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TR200200416T2 - İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. - Google Patents

İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Info

Publication number
TR200200416T2
TR200200416T2 TR2002/00416T TR200200416T TR200200416T2 TR 200200416 T2 TR200200416 T2 TR 200200416T2 TR 2002/00416 T TR2002/00416 T TR 2002/00416T TR 200200416 T TR200200416 T TR 200200416T TR 200200416 T2 TR200200416 T2 TR 200200416T2
Authority
TR
Turkey
Prior art keywords
substituted
esters derived
new esters
phenylcyclohexyl
compounds
Prior art date
Application number
TR2002/00416T
Other languages
English (en)
Inventor
Carlos Del Castillo Nieto Juan
Huguet Clotet Joan
De Ramon Amat Elisabet
Chalaux Freixa Maria
Mourella Mancini Marisabel
Original Assignee
Vita-Invest, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita-Invest, S. A. filed Critical Vita-Invest, S. A.
Publication of TR200200416T2 publication Critical patent/TR200200416T2/tr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Tramadol' den elde edilen ikame fenil-sikloheksil bilesimlerinden elde edilen yeni esterler, bunlarin elde edilme islemi ve analjezik özelliklere sahip olan ilacin hazirlanmasinda bunlarin kullanimi. Genel formülün (I) bu yeni bilesenleri daha yüksek bir analjezik aktiviteye, daha az toksiteye ve daha uzun bir etkinlik zamanina sahiptir.
TR2002/00416T 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. TR200200416T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.

Publications (1)

Publication Number Publication Date
TR200200416T2 true TR200200416T2 (tr) 2003-01-21

Family

ID=8305698

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2002/00416T TR200200416T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
TR2002/00415T TR200200415T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
TR2001/01160T TR200101160T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2002/00415T TR200200415T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.
TR2001/01160T TR200101160T2 (tr) 1998-11-06 1999-11-04 İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.

Country Status (39)

Country Link
US (1) US6455585B1 (tr)
EP (3) EP1219594B1 (tr)
JP (1) JP2002529442A (tr)
KR (1) KR100453613B1 (tr)
CN (1) CN1176902C (tr)
AP (1) AP1222A (tr)
AT (3) ATE257837T1 (tr)
AU (1) AU755681B2 (tr)
BG (1) BG105556A (tr)
BR (1) BR9915727A (tr)
CA (1) CA2349245A1 (tr)
CR (1) CR6368A (tr)
CU (1) CU23006A3 (tr)
CZ (1) CZ20011500A3 (tr)
DE (3) DE69911235T2 (tr)
DK (3) DK1219623T3 (tr)
EA (1) EA003742B1 (tr)
EE (1) EE200100246A (tr)
ES (4) ES2141688B1 (tr)
GE (1) GEP20033116B (tr)
HR (1) HRP20010412B1 (tr)
HU (1) HUP0104218A3 (tr)
ID (1) ID29017A (tr)
IL (1) IL142592A0 (tr)
IS (1) IS5934A (tr)
MA (1) MA26765A1 (tr)
MX (1) MXPA01004432A (tr)
NO (1) NO20012234D0 (tr)
NZ (1) NZ511739A (tr)
OA (1) OA11672A (tr)
PL (1) PL347492A1 (tr)
PT (3) PT1127871E (tr)
SI (3) SI1127871T1 (tr)
SK (1) SK284068B6 (tr)
TR (3) TR200200416T2 (tr)
UA (1) UA59477C2 (tr)
WO (1) WO2000027799A1 (tr)
YU (1) YU29601A (tr)
ZA (1) ZA200104026B (tr)

