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TR199701286T1 - Esters of carbapenems. - Google Patents

Esters of carbapenems.

Info

Publication number
TR199701286T1
TR199701286T1 TR97/01286T TR9701286T TR199701286T1 TR 199701286 T1 TR199701286 T1 TR 199701286T1 TR 97/01286 T TR97/01286 T TR 97/01286T TR 9701286 T TR9701286 T TR 9701286T TR 199701286 T1 TR199701286 T1 TR 199701286T1
Authority
TR
Turkey
Prior art keywords
carbapenems
esters
methyl
isobutyriloxymethyl
dioxylen
Prior art date
Application number
TR97/01286T
Other languages
Turkish (tr)
Inventor
Burton George
Frederick Moss Stephen
John Eglington Alfred
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508955.3A external-priority patent/GB9508955D0/en
Priority claimed from GBGB9508956.1A external-priority patent/GB9508956D0/en
Priority claimed from GBGB9508957.9A external-priority patent/GB9508957D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of TR199701286T1 publication Critical patent/TR199701286T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Formül (I)' in bir bilesimi, burada R; isobutiriloksimetil, (5-metil-2-okso-1,3-dioksilen-4-il) metil ve benzoiloksimetil' den olusan gruptan seçilir, bakteryal enfeksiyonlarin tedavisinde yararlidir.A compound of formula (I) wherein R is; isobutyriloxymethyl is selected from the group consisting of (5-methyl-2-oxo-1,3-dioxylen-4-yl) methyl and benzoyloxymethyl, it is useful in the treatment of bacterial infections.

TR97/01286T 1995-05-03 1996-05-02 Esters of carbapenems. TR199701286T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9508955.3A GB9508955D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508956.1A GB9508956D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508957.9A GB9508957D0 (en) 1995-05-03 1995-05-03 Novel compounds

Publications (1)

Publication Number Publication Date
TR199701286T1 true TR199701286T1 (en) 1998-02-21

Family

ID=27267696

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/01286T TR199701286T1 (en) 1995-05-03 1996-05-02 Esters of carbapenems.

Country Status (22)

Country Link
EP (1) EP0823910A1 (en)
JP (1) JPH11504910A (en)
KR (1) KR19990008355A (en)
CN (1) CN1185783A (en)
AR (1) AR005416A1 (en)
AU (1) AU5813996A (en)
BG (1) BG102014A (en)
BR (1) BR9608313A (en)
CA (1) CA2217990A1 (en)
CZ (1) CZ347597A3 (en)
EA (1) EA199700293A1 (en)
HU (1) HUP9801066A3 (en)
IL (1) IL118092A0 (en)
MA (1) MA23853A1 (en)
MX (1) MX9708421A (en)
NO (1) NO974994D0 (en)
OA (1) OA10632A (en)
PE (1) PE50697A1 (en)
PL (1) PL323141A1 (en)
SK (1) SK146497A3 (en)
TR (1) TR199701286T1 (en)
WO (1) WO1996034868A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902659A1 (en) 2006-06-23 2007-12-28 Pierre Fabre Medicament Sa DHA ESTER AND ITS USE IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES
WO2013157583A1 (en) * 2012-04-18 2013-10-24 大日本住友製薬株式会社 Novel carbapenem compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
AU7467194A (en) * 1993-08-18 1995-03-14 Sankyo Company Limited Crystalline carbapenem derivatives
CA2175054C (en) * 1993-10-29 2005-07-12 Steven Coulton 2-(pyrazol-3-yl)carbapenem derivatives

Also Published As

Publication number Publication date
EP0823910A1 (en) 1998-02-18
HUP9801066A2 (en) 1998-08-28
CZ347597A3 (en) 1998-08-12
SK146497A3 (en) 1998-05-06
NO974994L (en) 1997-10-30
NO974994D0 (en) 1997-10-30
BG102014A (en) 1998-11-30
MA23853A1 (en) 1996-12-31
BR9608313A (en) 1999-01-26
AR005416A1 (en) 1999-06-23
OA10632A (en) 2002-09-16
PL323141A1 (en) 1998-03-16
IL118092A0 (en) 1996-09-12
CA2217990A1 (en) 1996-11-07
EA199700293A1 (en) 1998-06-25
AU5813996A (en) 1996-11-21
JPH11504910A (en) 1999-05-11
HUP9801066A3 (en) 1999-01-28
CN1185783A (en) 1998-06-24
PE50697A1 (en) 1997-12-18
KR19990008355A (en) 1999-01-25
MX9708421A (en) 1998-02-28
WO1996034868A1 (en) 1996-11-07

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