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TNSN00104A1 - Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN00104A1
TNSN00104A1 TNTNSN00104A TNSN00104A TNSN00104A1 TN SN00104 A1 TNSN00104 A1 TN SN00104A1 TN TNSN00104 A TNTNSN00104 A TN TNSN00104A TN SN00104 A TNSN00104 A TN SN00104A TN SN00104 A1 TNSN00104 A1 TN SN00104A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isothiazole derivatives
novel isothiazole
Prior art date
Application number
TNTNSN00104A
Other languages
English (en)
Inventor
George Gant Thomas
Carl Noe Mark
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN00104A1 publication Critical patent/TNSN00104A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE 1 : DANS LAQUELLE Z, X, X1, R1, R2 ET R3 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT D'AFFECTIONS A MEDIATION PAR L'ANGIOGENESE CHEZ DES MAMMIFERES.
TNTNSN00104A 1999-05-19 2000-05-17 Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN00104A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13493399P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
TNSN00104A1 true TNSN00104A1 (fr) 2005-11-10

Family

ID=22465672

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN00104A TNSN00104A1 (fr) 1999-05-19 2000-05-17 Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (21)

Country Link
US (1) US6380214B1 (fr)
EP (1) EP1187826B1 (fr)
JP (2) JP3692041B2 (fr)
AR (1) AR029634A1 (fr)
AT (1) ATE349440T1 (fr)
AU (1) AU4137400A (fr)
BR (1) BR0010746A (fr)
CA (1) CA2374247C (fr)
CO (1) CO5170417A1 (fr)
DE (1) DE60032601T2 (fr)
DZ (1) DZ3042A1 (fr)
ES (1) ES2276681T3 (fr)
GT (1) GT200000069A (fr)
HN (1) HN2000000051A (fr)
MA (1) MA26733A1 (fr)
MX (1) MXPA01011920A (fr)
PA (1) PA8494101A1 (fr)
PE (1) PE20010152A1 (fr)
TN (1) TNSN00104A1 (fr)
UY (1) UY26143A1 (fr)
WO (1) WO2000071532A1 (fr)

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ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
AU2972701A (en) 2000-02-07 2001-08-14 Bristol Myers Squibb Co 3-aminopyrazole inhibitors of cyclin dependent kinases
GB0003154D0 (en) 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
BR0210357A (pt) * 2001-06-11 2004-06-29 Shire Biochem Inc Composto e métodos para o tratamento ou a prevenção de infecções pelo flavivìrus
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
SE0102617D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
US6989451B2 (en) * 2002-06-04 2006-01-24 Valeant Research & Development Heterocyclic compounds and uses thereof
AU2003232551A1 (en) * 2002-06-13 2003-12-31 Qlt Inc. Methods of using isothiazole derivatives to treat cancer or inflammation
JP4493494B2 (ja) * 2002-07-09 2010-06-30 ファスゲン，インク． ヒトおよび動物における微生物感染症の治療方法
WO2004005277A1 (fr) * 2002-07-09 2004-01-15 Fasgen, Inc. Nouveaux composés, compositions pharmaceutiques les contenant et méthodes d'utilisation desdits composés
AU2003281664A1 (en) 2002-07-25 2004-02-16 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
CA2506546A1 (fr) * 2002-11-15 2004-06-17 Exelixis, Inc. Modulateurs de kinase
DE60332482D1 (de) * 2002-12-10 2010-06-17 Virochem Pharma Inc Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen
SE0300091D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300092D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
EP1602647B1 (fr) * 2003-03-07 2013-10-16 Santen Pharmaceutical Co., Ltd. Nouveau compose comprenant un groupe 4-pyridylalkylthio utilise comme substitutif
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
NZ544920A (en) 2003-07-23 2009-11-27 Bayer Healthcare Llc 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
ES2368153T3 (es) * 2004-02-17 2011-11-14 Santen Pharmaceutical Co., Ltd. Nuevo compuesto cíclico que presenta un grupo 4-piridilalquiltio que presenta amino (no) sustituido introducido en el mismo.
PL1717229T3 (pl) * 2004-02-17 2011-11-30 Santen Pharmaceutical Co Ltd Nowy cykliczny związek mający grupę 4-pirydyloalkilotiolową z wprowadzoną do niej (nie)podstawioną grupą aminową
JP4626353B2 (ja) * 2004-02-17 2011-02-09 参天製薬株式会社 置換又は無置換アミノ基を導入した４−ピリジルアルキルチオ基を有する新規環式化合物
EP1735284A1 (fr) 2004-03-18 2006-12-27 Pfizer Limited Sulfamides n-(1-arylpyrazol-4l) et leur utilisation en tant qu'anti-parasitaires
CA2564325A1 (fr) 2004-04-30 2005-11-24 Bayer Pharmaceuticals Corporation Derives de pyrazolyl uree substitues utiles dans le traitement du cancer
CA2578023C (fr) * 2004-08-26 2012-05-15 Pfizer Products Inc. Procedes de preparation de derives d'isothiazole
JP4585978B2 (ja) * 2005-03-03 2010-11-24 参天製薬株式会社 キノリルアルキルチオ基を有する新規環式化合物
MX2007014117A (es) * 2005-05-13 2008-02-05 Virochem Pharma Inc Compuestos y metodos para el tratamiento o prevencion de infecciones de flavivirus.
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
AP2579A (en) 2006-11-15 2013-01-29 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
CA2678735A1 (fr) * 2007-02-26 2008-09-04 Santen Pharmaceutical Co., Ltd. Nouveau derive de pyrrole ayant un groupe ureide et un groupe aminocarbonyle comme substituants
WO2008153042A1 (fr) * 2007-06-11 2008-12-18 Kyowa Hakko Kirin Co., Ltd. Agent antitumoral
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2010151710A2 (fr) * 2009-06-25 2010-12-29 Medolution Limited Composés hétérocycliques substitués utilisés en tant qu'inhibiteurs de la kinase et leur procédé d'utilisation
MX2014011115A (es) 2012-03-16 2015-03-13 Axikin Pharmaceuticals Inc Inhibidores de 3,5-diaminopirazol cinasa.
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
MY191736A (en) 2014-12-23 2022-07-13 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors

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Also Published As

Publication number Publication date
DZ3042A1 (fr) 2004-03-27
AR029634A1 (es) 2003-07-10
DE60032601T2 (de) 2007-11-15
PA8494101A1 (es) 2003-09-05
GT200000069A (es) 2001-11-08
ES2276681T3 (es) 2007-07-01
WO2000071532A1 (fr) 2000-11-30
HN2000000051A (es) 2001-02-02
BR0010746A (pt) 2002-02-13
CO5170417A1 (es) 2002-06-27
JP2003500401A (ja) 2003-01-07
MA26733A1 (fr) 2004-12-20
UY26143A1 (es) 2000-12-29
MXPA01011920A (es) 2002-05-06
ATE349440T1 (de) 2007-01-15
JP2005008641A (ja) 2005-01-13
EP1187826B1 (fr) 2006-12-27
US6380214B1 (en) 2002-04-30
DE60032601D1 (de) 2007-02-08
PE20010152A1 (es) 2001-02-08
CA2374247C (fr) 2008-01-22
AU4137400A (en) 2000-12-12
CA2374247A1 (fr) 2000-11-30
JP3692041B2 (ja) 2005-09-07
EP1187826A1 (fr) 2002-03-20

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