TR201102068A2 - Crystalline substances containing tiotropium bromide - Google Patents
Crystalline substances containing tiotropium bromideInfo
- Publication number
- TR201102068A2 TR201102068A2 TR2011/02068A TR201102068A TR201102068A2 TR 201102068 A2 TR201102068 A2 TR 201102068A2 TR 2011/02068 A TR2011/02068 A TR 2011/02068A TR 201102068 A TR201102068 A TR 201102068A TR 201102068 A2 TR201102068 A2 TR 201102068A2
- Authority
- TR
- Turkey
- Prior art keywords
- tiotropium bromide
- substances containing
- crystalline substances
- containing tiotropium
- wavelengths
- Prior art date
Links
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- 229960000257 tiotropium bromide Drugs 0.000 title abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- 238000005079 FT-Raman Methods 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- 239000002178 crystalline material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Mevcut buluş, formül l'de gösterilen madde (Tiotropyum bromür) ve su içeren ve FT-Raman spektmmunda 3070, 3053, 2982, 2967, 1743, 1479, 1429, 1238, 1078, 699, 295 and 121 cm"' (± 2 cm"' şeklinde ifade edilir) dalganumaralannda pik içeren kristal madde l'e ve Tiotropyum bromür (formül I) ile CH2CI2 kanşımım veya bir hidratını içeren, FT-Raman 10 spektmmunda 3109, 3074, 3057, 3023, 2979, 2970, 2955, 2935, 1747, 1479, 1433, 1348, 1324, 1244, 1161, 1071, 1039, 1000, 962, 886, 859, 797, 753, 665, 651, 626, 538, 432, 289, 253, 209 ve 173 cm"' (± 2 cm"' olarak ifade edilmiştir) dalga numaralarında piklere sahip kristal maddeye ve bunlann elde edilmesinde kullanılacak metotlara ilişkindir.The present invention includes the substance shown in formula 1 (Tiotropium bromide) and water, and in the FT-Raman spectrum, 3070, 3053, 2982, 2967, 1743, 1479, 1429, 1238, 1078, 699, 295 and 121 cm '' (± 2). cm '') in the spectrum of FT-Raman 10, 3109, 3074, 3057, 3023, 2979, 2970, 2955, 2935, containing peak-containing crystalline substance 1 in wavelengths and a mixture of Tiotropium bromide (formula I) and CH2Cl2 or a hydrate , 1747, 1479, 1433, 1348, 1324, 1244, 1161, 1071, 1039, 1000, 962, 886, 859, 797, 753, 665, 651, 626, 538, 432, 289, 253, 209 and 173 cm " '(Expressed as ± 2 cm') relates to crystalline material having peaks in wavelengths and methods to be used to obtain them.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2011/02068A TR201102068A2 (en) | 2011-03-03 | 2011-03-03 | Crystalline substances containing tiotropium bromide |
| TR2011/11589A TR201111589A2 (en) | 2011-03-03 | 2011-11-23 | Tiotropium bromide anhydrous crystal form. |
| EP12716717.9A EP2681212A1 (en) | 2011-03-03 | 2012-03-05 | Crystalline compound comprising tiotropium bromide |
| EP12716718.7A EP2681213A1 (en) | 2011-03-03 | 2012-03-05 | Anhydrous crystalline form of tiotropium bromide |
| PCT/TR2012/000050 WO2012118462A1 (en) | 2011-03-03 | 2012-03-05 | Anhydrous crystalline form of tiotropium bromide |
| PCT/TR2012/000049 WO2012118461A1 (en) | 2011-03-03 | 2012-03-05 | Crystalline compound comprising tiotropium bromide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2011/02068A TR201102068A2 (en) | 2011-03-03 | 2011-03-03 | Crystalline substances containing tiotropium bromide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201102068A2 true TR201102068A2 (en) | 2012-09-21 |
Family
ID=46000279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2011/02068A TR201102068A2 (en) | 2011-03-03 | 2011-03-03 | Crystalline substances containing tiotropium bromide |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2681212A1 (en) |
| TR (1) | TR201102068A2 (en) |
| WO (1) | WO2012118461A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
| RU2567539C1 (en) * | 2015-02-04 | 2015-11-10 | Индивидуальный предприниматель Михайлов Олег Ростиславович | CRYSTALLINE γ-MODIFICATION (1α,2β,4β,5α,7β)-7-[(HYDROXYDI-2-THIENYLACETYL)OXY]-9,9-DIMETHYL-3-OXA-9-AZONIATRICYCLO[3,3,1,02,4]NONANE BROMIDE MONOHYDRATE, METHOD OF THEREOF OBTAINING AND THEREOF-BASED PHARMACEUTICAL COMPOSITION |
| WO2018084817A2 (en) * | 2016-11-04 | 2018-05-11 | Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ | A new form of active agent |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (en) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them |
| AU2002214996B2 (en) * | 2000-10-12 | 2007-03-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament |
| SK287262B6 (en) | 2001-06-22 | 2010-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline anhydrous tiotropium bromide, a process for its preparation, a pharmaceutical composition containing it and its use |
| PL1881980T3 (en) | 2005-05-02 | 2013-01-31 | Boehringer Ingelheim Int | Novel crystalline forms of tiotropium bromide |
| US20070167480A1 (en) * | 2005-12-19 | 2007-07-19 | Sicor Inc. | Pure and stable tiotropium bromide |
| WO2011015883A1 (en) * | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| CN102127069A (en) * | 2010-01-20 | 2011-07-20 | 鲁南制药集团股份有限公司 | Tiotropium bromide crystal |
-
2011
- 2011-03-03 TR TR2011/02068A patent/TR201102068A2/en unknown
-
2012
- 2012-03-05 EP EP12716717.9A patent/EP2681212A1/en not_active Withdrawn
- 2012-03-05 WO PCT/TR2012/000049 patent/WO2012118461A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2681212A1 (en) | 2014-01-08 |
| WO2012118461A1 (en) | 2012-09-07 |
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