EE200100246A - Asendatud fenüültsükloheksüülühendite uued esterderivaadid - Google Patents
Asendatud fenüültsükloheksüülühendite uued esterderivaadidInfo
- Publication number
- EE200100246A EE200100246A EEP200100246A EEP200100246A EE200100246A EE 200100246 A EE200100246 A EE 200100246A EE P200100246 A EEP200100246 A EE P200100246A EE P200100246 A EEP200100246 A EE P200100246A EE 200100246 A EE200100246 A EE 200100246A
- Authority
- EE
- Estonia
- Prior art keywords
- substituted
- ester derivatives
- novel ester
- phenylcyclohexyl
- compounds
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- 125000004351 phenylcyclohexyl group Chemical group C1(=CC=CC=C1)C1(CCCCC1)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C219/30—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009802329A ES2141688B1 (es) | 1998-11-06 | 1998-11-06 | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
| PCT/ES1999/000352 WO2000027799A1 (es) | 1998-11-06 | 1999-11-04 | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200100246A true EE200100246A (et) | 2002-12-16 |
Family
ID=8305698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200100246A EE200100246A (et) | 1998-11-06 | 1999-11-04 | Asendatud fenüültsükloheksüülühendite uued esterderivaadid |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6455585B1 (xx) |
| EP (3) | EP1219594B1 (xx) |
| JP (1) | JP2002529442A (xx) |
| KR (1) | KR100453613B1 (xx) |
| CN (1) | CN1176902C (xx) |
| AP (1) | AP1222A (xx) |
| AT (3) | ATE257837T1 (xx) |
| AU (1) | AU755681B2 (xx) |
| BG (1) | BG105556A (xx) |
| BR (1) | BR9915727A (xx) |
| CA (1) | CA2349245A1 (xx) |
| CR (1) | CR6368A (xx) |
| CU (1) | CU23006A3 (xx) |
| CZ (1) | CZ20011500A3 (xx) |
| DE (3) | DE69914231T2 (xx) |
| DK (3) | DK1219623T3 (xx) |
| EA (1) | EA003742B1 (xx) |
| EE (1) | EE200100246A (xx) |
| ES (4) | ES2141688B1 (xx) |
| GE (1) | GEP20033116B (xx) |
| HR (1) | HRP20010412B1 (xx) |
| HU (1) | HUP0104218A3 (xx) |
| ID (1) | ID29017A (xx) |
| IL (1) | IL142592A0 (xx) |
| IS (1) | IS5934A (xx) |
| MA (1) | MA26765A1 (xx) |
| MX (1) | MXPA01004432A (xx) |
| NO (1) | NO20012234D0 (xx) |
| NZ (1) | NZ511739A (xx) |
| OA (1) | OA11672A (xx) |
| PL (1) | PL347492A1 (xx) |
| PT (3) | PT1127871E (xx) |
| SI (3) | SI1219623T1 (xx) |
| SK (1) | SK284068B6 (xx) |
| TR (3) | TR200200415T2 (xx) |
| UA (1) | UA59477C2 (xx) |
| WO (1) | WO2000027799A1 (xx) |
| YU (1) | YU29601A (xx) |
| ZA (1) | ZA200104026B (xx) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2160534B1 (es) * | 1999-12-30 | 2002-04-16 | Vita Invest Sa | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. |
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| WO2004026291A1 (en) * | 2002-08-28 | 2004-04-01 | Shuyi Zhang | Oral formulations of ibuprofen and tramadol, methods and preparation thereof |
| EP1562567B1 (de) | 2002-11-22 | 2017-06-14 | Grünenthal GmbH | Kombination ausgewählter analgetika mit cox ii-inhibitoren |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102004034619A1 (de) * | 2004-07-16 | 2006-02-23 | Grünenthal GmbH | Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| TWI524904B (zh) | 2008-05-09 | 2016-03-11 | 歌林達股份有限公司 | 製備醫藥用固體劑型，尤指錠劑之方法，及製備固體劑型，尤指錠劑之前驅物之方法 |
| NZ596668A (en) | 2009-07-22 | 2013-09-27 | Gruenenthal Chemie | Oxidation-stabilized tamper-resistant dosage form |
| JP5667183B2 (ja) | 2009-07-22 | 2015-02-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 加熱溶融押出成型した制御放出性投与剤型 |
| EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
| ES2486791T3 (es) | 2010-09-02 | 2014-08-19 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación que comprende una sal inorgánica |
| WO2012100423A1 (en) * | 2011-01-27 | 2012-08-02 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
| EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
| PE20141650A1 (es) | 2011-07-29 | 2014-11-22 | Gruenenthal Chemie | Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco |
| EA201400172A1 (ru) | 2011-07-29 | 2014-06-30 | Грюненталь Гмбх | Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства |
| WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| ES2692944T3 (es) | 2012-04-18 | 2018-12-05 | Grünenthal GmbH | Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis |
