|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
CA2931267C
(en)
*
|
2013-11-22 |
2023-08-15 |
Cellectis |
A method of engineering allogenic and drug resistant t-cells for immunotherapy
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US9603927B2
(en)
|
2014-02-28 |
2017-03-28 |
Janssen Biotech, Inc. |
Combination therapies with anti-CD38 antibodies
|
|
US9732154B2
(en)
|
2014-02-28 |
2017-08-15 |
Janssen Biotech, Inc. |
Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
|
|
US10738278B2
(en)
*
|
2014-07-15 |
2020-08-11 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
SG10201913765YA
(en)
*
|
2014-07-21 |
2020-03-30 |
Novartis Ag |
Treatment of cancer using a cd33 chimeric antigen receptor
|
|
EP3177718B1
(en)
|
2014-07-30 |
2022-03-16 |
President and Fellows of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
KR20240075936A
(ko)
|
2014-10-31 |
2024-05-29 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
Cart 세포에서 유전자 발현의 변경 및 그의 용도
|
|
EP3025719B1
(en)
|
2014-11-26 |
2018-09-26 |
Miltenyi Biotec GmbH |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
|
PE20171094A1
(es)
|
2014-12-04 |
2017-08-07 |
Janssen Biotech Inc |
Anticuerpos anti-cd38 para el tratamiento de la leucemia linfoblastica aguda
|
|
IL290459B2
(en)
*
|
2014-12-05 |
2023-11-01 |
Hope City |
Modified T cells - CS1-targeted chimeric antigen receptor
|
|
WO2016100233A1
(en)
|
2014-12-15 |
2016-06-23 |
The Regents Of The University Of California |
Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
|
|
US11253546B2
(en)
|
2014-12-15 |
2022-02-22 |
The Regents Of The University Of California |
Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
|
|
EP3250605A1
(en)
|
2015-01-26 |
2017-12-06 |
Cellectis |
Anti-hsp70 specific chimeric antigen receptors (cars) for cancer immunotherapy
|
|
LT3253865T
(lt)
|
2015-02-06 |
2022-11-10 |
National University Of Singapore |
Metodai, skirti sustiprinti terapinių imuninių ląstelių veiksmingumą
|
|
EP3062105A1
(en)
*
|
2015-02-26 |
2016-08-31 |
Université de Bretagne Occidentale (U.B.O.) |
Processes for the diagnosis, prognosis and monitoring of the progression of Chronic Lymphoid Leukaemia (CLL) and/or of Systemic Lupus Erythematosus (SLE) using membrane STIM 1
|
|
PL3261651T3
(pl)
|
2015-02-27 |
2022-08-22 |
Icell Gene Therapeutics Llc |
Chimeryczne receptory antygenowe (car) ukierunkowane na nowotwory złośliwe układu krwiotwórczego, kompozycje i sposoby ich stosowania
|
|
AU2016231061B2
(en)
|
2015-03-11 |
2020-11-26 |
Cellectis |
Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients
|
|
CA2986254A1
(en)
|
2015-05-18 |
2016-11-24 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
CA2986594C
(en)
|
2015-05-20 |
2025-06-10 |
Tufts Medical Center Inc |
Anti-CD38 antibodies for the treatment of light chain amyloidosis and other CD38-positive hematological malignancies
|
|
CN115058395B
(zh)
|
2015-06-25 |
2025-07-18 |
美商生物细胞基因治疗有限公司 |
嵌合抗原受体(car)、组合物及其使用方法
|
|
US11173179B2
(en)
|
2015-06-25 |
2021-11-16 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
|
|
MA42895A
(fr)
*
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
EP3347474B1
(en)
*
|
2015-09-11 |
2020-11-04 |
Biosceptre (UK) Limited |
Chimeric antigen receptors and uses thereof
|
|
CN113774495A
(zh)
*
|
2015-09-25 |
2021-12-10 |
阿布维特罗有限责任公司 |
