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TR200102074T2 - Telmisartan polimorflarının elde edilme yöntemi ve ilaç yapımında kullanılması - Google Patents

Telmisartan polimorflarının elde edilme yöntemi ve ilaç yapımında kullanılması

Info

Publication number
TR200102074T2
TR200102074T2 TR2001/02074T TR200102074T TR200102074T2 TR 200102074 T2 TR200102074 T2 TR 200102074T2 TR 2001/02074 T TR2001/02074 T TR 2001/02074T TR 200102074 T TR200102074 T TR 200102074T TR 200102074 T2 TR200102074 T2 TR 200102074T2
Authority
TR
Turkey
Prior art keywords
polymorphs
obtaining
drug making
telmisartan
polymorph
Prior art date
Application number
TR2001/02074T
Other languages
English (en)
Inventor
Schneider Heinrich
Original Assignee
Boehringer Ingelheim Pharma Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Kg. filed Critical Boehringer Ingelheim Pharma Kg.
Publication of TR200102074T2 publication Critical patent/TR200102074T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bulus 4'[2-n-propil-4-metil-6-(1-metil benzimidazol-2-il) benzimidazol-1-ilmetil]bifenil-2-karbonik asit (INN: Telmisartan) polimorfu, özellikle termik analiz sirasinda diferensiyal tarama kalorimetrisi yardimiyla 183+2 C'de olusan endoterm maksimum ile karakterize edilen, formül (I) yapisindaki polimorf B sekli ile ilgilidir, Bulus ayrica adi geçen polimorflarin karisimlari, sekil B içeren telmisartan elde etme yöntemleri ve bunlarin bir ilaç yapiminda kullanilmalari ile de ilgilidir.Formül var...
TR2001/02074T 1999-01-19 2000-01-07 Telmisartan polimorflarının elde edilme yöntemi ve ilaç yapımında kullanılması TR200102074T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19901921A DE19901921C2 (de) 1999-01-19 1999-01-19 Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels

Publications (1)

Publication Number Publication Date
TR200102074T2 true TR200102074T2 (tr) 2001-12-21

Family

ID=7894715

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02074T TR200102074T2 (tr) 1999-01-19 2000-01-07 Telmisartan polimorflarının elde edilme yöntemi ve ilaç yapımında kullanılması

Country Status (36)

Country Link
EP (1) EP1144386B1 (tr)
JP (1) JP4700813B2 (tr)
KR (1) KR100658959B1 (tr)
CN (1) CN1144790C (tr)
AR (1) AR035475A1 (tr)
AT (1) ATE252564T1 (tr)
AU (1) AU765081B2 (tr)
BG (1) BG65027B1 (tr)
BR (1) BR0007584A (tr)
CA (1) CA2352436C (tr)
CO (1) CO5150238A1 (tr)
CZ (1) CZ297412B6 (tr)
DE (2) DE19901921C2 (tr)
DK (1) DK1144386T3 (tr)
EA (1) EA003065B1 (tr)
EE (1) EE04344B1 (tr)
ES (1) ES2208265T3 (tr)
HK (1) HK1041485B (tr)
HR (1) HRP20010514B1 (tr)
HU (1) HU227401B1 (tr)
IL (2) IL143634A0 (tr)
MY (1) MY122755A (tr)
NO (1) NO319823B1 (tr)
NZ (1) NZ513528A (tr)
PE (1) PE20001362A1 (tr)
PL (1) PL211829B1 (tr)
PT (1) PT1144386E (tr)
RS (1) RS50044B (tr)
SA (1) SA99200838B1 (tr)
SK (1) SK285429B6 (tr)
TR (1) TR200102074T2 (tr)
TW (1) TWI280241B (tr)
UA (1) UA56358C2 (tr)
UY (1) UY25980A1 (tr)
WO (1) WO2000043370A1 (tr)
ZA (1) ZA200104771B (tr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10153737A1 (de) * 2001-10-31 2003-05-28 Boehringer Ingelheim Pharma Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US6737432B2 (en) 2001-10-31 2004-05-18 Boehringer Ingelheim Pharma Kg Crystalline form of telmisartan sodium
AU2002242676B2 (en) * 2002-01-16 2008-05-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bilayer pharmaceutical tablet comprising telmisartan and a diuretic and preparation thereof
DE10314702A1 (de) 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
GB2414019A (en) * 2004-05-11 2005-11-16 Cipla Ltd One-step preparation of telmisartan by condensation and hydrolysis
CN101039917A (zh) 2004-10-15 2007-09-19 特瓦制药工业有限公司 制备替米沙坦的方法
US7943781B2 (en) 2004-10-18 2011-05-17 Dr. Reddy's Laboratories Limited Process for preparing telmisartan
US8637078B2 (en) 2005-11-24 2014-01-28 Boehringer Ingelheim International Gmbh Bilayer tablet comprising telmisartan and diuretic
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
AR076913A1 (es) 2009-05-20 2011-07-20 Boehringer Ingelheim Vetmed Solucion farmaceutica bebible de telmisartan. metodo para preparar la solucion
PL2443094T3 (pl) 2009-06-19 2013-08-30 Krka Tovarna Zdravil D D Novo Mesto Sposób wytwarzania telmisartanu
EP2277866A1 (en) 2009-06-22 2011-01-26 Inke, S.A. Process for preparing telmisartan
EP2448575A2 (en) 2009-07-02 2012-05-09 Bilgic Mahmut Pharmaceutical composition increasing solubility and stability
EP2448576A2 (en) 2009-07-02 2012-05-09 Mahmut Bilgic Solubility enhancing pharmaceutical composition
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
ITMI20102416A1 (it) * 2010-12-27 2012-06-28 Chemelectiva S R L Intermedio per la preparazione di un principio attivo e processo per la sua preparazione
EP2612658A1 (en) 2012-01-05 2013-07-10 Laboratorios Lesvi, S.L. Pharmaceutical compositions of 4'-[(1,4'dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid and is 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
JP6147546B2 (ja) * 2013-04-10 2017-06-14 株式会社トクヤマ 酢酸が低減されたテルミサルタンａ型結晶の製造方法
EP2979691A1 (en) 2014-07-30 2016-02-03 Boehringer Ingelheim International GmbH Oral disintegrating tablet
JP6275596B2 (ja) * 2014-09-03 2018-02-07 株式会社トクヤマ テルミサルタンのアンモニウム塩の製造方法
JP5871294B1 (ja) 2015-02-27 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 即時放出経口錠剤
KR20170001921A (ko) 2015-06-26 2017-01-05 대원제약주식회사 안정성이 개선된 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
KR20170012703A (ko) 2015-07-22 2017-02-03 대원제약주식회사 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
EP3463309B1 (en) 2016-05-30 2020-06-17 Boehringer Ingelheim International GmbH Fixed dose combination of telmisartan, hydrochlorothiazide and amlodipine
KR102044223B1 (ko) * 2016-09-12 2019-11-13 성균관대학교산학협력단 텔미사르탄을 포함하는 고체 분산체 및 이의 제조방법
CN106749036B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-庚二酸共晶及其制备方法和应用
CN106749037B (zh) * 2016-12-21 2019-06-21 山东大学 一种无定型的替米沙坦-戊二酸共晶及其制备方法和应用
ES2979279T3 (es) 2017-07-07 2024-09-25 Boehringer Ingelheim Vetmedica Gmbh Telmisartán para la profilaxis o el tratamiento de la hipertensión en gatos
CN109851562A (zh) * 2019-01-30 2019-06-07 浙江省食品药品检验研究院 一种替米沙坦晶体及其制备方法
WO2023001880A1 (en) 2021-07-22 2023-01-26 Krka, D. D., Novo Mesto Bilayer tablet comprising telmisartan and indapamide
TW202508593A (zh) 2023-05-24 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 包含一或多種sglt-2抑制劑及匹莫苯坦(pimobendan)及/或替米沙坦(telmisartan)之非人類哺乳動物心臟病之組合治療及/或預防
AU2024277852A1 (en) 2023-05-24 2025-10-16 Boehringer Ingelheim Vetmedica Gmbh Combination treatment and/or prevention of renal diseases and/or hypertension in non-human mammals comprising one or more sglt-2 inhibitors and telmisartan
US20250195525A1 (en) 2023-12-15 2025-06-19 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonist for the prevention of systemic diseases in cats

