TW200519102A - Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors - Google Patents

Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors

Info

Publication number: TW200519102A
Authority: TW; Taiwan
Prior art keywords: hydronopol; agonists; quinazolinone derivatives; receptors; benzimidazolone
Prior art date: 2003-10-03

Application number

TW093129412A

Other languages

English (en)

Inventor

Hartog Jacobus A J Den

Samuel David

Daniel Jasserand

Scharrenburg Gustaaf J M Van

Stuivenberg Herman H Van

Tinka Tuinstra

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-29

Publication date

2005-06-16

2004-09-29 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2005-06-16 Publication of TW200519102A publication Critical patent/TW200519102A/zh

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 3
108010020615 nociceptin receptor Proteins 0.000 title abstract 3
RCRVMCSPZAMFKV-UHFFFAOYSA-N 2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethanol Chemical group C1C2C(C)(C)C1CCC2CCO RCRVMCSPZAMFKV-UHFFFAOYSA-N 0.000 title abstract 2
239000000556 agonist Substances 0.000 title abstract 2
150000008641 benzimidazolones Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
102000048266 Nociceptin Human genes 0.000 abstract 1
108090000622 Nociceptin Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
MYONAGGJKCJOBT-UHFFFAOYSA-N benzimidazol-2-one Chemical compound C1=CC=CC2=NC(=O)N=C21 MYONAGGJKCJOBT-UHFFFAOYSA-N 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
PULGYDLMFSFVBL-SMFNREODSA-N nociceptin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)[C@@H](C)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 PULGYDLMFSFVBL-SMFNREODSA-N 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Dermatology (AREA)
Immunology (AREA)
Psychology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Virology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)

TW093129412A 2003-10-03 2004-09-29 Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors TW200519102A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03103671		2003-10-03

Publications (1)

Publication Number	Publication Date
TW200519102A true TW200519102A (en)	2005-06-16

Family

ID=34924113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW093129412A TW200519102A (en)	2003-10-03	2004-09-29	Hydronopol substituted benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors

Country Status (15)

Country	Link
US (1)	US7851630B2 (zh)
EP (1)	EP1670457A1 (zh)
JP (1)	JP2007507470A (zh)
CN (1)	CN1838951A (zh)
AR (1)	AR045843A1 (zh)
AU (1)	AU2004277346B2 (zh)
BR (1)	BRPI0414494A (zh)
CA (1)	CA2534833A1 (zh)
MX (1)	MXPA06002065A (zh)
RU (1)	RU2357964C2 (zh)
SA (1)	SA04250319B1 (zh)
TW (1)	TW200519102A (zh)
UA (1)	UA83870C2 (zh)
WO (1)	WO2005032547A1 (zh)
ZA (1)	ZA200603472B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2623722A1 (en) *	2005-09-30	2007-04-12	F. Hoffmann-La Roche Ag	Indane derivatives as mch receptor antagonists
DE102007009235A1 (de) *	2007-02-22	2008-09-18	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
TWI448289B (zh)	2007-08-31	2014-08-11	Purdue Pharma Lp	經取代之喹啉型哌啶化合物及其用途
CN102675226B (zh) *	2012-05-24	2014-04-23	西南大学	3-取代-1-甲基-2，4-喹唑啉二酮类化合物及其制备方法和应用
WO2014030743A1 (ja) *	2012-08-24	2014-02-27	武田薬品工業株式会社	複素環化合物
US9951038B2 (en)	2012-12-27	2018-04-24	Purdue Pharma L.P.	Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
CN103420944A (zh) *	2013-07-26	2013-12-04	江西农业大学	一种合成顺式氢化诺卜基甲酰胺类化合物的方法
GB201820165D0 (en) *	2018-12-11	2019-01-23	Ucb Biopharma Sprl	Therapeutic agents
CA3224323A1 (en) *	2021-07-14	2023-01-19	Jian Wang	Piperidine derivative, and pharmaceutical composition thereof, preparation method therefor, and use thereof
CN115124441B (zh) *	2022-06-30	2024-04-02	南京林业大学	一类诺卜酸酰肼类化合物的制备方法和产品及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2097031A1 (en)	1970-07-29	1972-03-03	Berri Balzac	2-aminoethoxyethyl-6,6-dimethyl nor pinane derivs - local anaesthetics spasmolytics and anticholinergics
IT1251144B (it) *	1991-07-30	1995-05-04	Boehringer Ingelheim Italia	Derivati del benzimidazolone
ATE276242T1 (de)	1997-05-30	2004-10-15	Banyu Pharma Co Ltd	2-oxoimidazol-derivate
JP3342478B2 (ja)	1998-01-19	2002-11-11	ファイザー製薬株式会社	Ｏｒｌ１−レセプターアゴニストとしての４−（２−ケト−１−ベンズイミダゾリニル）ピペリジン化合物
US6340681B1 (en) *	1999-07-16	2002-01-22	Pfizer Inc	2-benzimidazolylamine compounds as ORL-1-receptor agonists
JP2003524634A (ja)	1999-12-06	2003-08-19	ユーロ−セルティーク，エス．エイ．	ノシセプチン受容体親和性を有するベンズイミダゾール化合物
KR20040047877A (ko) *	2001-10-02	2004-06-05	아카디아 파마슈티칼스 인코포레이티드	무스카린 제제로서 벤즈이미다졸리디논 유도체
SA04250305B1 (ar) *	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
AR046756A1 (es) *	2003-12-12	2005-12-21	Solvay Pharm Gmbh	Derivados de hidronopol como agonistas de receptores orl-1 humanos.