用于对天然配对t细胞受体序列进行t细胞受体靶向鉴别的高通量方法
|
|
DK3680329T3
(da)
|
2015-10-05 |
2021-08-23 |
Prec Biosciences Inc |
Modificerede meganukleaser med genkendelsesekvenser der findes i genet for den humane t-cellereceptor-alpha-konstantregion
|
|
IL296340A
(en)
|
2015-10-05 |
2022-11-01 |
Prec Biosciences Inc |
Genetically modified cells containing a modified human t cell receptor alpha constant region gene
|
|
WO2017066760A1
(en)
*
|
2015-10-16 |
2017-04-20 |
The Trustees Of Columbia University In The City Of New York |
Compositions and methods for inhibition of lineage specific antigens
|
|
WO2017070633A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Evolved cas9 proteins for gene editing
|
|
HRP20220680T1
(hr)
|
2015-11-03 |
2022-07-08 |
Janssen Biotech, Inc. |
Potkožne formulacije protutijela anti-cd38 i njihove uporabe
|
|
JP2019500028A
(ja)
*
|
2015-11-19 |
2019-01-10 |
ブラッドセンター リサーチ ファウンデーション |
癌免疫療法で使用するための二重特異性t細胞を製造する方法
|
|
CN105368859B
(zh)
*
|
2015-11-25 |
2019-10-18 |
王任直 |
一种嵌合抗原受体hCD87-CAR及载有hCD87-CAR基因结构的慢病毒及质粒及其应用
|
|
CN108699159B
(zh)
*
|
2016-02-15 |
2022-07-29 |
地方独立行政法人神奈川县立病院机构 |
膜型粘蛋白样蛋白质的识别及其医疗应用
|
|
CA3016098A1
(en)
|
2016-03-04 |
2017-09-08 |
Morphosys Ag |
Clinical assessment of m-protein response in multiple myeloma
|
|
WO2017177175A1
(en)
*
|
2016-04-07 |
2017-10-12 |
The George Washington University |
Methods and compositions targeting retroviral latency
|
|
WO2017178585A1
(en)
|
2016-04-15 |
2017-10-19 |
Cellectis |
A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
|
|
US20190111079A1
(en)
*
|
2016-04-15 |
2019-04-18 |
Zymeworks Inc. |
Multi-specific antigen-binding constructs targeting immunotherapeutics
|
|
US20190328783A1
(en)
|
2016-04-15 |
2019-10-31 |
Cellectis |
A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression
|
|
MA44869A
(fr)
*
|
2016-05-06 |
2019-03-13 |
Editas Medicine Inc |
Cellules génétiquement modifiées et leurs procédés de fabrication
|
|
WO2017214569A1
(en)
*
|
2016-06-09 |
2017-12-14 |
Regents Of The University Of Minnesota |
Genome-edited nk cell and methods of making and using
|
|
CA3029197A1
(en)
|
2016-06-24 |
2017-12-28 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptors (cars), compositions and methods thereof
|
|
EP3494138A1
(en)
|
2016-08-02 |
2019-06-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
EP3494132A4
(en)
*
|
2016-08-03 |
2020-03-18 |
Washington University |
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
|
|
JP7201153B2
(ja)
|
2016-08-09 |
2023-01-10 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
プログラム可能cas9-リコンビナーゼ融合タンパク質およびその使用
|
|
JP7215808B2
(ja)
|
2016-08-12 |
2023-01-31 |
ツールゲン インコーポレイテッド |
操作された免疫調節エレメントおよび変更された免疫
|
|
US10576167B2
(en)
*
|
2016-08-17 |
2020-03-03 |
Factor Bioscience Inc. |
Nucleic acid products and methods of administration thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CA3039136A1
(en)
|
2016-09-02 |
2018-03-08 |
The Regents Of The University Of California |
Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments
|
|
CA3038532A1
(en)
|
2016-10-05 |
2018-04-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Bryostatin compounds and methods of preparing the same
|
|
JP7217970B2
(ja)
|
2016-10-07 |
2023-02-06 |
ティーシーアール2 セラピューティクス インク. |
融合タンパク質を用いてt細胞受容体をリプログラミングするための組成物及び方法
|
|
IL265962B2
(en)
*
|
2016-10-10 |
2025-10-01 |
