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PE50697A1 - ANTIBACTERIAL COMPOUND OF CARBAPENEM AND PREPARATION PROCEDURE - Google Patents

ANTIBACTERIAL COMPOUND OF CARBAPENEM AND PREPARATION PROCEDURE

Info

Publication number
PE50697A1
PE50697A1 PE1996000312A PE00031296A PE50697A1 PE 50697 A1 PE50697 A1 PE 50697A1 PE 1996000312 A PE1996000312 A PE 1996000312A PE 00031296 A PE00031296 A PE 00031296A PE 50697 A1 PE50697 A1 PE 50697A1
Authority
PE
Peru
Prior art keywords
methyl
preparation procedure
carbapenem
antibacterial compound
dioxolen
Prior art date
Application number
PE1996000312A
Other languages
Spanish (es)
Inventor
George Burton
Stephen Frederick Moss
Alfred John Eglington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508955.3A external-priority patent/GB9508955D0/en
Priority claimed from GBGB9508956.1A external-priority patent/GB9508956D0/en
Priority claimed from GBGB9508957.9A external-priority patent/GB9508957D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE50697A1 publication Critical patent/PE50697A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A ANTIBIOTICOS DE FORMULA (I), EN DONDE: R ES a) ISOBUTIRILOXIMETILO; o b) BENZOILOMETILO; o c) (5-METIL-2-OXO-1,3-DIOXOLEN-4-IL)METILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE: TRATAR UN COMPUESTO (I), EN DONDE: R ES UN CATION DE METAL ALCALINO, CON A) XCH2OCOCH(CH3)2; o B) XCH2OCOC6H5; o C) (5-METIL-2-OXO-1,3-DIOXOLEN-4-IL)METILO DE X, EN DONDE X ES UN GRUPO SALIENTE. ESTOS ANTIBIOTICOS SE CARACTERIZAN POR SER PARTICULARMENTE EFICACES FRENTE A ORGANISMOS PRODUCTORES DE BETA LACTAMASA, PRESENTANDO COMO VENTAJA DIFERENCIAL UNA ESTABILIDAD MEJORADA A LA ACCION HIDROLITICA DE LA ENZIMA RENAL DESHIDROPEPTIDASA-1IT REFERS TO ANTIBIOTICS OF FORMULA (I), WHERE: R IS a) ISOBUTIRILOXIMETILO; or b) BENZOILOMETILO; or c) (5-METHYL-2-OXO-1,3-DIOXOLEN-4-IL) METHYL. IT ALSO REFERS TO THE PREPARATION PROCEDURE OF (I), WHICH INCLUDES: TREATING A COMPOUND (I), WHERE: R IS AN ALKALINE METAL CATION, WITH A) XCH2OCOCH (CH3) 2; or B) XCH2OCOC6H5; or C) (5-METHYL-2-OXO-1,3-DIOXOLEN-4-IL) METHYL OF X, WHERE X IS AN OUTGOING GROUP. THESE ANTIBIOTICS ARE CHARACTERIZED FOR BEING PARTICULARLY EFFECTIVE AGAINST BETA LACTAMASE PRODUCING AGENCIES, PRESENTING AS A DIFFERENTIAL ADVANTAGE A HYDROLYTIC STABILITY OF THE RENAL DEHYDROPEPTIDASE-1

PE1996000312A 1995-05-03 1996-05-03 ANTIBACTERIAL COMPOUND OF CARBAPENEM AND PREPARATION PROCEDURE PE50697A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9508955.3A GB9508955D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508956.1A GB9508956D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508957.9A GB9508957D0 (en) 1995-05-03 1995-05-03 Novel compounds

Publications (1)

Publication Number Publication Date
PE50697A1 true PE50697A1 (en) 1997-12-18

Family

ID=27267696

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000312A PE50697A1 (en) 1995-05-03 1996-05-03 ANTIBACTERIAL COMPOUND OF CARBAPENEM AND PREPARATION PROCEDURE

Country Status (22)

Country Link
EP (1) EP0823910A1 (en)
JP (1) JPH11504910A (en)
KR (1) KR19990008355A (en)
CN (1) CN1185783A (en)
AR (1) AR005416A1 (en)
AU (1) AU5813996A (en)
BG (1) BG102014A (en)
BR (1) BR9608313A (en)
CA (1) CA2217990A1 (en)
CZ (1) CZ347597A3 (en)
EA (1) EA199700293A1 (en)
HU (1) HUP9801066A3 (en)
IL (1) IL118092A0 (en)
MA (1) MA23853A1 (en)
MX (1) MX9708421A (en)
NO (1) NO974994D0 (en)
OA (1) OA10632A (en)
PE (1) PE50697A1 (en)
PL (1) PL323141A1 (en)
SK (1) SK146497A3 (en)
TR (1) TR199701286T1 (en)
WO (1) WO1996034868A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902659A1 (en) 2006-06-23 2007-12-28 Pierre Fabre Medicament Sa DHA ESTER AND ITS USE IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES
WO2013157583A1 (en) * 2012-04-18 2013-10-24 大日本住友製薬株式会社 Novel carbapenem compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
AU7467194A (en) * 1993-08-18 1995-03-14 Sankyo Company Limited Crystalline carbapenem derivatives
CA2175054C (en) * 1993-10-29 2005-07-12 Steven Coulton 2-(pyrazol-3-yl)carbapenem derivatives

Also Published As

Publication number Publication date
EP0823910A1 (en) 1998-02-18
HUP9801066A2 (en) 1998-08-28
CZ347597A3 (en) 1998-08-12
SK146497A3 (en) 1998-05-06
NO974994L (en) 1997-10-30
NO974994D0 (en) 1997-10-30
BG102014A (en) 1998-11-30
MA23853A1 (en) 1996-12-31
BR9608313A (en) 1999-01-26
AR005416A1 (en) 1999-06-23
OA10632A (en) 2002-09-16
PL323141A1 (en) 1998-03-16
IL118092A0 (en) 1996-09-12
CA2217990A1 (en) 1996-11-07
EA199700293A1 (en) 1998-06-25
AU5813996A (en) 1996-11-21
JPH11504910A (en) 1999-05-11
HUP9801066A3 (en) 1999-01-28
CN1185783A (en) 1998-06-24
KR19990008355A (en) 1999-01-25
MX9708421A (en) 1998-02-28
TR199701286T1 (en) 1998-02-21
WO1996034868A1 (en) 1996-11-07

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