| US9339484B2 (en) * | 2012-05-10 | 2016-05-17 | Cellix Bio Private Limited | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| BR112015026549A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem à prova de violação contendo uma ou mais partículas |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| AU2014289187B2 (en) | 2013-07-12 | 2019-07-11 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| AU2014356581C1 (en) | 2013-11-26 | 2020-05-28 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| MX2016014738A (es) | 2014-05-12 | 2017-03-06 | Gruenenthal Gmbh | Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol. |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1199764B (de) * | 1963-04-02 | 1965-09-02 | Gruenenthal Chemie | Verfahren zur Herstellung von basisch substituierten Phenolaethern |
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
-
1998
- 1998-11-06 ES ES009802329A patent/ES2141688B1/es not_active Expired - Fee Related
-
1999
- 1999-04-11 UA UA2001063799A patent/UA59477C2/uk unknown
- 1999-11-04 DE DE69914231T patent/DE69914231T2/de not_active Expired - Fee Related
- 1999-11-04 OA OA1200100111A patent/OA11672A/en unknown
- 1999-11-04 BR BR9915727-6A patent/BR9915727A/pt not_active IP Right Cessation
- 1999-11-04 DK DK02075837T patent/DK1219623T3/da active
- 1999-11-04 EP EP02075838A patent/EP1219594B1/en not_active Expired - Lifetime
- 1999-11-04 AP APAP/P/2001/002161A patent/AP1222A/en active
- 1999-11-04 EE EEP200100246A patent/EE200100246A/xx unknown
- 1999-11-04 TR TR2002/00415T patent/TR200200415T2/xx unknown
- 1999-11-04 SI SI9930541T patent/SI1219623T1/xx unknown
- 1999-11-04 AT AT02075837T patent/ATE257837T1/de not_active IP Right Cessation
- 1999-11-04 KR KR10-2001-7005667A patent/KR100453613B1/ko not_active Expired - Fee Related
- 1999-11-04 US US09/831,177 patent/US6455585B1/en not_active Expired - Fee Related
- 1999-11-04 EA EA200100476A patent/EA003742B1/ru not_active IP Right Cessation
- 1999-11-04 ES ES02075837T patent/ES2213731T3/es not_active Expired - Lifetime
- 1999-11-04 HR HR20010412A patent/HRP20010412B1/xx not_active IP Right Cessation
- 1999-11-04 TR TR2002/00416T patent/TR200200416T2/xx unknown
- 1999-11-04 TR TR2001/01160T patent/TR200101160T2/xx unknown
- 1999-11-04 CZ CZ20011500A patent/CZ20011500A3/cs unknown
- 1999-11-04 IL IL14259299A patent/IL142592A0/xx unknown
- 1999-11-04 NZ NZ511739A patent/NZ511739A/xx unknown
- 1999-11-04 AT AT02075838T patent/ATE257817T1/de not_active IP Right Cessation
- 1999-11-04 AT AT99953994T patent/ATE249418T1/de not_active IP Right Cessation
- 1999-11-04 YU YU29601A patent/YU29601A/sh unknown
- 1999-11-04 SI SI9930540T patent/SI1219594T1/xx unknown
- 1999-11-04 DK DK99953994T patent/DK1127871T3/da active
- 1999-11-04 PT PT99953994T patent/PT1127871E/pt unknown
- 1999-11-04 PL PL99347492A patent/PL347492A1/xx unknown
- 1999-11-04 CN CNB998129259A patent/CN1176902C/zh not_active Expired - Fee Related
- 1999-11-04 DK DK02075838T patent/DK1219594T3/da active
- 1999-11-04 SI SI9930450T patent/SI1127871T1/xx unknown
- 1999-11-04 ID IDW00200101215A patent/ID29017A/id unknown
- 1999-11-04 WO PCT/ES1999/000352 patent/WO2000027799A1/es not_active Ceased
- 1999-11-04 ES ES99953994T patent/ES2207298T3/es not_active Expired - Lifetime
- 1999-11-04 SK SK584-2001A patent/SK284068B6/sk unknown
- 1999-11-04 ES ES02075838T patent/ES2213732T3/es not_active Expired - Lifetime
- 1999-11-04 JP JP2000580979A patent/JP2002529442A/ja active Pending
- 1999-11-04 PT PT02075838T patent/PT1219594E/pt unknown
- 1999-11-04 MX MXPA01004432A patent/MXPA01004432A/es unknown
- 1999-11-04 CA CA002349245A patent/CA2349245A1/en not_active Abandoned
- 1999-11-04 EP EP99953994A patent/EP1127871B1/en not_active Expired - Lifetime
- 1999-11-04 EP EP02075837A patent/EP1219623B1/en not_active Expired - Lifetime
- 1999-11-04 DE DE69914229T patent/DE69914229T2/de not_active Expired - Fee Related
- 1999-11-04 HU HU0104218A patent/HUP0104218A3/hu unknown
- 1999-11-04 AU AU10473/00A patent/AU755681B2/en not_active Ceased
- 1999-11-04 DE DE69911235T patent/DE69911235T2/de not_active Expired - Fee Related
- 1999-11-04 GE GEAP19995930A patent/GEP20033116B/en unknown
- 1999-11-04 PT PT02075837T patent/PT1219623E/pt unknown
-
2001
- 2001-05-03 IS IS5934A patent/IS5934A/is unknown
- 2001-05-04 NO NO20012234A patent/NO20012234D0/no unknown
- 2001-05-07 CU CU2001010920010109A patent/CU23006A3/es unknown
- 2001-05-16 CR CR6368A patent/CR6368A/es not_active Application Discontinuation
- 2001-05-17 ZA ZA200104026A patent/ZA200104026B/en unknown
- 2001-05-23 MA MA26211A patent/MA26765A1/fr unknown
- 2001-06-01 BG BG105556A patent/BG105556A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB1A | Change in the ownership or in the address of the owner |