Nat Institute For Biotechnology In The Negev Ltd |
Non-cytotoxic adapted cells and their use
|
|
CN106544321B
(zh)
*
|
2016-10-13 |
2019-01-29 |
北京艺妙神州医疗科技有限公司 |
通用型car-t细胞及其制备方法和用途
|
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
|
CN110139675B
(zh)
*
|
2016-10-31 |
2023-09-29 |
西雅图儿童医院(Dba西雅图儿童研究所) |
用具有工程化稳定的内源性foxp3基因表达的cd4t细胞治疗自身免疫疾病的方法
|
|
EP3535423B1
(en)
*
|
2016-11-07 |
2022-01-05 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Methods for selecting therapy for a cancer patient
|
|
CA3043356A1
(en)
*
|
2016-11-09 |
2018-05-17 |
Musc Foundation For Research Development |
Cd38-nad+ regulated metabolic axis in anti-tumor immunotherapy
|
|
EP3538549A1
(en)
*
|
2016-11-10 |
2019-09-18 |
iOmx Therapeutics AG |
Or10h1 antigen binding proteins and uses thereof
|
|
EP3321280B8
(en)
*
|
2016-11-10 |
2021-03-10 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts |
Immune modulators for reducing immune-resistance in melanoma and other proliferative diseases
|
|
CA3043752A1
(en)
|
2016-11-22 |
2018-05-31 |
National University Of Singapore |
Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
|
|
CN110177803A
(zh)
|
2016-11-22 |
2019-08-27 |
T细胞受体治疗公司 |
用于使用融合蛋白进行tcr重新编程的组合物和方法
|
|
US11337975B2
(en)
*
|
2016-11-23 |
2022-05-24 |
Acetylon Pharmaceuticals, Inc. |
Pharmaceutical combinations comprising a histone deacetylase inhibitor and a CD38 inhibitor and methods of use thereof
|
|
MX2019006598A
(es)
*
|
2016-12-09 |
2019-10-15 |
Onkimmune Ltd |
Celulas asesinas naturales modificadas geneticamente y sus usos.
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN110494451B
(zh)
|
2017-01-13 |
2023-12-01 |
塞尔达拉医疗有限责任公司 |
靶向tim-1的嵌合抗原受体
|
|
US10440535B2
(en)
|
2017-01-25 |
2019-10-08 |
The George Washington University |
System and method for asset-agnostic wireless monitoring and predictive maintenance of deployed assets
|
|
US20200306375A1
(en)
*
|
2017-02-22 |
2020-10-01 |
Aleta Biotherapeutics Inc. |
Compositions and methods for tumor transduction
|
|
BR112019017403A2
(pt)
*
|
2017-02-22 |
2020-04-14 |
Aleta Biotherapeutics Inc |
composições e métodos para o tratamento de câncer
|
|
EP3589291A4
(en)
|
2017-02-28 |
2020-11-25 |
Vor Biopharma, Inc. |
COMPOSITIONS AND METHODS OF INHIBITION OF LINE-SPECIFIC PROTEINS
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
KR102687373B1
(ko)
|
2017-03-23 |
2024-07-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
PT3592379T
(pt)
|
2017-03-31 |
2024-05-31 |
Cellectis Sa |
Células imunitárias manipuladas universais dotadas de recetor antigénico quimérico anti-cd22
|
|
CN118389601A
(zh)
*
|
2017-05-08 |
2024-07-26 |
株式会社图尔金 |
经人工操纵的免疫细胞
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
JP7356354B2
(ja)
|
2017-05-12 |
2023-10-04 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
細胞の操作のための材料及び方法並びに免疫腫瘍学におけるその使用
|
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
US12384830B2
(en)
*
|
2017-06-02 |
2025-08-12 |
Regents Of The University Of Minnesota |
Compositions and methods for improving immunotherapy
|
|
CN106978445A
(zh)
*
|
2017-06-12 |
2017-07-25 |
内蒙古大学 |
CRISPER‑Cas9系统介导的山羊EDAR基因敲除的方法
|
|
SG10202109108UA
(en)
*
|
2017-06-21 |
2021-09-29 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptors (cars), compositions and methods thereof
|
|
CA3068465A1
(en)
|
2017-06-30 |
2019-01-03 |
