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TNSN00153A1 - NEW PROCESS FOR OBTAINING 2- (2- PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDO-AZOL DERIVATIVES - Google Patents

NEW PROCESS FOR OBTAINING 2- (2- PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDO-AZOL DERIVATIVES

Info

Publication number
TNSN00153A1
TNSN00153A1 TNTNSN00153A TNSN00153A TNSN00153A1 TN SN00153 A1 TNSN00153 A1 TN SN00153A1 TN TNSN00153 A TNTNSN00153 A TN TNSN00153A TN SN00153 A TNSN00153 A TN SN00153A TN SN00153 A1 TNSN00153 A1 TN SN00153A1
Authority
TN
Tunisia
Prior art keywords
pyridinylmethylsulfinyl
benzimido
radical
obtaining
new process
Prior art date
Application number
TNTNSN00153A
Other languages
French (fr)
Inventor
Fau De Casa Miguel
Juana-Muno
Maria Gelpi Vintro Jose
Molina Ponce Andres
Cosme Gome Antonio
Original Assignee
Sint Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sint Quimica Sa filed Critical Sint Quimica Sa
Publication of TNSN00153A1 publication Critical patent/TNSN00153A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDE DE PREPARATION DE DERIVES DE 2-(2- PYRIDINYLMETHYLSULFINYLE)-1H-BENZIMIDO-AZOL DE FORMULE GENERALE (I) : DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ALCOYLE ; R' REPRESENTE UNE CHAINE D'ALCOYLES, QUI PEUT ETRE INTERROMPUE OU NON PAR UN ATOME D'OXYGENE ; R" REPRESENTE UN RADICAL ALCOYLE OU ALCOXY ; R"' REPRESENTE UN ATOME D'HYDROGENE OU UN RESTE ALCOXY QUI PEUT ETRE REMPLACE OU NON, CARACTERISE PAR LE FAIT QUE LEDIT PROCEDE SE MENE A BOUT AU MOYEN DE LA SUBSTITUTION D'UN HALOGENE DANS LA POSITION "4" DE L'ANNEAU DE PYRIDINE DES COMPOSANTS DE FORMULE GENERALE (VIII) PAR UN ALCOXYDE EN PRESENCE D'UNE BASE ET AU SEIN D'UN SOLVANT POLAIRE APROTIQUE ; OU IL SE MENE A BOUT AU MOYEN DE LA SUBSTITUTION D'UN GROUPE "NITRE" DANS LA POSITION "4" DE L'ANNEAU DE PYRIDINE DES COMPOSANTS DE FORMULE (XVII) PAR UN RADICAL ALCOXYDE R'O- EN PRESENCE D'UNE BASE ET AU SEIN D'UN MELANGE DE SOVANTS CONSTITUE PAR L'ALCOOL R'OH CORRESPONDANT ET UN AUTRE SOLVANTS POLAIRE APROTIQUE.PROCESS FOR THE PREPARATION OF 2- (2- PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDO-AZOL DERIVATIVES OF GENERAL FORMULA (I): IN WHICH R REPRESENTS A HYDROGEN ATOM OR AN ALKYL RADICAL; REPRESENTS A CHAIN OF ALCOYLS, WHICH MAY BE INTERRUPTED OR NOT BY AN OXYGEN ATOM; R "REPRESENTS AN ALCOYL OR ALCOXY RADICAL; R" 'REPRESENTS A HYDROGEN ATOM OR AN ALCOXY REMAINING WHICH CAN BE REPLACED OR NOT, CHARACTERIZED BY THE FACT THAT SUCH SUBSTITUTION OF A HALOGEN IS POSITION "4" OF THE PYRIDINE RING OF THE COMPONENTS OF GENERAL FORMULA (VIII) BY AN ALCOXIDE IN THE PRESENCE OF A BASE AND WITHIN AN APROTIC POLAR SOLVENT; OR IT IS TAKEN TO END BY MEANS OF THE SUBSTITUTION OF A GROUP "NITER" IN POSITION "4" OF THE PYRIDINE RING OF THE COMPONENTS OF FORMULA (XVII) BY A RADICAL ALCOXIDE R'O- IN THE PRESENCE OF A BASE AND WITHIN A MIXTURE OF SOVANTS CONSTITUTED BY THE CORRESPONDING R'OH ALCOHOL AND ANOTHER APROTIC POLAR SOLVENTS.

