[go: up one dir, main page]

TR200100868T2 - Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları. - Google Patents

Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları.

Info

Publication number
TR200100868T2
TR200100868T2 TR2001/00868T TR200100868T TR200100868T2 TR 200100868 T2 TR200100868 T2 TR 200100868T2 TR 2001/00868 T TR2001/00868 T TR 2001/00868T TR 200100868 T TR200100868 T TR 200100868T TR 200100868 T2 TR200100868 T2 TR 200100868T2
Authority
TR
Turkey
Prior art keywords
manufacture
benzocyclohepta
indeno
naphtho
derivatives
Prior art date
Application number
TR2001/00868T
Other languages
English (en)
Inventor
Jahne Gerhard
Glombik Heiner
Geisen Karl
Bickel Martin
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200100868T2 publication Critical patent/TR200100868T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Polisiklik dihidrotiyazoller, imal edilmelerine yönelik yöntem ve ilaç maddesi olarak kullanimlari. Bulus polisiklik dihidrotiyazoller ve ayrica onlarin fizyolojik olarak hazmedilebilen tuzlari ve fizyolojik islevleri olan türevleri. Formül 1'in (FORMÜL VAR) içerisindeki artiklarin belirtilmis olan anlamlara geldigi, ve ayrica onlarin fizyolojik olarak hazmedilebilen tuzlari ve onlarin imal edilmesine yönelik yöntem tanimlanmaktadir. Bilesimler örnegin anorektikler olarak birebirdirler.
TR2001/00868T 1998-09-29 1999-09-16 Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları. TR200100868T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19844547A DE19844547C2 (de) 1998-09-29 1998-09-29 Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
TR200100868T2 true TR200100868T2 (tr) 2001-09-21

Family

ID=7882588

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00868T TR200100868T2 (tr) 1998-09-29 1999-09-16 Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları.

Country Status (25)

Country Link
US (2) US6090833A (tr)
EP (1) EP1119557B1 (tr)
JP (1) JP3542078B2 (tr)
KR (1) KR20010079952A (tr)
CN (1) CN1143852C (tr)
AR (1) AR020662A1 (tr)
AT (1) ATE255569T1 (tr)
AU (1) AU755158B2 (tr)
BR (1) BR9915014A (tr)
CA (1) CA2345359A1 (tr)
DE (2) DE19844547C2 (tr)
DK (1) DK1119557T3 (tr)
ES (1) ES2212673T3 (tr)
HK (1) HK1040080B (tr)
HU (1) HUP0103504A3 (tr)
ID (1) ID29578A (tr)
IL (1) IL142096A0 (tr)
NO (1) NO318388B1 (tr)
NZ (1) NZ510399A (tr)
PL (1) PL347072A1 (tr)
PT (1) PT1119557E (tr)
RU (1) RU2217427C2 (tr)
TR (1) TR200100868T2 (tr)
WO (1) WO2000018749A1 (tr)
ZA (1) ZA200102446B (tr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT1230230E (pt) * 1999-11-05 2003-12-31 Aventis Pharma Gmbh Derivados de indeno-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorexigenico
BR0108605A (pt) 2000-02-23 2002-11-19 Aventis Pharma Gmbh Derivados de 8,8a-dihidro-indeno[1,2-d]tiazol, que na posição 8a são substituìdos; processos para a sua preparação e seu emprego como medicamentos, por exemplo, como anoréxicos
DE10008274A1 (de) 2000-02-23 2001-08-30 Aventis Pharma Gmbh Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2001244136B2 (en) * 2000-02-26 2005-04-14 Sanofi-Aventis Deutschland Gmbh 8,8a-dihydro-indeno[1,2-d]thiazole derivatives with a sulphonamido or sulphono substituent in the 2 position, method for production thereof and use thereof as medicament
DE10142722A1 (de) 2001-08-31 2003-03-27 Aventis Pharma Deutschland GmbH, 65929 Frankfurt C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10142665B4 (de) * 2001-08-31 2004-05-06 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-one und ihre Derivate
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2005097127A2 (en) 2004-04-02 2005-10-20 Merck & Co., Inc. Method of treating men with metabolic and anthropometric disorders
NZ574710A (en) 2006-09-07 2012-02-24 Nycomed Gmbh Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus
WO2008149346A2 (en) 2007-06-04 2008-12-11 Ben Gurion University Of The Negev Research And Development Authority Enhanced sensitivity polymerase chain reactions
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
SG192941A1 (en) 2011-02-25 2013-09-30 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
KR20150036245A (ko) 2012-08-02 2015-04-07 머크 샤프 앤드 돔 코포레이션 항당뇨병 트리시클릭 화합물
MX2015010935A (es) 2013-02-22 2015-10-29 Merck Sharp & Dohme Compuestos biciclicos antidiabeticos.
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2016005995A (es) 2013-11-05 2016-08-17 Ben-Gurion Univ Of The Negev Res And Dev Authority Compuestos para el tratamiento de diabetes y complicaciones de la enfermedad derivadas de la misma.
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. ANTIDIABETIC SPIROCHROMAN COMPOUNDS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2942003A (en) * 1957-06-06 1960-06-21 Gen Aniline & Film Corp Process for preparing naphtho [1, 2-d]-thiazoles
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
CA1292226C (en) * 1986-01-16 1991-11-19 Terumi Hachiya Indenothiazole derivative and process for preparing the same
JPH0514068A (ja) * 1991-07-03 1993-01-22 Shimada Phys & Chem Ind Co Ltd 並列増幅部切換型高周波低雑音増幅装置
JP3197602B2 (ja) * 1992-02-17 2001-08-13 久光製薬株式会社 チアゾール類縁化合物及び皮膚外用剤
WO1995024399A1 (en) * 1994-03-11 1995-09-14 Yamanouchi Pharmaceutical Co., Ltd. 5-ht3 receptor agonist, novel thiazole derivative, and intermediate therefor
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use

