TW200300798A - Mutatant CYP2D6 genes - Google Patents

Mutatant CYP2D6 genes Download PDF

Info

Publication number: TW200300798A
Authority: TW; Taiwan
Prior art keywords: base; leu; ctg; val; ala
Prior art date: 2001-12-06

Application number

TW091135321A

Other languages

English (en)

Chinese (zh)

Inventor

Mitsue Taniyama

Kazuo Ogawa

Naoko Tsuchiya

Tomoko Hibino

Original Assignee

Tsumura & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-06

Filing date

2002-12-05

Publication date

2003-06-16

2002-12-05 Application filed by Tsumura & Co filed Critical Tsumura & Co

2003-06-16 Publication of TW200300798A publication Critical patent/TW200300798A/zh

Links

108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 title abstract description 46
108090000623 proteins and genes Proteins 0.000 claims abstract description 101
108020004707 nucleic acids Proteins 0.000 claims abstract description 39
102000039446 nucleic acids Human genes 0.000 claims abstract description 39
150000007523 nucleic acids Chemical class 0.000 claims abstract description 39
230000035772 mutation Effects 0.000 claims abstract description 32
238000006467 substitution reaction Methods 0.000 claims abstract description 14
239000002773 nucleotide Substances 0.000 claims abstract description 8
125000003729 nucleotide group Chemical group 0.000 claims abstract description 8
238000011049 filling Methods 0.000 claims description 67
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230000002079 cooperative effect Effects 0.000 claims description 38
238000000034 method Methods 0.000 claims description 35
239000000523 sample Substances 0.000 claims description 33
230000002503 metabolic effect Effects 0.000 claims description 22
239000003814 drug Substances 0.000 claims description 21
229940079593 drug Drugs 0.000 claims description 17
238000004458 analytical method Methods 0.000 claims description 16
102000004169 proteins and genes Human genes 0.000 claims description 14
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- C12N9/0004—Oxidoreductases (1.)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers

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TW091135321A 2001-12-06 2002-12-05 Mutatant CYP2D6 genes TW200300798A (en)

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JP (1)	JP2005176601A (fr)
AU (1)	AU2002354430A1 (fr)
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EP1781811B1 (fr) *	2004-06-30	2010-06-23	Luminex Molecular Diagnostics, Inc.	Procede permettant de detecter des mutations dans le gene codant le cytochrome p450-2d6

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CA2128399A1 (fr) *	1993-07-20	1995-01-21	Koji Hayashi	Methode pour l'evaluation de l'innocuite d'un compose chimmique au moyen d'une levure recombinante qui renferme le gene du cytochrome p450 humain
US7250252B2 (en) *	1999-12-30	2007-07-31	David Aaron Katz	Amplification based polymorphism detection

2001
- 2001-12-06 JP JP2001372548A patent/JP2005176601A/ja active Pending
2002
- 2002-12-05 WO PCT/JP2002/012748 patent/WO2003050282A1/fr not_active Ceased
- 2002-12-05 AU AU2002354430A patent/AU2002354430A1/en not_active Abandoned
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AU2002354430A1 (en)	2003-06-23
WO2003050282A1 (fr)	2003-06-19
JP2005176601A (ja)	2005-07-07

Publication	Publication Date	Title
US6525185B1 (en)	2003-02-25	Polymorphisms associated with hypertension
WO2001047944A2 (fr)	2001-07-05	Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation correspondants
KR101141543B1 (ko)	2012-05-03	Ａｌｄｈ4ａ1, ｐｉｎｋ1, ｄｄｏｓｔ, ｋｉｆ17, ｌｍｘ1ａ, ｓｒｇａｐ2, ａｓｂ3, ｐｓｍｅ4, ａｎｘａ4, ｇｍｃｌ1, 및 ｍａｐ2 유전자로부터 유래된 단일염기다형을 포함하는 폴리뉴클레오티드, 이를 포함하는 마이크로어레이 및 진단키트, 및 이를 이용한 분석방법
WO2001024681A2 (fr)	2001-04-12	Alterations dans les genes kvlqt1 et scn5a du syndrome du qt long et methodes de detection
JP2004537311A (ja)	2004-12-16	摂食障害に関連する遺伝子およびｓｎｐ
CA2351576A1 (fr)	2000-05-25	Acides nucleiques contenant des polymorphismes d'un seul nucleotide et utilisations de ces acides nucleiques
CA2344978A1 (fr)	2000-04-20	Genes, proteines et marqueurs bialleliques lies a une maladie du systeme nerveux central
US6242181B1 (en)	2001-06-05	Methods for diagnosing hypertension by detecting a mutation in the human G protein β3 subunit gene
KR101141185B1 (ko)	2012-07-12	치료의 제안된 효능 검출용 마커
TW200300798A (en)	2003-06-16	Mutatant CYP2D6 genes
WO2001048245A2 (fr)	2001-07-05	Acides nucleiques contenant des polymorphismes de nucleotides simples, et procedes d'utilisation correspondants
JP2007143504A (ja)	2007-06-14	高血圧の遺伝子マーカー
US20030232365A1 (en)	2003-12-18	BDNF polymorphisms and association with bipolar disorder
WO2021050608A1 (fr)	2021-03-18	Nouveaux marqueurs génétiques pour le syndrome de tachycardie orthostatique posturale (pots) et leurs méthodes d'utilisation pour le diagnostic et le traitement de celui-ci
US20040235041A1 (en)	2004-11-25	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US20030170679A1 (en)	2003-09-11	Single nucleotide polymorphisms in GH-1
JP4728949B2 (ja)	2011-07-20	心臓血管疾患の危険を評価するためのｐａｒ１多型の解析および使用
CA2294572A1 (fr)	2000-07-27	Compositions genetiques et methodes connexes
US20040235026A1 (en)	2004-11-25	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
KR20110109612A (ko)	2011-10-06	트라마돌 구토 부작용 예후 유전표지 조합
AU2151600A (en)	2000-06-05	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
EP1250456A2 (fr)	2002-10-23	Acides nucleiques renfermant des polymorphismes de nucleotide simple et procede d'utilisation associe
Aihara et al.	2001	Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14. 3
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KR100909372B1 (ko)	2009-07-24	단일염기다형을 포함하는 폴리뉴클레오티드를 이용한조기폐경 진단방법