Precision Biosciences, Inc. |
Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene
|
|
WO2019002633A1
(en)
|
2017-06-30 |
2019-01-03 |
Cellectis |
CELLULAR IMMUNOTHERAPY FOR REPETITIVE ADMINISTRATION
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
CN107312800B
(zh)
*
|
2017-08-01 |
2020-02-07 |
北京舜雷科技有限公司 |
能敲低内源性pd-1表达的cik及其制备方法与应用
|
|
US20190038733A1
(en)
|
2017-08-10 |
2019-02-07 |
National University Of Singapore |
T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
|
|
CN107541526B
(zh)
*
|
2017-08-23 |
2019-12-10 |
北京瑞健科技有限公司 |
能敲低内源性ctla4表达的cik及制备方法与应用
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
EP3697906A1
(en)
|
2017-10-16 |
2020-08-26 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
AU2018359527A1
(en)
|
2017-10-31 |
2020-05-07 |
Janssen Biotech, Inc. |
Methods of treating high risk multiple myeloma
|
|
JP7447006B2
(ja)
|
2017-11-01 |
2024-03-11 |
ジュノー セラピューティクス インコーポレイテッド |
B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体
|
|
AU2018362014A1
(en)
*
|
2017-11-03 |
2020-05-28 |
Sorrento Therapeutics, Inc. |
CD38-directed chimeric antigen receptor constructs
|
|
GB201719169D0
(en)
|
2017-11-20 |
2018-01-03 |
Univ College Cardiff Consultants Ltd |
Novel T-cell receptor and ligand
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US12398373B2
(en)
|
2017-12-22 |
2025-08-26 |
Fate Therapeutics, Inc. |
Enhanced immune effector cells and use thereof
|
|
JP7372920B2
(ja)
|
2017-12-29 |
2023-11-01 |
セレクティス |
Car t細胞の作製を改良するための方法
|
|
US20230158070A1
(en)
|
2018-01-30 |
2023-05-25 |
Cellectis |
Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen
|
|
BR112020015662A2
(pt)
*
|
2018-02-01 |
2020-12-08 |
Pfizer Inc. |
Receptores de antígeno quimérico direcionados a cd70
|
|
EP3746482A1
(en)
|
2018-02-01 |
2020-12-09 |
Pfizer Inc. |
Antibodies specific for cd70 and their uses
|
|
CN112512594A
(zh)
*
|
2018-03-23 |
2021-03-16 |
瑞非生物科技有限公司 |
经由基因调节多肽的条件性核定位的基因调节
|
|
EP3775228A4
(en)
*
|
2018-03-29 |
2022-02-23 |
Fate Therapeutics, Inc. |
ENHANCED IMMUNE EFFECTIVE CELLS AND THEIR USE
|
|
AU2019247199A1
(en)
*
|
2018-04-05 |
2020-10-15 |
Editas Medicine, Inc. |
T cells expressing a recombinant receptor, related polynucleotides and methods
|
|
JP7304888B2
(ja)
|
2018-04-12 |
2023-07-07 |
プレシジョン バイオサイエンシズ,インク. |
ヒトt細胞受容体アルファ定常領域遺伝子に特異性を有する最適化された操作されたヌクレアーゼ
|
|
US12473342B2
(en)
*
|
2018-04-27 |
2025-11-18 |
The Trustees Of The University Of Pennsylvania |
Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis
|
|
WO2019210042A1
(en)
|
2018-04-27 |
2019-10-31 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Expression of foxp3 in edited cd34+ cells
|
|
CN112105420A
(zh)
|
2018-05-11 |
2020-12-18 |
克里斯珀医疗股份公司 |
用于治疗癌症的方法和组合物
|
|
WO2019222423A1
(en)
*
|
2018-05-15 |
2019-11-21 |
The Brigham And Women's Hospital, Inc. |
Compositions and methods related to tumor cell killers and vaccines
|
|
GB2589246A
(en)
|
2018-05-16 |
2021-05-26 |
Synthego Corp |
Methods and systems for guide RNA design and use
|
|
EP3797160A1
(en)
|
2018-05-23 |
2021-03-31 |
The Broad Institute Inc. |
Base editors and uses thereof
|
|
JP7584299B2
(ja)
|
2018-05-23 |
2024-11-15 |
ナショナル ユニバーシティ オブ シンガポール |
T細胞悪性腫瘍の免疫療法のためのcd2表面発現の遮断およびキメラ抗原受容体の発現
|
|
CA3103610A1
(en)
*
|
2018-06-12 |
2019-12-19 |
The Regents Of The University Of California |
