TR200201567T2 - Active fluorescent contrast agent and fluorescence imaging in the near infrared light region. - Google Patents
Active fluorescent contrast agent and fluorescence imaging in the near infrared light region.Info
- Publication number
- TR200201567T2 TR200201567T2 TR2002/01567T TR200201567T TR200201567T2 TR 200201567 T2 TR200201567 T2 TR 200201567T2 TR 2002/01567 T TR2002/01567 T TR 2002/01567T TR 200201567 T TR200201567 T TR 200201567T TR 200201567 T2 TR200201567 T2 TR 200201567T2
- Authority
- TR
- Turkey
- Prior art keywords
- contrast agent
- infrared
- fluorescence
- light region
- region
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 5
- 238000000799 fluorescence microscopy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Abstract
Bir molekül içinde üç ya da daha çok sülfonik asit grubuna sahip olan bir bilesigi içeren bir kizilötesine yakin isik bölgesinde aktif fluoresan kontrast maddesi ve bir fluoresans görüntü alma yöntemi anlatilmistir, bu yöntem, bu bulusun kizilötesine yakin isik bölgesinde aktif fluoresan kontrast maddesinin bir canli vücut içine verilmesi, vücudun bir uyarim isigina maruz birakilmasi ve kontrast maddesinden gelen kizilötesi bölgeye yakin fluoresansin bulgulanmasini içermektedir. Bu bulusun kizilötesine yakin isik bölgesinde akif fluoresan kontrast maddesi bir uyarim isigi ile uyarilmakta ve kizil ötesi bölgesine yakin bölgede fluoresans nesretmektedir. Bu kizilötesi fluoresansi biyolojik dokular içinden geçiste üstündür. Bu yüzden, canli bir vücudun derin bir kismindaki lezyonlarin bulgulanmasi mümkün kilinmistir.A fluorescence contrast agent and a fluorescence imaging method are described in a near-infrared light region containing a compound having three or more sulfonic acid groups in a molecule, which method involves the active fluorescent contrast agent in the light region near the infrared of this invention. administration includes exposing the body to an excitation light and detection of fluorescence near the infrared region from the contrast agent. In the light region close to the infrared of this invention, the active fluorescent contrast agent is stimulated by a stimulus light and generates fluorescence in the region near the infrared region. This infrared fluorescence is superior in transition through biological tissues. Therefore, it was possible to detect lesions in a deep part of a living body.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1999/009959 WO2001043781A1 (en) | 1999-12-15 | 1999-12-15 | Near infrared fluorescent contrast agent and fluorescence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200201567T2 true TR200201567T2 (en) | 2002-11-21 |
Family
ID=8167530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/01567T TR200201567T2 (en) | 1999-12-15 | 1999-12-15 | Active fluorescent contrast agent and fluorescence imaging in the near infrared light region. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1237583A1 (en) |
| JP (1) | JP2003517025A (en) |
| KR (1) | KR20020082207A (en) |
| CN (1) | CN1217701C (en) |
| AU (1) | AU2097500A (en) |
| BG (1) | BG106822A (en) |
| BR (1) | BR9917587A (en) |
| CA (1) | CA2394539C (en) |
| EA (1) | EA200200635A1 (en) |
| EE (1) | EE200200321A (en) |
| HU (1) | HUP0204024A2 (en) |
| IL (1) | IL149798A0 (en) |
| MX (1) | MXPA02005806A (en) |
| NO (1) | NO328630B1 (en) |
| PL (1) | PL355891A1 (en) |
| SK (1) | SK8142002A3 (en) |
| TR (1) | TR200201567T2 (en) |
| WO (1) | WO2001043781A1 (en) |
| YU (1) | YU44402A (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (en) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | Fluorescent contrast agent |
| JP5074044B2 (en) | 2007-01-18 | 2012-11-14 | オリンパス株式会社 | Fluorescence observation apparatus and method of operating fluorescence observation apparatus |