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ES2160534B1 (es) * 1999-12-30 2002-04-16 Vita Invest Sa Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
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US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
AU2003264311A1 (en) * 2002-08-28 2004-04-08 Jin Wang Oral formulations of ibuprofen and tramadol, methods and preparation thereof
PT1562567T (pt) * 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
AU2009207796B2 (en) 2008-01-25 2014-03-27 Grunenthal Gmbh Pharmaceutical dosage form
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
CA2765971C (en) 2009-07-22 2017-08-22 Gruenenthal Gmbh Hot-melt extruded controlled release dosage form
ES2428938T3 (es) 2009-07-22 2013-11-12 Grünenthal GmbH Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación
EP2383255A1 (en) * 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
PL2611425T3 (pl) 2010-09-02 2014-09-30 Gruenenthal Gmbh Odporna na ingerencję postać dawki zawierająca polimer anionowy
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
HRP20171458T1 (hr) 2011-07-29 2017-11-17 Grünenthal GmbH Tableta otporna na mijenjanje koja pruža neposredno oslobađanje lijeka
PL2736495T3 (pl) 2011-07-29 2018-01-31 Gruenenthal Gmbh Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku
WO2013127831A1 (en) 2012-02-28 2013-09-06 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
LT2838512T (lt) 2012-04-18 2018-11-12 Grünenthal GmbH Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US9339484B2 (en) * 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
JP2017518980A (ja) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールを含む、改変防止即時放出カプセル製剤
KR20170139158A (ko) 2015-04-24 2017-12-18 그뤼넨탈 게엠베하 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태
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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
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Also Published As

Publication number Publication date
EA200100476A1 (ru) 2002-02-28
DK1219594T3 (da) 2004-04-19
DE69914229D1 (de) 2004-02-19
UA59477C2 (uk) 2003-09-15
SI1127871T1 (en) 2004-02-29
CA2349245A1 (en) 2000-05-18
DE69914231D1 (de) 2004-02-19
ES2141688B1 (es) 2001-02-01
PL347492A1 (en) 2002-04-08
SI1219594T1 (en) 2004-06-30
EP1219594A1 (en) 2002-07-03
CN1325377A (zh) 2001-12-05
HRP20010412B1 (en) 2004-04-30
YU29601A (sh) 2003-04-30
CU23006A3 (es) 2004-12-17
HUP0104218A2 (hu) 2002-03-28
KR20010080942A (ko) 2001-08-25
EP1219594B1 (en) 2004-01-14
EP1219623B1 (en) 2004-01-14
PT1219623E (pt) 2004-04-30
ES2213732T3 (es) 2004-09-01
TR200200415T2 (tr) 2002-06-21
EP1219623A1 (en) 2002-07-03
SI1219623T1 (en) 2004-06-30
PT1219594E (pt) 2004-04-30
ATE257837T1 (de) 2004-01-15
DE69911235T2 (de) 2004-07-01
AU755681B2 (en) 2002-12-19
ES2213731T3 (es) 2004-09-01
HUP0104218A3 (en) 2002-11-28
ATE249418T1 (de) 2003-09-15
SK5842001A3 (en) 2001-12-03
NO20012234L (no) 2001-05-04
NO20012234D0 (no) 2001-05-04
HRP20010412A2 (en) 2002-12-31
AP1222A (en) 2003-11-06
ZA200104026B (en) 2002-05-17
DE69914229T2 (de) 2004-12-09
GEP20033116B (en) 2003-11-25
CN1176902C (zh) 2004-11-24
JP2002529442A (ja) 2002-09-10
MXPA01004432A (es) 2002-09-18
CZ20011500A3 (cs) 2001-09-12
IL142592A0 (en) 2002-03-10
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
BR9915727A (pt) 2001-09-04
PT1127871E (pt) 2003-12-31
DE69911235D1 (de) 2003-10-16
EP1127871A1 (en) 2001-08-29
US6455585B1 (en) 2002-09-24
KR100453613B1 (ko) 2004-10-20
DK1127871T3 (da) 2003-11-24
WO2000027799A1 (es) 2000-05-18
ES2141688A1 (es) 2000-05-16
CR6368A (es) 2002-04-08
ATE257817T1 (de) 2004-01-15
EP1127871B1 (en) 2003-09-10
DE69914231T2 (de) 2004-11-11
IS5934A (is) 2001-05-03
NZ511739A (en) 2002-11-26
OA11672A (en) 2005-01-12
MA26765A1 (fr) 2004-12-20
EA003742B1 (ru) 2003-08-28
ID29017A (id) 2001-07-26
TR200101160T2 (tr) 2002-01-21
ES2207298T3 (es) 2004-05-16
SK284068B6 (sk) 2004-09-08
BG105556A (en) 2001-12-29
AU1047300A (en) 2000-05-29

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