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SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5139114A (en) * 1991-03-18 1992-08-18 Abex Corporation Visible brake block wear indicator

Also Published As

Publication number Publication date
SK10202001A3 (sk) 2001-12-03
PE20001362A1 (es) 2000-12-15
UY25980A1 (es) 2001-08-27
YU51101A (sh) 2004-05-12
HU227401B1 (en) 2011-05-30
NZ513528A (en) 2003-08-29
HRP20010514A2 (en) 2002-08-31
BG105654A (bg) 2002-01-31
BG65027B1 (bg) 2006-12-29
AU765081B2 (en) 2003-09-11
EA200100730A1 (ru) 2002-02-28
CA2352436A1 (en) 2000-07-27
HUP0105148A3 (en) 2003-01-28
PT1144386E (pt) 2004-03-31
AU2288100A (en) 2000-08-07
EP1144386B1 (de) 2003-10-22
HUP0105148A2 (hu) 2002-07-29
KR20010101552A (ko) 2001-11-14
NO319823B1 (no) 2005-09-19
CA2352436C (en) 2010-03-23
SA99200838B1 (ar) 2006-03-06
MY122755A (en) 2006-05-31
NO20013560L (no) 2001-09-18
CO5150238A1 (es) 2002-04-29
ATE252564T1 (de) 2003-11-15
DK1144386T3 (da) 2004-01-12
UA56358C2 (uk) 2003-05-15
EE200100375A (et) 2002-10-15
IL143634A (en) 2006-10-05
RS50044B (sr) 2008-11-28
KR100658959B1 (ko) 2006-12-19
JP4700813B2 (ja) 2011-06-15
CN1336920A (zh) 2002-02-20
CN1144790C (zh) 2004-04-07
IL143634A0 (en) 2002-04-21
HK1041485B (zh) 2004-10-08
HRP20010514B1 (en) 2010-01-31
BR0007584A (pt) 2001-11-06
CZ20012634A3 (cs) 2001-10-17
EE04344B1 (et) 2004-08-16
ZA200104771B (en) 2002-12-02
DE19901921C2 (de) 2001-01-04
JP2002535315A (ja) 2002-10-22
ES2208265T3 (es) 2004-06-16
PL211829B1 (pl) 2012-06-29
HK1041485A1 (en) 2002-07-12
AR035475A1 (es) 2004-06-02
DE50004150D1 (de) 2003-11-27
SK285429B6 (sk) 2007-01-04
EP1144386A1 (de) 2001-10-17
TWI280241B (en) 2007-05-01
CZ297412B6 (cs) 2006-12-13
NO20013560D0 (no) 2001-07-18
EA003065B1 (ru) 2002-12-26
WO2000043370A1 (de) 2000-07-27
DE19901921A1 (de) 2000-08-03
PL349425A1 (en) 2002-07-29

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