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TR200200076T2 - Oral yoldan aktif androjenler - Google Patents

Oral yoldan aktif androjenler

Info

Publication number
TR200200076T2
TR200200076T2 TR2002/00076T TR200200076T TR200200076T2 TR 200200076 T2 TR200200076 T2 TR 200200076T2 TR 2002/00076 T TR2002/00076 T TR 2002/00076T TR 200200076 T TR200200076 T TR 200200076T TR 200200076 T2 TR200200076 T2 TR 200200076T2
Authority
TR
Turkey
Prior art keywords
alkyl
hydrogen
orally active
active androgens
acyl
Prior art date
Application number
TR2002/00076T
Other languages
English (en)
Inventor
Jan Jozef Loozen Hubert
Leysen Dirk
Van Der Louw Jaap
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of TR200200076T2 publication Critical patent/TR200200076T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Yeni, oral yoldan aktif androjenler, 7 alfa ikameli delta14-nandrolon türevleridir. Bilesikler, fomül (I)'e sahiptirler; buradaki R1, O, (H,H) (H, OR), NOR'dir; R, hidrojen, (C1-6) alkil veya (C1-6) asildir; R2, herbiri seçime bagli olarak halojenle ikame edilen (C2-4) alkil, (C2-4) alkenil veya (C2-4) alkinilden olusan gruptan seçilir; veya R2, herbiri seçime bagli olarak (C1-2) alkil veya halojenle ikame edilen siklopropil veya siklopropenildir; R3, hidrojen, (C^-2) alkil veya etenildir; R4, (C1-2) alkildir; R5, hidrojen veya (C1-15) asildir; ve nokta nokta çizgiler, seçime bagli baglari gösterirler (FORMÜL VAR).
TR2002/00076T 1999-07-16 2000-07-10 Oral yoldan aktif androjenler TR200200076T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202348 1999-07-16

Publications (1)

Publication Number Publication Date
TR200200076T2 true TR200200076T2 (tr) 2002-04-22

Family

ID=8240463

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00076T TR200200076T2 (tr) 1999-07-16 2000-07-10 Oral yoldan aktif androjenler

Country Status (28)

Country Link
US (3) US6313108B1 (tr)
EP (1) EP1203011B1 (tr)
JP (1) JP2003505394A (tr)
KR (1) KR20020092890A (tr)
CN (1) CN1360589A (tr)
AR (1) AR024746A1 (tr)
AT (1) ATE257159T1 (tr)
AU (1) AU770412B2 (tr)
BR (1) BR0012489A (tr)
CA (1) CA2379223A1 (tr)
CO (1) CO5200765A1 (tr)
CZ (1) CZ2002192A3 (tr)
DE (1) DE60007530T2 (tr)
ES (1) ES2213596T3 (tr)
HK (1) HK1043797A1 (tr)
HU (1) HUP0201952A3 (tr)
IL (1) IL147332A0 (tr)
MX (1) MXPA02000601A (tr)
NO (1) NO20020222L (tr)
NZ (1) NZ516525A (tr)
PE (1) PE20010330A1 (tr)
PL (1) PL353007A1 (tr)
RU (1) RU2002103883A (tr)
SK (1) SK712002A3 (tr)
TR (1) TR200200076T2 (tr)
TW (1) TW548277B (tr)
WO (1) WO2001005806A1 (tr)
ZA (1) ZA200200106B (tr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5209600A (en) * 1999-04-06 2000-10-23 Akzo Nobel N.V. Orally active androgens
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
EP1272196B1 (en) * 2000-03-31 2006-08-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha,11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
BR0112791A (pt) * 2000-07-28 2003-06-24 Akzo Nobel Nv Composto esteroidal 16alfa-substituido, uso do mesmo, métodos de tratamento para ativação seletiva de receptores de estrogênio do subtipo alfa, e para terapia de reposição hormonal ou contracepção, e, composição farmacêutica
DK1379253T3 (da) * 2001-03-30 2006-06-26 Us Gov Health & Human Serv Fremgangsmåde til fremstilling og anvendelse af farmaceutiske formuleringer omfattende 7alfa, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-on og 17-estere heraf
RS51490B (sr) * 2002-01-21 2011-04-30 N.V. Organon POSTUPAK ZA IZRADU 7α-METILSTEROIDA
GB0304927D0 (en) * 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
EP2350111A1 (en) * 2008-10-15 2011-08-03 Synthon B.V. Processes and intermediates for the production of fulvestrant
MX341561B (es) 2011-06-01 2016-08-25 Estetra Sprl Proceso para la produccion de intermediarios de estetrol.
PL2714712T3 (pl) * 2011-06-01 2017-05-31 Estetra S.P.R.L. Metoda wytwarzania półproduktów estetrolu
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
PL2764008T3 (pl) * 2011-10-07 2017-04-28 Estetra S.P.R.L. Sposób wytwarzania estetrolu
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
JP6866560B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
MA44206B1 (fr) 2015-06-18 2021-04-30 Estetra Sprl Comprimé orodispersible comprenant estetrol
JP6863547B2 (ja) 2015-06-18 2021-04-21 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
CN116693587A (zh) * 2017-02-23 2023-09-05 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712312B (en) * 1970-04-28 1972-01-26 Ochsner Med Found Alton 4,14-estradiene compounds

Also Published As

Publication number Publication date
MXPA02000601A (es) 2002-07-30
SK712002A3 (en) 2002-06-04
DE60007530D1 (de) 2004-02-05
TW548277B (en) 2003-08-21
US20030087886A1 (en) 2003-05-08
CZ2002192A3 (cs) 2002-06-12
NO20020222D0 (no) 2002-01-15
CA2379223A1 (en) 2001-01-25
AU6562900A (en) 2001-02-05
US6541465B2 (en) 2003-04-01
IL147332A0 (en) 2002-08-14
ATE257159T1 (de) 2004-01-15
NZ516525A (en) 2003-06-30
US6780854B2 (en) 2004-08-24
PL353007A1 (en) 2003-09-22
RU2002103883A (ru) 2004-02-27
US6313108B1 (en) 2001-11-06
KR20020092890A (ko) 2002-12-12
HUP0201952A2 (en) 2002-10-28
PE20010330A1 (es) 2001-03-22
HUP0201952A3 (en) 2003-10-28
CN1360589A (zh) 2002-07-24
EP1203011A1 (en) 2002-05-08
JP2003505394A (ja) 2003-02-12
BR0012489A (pt) 2002-04-02
NO20020222L (no) 2002-01-25
WO2001005806A1 (en) 2001-01-25
EP1203011B1 (en) 2004-01-02
DE60007530T2 (de) 2004-12-23
AU770412B2 (en) 2004-02-19
AR024746A1 (es) 2002-10-23
CO5200765A1 (es) 2002-09-27
HK1043797A1 (zh) 2002-09-27
ES2213596T3 (es) 2004-09-01
ZA200200106B (en) 2003-06-25
US20020022609A1 (en) 2002-02-21

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