL337794A1 (en)	2000-09-11	Pharmaceutic agent for oral administration containing an active substance and cyclodextrin
BG106251A (en)	2002-08-30	Levodopa (carbidopa) entacapone pharmaceutical preparation
CA2327973A1 (en)	2001-06-18	Storage system for powdered pharmaceuticals, and inhaler equipped with this system
ZA9810631B (en)	1999-05-24	Spheriods preparation process and pharmaceutical compositions
AP1776A (en)	2007-08-28	Reconstitutable parenteral composition containing a cox-2 inhibitor.
CA2360220A1 (en)	2000-08-17	Oxadiazole compounds and compositions for delivering active agents
MY151468A (en)	2014-05-30	Controlled release solid preparation
TW200605905A (en)	2006-02-16	1,4 o-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
BRPI0412364A (pt)	2006-09-05	composição farmacêutica sólida, compreendendo amisulpride
MY151470A (en)	2014-05-30	Controlled release solid preparation
BR0013106A (pt)	2002-07-23	Composição farmacêutica flutuante, comprimido, e processo de prepapação de um comprimido.
PL1853292T3 (pl)	2010-01-29	Kompozycja farmaceutyczna, zawierająca związki glutationu i betalainy, do prewencji i do zwalczania raka
YU72802A (sh)	2006-01-16	Farmaceutske smeše koje sadrže oligosaharide, novi oligosaharidi i njihovo dobijanje