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TNSN07066A1 - Inhibiteurs de l'arn-polymerase, dependant d'arn, du virus de l'hepatite c, et compositions et traitements les utilisant - Google Patents

Inhibiteurs de l'arn-polymerase, dependant d'arn, du virus de l'hepatite c, et compositions et traitements les utilisant

Info

Publication number
TNSN07066A1
TNSN07066A1 TNP2007000066A TNSN07066A TNSN07066A1 TN SN07066 A1 TNSN07066 A1 TN SN07066A1 TN P2007000066 A TNP2007000066 A TN P2007000066A TN SN07066 A TNSN07066 A TN SN07066A TN SN07066 A1 TNSN07066 A1 TN SN07066A1
Authority
TN
Tunisia
Prior art keywords
rna
hepatitis
virus
treatments
compositions
Prior art date
Application number
TNP2007000066A
Other languages
English (en)
Inventor
Javier Gonzalaz
Tanya Michelle Jewell
Hui Li
Angelica Linton
John Howard Tatlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN07066A1 publication Critical patent/TNSN07066A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention propose des composés de formule (4), Et leurs sels et produits de solvatation pharmaceutiquement acceptables, qui sont utiles comme inhibiteurs de l'enzyme polymérase du virus de l'hépatite c (HCV) et qui sont également utiles pour le traitement d'infections par le HCV chez des mammifères infectés par le HCV. La présente invention propose également des compositions pharmaceutiques comprenant des composés de formule (4), ou leurs sels ou produits de solvatation pharmaceutiquement acceptables. En outre, la présente invention propose des composés intermédiaires et des procédés utiles dans la préparation des composés de formule (4).
TNP2007000066A 2004-08-18 2007-02-16 Inhibiteurs de l'arn-polymerase, dependant d'arn, du virus de l'hepatite c, et compositions et traitements les utilisant TNSN07066A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60261804P 2004-08-18 2004-08-18
PCT/IB2005/002697 WO2006018725A1 (fr) 2004-08-18 2005-08-05 Inhibiteurs de polymerase d'arn dependant d'arn du virus de l'hepatite c et compositions et traitement utilisant ces inhibiteurs

Publications (1)

Publication Number Publication Date
TNSN07066A1 true TNSN07066A1 (fr) 2008-06-02

Family

ID=35429645

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000066A TNSN07066A1 (fr) 2004-08-18 2007-02-16 Inhibiteurs de l'arn-polymerase, dependant d'arn, du virus de l'hepatite c, et compositions et traitements les utilisant

Country Status (42)

Country Link
US (3) US7151105B2 (fr)
EP (1) EP1781662B1 (fr)
JP (1) JP4372195B2 (fr)
KR (1) KR100851178B1 (fr)
CN (2) CN101538268B (fr)
AP (1) AP2313A (fr)
AR (1) AR050699A1 (fr)
AT (1) ATE506364T1 (fr)
AU (1) AU2005273619B2 (fr)
BR (1) BRPI0514425A (fr)
CA (1) CA2577525C (fr)
CR (2) CR8935A (fr)
CY (1) CY1111480T1 (fr)
DE (1) DE602005027580D1 (fr)
DK (1) DK1781662T3 (fr)
EA (1) EA012605B1 (fr)
EC (1) ECSP077264A (fr)
ES (1) ES2361845T3 (fr)
GE (2) GEP20094751B (fr)
GT (1) GT200500221A (fr)
HN (1) HN2005000449A (fr)
HR (1) HRP20110458T1 (fr)
IL (2) IL180933A (fr)
MA (1) MA28803B1 (fr)
MX (1) MX2007001527A (fr)
MY (1) MY146123A (fr)
NI (1) NI200700043A (fr)
NL (1) NL1029755C2 (fr)
NO (1) NO20071274L (fr)
NZ (1) NZ552874A (fr)
PE (1) PE20060677A1 (fr)
PL (1) PL1781662T3 (fr)
PT (1) PT1781662E (fr)
RS (1) RS51794B (fr)
SI (1) SI1781662T1 (fr)
SV (1) SV2007002202A (fr)
TN (1) TNSN07066A1 (fr)
TW (1) TWI376379B (fr)
UA (1) UA88909C2 (fr)
UY (1) UY29068A1 (fr)
WO (1) WO2006018725A1 (fr)
ZA (1) ZA200700779B (fr)

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Also Published As

Publication number Publication date
RS51794B (sr) 2011-12-31
ZA200700779B (en) 2008-11-26
ATE506364T1 (de) 2011-05-15
NL1029755C2 (nl) 2006-10-18
WO2006018725A1 (fr) 2006-02-23
SV2007002202A (es) 2007-03-20
AP2313A (en) 2011-10-31
HK1109617A1 (en) 2008-06-13
UY29068A1 (es) 2006-03-31
AP2007003918A0 (en) 2007-02-28
IL180933A0 (en) 2007-07-04
EA012605B1 (ru) 2009-10-30
NO20071274L (no) 2007-05-14
HN2005000449A (es) 2009-10-30
US20060122399A1 (en) 2006-06-08
DK1781662T3 (da) 2011-06-27
DE602005027580D1 (de) 2011-06-01
HRP20110458T1 (hr) 2011-07-31
UA88909C2 (ru) 2009-12-10
US7151105B2 (en) 2006-12-19
CN101538268A (zh) 2009-09-23
CN101006092B (zh) 2013-04-17
AU2005273619A1 (en) 2006-02-23
SI1781662T1 (sl) 2011-07-29
US7622605B2 (en) 2009-11-24
PT1781662E (pt) 2011-07-01
KR100851178B1 (ko) 2008-08-08
CR8935A (es) 2007-07-24
PE20060677A1 (es) 2006-08-11
KR20070044057A (ko) 2007-04-26
CN101538268B (zh) 2011-07-27
AU2005273619B2 (en) 2009-05-28
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GT200500221A (es) 2006-06-21
JP4372195B2 (ja) 2009-11-25
ES2361845T3 (es) 2011-06-22
US20070015764A1 (en) 2007-01-18
EA200700338A1 (ru) 2007-08-31
CA2577525C (fr) 2010-03-30
GEP20115305B (en) 2011-10-10
US8268835B2 (en) 2012-09-18
TW200612898A (en) 2006-05-01
MX2007001527A (es) 2007-03-27
CN101006092A (zh) 2007-07-25
MA28803B1 (fr) 2007-08-01
NI200700043A (es) 2008-01-02
CA2577525A1 (fr) 2006-02-23
MY146123A (en) 2012-06-29
CR20110153A (es) 2011-04-26
IL192919A0 (en) 2009-02-11
BRPI0514425A (pt) 2008-06-10
JP2008509984A (ja) 2008-04-03
EP1781662B1 (fr) 2011-04-20
US20090281122A1 (en) 2009-11-12
IL180933A (en) 2011-08-31
CY1111480T1 (el) 2015-08-05
ECSP077264A (es) 2007-04-26
EP1781662A1 (fr) 2007-05-09
NL1029755A1 (nl) 2006-02-21
TWI376379B (en) 2012-11-11
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AR050699A1 (es) 2006-11-15
PL1781662T3 (pl) 2011-08-31

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