Single-chain bispecific chimeric antigen receptors for the treatment of cancer
|
|
CA3110836A1
(en)
|
2018-06-14 |
2019-12-19 |
Bluebird Bio, Inc. |
Cd79a chimeric antigen receptors
|
|
CN110623980A
(zh)
*
|
2018-06-25 |
2019-12-31 |
深圳宾德生物技术有限公司 |
靶向cd38的嵌合抗原受体t细胞在自身免疫性疾病中的应用
|
|
CN112334479A
(zh)
*
|
2018-07-13 |
2021-02-05 |
南京传奇生物科技有限公司 |
用于治疗感染性疾病的共受体系统
|
|
CN110819589B
(zh)
*
|
2018-08-13 |
2022-10-11 |
上海科技大学 |
一种增强免疫效应细胞功能的方法
|
|
MX2021002415A
(es)
|
2018-08-28 |
2021-09-21 |
Vor Biopharma Inc |
Celulas madre hematopoyeticas modificadas geneticamente y usos de las mismas.
|
|
CN110904045A
(zh)
*
|
2018-09-17 |
2020-03-24 |
中国科学院动物研究所 |
经修饰的t细胞、其制备方法及用途
|
|
EP3629021A1
(en)
*
|
2018-09-26 |
2020-04-01 |
Euroimmun Medizinische Labordiagnostika AG |
Diagnosis of a neuroautoimmune disease
|
|
CA3114911A1
(en)
*
|
2018-10-04 |
2020-04-09 |
Rutgers, The State University Of New Jersey |
Methods of reducing type 2 cytokine-mediated inflammation using neuromedin peptides
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
BR112021008263A2
(pt)
*
|
2018-10-31 |
2021-08-10 |
Humanigen, Inc. |
materiais e métodos para tratamento de câncer
|
|
WO2020092848A2
(en)
|
2018-11-01 |
2020-05-07 |
Juno Therapeutics, Inc. |
Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
|
|
WO2020102721A1
(en)
*
|
2018-11-16 |
2020-05-22 |
Rapa Therapeutics, Llc |
Immune monitoring of neuro-inflammatory amyotrophic lateral sclerosis (als)
|
|
CN113412119B
(zh)
|
2018-11-30 |
2024-12-20 |
莱蒂恩技术公司 |
用于用抗cd38免疫治疗来治疗癌症的组合物和方法
|
|
AR117327A1
(es)
|
2018-12-20 |
2021-07-28 |
23Andme Inc |
Anticuerpos anti-cd96 y métodos de uso de estos
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN118546960A
(zh)
|
2019-03-05 |
2024-08-27 |
恩卡尔塔公司 |
Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
|
|
SG11202109882VA
(en)
|
2019-03-19 |
2021-10-28 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
CA3134223A1
(en)
*
|
2019-03-21 |
2020-09-24 |
Onk Therapeutics Limited |
Modified immune effector cells with increased resistance to cell death
|
|
WO2020194243A1
(en)
*
|
2019-03-28 |
2020-10-01 |
Janssen Biotech, Inc. |
Clinically proven subcutaneous pharmaceutical compositions comprising anti-cd38 antibodies and their uses in combination with lenalidomide and dexamethasone
|
|
US20200316197A1
(en)
*
|
2019-03-28 |
2020-10-08 |
Janssen Biotech, Inc. |
Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Bortezomib and Dexamethasone
|
|
US20200330593A1
(en)
*
|
2019-03-28 |
2020-10-22 |
Janssen Biotech, Inc. |
Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Bortezomib, Mephalan and Prednisone
|
|
US20200308296A1
(en)
*
|
2019-03-28 |
2020-10-01 |
Janssen Biotech, Inc. |
Clinically Proven Subcutaneous Pharmaceutical Compositions Comprising Anti-CD38 Antibodies and Their Uses in Combination with Pomalidomide and Dexamethasone
|
|
CN116200342A
(zh)
|
2019-04-03 |
2023-06-02 |
精密生物科学公司 |
包含microRNA适应的shRNA(shRNAmiR)的遗传修饰的免疫细胞
|
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
PH12021552963A1
(en)
|
2019-04-30 |
2022-07-25 |
Crispr Therapeutics Ag |
Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
|
|
CN114072141A
(zh)
*
|
2019-05-21 |
2022-02-18 |
小利兰·斯坦福大学托管委员会 |
用于增强免疫疗法的苔藓虫素化合物
|
|
MX2021015495A
(es)
*
|
2019-06-14 |
2022-04-18 |
2Seventy Bio Inc |
Composiciones y métodos para tratar cáncer.