| US8344158B2 (en) * | 2007-08-15 | 2013-01-01 | Washington University | Fluorescent polymethine cyanine dyes |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| EP2470887B1 (en) | 2009-08-28 | 2020-03-11 | VisEn Medical, Inc. | Systems for tomographic imaging in diffuse media using a hybrid inversion technique |
| JP2011046663A (en) | 2009-08-28 | 2011-03-10 | Fujifilm Corp | Near infrared fluorescent imaging agent |
| US8401619B2 (en) | 2009-09-22 | 2013-03-19 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| CA2787129A1 (en) * | 2010-01-14 | 2011-07-21 | The Regents Of The University Of California | Devices, systems and methods to detect and reduce or prevent entry of inflammatory mediators into milk ducts |
| GB201010878D0 (en) | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| EP3338617B1 (en) | 2012-01-23 | 2020-08-19 | Washington University | Goggle imaging systems and devices |
| CN104853669B (en) | 2012-10-15 | 2017-07-21 | 文森医学公司 | The system of the diffusing media imaging of cross-modality weighted feature with fluorescence and bioluminescence source, method and apparatus |
| US20170232119A1 (en) | 2013-03-15 | 2017-08-17 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| MX358184B (en) | 2013-03-15 | 2018-08-08 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors. |
| RU2016127260A (en) | 2013-12-31 | 2018-02-06 | Мемориал Слоун Кеттеринг Кэнсэ Сентр | SYSTEMS, METHODS AND DEVICE FOR MULTI-CHANNEL DISPLAY OF FLUORESCENT SOURCES IN REAL TIME |
| CA2970719C (en) | 2014-12-15 | 2023-08-01 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| WO2016179350A1 (en) | 2015-05-06 | 2016-11-10 | Washington University | Compounds having rd targeting motifs and methods of use thereof |
| CN107949385B (en) | 2015-06-03 | 2021-04-09 | 瑟吉麦博股份公司 | Fluorescent Conjugates |
| CN105222828B (en) * | 2015-09-30 | 2017-05-24 | 东南大学 | Synchronization measurement device for wall-adherent jet speed field and concentration field and method |
| JP2019509252A (en) | 2015-12-15 | 2019-04-04 | メモリアル スローン ケタリング キャンサー センター | Imaging systems and methods for tissue differentiation, eg, visualization during surgery |
| BR112019010947A2 (en) | 2016-11-30 | 2019-10-01 | Univ Cornell | ultra-small inhibitor functionalized nanoparticles and methods thereof |
| CN111970960A (en) | 2018-03-30 | 2020-11-20 | 珀金埃尔默健康科学有限公司 | System and method for 3D reconstruction of anatomical organs and contents using Short Wave Infrared (SWIR) projection tomography |
| WO2021119423A1 (en) | 2019-12-13 | 2021-06-17 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
| US11964965B2 (en) * | 2020-05-08 | 2024-04-23 | On Target Laboratories, LLC | Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof |
| EP4015004A1 (en) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglycan specific branched peptides |
| EP4334394A4 (en) * | 2021-05-04 | 2025-01-08 | University of Notre Dame du Lac | DEUTERATED INDOLE HEPTAMETHINE CYANINE DYES |
| CN114459862B (en) * | 2022-01-13 | 2024-12-17 | 华腾实业（深圳）股份有限公司 | High-recognition fungus fluorescent staining solution |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403928A (en) * | 1990-05-15 | 1995-04-04 | Diatron Corporation | Fluorescent marker components and fluorescent probes |
| CN1093768C (en) * | 1995-01-30 | 2002-11-06 | 第一化学药品株式会社 | Diagnostic marker |
| JP2000095758A (en) * | 1998-09-18 | 2000-04-04 | Schering Ag | Near-infrared, fluorescent contrast medium, and its production |
-
1999
- 1999-12-15 TR TR2002/01567T patent/TR200201567T2/en unknown
- 1999-12-15 SK SK814-2002A patent/SK8142002A3/en unknown
- 1999-12-15 JP JP2001544917A patent/JP2003517025A/en active Pending
- 1999-12-15 MX MXPA02005806A patent/MXPA02005806A/en unknown
- 1999-12-15 WO PCT/EP1999/009959 patent/WO2001043781A1/en not_active Ceased
- 1999-12-15 YU YU44402A patent/YU44402A/en unknown
- 1999-12-15 AU AU20975/00A patent/AU2097500A/en not_active Abandoned
- 1999-12-15 CA CA002394539A patent/CA2394539C/en not_active Expired - Fee Related
- 1999-12-15 EP EP99965468A patent/EP1237583A1/en not_active Withdrawn
