TR199701577T1 - Dopamin sistemindeki bozukluklara bagli hastaliklarin tedavisi. - Google Patents
Dopamin sistemindeki bozukluklara bagli hastaliklarin tedavisi.Info
- Publication number
- TR199701577T1 TR199701577T1 TR97/01577T TR9701577T TR199701577T1 TR 199701577 T1 TR199701577 T1 TR 199701577T1 TR 97/01577 T TR97/01577 T TR 97/01577T TR 9701577 T TR9701577 T TR 9701577T TR 199701577 T1 TR199701577 T1 TR 199701577T1
- Authority
- TR
- Turkey
- Prior art keywords
- alkyl
- carbonyl
- amino
- hydrogen
- treatment
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003638 dopamine Drugs 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 201000010099 disease Diseases 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 lower-alkyl Inorganic materials 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bulus, genel formül (I)'e sahip bilesiklerin kullanimi ile ilgilidir; burada R1= hidrojen, düsük alkil, halojen, düsük alkoksi veya nitro; R2= hidrojen, düsük alkil veya triflorometil; ve R3= hidrojen, düsük alkil, triflorometil, benzil, hidroksi-düsük-alkil, düsük alkoksi, düsük-alkil-karbonil-amino, karbonil-düsük-alkil, benzil, di-düsük-alkil-amino-karbonil, karbonil-amino veya amino-karbonil-amino; veya R2 ve R3 birlikte opsiyonel olarak birlesmis bir benzen halkasi ve R4= hidrojen veya halojen'i ifade etmektedir. Ayrica formül (I)'e sahip bilesiklerin farmasötik olarak kabul edilebilir tuzlarinin dopamin sistemindeki bozukluklara bagli hastaliklarin tedavisi veya önlenmesinde ve ilgili ilaçlarin üretimlerinde kullanilmasi ile ilgilidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH170495 | 1995-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199701577T1 true TR199701577T1 (tr) | 1998-06-22 |
Family
ID=4216657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR97/01577T TR199701577T1 (tr) | 1995-06-09 | 1996-06-04 | Dopamin sistemindeki bozukluklara bagli hastaliklarin tedavisi. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5698565A (tr) |
| EP (1) | EP0837680B1 (tr) |
| JP (1) | JP3004732B2 (tr) |
| AT (1) | ATE198984T1 (tr) |
| AU (1) | AU6300396A (tr) |
| BR (1) | BR9609196A (tr) |
| CA (1) | CA2222226A1 (tr) |
| DE (1) | DE69611727T2 (tr) |
| DK (1) | DK0837680T3 (tr) |
| ES (1) | ES2154828T3 (tr) |
| GR (1) | GR3035703T3 (tr) |
| PT (1) | PT837680E (tr) |
| TR (1) | TR199701577T1 (tr) |
| WO (1) | WO1996041629A1 (tr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT885004E (pt) * | 1996-03-08 | 2002-08-30 | Hoffmann La Roche | Utilizacao de derivados de 4-fenil-3,6-di-hidro-2h-piridilo como bloqueadores dos subtipos dos receptores nmda |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816434A (en) * | 1966-06-24 | 1974-06-11 | Hoffmann La Roche | 4-(3-(4-phenyl-piperidino)-2-hydroxy-propoxy)-benzophenones |
| CH474511A (tr) * | 1966-06-24 | 1969-06-30 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | |
| NL133317C (tr) * | 1966-06-24 | 1900-01-01 | ||
| CH507239A (de) * | 1968-12-24 | 1971-05-15 | Hoffmann La Roche | Verfahren zur Herstellung von aromatischen Äthern |
| CH558354A (de) * | 1970-06-17 | 1975-01-31 | Hoffmann La Roche | Verfahren zur herstellung von aromatischen aethern. |
| JPS57145872A (en) * | 1981-03-05 | 1982-09-09 | Otsuka Pharmaceut Co Ltd | Carbostyrile derivative |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
-
1996
- 1996-04-29 US US08/639,386 patent/US5698565A/en not_active Expired - Fee Related
- 1996-06-04 WO PCT/EP1996/002430 patent/WO1996041629A1/en not_active Ceased
- 1996-06-04 AT AT96921928T patent/ATE198984T1/de not_active IP Right Cessation
- 1996-06-04 EP EP96921928A patent/EP0837680B1/en not_active Expired - Lifetime
- 1996-06-04 JP JP9502585A patent/JP3004732B2/ja not_active Expired - Lifetime
- 1996-06-04 ES ES96921928T patent/ES2154828T3/es not_active Expired - Lifetime
- 1996-06-04 PT PT96921928T patent/PT837680E/pt unknown
- 1996-06-04 TR TR97/01577T patent/TR199701577T1/tr unknown
- 1996-06-04 DE DE69611727T patent/DE69611727T2/de not_active Expired - Fee Related
- 1996-06-04 CA CA002222226A patent/CA2222226A1/en not_active Abandoned
- 1996-06-04 DK DK96921928T patent/DK0837680T3/da active
- 1996-06-04 BR BR9609196A patent/BR9609196A/pt not_active Application Discontinuation
- 1996-06-04 AU AU63003/96A patent/AU6300396A/en not_active Abandoned
-
2001
- 2001-04-05 GR GR20010400551T patent/GR3035703T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5698565A (en) | 1997-12-16 |
| ATE198984T1 (de) | 2001-02-15 |
| JPH10506651A (ja) | 1998-06-30 |
| DE69611727D1 (de) | 2001-03-08 |
| EP0837680A1 (en) | 1998-04-29 |
| ES2154828T3 (es) | 2001-04-16 |
| MX9709393A (es) | 1998-07-31 |
| JP3004732B2 (ja) | 2000-01-31 |
| PT837680E (pt) | 2001-07-31 |
| AU6300396A (en) | 1997-01-09 |
| DK0837680T3 (da) | 2001-05-07 |
| GR3035703T3 (en) | 2001-07-31 |
| CA2222226A1 (en) | 1996-12-27 |
| WO1996041629A1 (en) | 1996-12-27 |
| BR9609196A (pt) | 1999-05-11 |
| DE69611727T2 (de) | 2001-08-23 |
| EP0837680B1 (en) | 2001-01-31 |
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