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SV2002000126A - NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL REF. A-149206 - Google Patents

NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL REF. A-149206

Info

Publication number
SV2002000126A
SV2002000126A SV2000000126A SV2000000126A SV2002000126A SV 2002000126 A SV2002000126 A SV 2002000126A SV 2000000126 A SV2000000126 A SV 2000000126A SV 2000000126 A SV2000000126 A SV 2000000126A SV 2002000126 A SV2002000126 A SV 2002000126A
Authority
SV
El Salvador
Prior art keywords
piridinilmetilsulfinil
benzimidazol
ref
obtaining derivatives
new procedure
Prior art date
Application number
SV2000000126A
Other languages
Spanish (es)
Inventor
Casa-Juana Munoz Miguel Fau De
Antonio Cosme Gomez
Vintro Jose Maria Gelpi
Ponce Andres Molina
Original Assignee
Sint Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sint Quimica Sa filed Critical Sint Quimica Sa
Publication of SV2002000126A publication Critical patent/SV2002000126A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 2-(2- PIRIDINILMETILSULFINIL)-1H-BENZIMIDAZOL DE FORMULA GENERAL (I), DONDE R= H O ALQUILO; R'= CADENA ALQUILICA INTERRUMPIDA O NO POR 0, R''=ALQUILO O ALCOXI; R'''=H O ALCOXI SUBSTITUIDO O NO, CARACTERIZADO PORQUE SE LLEVA A CABO MEDIANTE LA SUBSTITUCION DE UN HALOGENO EN LA POSICION 4 DEL ANILLO DE PIRIDINA DE LOS COMPUESTOS DE FORMULA GENERAL(VIII) POR 3-METOXI PROPANO O METANOL EN PRESENCIA DE UNA BASE Y EN EL SENO DE UNA MEZCLA DE DISOLVENTES CONSTITUIDA POR EL CORRESPONDIENTE ALCOHOL R'OH Y OTRO DISOLVENTE POLAR APROTICO. ES UTIL EN EL TRATAMIENTO O PREVENCION DE LAS ULCERAS PEPTICAS.PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2- PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL OF GENERAL FORMULA (I), WHERE R = H OR RENT; R '= ALKYL CHAIN INTERRUPTED OR NOT BY 0, R' '= RENT OR ALCOXI; R '' '= HO ALCOXI SUBSTITUTED OR NOT, CHARACTERIZED BECAUSE IT IS CARRIED OUT BY REPLACING A HALOGEN IN POSITION 4 OF THE PIRIDINE RING OF THE GENERAL FORMULA COMPOUNDS (VIII) BY 3-METOXI PROPANE OR METHANOL IN THE PRESENCE OF A BASE AND IN THE BREAST OF A MIXTURE OF SOLVENTS CONSTITUTED BY THE CORRESPONDING ALCOHOL R'OH AND ANOTHER APROTIC POLAR SOLVENT. IT IS USEFUL IN THE TREATMENT OR PREVENTION OF PEPTIC ULCERAS.

SV2000000126A 1999-07-14 2000-07-13 NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL REF. A-149206 SV2002000126A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901579A ES2166269B1 (en) 1999-07-14 1999-07-14 NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.

Publications (1)

Publication Number Publication Date
SV2002000126A true SV2002000126A (en) 2002-02-05

Family

ID=8309223

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000126A SV2002000126A (en) 1999-07-14 2000-07-13 NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL REF. A-149206

Country Status (6)

Country Link
AU (1) AU5558800A (en)
EG (1) EG23175A (en)
ES (1) ES2166269B1 (en)
SV (1) SV2002000126A (en)
TN (1) TNSN00153A1 (en)
WO (1) WO2001004109A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2185459B1 (en) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa PROCEDURE FOR OBTAINING PANTOPRAZOL AND INTERMEDIATE COMPOUNDS FOR THE SAME.
WO2003101452A1 (en) * 2002-06-03 2003-12-11 Aurobindo Pharma Ltd. Process for the preparation of highly pure rabeprazole sodium salt
EP1572680A2 (en) 2002-12-19 2005-09-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation.
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
AU2003288703A1 (en) * 2003-12-05 2005-06-24 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
SE0400410D0 (en) 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US7557217B2 (en) 2004-06-30 2009-07-07 Eisai R&D Management Co., Ltd. Process for production of benzimidazole derivative salt precipitate
AU2005315390B2 (en) * 2004-12-16 2011-10-27 Cipla Limited Process for the preparation of pantoprazole sodium
ES2264362B1 (en) * 2004-12-22 2007-11-01 Laboratorios Viñas S.A. "PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSUFINIL-1H-BENZIMIDAZOLES").
ATE473222T1 (en) * 2005-02-21 2010-07-15 Ltd Cipla NEW METHOD FOR SYNTHESIS OF PROTON PUMP INHIBITORS
ES2273564B1 (en) * 2005-03-22 2008-04-01 Quimica Sintetica, S.A. PROCEDURE FOR THE PREPARATION OF PANTOPRAZOLE.
JP2008534578A (en) * 2005-03-30 2008-08-28 ルピン・リミテッド Improved preparation of rabeprazole sodium
MX2010010049A (en) * 2008-03-18 2010-10-04 Reddys Lab Ltd Dr Dexlansoprazole process and polymorphs.
KR20130087509A (en) 2010-06-24 2013-08-06 씨아이피엘에이 엘티디. Salt and polymorphs of dexrabeprazole
CN102993181B (en) * 2012-12-26 2014-07-23 山东大学 Preparation method of esomeprazole and preparation method of esomeprazole salt
CN104098516B (en) * 2013-04-15 2016-12-28 北大方正集团有限公司 A kind of intermediate for preparing esomeprazole or its sodium salt and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES2037608B1 (en) * 1991-12-02 1994-04-01 Techquin Etablissment PROCEDURE FOR OBTAINING 2 (((3-METHYL-4- (2,2,2, -TRIFLUOROETOXI) -2-PIRIDINIL) -METIL) SULFINIL) -1H-BENZIMIDAZOLE ".
ES2037609B1 (en) * 1991-12-02 1994-04-01 Techquin Etablissment PROCEDURE FOR OBTAINING 2 - ((((3-METHYL-4- (2,2,2-TRIFLUROETOXI) -2-PIRIDINIL) -METIL) SULFINIL) -1H-BENZIMIDAZOLE.
ES2060541B1 (en) * 1993-02-26 1995-11-16 Vinas Lab NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Also Published As

Publication number Publication date
ES2166269A1 (en) 2002-04-01
WO2001004109A1 (en) 2001-01-18
TNSN00153A1 (en) 2002-05-30
ES2166269B1 (en) 2003-04-01
AU5558800A (en) 2001-01-30
EG23175A (en) 2004-06-30

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