TNTNSN00153A 1999-07-14 2000-07-31 NEW PROCESS FOR OBTAINING 2- (2- PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDO-AZOL DERIVATIVES TNSN00153A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901579A ES2166269B1 (en) 1999-07-14 1999-07-14 NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.

Publications (1)

Publication Number Publication Date
TNSN00153A1 true TNSN00153A1 (en) 2002-05-30

Family

ID=8309223

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN00153A TNSN00153A1 (en) 1999-07-14 2000-07-31 NEW PROCESS FOR OBTAINING 2- (2- PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDO-AZOL DERIVATIVES

Country Status (6)

Country Link
AU (1) AU5558800A (en)
EG (1) EG23175A (en)
ES (1) ES2166269B1 (en)
SV (1) SV2002000126A (en)
TN (1) TNSN00153A1 (en)
WO (1) WO2001004109A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2185459B1 (en) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa PROCEDURE FOR OBTAINING PANTOPRAZOL AND INTERMEDIATE COMPOUNDS FOR THE SAME.
WO2003101452A1 (en) * 2002-06-03 2003-12-11 Aurobindo Pharma Ltd. Process for the preparation of highly pure rabeprazole sodium salt
EP1572680A2 (en) 2002-12-19 2005-09-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation.
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
AU2003288703A1 (en) * 2003-12-05 2005-06-24 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
SE0400410D0 (en) 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US7557217B2 (en) 2004-06-30 2009-07-07 Eisai R&D Management Co., Ltd. Process for production of benzimidazole derivative salt precipitate
AU2005315390B2 (en) * 2004-12-16 2011-10-27 Cipla Limited Process for the preparation of pantoprazole sodium
ES2264362B1 (en) * 2004-12-22 2007-11-01 Laboratorios Viñas S.A. "PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSUFINIL-1H-BENZIMIDAZOLES").
ATE473222T1 (en) * 2005-02-21 2010-07-15 Ltd Cipla NEW METHOD FOR SYNTHESIS OF PROTON PUMP INHIBITORS
ES2273564B1 (en) * 2005-03-22 2008-04-01 Quimica Sintetica, S.A. PROCEDURE FOR THE PREPARATION OF PANTOPRAZOLE.
JP2008534578A (en) * 2005-03-30 2008-08-28 ルピン・リミテッド Improved preparation of rabeprazole sodium
MX2010010049A (en) * 2008-03-18 2010-10-04 Reddys Lab Ltd Dr Dexlansoprazole process and polymorphs.
KR20130087509A (en) 2010-06-24 2013-08-06 씨아이피엘에이 엘티디. Salt and polymorphs of dexrabeprazole
CN102993181B (en) * 2012-12-26 2014-07-23 山东大学 Preparation method of esomeprazole and preparation method of esomeprazole salt
CN104098516B (en) * 2013-04-15 2016-12-28 北大方正集团有限公司 A kind of intermediate for preparing esomeprazole or its sodium salt and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES2037608B1 (en) * 1991-12-02 1994-04-01 Techquin Etablissment PROCEDURE FOR OBTAINING 2 (((3-METHYL-4- (2,2,2, -TRIFLUOROETOXI) -2-PIRIDINIL) -METIL) SULFINIL) -1H-BENZIMIDAZOLE ".
ES2037609B1 (en) * 1991-12-02 1994-04-01 Techquin Etablissment PROCEDURE FOR OBTAINING 2 - ((((3-METHYL-4- (2,2,2-TRIFLUROETOXI) -2-PIRIDINIL) -METIL) SULFINIL) -1H-BENZIMIDAZOLE.
ES2060541B1 (en) * 1993-02-26 1995-11-16 Vinas Lab NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Also Published As

Publication number Publication date
SV2002000126A (en) 2002-02-05
ES2166269A1 (en) 2002-04-01
WO2001004109A1 (en) 2001-01-18
ES2166269B1 (en) 2003-04-01
AU5558800A (en) 2001-01-30
EG23175A (en) 2004-06-30

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