|
|
JP7652396B2
(ja)
*
|
2019-08-16 |
2025-03-27 |
エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド |
骨髄性悪性腫瘍を処置するためのキメラ抗原受容体
|
|
US12344656B2
(en)
*
|
2019-09-06 |
2025-07-01 |
Crispr Therapeutics Ag |
Genetically engineered T cells having improved persistence in culture
|
|
JP2022548925A
(ja)
*
|
2019-09-18 |
2022-11-22 |
モメンタ ファーマシューティカルズ インコーポレイテッド |
CD38を標的とした改変されたFc抗原結合ドメイン構築物に関する組成物及び方法
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
US20210139935A1
(en)
*
|
2019-11-13 |
2021-05-13 |
Crispr Therapeutics Ag |
Methods of manufacturing car-t cells
|
|
US20220380433A1
(en)
*
|
2019-11-13 |
2022-12-01 |
Shanghai Pharmaceuticals Holding Co., Ltd. |
Tmem59 protein dimer or chimeric expression receptor improving t cell function
|
|
WO2022250433A1
(ko)
*
|
2021-05-24 |
2022-12-01 |
주식회사 센트릭스바이오 |
Cd300c 항원 또는 그의 수용체에 특이적으로 결합하는 키메라 항원 수용체
|
|
BR112022013445A2
(pt)
*
|
2020-01-08 |
2022-09-13 |
Univ Texas |
Método de modificação de células exterminadoras naturais para direcionar tumores cd70-positivos
|
|
CN111196858B
(zh)
*
|
2020-02-05 |
2021-02-09 |
武汉科技大学 |
一种治疗血液肿瘤合并hiv感染的双特异性嵌合抗原受体、基因、构建方法及其应用
|
|
KR20220160053A
(ko)
*
|
2020-03-27 |
2022-12-05 |
더 트러스티즈 오브 인디애나 유니버시티 |
다발성 골수종에서의 면역요법 표적 및 그의 식별 방법
|
|
CN115777017A
(zh)
*
|
2020-05-06 |
2023-03-10 |
亘喜生物科技(上海)有限公司 |
用于t细胞工程改造的组合物及方法
|
|
KR20230019843A
(ko)
|
2020-05-08 |
2023-02-09 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물
|
|
IL298510A
(en)
*
|
2020-06-12 |
2023-01-01 |
Nkarta Inc |
Genetically modified natural killer cells for cd70-directed cancer immunotherapy
|
|
JP2023530182A
(ja)
|
2020-06-22 |
2023-07-13 |
ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド |
多重サブユニットタンパク質モジュール、それを発現する細胞、及びその使用
|
|
CN111796101B
(zh)
*
|
2020-07-14 |
2022-08-26 |
汕头市中心医院 |
Notch3蛋白表达量检测剂联合cypa蛋白表达量检测剂在预测癌症治疗疗效的用途
|
|
IL303262A
(en)
*
|
2020-12-02 |
2023-07-01 |
Univ Jefferson |
Desmoglein 2-directed chimeric antigen receptor (car) constructs and methods of use
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
CA3201621A1
(en)
|
2020-12-03 |
2022-06-09 |
Century Therapeutics, Inc. |
Genetically engineered cells and uses thereof
|
|
JP2024500847A
(ja)
|
2020-12-18 |
2024-01-10 |
センチュリー セラピューティクス,インコーポレイテッド |
適合可能な受容体特異性を有するキメラ抗原受容体システム
|
|
WO2022210487A1
(ja)
*
|
2021-03-29 |
2022-10-06 |
タカラバイオ株式会社 |
抗原に特異的な受容体を発現する免疫細胞の製造方法
|
|
US20240180963A1