- 1999-12-15 IL IL14979899A patent/IL149798A0/en not_active IP Right Cessation
- 1999-12-15 PL PL99355891A patent/PL355891A1/en not_active Application Discontinuation
- 1999-12-15 EE EEP200200321A patent/EE200200321A/en unknown
- 1999-12-15 KR KR1020027007635A patent/KR20020082207A/en not_active Ceased
- 1999-12-15 HU HU0204024A patent/HUP0204024A2/en unknown
- 1999-12-15 BR BR9917587-8A patent/BR9917587A/en not_active Application Discontinuation
- 1999-12-15 EA EA200200635A patent/EA200200635A1/en unknown
- 1999-12-15 CN CN998170437A patent/CN1217701C/en not_active Expired - Fee Related
-
2002
- 2002-06-13 BG BG106822A patent/BG106822A/en unknown
- 2002-06-14 NO NO20022837A patent/NO328630B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1384760A (en) | 2002-12-11 |
| WO2001043781A1 (en) | 2001-06-21 |
| EP1237583A1 (en) | 2002-09-11 |
| NO328630B1 (en) | 2010-04-12 |
| NO20022837D0 (en) | 2002-06-14 |
| IL149798A0 (en) | 2002-11-10 |
| EA200200635A1 (en) | 2002-12-26 |
| CA2394539A1 (en) | 2001-06-21 |
| KR20020082207A (en) | 2002-10-30 |
| AU2097500A (en) | 2001-06-25 |
| BG106822A (en) | 2003-01-31 |
| NO20022837L (en) | 2002-06-14 |
| YU44402A (en) | 2005-03-15 |
| SK8142002A3 (en) | 2002-12-03 |
| CA2394539C (en) | 2009-10-27 |
| PL355891A1 (en) | 2004-05-31 |
| CN1217701C (en) | 2005-09-07 |
| EE200200321A (en) | 2003-10-15 |
| BR9917587A (en) | 2002-08-06 |
| HUP0204024A2 (en) | 2003-04-28 |
| MXPA02005806A (en) | 2010-10-26 |
| JP2003517025A (en) | 2003-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR200201567T2 (en) | Active fluorescent contrast agent and fluorescence imaging in the near infrared light region. | |
| TR200100746T2 (en) | Infrared fluorescent contrast agent and fluorescence image | |
| US8841320B2 (en) | Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging | |
| Deng et al. | Near-infrared fluorescence imaging in the largely unexplored window of 900-1,000 nm | |
| CN104955484B (en) | Prostate-specific antigen medicament and its application method for prostate cancer imaging | |
| ATE420592T1 (en) | FLUORESCENCE-MEDIATED MOLECULAR TOMOGRAPHY | |
| AU2017368005A1 (en) | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof | |
| ATE291878T1 (en) | METHOD FOR AVOIDING FLUORESCENCE QUENCHMENT | |
| WO2011153331A2 (en) | Optical sensor conjugates for detecting reactive oxygen and/or reactive nitrogen species in vivo | |
| CY1105322T1 (en) | METHODS AND COMPOSITIONS FOR THE DETECTION OF PATHOLOGICAL EVENTS | |
| KR20180093961A (en) | System distinctions, for example imaging systems and methods for intraoperative visualization | |
| Yoon et al. | Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer | |
| EP1706145A4 (en) | AUTOANTIBODIES AS EXCIPIENTS WITH PHARMACEUTICAL COMPOUNDS FOR TUMOR IMAGING AND TREATMENT OF CANCER | |
| EP4057900A1 (en) | Identification of degradative species | |
| US7738946B2 (en) | System, method and apparatus for the detection of patient-borne fluorescing materials | |
| ATE323176T1 (en) | DETECTION OF BREAST TUMOR VIRUS-LIKE SEQUENCES IN HUMAN BREAST CANCER | |
| CN105682689B (en) | For detecting the diagnostic device of disease correlation target structure | |
| CN109745569B (en) | Electrochromic material based H2S-activated probes and biological applications thereof | |
| TR200202652T2 (en) | Infrared fluorescent contrast agent and fluorescence image | |
| JP7690040B2 (en) | Apparatus and method for detecting fluorescence | |
| Malankar et al. | Engineering NIR probes to enhance affinity and clinical workflow compatibility for prostate cancer imaging | |
| Moin et al. | Fluorescent imaging of tumors | |
| He et al. | FCLA-assisted photodynamic diagnosis | |
| JP2005145921A (en) | Fluorescent contrast medium for diagnosis and method for fluorescence imaging diagnosis | |
| CY1114765T1 (en) | Activation of ACE2 for the treatment of heart, lung and kidney disease and hypertension |