Also Published As

Publication number Publication date
NZ510399A (en) 2003-10-31
IL142096A0 (en) 2002-03-10
NO20011503D0 (no) 2001-03-23
ZA200102446B (en) 2001-09-28
AU5978799A (en) 2000-04-17
DE59907961D1 (de) 2004-01-15
NO318388B1 (no) 2005-03-14
CA2345359A1 (en) 2000-04-06
AU755158B2 (en) 2002-12-05
CN1143852C (zh) 2004-03-31
DE19844547A1 (de) 2000-03-30
DE19844547C2 (de) 2002-11-07
PL347072A1 (en) 2002-03-11
ATE255569T1 (de) 2003-12-15
KR20010079952A (ko) 2001-08-22
NO20011503L (no) 2001-03-23
HUP0103504A2 (hu) 2002-07-29
JP3542078B2 (ja) 2004-07-14
DK1119557T3 (da) 2004-04-13
HK1040080A1 (en) 2002-05-24
JP2002525363A (ja) 2002-08-13
WO2000018749A1 (de) 2000-04-06
US6291486B1 (en) 2001-09-18
CN1320120A (zh) 2001-10-31
HK1040080B (zh) 2004-08-20
EP1119557B1 (de) 2003-12-03
BR9915014A (pt) 2001-08-07
US6090833A (en) 2000-07-18
AR020662A1 (es) 2002-05-22
PT1119557E (pt) 2004-04-30
ID29578A (id) 2001-09-06
EP1119557A1 (de) 2001-08-01
RU2217427C2 (ru) 2003-11-27
ES2212673T3 (es) 2004-07-16
HUP0103504A3 (en) 2002-10-28

Similar Documents

Publication Publication Date Title
TR200100868T2 (tr) Indeno-,nafto-, benzosiklohepta-dihidrotiyazol türevleri, imalatları, anorektal ilaç olarak kullanılmaları.
TR200100894T2 (tr) Aril ikameli propanolamin türevleri, imalat yöntemleri, ilaç maddeleri, kullanımları.
SE9504661D0 (sv) New compounds
TR200003632T2 (tr) Benzotiyepin-1,1-dioksid türevleri, üretim yöntemi, bunları içeren ilaçlar.
MXPA03011510A (es) Derivados de5-halo-triptamina usados como ligandos de receptores de serotonina 5-ht-6 y/o 5-ht-7.
BG103413A (en) Derivatives of sulphinic acid, their production and application
ID23666A (id) Senyawa-senyawa kimia
PT1073470E (pt) Composicoes farmaceuticas contendo compostos com actividade capaz de melhorar a absorcao de ingredientes activos
IS2648B (is) Amínósýklóhexýletersambönd og notkun þeirra
ATE316083T1 (de) Adamantanderivate
MY124122A (en) Heterocyclic derivatives
WO2003045878A3 (en) 2,w-diaminocarboxylic acid compounds
CA2244785A1 (en) Pentafluorobenzenesulfonamides and analogs
DE68906609D1 (de) Dopamin-vorlaeufer.
MY115211A (en) Novel amino acid derivatives, their preparation and use
TR200101163T2 (tr) Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları
TR199700206A2 (tr) Floralkil- ve floralkoksi ikame edilmis heterosiklik bradikinin-antagonistleri, bunlarin imal edilmesine mahsus usul ve bunlarin kullanilmalari.
SE8804628D0 (sv) New compounds
NO306116B1 (no) Ny benzotiadiazinforbindelse og farmasöytiske sammensetninger
TR200100896T2 (tr) İkameli propanol türevleri, imalat yöntemleri, bileşimleri içeren ilaçlar, kullanımları
EP0387821A3 (de) 2-Alkyl-4-arylmethylaminochinoline, ihre Verwendung und daraus hergestellte Arzneimittel
MX9700807A (es) Derivados de 3-azabiciclo (3.2.0)heptano n-sustituidos utiles como neurolepticos.
BG104232A (bg) Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
DE69521122D1 (de) 2,3,4,5-tetrahydro-1h-3-benzazepin säure-additions-salze