(en)
*
|
2021-04-05 |
2024-06-06 |
Altheia Science S.R.L. |
Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigens
|
|
KR20240005850A
(ko)
*
|
2021-05-24 |
2024-01-12 |
주식회사 센트릭스바이오 |
Cd300c 항원 또는 그의 수용체에 특이적으로 결합하는키메라 항원 수용체
|
|
CN113671196B
(zh)
*
|
2021-07-29 |
2023-09-12 |
中国人民解放军空军军医大学 |
Lair-1分子与脂联素的相互作用对于t细胞活化作用影响的研究方法
|
|
US20250019724A1
(en)
*
|
2021-11-18 |
2025-01-16 |
Correctsequence Therapeutics |
Regeneration of surface antigen-negative cells
|
|
CN114350616A
(zh)
*
|
2022-01-24 |
2022-04-15 |
深圳市先康达生命科学有限公司 |
一种免疫细胞及其制备方法和应用
|
|
US20250121004A1
(en)
*
|
2022-01-25 |
2025-04-17 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods comprising anti-cd38 chimeric antigen receptors (cars)
|
|
US20250154238A1
(en)
*
|
2022-03-04 |
2025-05-15 |
Yale University |
Methods and compositions for treating and preventing fibrosis
|
|
EP4482872A2
(en)
*
|
2022-03-07 |
2025-01-01 |
Nkarta, Inc. |
Multiplex gene edited cells for cd70-directed cancer immunotherapy
|
|
CN114397464B
(zh)
*
|
2022-03-24 |
2022-06-10 |
天津德祥生物技术有限公司 |
一种红细胞膜碎片与载体的偶联复合物、其偶联方法和应用
|
|
AU2023250214A1
(en)
*
|
2022-04-05 |
2024-11-21 |
Altheia Science S.R.L. |
Treatment of myeloid disorders and acute leukemias targeting novel tumor specific antigens
|
|
CN114569709B
(zh)
*
|
2022-05-05 |
2022-07-12 |
苏州慧疗生物医药科技有限公司 |
高表达adam-28的黑色素瘤自体肿瘤疫苗的制备方法及其应用
|
|
CN115951055B
(zh)
*
|
2022-12-13 |
2024-10-15 |
湖南湘医投蕙尧生命科技有限公司 |
一种癌症相关蛋白及其抗体和应用
|
|
WO2024154122A1
(en)
|
2023-01-18 |
2024-07-25 |
Gilboa Therapeutics LTD |
Immune cells expressing a complement receptor and uses thereof
|
|
TW202515994A
(zh)
*
|
2023-08-14 |
2025-04-16 |
美商英特利亞醫療公司 |
用於對cd70進行基因修飾之組合物及方法
|
|
WO2025059162A1
(en)
|
2023-09-11 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Car-engager containing il-2 variants to enhance the functionality of car t cells
|
|
JP2025074700A
(ja)
*
|
2023-10-30 |
2025-05-14 |
学校法人藤田学園 |
抗cd38-carを発現する細胞傷害性免疫担当細胞、その製造方法、および当該免疫担当細胞を含む医薬組成物
|
|
CN118108860B
(zh)
*
|
2024-03-07 |
2025-04-29 |
南京澄实生物医药科技有限公司 |
一种基于FcRn可提高细胞免疫水平的重组疫苗及应用
|
|
PL448316A1
(pl)
*
|
2024-04-24 |
2025-10-27 |
Uniwersytet Łódzki |
Preparat biologiczny zawierający limfocyty pozbawione adhezyjnego receptora oddziałującego z białkami G F5 o działaniu przeciwnowotworowym
|
|
CN119684463B
(zh)
*
|
2024-12-25 |
2025-09-12 |
武汉爱博泰克生物科技有限公司 |
抗人ceacam5蛋白的抗体、抗体对和试剂盒及应用
|