2004
- 2004-09-28 AR ARP040103510A patent/AR045843A1/es not_active Application Discontinuation
- 2004-09-29 US US10/952,180 patent/US7851630B2/en not_active Expired - Fee Related
- 2004-09-29 TW TW093129412A patent/TW200519102A/zh unknown
- 2004-10-01 UA UAA200604720A patent/UA83870C2/ru unknown
- 2004-10-01 BR BRPI0414494-5A patent/BRPI0414494A/pt not_active IP Right Cessation
- 2004-10-01 JP JP2006530268A patent/JP2007507470A/ja not_active Withdrawn
- 2004-10-01 WO PCT/EP2004/052392 patent/WO2005032547A1/en not_active Ceased
- 2004-10-01 CN CNA2004800240298A patent/CN1838951A/zh active Pending
- 2004-10-01 CA CA002534833A patent/CA2534833A1/en not_active Abandoned
- 2004-10-01 MX MXPA06002065A patent/MXPA06002065A/es unknown
- 2004-10-01 AU AU2004277346A patent/AU2004277346B2/en not_active Ceased
- 2004-10-01 EP EP04791109A patent/EP1670457A1/en not_active Withdrawn
- 2004-10-01 RU RU2006110519/04A patent/RU2357964C2/ru active
- 2004-10-02 SA SA4250319A patent/SA04250319B1/ar unknown
2006
- 2006-05-02 ZA ZA200603472A patent/ZA200603472B/en unknown

Also Published As

Publication number	Publication date
EP1670457A1 (en)	2006-06-21
RU2357964C2 (ru)	2009-06-10
UA83870C2 (ru)	2008-08-26
MXPA06002065A (es)	2006-05-19
AU2004277346A1 (en)	2005-04-14
CN1838951A (zh)	2006-09-27
BRPI0414494A (pt)	2006-11-14
SA04250319B1 (ar)	2008-07-19
WO2005032547A1 (en)	2005-04-14
US7851630B2 (en)	2010-12-14
US20050075355A1 (en)	2005-04-07
AU2004277346B2 (en)	2009-02-19
ZA200603472B (en)	2007-09-26
CA2534833A1 (en)	2005-04-14
JP2007507470A (ja)	2007-03-29
RU2006110519A (ru)	2006-07-27
AR045843A1 (es)	2005-11-16

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